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Carbon nanotube micropillars trigger guided growth of complex human neural stem cells networks

Nano Research 2019年第11期12卷 2894-2899页

作者： Gabriela S.Lorite Laura Yla-Outinen Lauriane Janssen Olli Pitkanen Tiina Joki Janne T.Koivisto Minna Kellomaki Robert Vajtai Susanna Narkilahti Krisztian Kordas Microelectronics Research Unit University of OuluOuluPO BOX 4500FI 90014Finland NeuroGroup BioMediTech and Faculty of Medicine and Health technologyTampere UniversityArvo Ylpön katu 34TampereFI 33520Finland Biomaterials&Tissue Engineering Group BioMediTechFaculty of Medicine and Health TechnologyTampere UniversityPO Box 527TampereFI 33101Finland Department of Materials Science and Nanoengineering Rice UniversityP.O.Box 1892HoustonTX77251-1892USA

New strategies for spatially controlled growth of human neurons may provide viable solutions to treat and recover peripheral or spinal cord *** topography cues are known to promote attachment and direct proliferation of many cell types,guided outgrowth of human neurites has been found difficult to achieve so ***,three-dimensional(3D)micropatterned carbon nanotube(CNT)templates are used to effectively direct human neurite stem cell *** exploiting the mechanical flexibility,electrically conductivity and texture of the 3D CNT micropillars,a perfect environment is created to achieve specific guidance of human neurites,which may lead to enhanced therapeutic effects within the injured spinal cord or peripheral *** is found that the 3D CNT micropillars grant excellent anchoring for adjacent neurites to form seamless neuronal networks that can be grown to any arbitrary shape and *** from clear practical relevance in regenerative medicine,these results using the CNT based templates on Si chips also can pave the road for new types of microelectrode arrays to study cell network electrophysiology.

关键词： carbon nanotubes multiple cues guided neurite outgrowth human neural stem cells neuronal networks

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Structured PDMS Chambers for Enhanced Human Neuronal Cell Activity on MEA Platforms

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Journal of Bionic Engineering 2012年第1期9卷 1-10页

作者： Joose Kreutzer Laura Yla-Outinen Paula Karna Tiina Kaarela Jarno Mikkonen Heli Skottman Susanna Narkilahti Pasi KaUio Department of Automation Science and Engineering Tampere University of Technology Korkeakoulunkatu 3 33720 Tampere Finland biomeditech Biokatu 10 33520 Tampere Finland NeuroGroup Institute of Biomedical Technology University of Tampere Biokatu 12 33520 Tampere Finland The Science Center of Pirkanmaa Hospital District Biokatu 12 33521 Tampere Finland Department of Psychology University of Jyvdskyld Ylistonmgientie 33 40500 Jyvdskyla Finland

Structured poly（dimethylsiloxane）（PDMS） chambers were designed and fabricated to enhance the signaling of human Embryonic Stem Cell （hESC） - derived neuronal networks on Microelectrode Array （MEA） platforms. The structured PDMS chambers enable cell seeding on restricted areas and thus, reduce the amount of needed coating materials and cells. In addition, the neuronal cells formed spontaneously active networks faster in the structured PDMS chambers than that in control chambers. In the PDMS chambers, the neuronal networks were more active and able to develop their signaling into organized signal trains faster than control cultures. The PDMS chamber design enables much more repeatable analysis and rapid growth of functional neuronal network in vitro. Moreover, due to its easy and cheap fabrication process, new configurations can be easily fabricated based on investigator requirements.

关键词： cell culturing electrical activity human embryonic stem cells microelectrode array poly(dimethylsiloxane)

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Ocular renin-angiotensin system with special reference in the anterior part of the eye

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World Journal of Ophthalmology 2015年第3期5卷 110-124页

作者： Mervi Holappa Heikki Vapaatalo Anu Vaajanen biomeditech University of Tampere Institute of Biomedicine PharmacologyUniversity of Helsinki Department of Ophthalmology Tampere University Hospital SILK Department of OphthalmologySchool of MedicineUniversity of Tampere

The renin-angiotensin system(RAS) regulates blood pressure(BP) homeostasis, systemic fluid volume and electrolyte balance. The RAS cascade includes over twenty peptidases, close to twenty angiotensin peptides and at least six receptors. Out of these, angiotensin Ⅱ, angiotensin converting enzyme 1 and angiotensin Ⅱ type 1 receptor(AngⅡ-ACE1-AT1R) together with angiotensin(1-7), angiotensin converting enzyme 2 and Mas receptor(Ang(1-7)-ACE2-Mas R) are regarded as the main components of RAS. In addition to circulating RAS, local RA-system exists in various organs. Local RA-systems are regarded as tissue-specific regulatory system accounting for local effects and long term changes in different organs. Many of the central components such as the two main axes of RAS: AngⅡ-ACE1-AT1 R and Ang(1-7)-ACE2-Mas R, have been identified in the human eye. Furthermore, it has been shown that systemic antihypertensive RAS- inhibiting medications lower intraocular pressure(IOP). These findings suggest the crucial role of RAS not only in the regulation of BP but also in the regulation of IOP, and RAS potentially plays a role in the development of glaucoma and antiglaucomatous drugs.

关键词： Angiotensin converting enzyme 1 Angiotensin converting enzyme 2 Angiotensin converting enzyme-inhibitors AngiotensinⅡ Angiotensin(1-9) Angiotensin(1-7) Glaucoma Intraocular pressure Renin-angiotensin system

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