检索结果-南通市图书馆

Understanding of tip clearance flow structure in high speed mixed flow compressor

在线全文

学校读者我要写书评

暂无评论

Propulsion and Power Research 2023年第3期12卷 356-379页

作者： Hemant Kumar Chetan S.mistry department of Aerospace Engineering Indian Institute of TechnologyKharagpurWest Bengal 721302India

This paper addresses the necessity to make a physical interpretation of a highly complex three-dimensional tip clearance flow field study for high-speed mixed-flow compressor having stage exit static pressure to inlet total pressure ratio of 3.8 with 39,836 rpm rotor *** four different tip configurations namely the constant(l Z 0.016 and 0.019)and variable(l Z 0.011(inlet)-0.019(exit)and 0.019(inlet)-0.022(exit))tip clearances were numerically analysed using available experimental *** numerical investigation reveals that in contrast to the classic jet-wake pattern,two anomalous velocity profiles formed at the impeller exit which results in pressure losses in the vaneless *** the impeller inlet,the tip leakage flow rolls up to discrete tip leakage vortex structure for each tip clearance *** results in the formation of a region of momentum deficit,recirculation zone,which gets weakened as it moves *** tip clearance configuration is observed to profoundly influence the extent and vorticity of the tip leakage *** the splitter blade passage,the tip leakage flow and Coriolis flow interact with passage flow,resulting in the formation of two secondary passage vortices that move downstream along the pressure and suction surface of the splitter *** tip clearance configuration directly influences the impeller exit jetwake pattern by modulating the secondary passage vortices trajectory and ***,off-design analysis for tip clearances l Z 0.016 and l Z 0.019,depict distinctive tip leakage vortex *** operating near the stall conditions(80%of design mass flow rate),l Z 0.019 exhibits bubble shape tip leakage vortex breakdown occurring near the impeller *** result in a substantial change in the tip leakage vortex nature;expansion of the recirculation zone and early weakening of the vorticity in the tip leakage *** is observed that vortex breakdown plays a vital role in characte

关键词： Recirculation zone Vortex breakdown Tip leakage flow Mixed-flow compressor Jet-wake flow Vaned-diffuser

Flor Revisited(Again):eQTL and Mutational Analysis of NB-LRR Mediated Immunity to Powdery Mildew in Barley

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2014年第2期13卷 237-243页

作者： Roger Wise Priyanka Surana Greg Fuerst Ruo Xu Divya mistry Julie Dickerson Dan Nettleton Corn Insects and Crop Genetics Research Unit U.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011USA department of Plant Pathology & Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011USA department of Statistics Iowa State UniversityAmesIowa 50011USA department of Electrical and Computer Engineering Iowa State UniversityAmesIowa 50011USA

Genes encoding early signaling events in pathogen defense often are identified only by their phenotype. Such genes involved in barley-powdery mildew interactions include Mla, specifying race-specific resistance; Rarl （Required for Mla12-specified resistance1）, and Roml （Restoration of Mla-specified resistancel）. The HSP90-SGT1-RAR1 complex appears to function as chaperone in MLA-specified resistance, however, much remains to be discovered regarding the precise signaling underlying plant immunity. Genetic analyses of fast-neutron mutants derived from CI 16151 （Mla6） uncovered a novel locus, designated Rar3 （R_equired for Mla6-specified resitance3）. Rar3 segregates independent of Mla6 and Rarl, and rar3 mutants are susceptible to Blumeria graminis f. sp. hordei （Bgh） isolate 5874 （A VRar）, whereas, wild-type progenitor plants are resistant. Comparative expression analyses of the rar3 mutant vs. its wild-type progenitor were conducted via Barleyl GeneChip and GAIIx paired-end RNA-Seq. Whereas Rarl affects transcription of relatively few genes; Rar3 appears to influence thousands, notably in genes controlling ATP binding, catalytic activity, transcription, and phosphorylation; possibly membrane bound or in the nucleus, eQTL analysis of a segregating doubled haploid population identified over two-thousand genes as being regulated by Mla （q value/FDR=0.00001）, a subset of which are significant in Rar3 interactions. The intersection of datasets derived from mla-loss-of-function mutants, Mla-associated eQTL, and rar3-mediated transcriptome reprogramming are narrowing the focus on essential genes required for Mla-specified immunity.

关键词： eQTL transcript profiling immunity resistance signaling barley Blumeria graminis

Vascular endothelial growth factor attenuates hepatic sinusoidal capillarization in thioacetamide-induced cirrhotic rats

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第15期14卷 2349-2357页

作者： Hao Xu Bao-Min Shi Xiao-Fei Lu Feng Liang Xing Jin Tai-Huang Wu Jian Xu department of Hepatobiliary and Pancreas Surgery Shandong Provincial Hospital Clinical College of Shandong University Jinan 25002 l Shandong Province China department of Vascular Surgery Shandong Provincial Hospital Clinical College of Shandong University Jinan 250021 Shandong Province China

AIM: To investigate the effect of vascular endothelial growth factor (VEGF) transfection on hepatic sinusoidal capillarization. METHODS: Enhanced green fluorescent protein (EGFP)/ VEGF transfection was confirmed by immunofluorescence microscopy and immunohistoche-mistry both in primary hepatocytes and in normal liver. Cirrhotic rats were generated by thioacetamide (TAA) administration and then divided into a treatment group, which received injections of 400 μg of plasmid DNA encoding an EGFP- VEGF fusion protein, and a blank group, which received an equal amount of normal saline through the portal vein. The portal vein pressure was measured in the normal and cirrhotic state, in treated and blank groups. The average number of fenestrae per hepatic sinusoid was determined using transmission electron microscopy (TEM), while the relative abundance of VEGF transcripts was examined by Gene array. RESULTS: Green fluorescent protein was observed in the cytoplasms of liver cells under immunofluorescence microscopy 24 h after transfection with EGFP/VEGF plasmid in vitro. Staining with polyclonal antibodies against VEGF illustrated that hepatocytes expressedimmunodetectable VEGF both in vitro and in vitro. There were significant differences in the number of fenestrae and portal vein pressures between normal and cirrhotic rats (7.40 ± 1.71 vs 2.30 ± 1.16 and 9.32 ± 0.85 cmH2O vs 17.92 ± 0.90 cmH2O, P < 0.01), between cirrhotic and treated rats (2.30 ± 1.16 cmH2O vs 4.60 ± 1.65 and 17.92 ± 0.90 cmH2O vs 15.52 ± 0.93 cmH2O, P < 0.05) and between the treatment group and the blank group (4.60 ± 1.65 cmH2O vs 2.10 ± 1.10 cmH2O and 15.52 ± 0.93 cmH2O vs 17.26 ± 1.80 cmH2O, P < 0.05). Gene- array analysis revealed that the relative abundance of transcripts of VEGF family members decreased in the cirrhotic state and increased after transfection. CONCLUSION: Injection of a plasmid encoding VEGF through the portal vein is an effective method to induce the formation of fenestrae and decre

关键词： Liver cirrhosis Hepatic sinusoid capillari-zation Fenestrae Vascular endothelial growth factor Transmission electrical microscopy Ultrastructure Genearray

Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2022年第1期12卷 164-177页

作者： Surajit mistry Subhasish Burman Subhasis Roy Nilendu Jyoti Maitra Rajiv Roy Abhijit Chanda department of Periodontics Burdwan Dental College&HospitalBurdwan713101India department of Oral&Maxillofacial Surgery Burdwan Dental College&HospitalBurdwan713101India department of Veterinary Clinical Complex(Surgery&Radiology) West Bengal University of Animal&Fishery SciencesKolkata700037India Directorate of Research Extension&Farms West Bengal University of Animal&Fishery SciencesKolkata700037India department of Orthopaedics Calcutta National Medical College&HospitalKolkata700014India School of Bio-Science&Engineering Jadavpur UniversityKolkata734432India

A multi-barrier antibiotics loaded biodegradable composite bone cement for resolving chronic osteomyelitis has been studied to understand the physico-mechanical properties,drug loading/eluting efficiency,and different merits and demerits prior to clinical *** successful induction of bone infection in 28 rabbits using methicillin-resistant Staphylococcus aureus(MRSA)strains,calcium sulfate/bioactive glass based composite cement was implanted in 12 defects to assess its performance over parenteral therapy with microscopic and radiological examination for 90 *** composite cement revealed acceptable physico-mechanical properties and controlled drug elution ***,the antibiotics concentrations in bone up to 42 days were sufficient to kill MRSA without eliciting adverse drug *** striking feature of platelets aggregation by composite cement could assist bone *** controlled degradation with simultaneous entrapment of composite cement within the osteoid tissues and complete repair of infected cortical defects(holes)in rabbit tibia at 6 weeks indicated the excellent anti-infective and osteoconductive properties of composite ***,the animal study demonstrated the superiority of composite over injectable antibiotic therapy based on infection resolution and bone *** thereby conclude that the composite cement can be effectively applied in the treatment of resistant cases of chronic osteomyelitis.

关键词： Antibiotics Biodegradable composite Osteomyelitis MRSA strains Osteoconduction

Investigation of anticancer potencies of newly generated Schiff base imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第3期28卷 602-606页

作者： Nikhil M. Parekh Bhupendra M. mistry Muthuraman Pandurangan Surendra K. Shinde Rahul V. Patel department of Mathematics Science & Humanities Shroff S. R. Rotary Institute of Chemical Technology Valia 393135 India Organic Research Laboratory Department of Bioresources and Food Sdence College of Life and Environmental Sciences Konkuk University Seoul 143 701Republic of Korea College of Life Science and Biotechnology Department of Biological and Environmental Science Dongguk University 32 llsandong-gu Goyang-siGyeonggi-do 410-820 Republic of Korea department of Food Science and Biotechnology Dongguk University-Seoul llsandong-gu Goyang-si Gyeonggi-do 410-820 Republic of Korea

A new series of multi-heterocyclic Schiff base was constructed starting from 4＇-（imidazol-1-yl[56_TD$IF]）-acetophenone which was converted to its 2-bromoethanone precursor which on cyclic condensation with thiourea yielded final thiazol-2-amine intermediate（3） to be reacted with substituted aldehydes to generate final imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines（4a–4i）. New Schiff base was investigated for their in vitro cytotoxic efficacies against a panel of three human cancer cell lines namely, MCF7（human breast cancer）, HCT116（human colon cancer）, and DU145（human prostate cancer） and one normal skin fibroblast（SF）. Most of these synthetic derivatives shown important cytotoxic actions against individual carcinoma cell line collections, but weak actions against SF, which is as anticipated. Observations of SAR suggested that the difference in the characteristics of substituents attached to the Schiff base function leads to the interesting variations within pharmacological effects of resultant molecular systems. Structural analysis performed using FT-IR,~1H NMR,^（13）C NMR spectroscopy and CHN analysis for final potent anticancer Schiff base, which warrant further investigations.

关键词： Schiff Base Imidazole Thiazole Anticancer Drug designing SAR

VGluT1- and GAD-immunoreactive terminals in synaptic contact with PAGimmunopositive neurons in principal sensory trigeminal nucleus of rat

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第2期28卷 180-184页

作者： Yu-lin DONG Fu-xing ZHANG You-wang PANG Jin-lian LI~2 department of Anatomy and K.K.Leung Brain Research Center,the Fourth Military Medical University Xi’an 710032,China department of Anatomy and K.K. Leung Brain Research Center the Fourth Military Medical University Xi'an China

Aim:To trace the origin of abundant vesicular glutamate transporter l-like immu-noreactive(VGluT1-LI)axon terminals in the dorsal division of the principal sen-sory trigeminal nucleus(Vpd)and the relationships between VGluT 1-LI,as well asthe glutamic acid decarboxylase(GAD)-LI axon terminals,and phosphate-activated glutaminase(PAG)-LI thalamic projecting neurons in the ***:Following unilateral trigeminal rhizotoMy,triple-immunofluorescence histoche-mistry for VGluT1,GAD and PAG and the immunogold-silver method for VGluTlor GAD,combined with the immunoperoxidase method for PAG were performed,***:After unilateral trigeminal rhizotomy,the density of VGluTl-like immunoreactivity(IR)in the Vpd on the lesion side was reduced compared toits contralateral *** the confocal laser-scanning microscope,theVGluT1-LI or GAD-LI axon terminals were observed to be in close apposition tothe PAG-LI thalamic projecting neuronal profiles,and further electron microscopeimmunocytochemistry confirmed that VGluTl-and GAD-LI axon terminals madeasymmetrical and symmetrical synapses upon the PAG-LI neuronal ***:The present results suggest that the VGluTl-LI axon terminals,whichmainly arise from the primary afferents of the trigeminal ganglion,along with thePAG-LI neuronal profiles,form the key synaptic connection involved in sensorysignaling.

关键词： trigeminal vesicular glutamate transporter 1 glutamic acid decarboxylase phosphateactivated glutaminase rats

Quantitative changes of nitrergic neurons during postnatal development of chicken myenteric plexus

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第10期14卷 886-895页

作者： Ping YANG Jameel Ahmed GANDAHI Qian ZHANG Lin-li ZHANG Xun-guang BIAN Li WU Yi LIU Qiu-sheng CHEN Key Laboratory of Animal Physiology and biochemistry College of Veterinary MedicineNanjing Agricultural University department of Anatomy and Histology Sindh Agriculture University

Objective: Information regarding the development of the enteric nervous system(ENS) is important for understanding the functional abnormalities of the *** fertilized chicken eggs provide easy access to embryos,chicken models have been widely used to study embryonic development of myenteric plexus;however,no study has been focused on the postnatal *** aim of this study was to perform a qualitative and quantitative analysis of the nitrergic neurons in the myenteric plexus of developing chickens in the postnatal ***: Whole-mount preparations of the myenteric plexus were made in 7-d,15-d,and 40-d old(adult) chickens of either sex(n=15).The myenteric plexus was studied after nicotinamide adenine dinucleotide phosphate diaphorase(NADPH-d) histochemistry using light microscopy,digital photography,and Image-Pro Plus 6.0 *** numbers of positively stained neurons and ganglia were counted in the duodenum,jejunum,ileum,caecum,and colon in the different age *** were expressed as mean±standard deviation(SD),and statistical analysis was performed using a one-way analysis of variance(ANOVA) ***: The positively stained neurons showed various morphologies and staining intensities,and formed bead-shaped and U-shaped arrangements in the myenteric *** densities of neurons and ganglia increased with ***,the number of positive neurons per ganglion *** number of NADPH-d-positive neurons was highest in the colon,followed by the ileum,the jejunum,the duodenum,and the caeca in all age ***: Developmental changes in the myenteric plexus of chickens continue in the postnatal period,indicating that the maturation process of the gastrointestinal function is *** addition,no significant difference is happening among different intestinal segments during postnatal development,suggesting that the function of different intestinal segments had been determined after birth.

关键词： NADPH-d histochemistry Enteric nervous system(ENS) Development Myenteric plexus Chicken

Experimental investigation of a high aspect ratio,low speed contra-rotating fan stage with complex inflow distortion

在线全文

学校读者我要写书评

暂无评论

Propulsion and Power Research 2014年第2期3卷 68-81页

作者： Chetan mistry A.M.Pradeepn department of Aerospace Engineering Indian Institute of TechnologyBombayMaharashtra 400076India

This paper focuses on the response of a high aspect ratio,low speed contra-rotating fan with complex inflow *** total pressure at the inlet is artificially distorted by means of two different sets of screens with different porosities to generate a hub-strong complex distortion and a tip-strong complex *** flow analyses were conducted for the design speed of rotor-1 in combination with off design speeds of rotor-2 both for the design and the peak pressure mass flow *** order to understand the extent of inlet distortion,the distortion sector was rotated circumferentially at intervals of 151 to cover the entire *** measurements of total pressure,static pressure,velocity components and flow angles were carried out at the inlet of the first rotor,between the two rotors and at the exit of the second rotor using three seven hole *** study reveals a few interesting aspects on the effect of complex inflow distortion on the flow behavior of a contra-rotating *** presence of a low porosity screen reduces the magnitude of axial velocity and generates higher spread of distortion near the localized region of placement of the *** hub-strong complex distortion has a greater effect of presence of this low porosity screen in both circumferential and radial *** leads to higher stagnation pressure variation at the *** the other hand,for the tip-strong complex distortion case,the extent of distortion is observed to be higher in the circumferential direction towards the casing rather than *** localized improvement in the flow(in tip-strong inflow distortion)near the tip region improves the performance both in terms of pressure rise and efficiency of stage compared to hub–strong complex distortion.

关键词： Complex inflow distortion Hub-strong complex distortion Tip-strong complex distortion Contra-rotating fan

Review: Bioengineering approach for the repair and regeneration of peripheral nerve

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2019年第1期4卷 107-113页

作者： Joshua Moskow Bryan Ferrigno Nikhil mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah Sangamesh G.Kumbar epartment of Orthopaedic Surgery University of Connecticut Health263Farmington Ave.FarmingtonCT 06030USA department of Biomedical Engineering University of Connecticut260Glenbrook RoadUnit 3247StorrsCT 06269USA department of Surgery University of Connecticut Health263 Farmington Ave.FarmingtonCT 06030USA department of Pharmaceutical Sciences School of PharmacyUniversity of Saint Joseph229 Trumbull St.Hartford CT 06103USA

Complex craniofacial surgeries of damaged tissues have several limitations,which present complications and challenges when trying to replicate facial function and *** treatment techniques have shown suitable nerve function regeneration with various *** technology continues to advance,new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and *** article will summarize recent bioengineering strategies involving biodegradable composite scaffolds,bioactive factors,and external stimuli alone or in combination to support peripheral nerve *** emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process.

关键词： Peripheral nerve regeneration Composite materials Growth factor Electrical stimulation