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Unraveling brain aging through the lens of oral microbiota

Neural Regeneration research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain protection and National Clinical research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina beijing institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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Dynamic emission characteristics and control strategies of air pollutants from motor vehicles in downtown beijing,China

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Journal of environmental Sciences 2024年第2期136卷 637-646页

作者： Yan Shen Tongran Wu Aiping Lian Jie Gao Fei Peng Guohua Song Xuefang Wu Yangyang Cui Xinyu Liu Yunfei Wan Jing Yan Yifeng Xue National Engineering research Center of Urban environmental Pollution Control Beijing Municipal Research Institute of Eco-Environmental ProtectionBeijing 100037China beijing municipal ecology and Environment Bureau Beijing 100048China beijing Jiaotong University Beijing 100091China

This study combined the real-time monitoring and investigation of traffic flows to comprehensively analyze the road traffic flow and vehicle structure in downtown beijing.A dynamic emission inventory of motor vehicle air pollutants in downtown beijing in 2021 was established,and the impact of these emissions on air quality was simulated and quantified,and different emission reduction control scenarios were proposed to evaluate their environmental improvement effects and explore measures to mitigate the impact of pollution *** results show that the high traffic flow and the structure of the motor vehicle emissions in downtown beijing are the main causes of severe motor vehicle *** data shows that traffic flow in central beijing is dominated by small passenger vehicles,while the vehicle mix is better than in other regions,with 72.0%of vehicles meeting"National V"or higher emission ***,to achieve higher air quality goals,further reducing vehicle emissions is *** on dynamic traffic flow,the average daily emissions of nitrogen oxides(NOX),particulate matters(PM_(2.5))and volatile organic compounds(VOC)from motor vehicles in central beijing are 17.7 tons,0.6 tons and 14.0 tons,respectively,accounting for 23.0%of the city’s average daily motor vehicle *** a zero-emission zone for motor vehicles were implemented in central beijing,the annual average emission level of pollutants will be reduced by 10.4%to 21.0%.The designation of ultra-low emission zones for motor vehicles could be effective in improving the air quality in the center of beijing.

关键词： Motor vehicle Air pollutant Emission characteristics Control strategy beijing

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Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao Jingli Sun Yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China beijing institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and protection Data Center University of Science and Technology BeijingBeijing 100083China institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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Exploring the heavy air pollution in beijing in the fourth quarter of 2015： assessment of environmental benefits for red alerts

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Frontiers of Earth Science 2018年第2期12卷 361-372页

作者： Teng NIE Lei NIE Zhen ZHOU Zhanshan WANG Yifeng XUE Jiajia GAO Xiaoqing WU Shoubin FAN Linglong CHENG National Engineering research Center of Urban environmental Pollution Control Beijing Municipal Research Institute of Environmental Protection Beijing 100037 China beijing municipal environmental Monitoring Center Beijing 100048 China Department of Air Pollution Control Beijing Municipal Institute of Labour Protection Beijing 100054 China

In recent years, beijing has experienced severeair pollution which has caused widespread public *** to the same period in 2014, the first threequarters of 2015 exhibited significantly improved airquality. However, the air quality sharply declined in thefourth quarter of 2015, especially in November andDecember. During that time, beijing issued the first redalert for severe air pollution in history. In total, 2 red alerts,3 orange alerts, 3 yellow alerts, and 3 blue alerts wereissued based on the adoption of relatively temporaryemergency control measures to mitigate air pollution. Thisstudy explored the reasons for these variations in airquality and assessed the effectiveness of emergency alertsin addressing severe air pollution. A synthetic analysis ofemission variations and meteorological conditions wasperformed to better understand these extreme air pollutionepisodes in the fourth quarter of 2015. The results showedthat compared to those in the same period in 2014, thedaily average emissions of air pollutants decreased in thefourth quarter of 2015. However, the emission levels ofprimary pollutants were still relatively high, which was themain intrinsic cause of haze episodes, and unfavorablemeteorological conditions represented important externalfactors. Emergency control measures for heavy airpollution were implemented during this red alert period,decreasing the emissions of primary air pollutants byapproximately 36% and the PMa.5 concentration by 11%-21%.

关键词： heavy air pollution red alert emissions

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina beijing Engineering research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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Characteristics of particulate-bound polycyclic aromatic hydrocarbons emitted from industrial grade biomass boilers

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Journal of environmental Sciences 2016年第2期28卷 28-34页

作者： Xiaoyang Yang Chunmei Geng Xuesong Sun Wen Yang Xinhua Wang Jianhua Chen State Key Laboratory of environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012China beijing municipal research institute of environmental protection Beijing 100037 China

Polycyclic aromatic hydrocarbons（PAHs） are carcinogenic or mutagenic and are important toxic pollutants in the flue gas of boilers. Two industrial grade biomass boilers were selected to investigate the characteristics of particulate-bound PAHs： one biomass boiler retro-fitted from an oil boiler（BB1） and one specially designed（BB2） biomass boiler. One coal-fired boiler was also selected for comparison. By using a dilution tunnel system, particulate samples from boilers were collected and 10 PAH species were analyzed by gas chromatography–mass spectrometry（GC–MS）. The total emission factors（EFs） of PAHs ranged from 0.0064 to0.0380 mg/kg, with an average of 0.0225 mg/kg, for the biomass boiler emission samples. The total PAH EFs for the tested coal-fired boiler were 1.8 times lower than the average value of the biomass boilers. The PAH diagnostic ratios for wood pellets and straw pellets were *** ratio of indeno（1,2,3-cd）pyrene/[indeno（1,2,3-cd）pyrene ＋ benzo（g,h,i）perylene] for the two biomass boilers was lower than those of the reference data for other burning devices, which can probably be used as an indicator to distinguish the emission of biomass boilers from that of industrial coal-fired boilers and residential stoves. The toxic potential of the emission from wood pellet burning was higher than that from straw pellet burning, however both of them were much lower than residential stove exhausts.

关键词： Polycyclic aromatic hydrocarbons Industrial grade biomass boiler Emission factor Diagnostic ratio Potential toxicity risk

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Effects of metal and acidic sites on the reaction by-products of butyl acetate oxidation over palladium-based catalysts

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Journal of environmental Sciences 2014年第3期26卷 702-707页

作者： Lin Yue Chi He Zhengping Hao Shunbing Wang Hailin Wang Department of environmental Nano-materials Research Center for Eco-Environmental SciencesChinese Academy of Sciences The Administrative Center for China's Agenda 21 National Urban environmental Pollution Control Engineering Techniques research Center Beijing Municipal Research Institute of Environmental Protection

Catalytic oxidation is widely used in pollution control technology to remove volatile organic compounds. In this study, Pd/ZSM-5 catalysts with different Pd contents and acidic sites were prepared via the impregnation method. All the catalysts were characterized by means of N2 adsorption- desorption, X-ray fluorescence （XRF）, HE temperature programmed reduction （H2-TPR）, and NH3 temperature programmed desorption （NH3-TPD）. Their catalytic performance was investigated in the oxidation of butyl acetate experiments. The by-products of the reaction were collected in thermal desorption tubes and identified by gas chromatography/mass spectrometry. It was found that the increase of Pd content slightly changed the catalytic activity of butyl acetate oxidation according to the yield of CO2 achieved at 90%, but decreased the cracking by-products, whereas the enhancement of strong acidity over Pd-based catalysts enriched the by-product species. The butyl acetate oxidation process involves a series of reaction steps including protolysis, dehydrogenation, dehydration, cracking, and isomerization. Generally, butyl acetate was cracked to acetic acid and 2- methylpropene and the latter was an intermediate of the other by-products, and the oxidation routes of typical by-products were proposed. Trace amounts of 3-methylpentane, hexane, 2-methylpentane, pentane, and 2-methylbutane originated from iso4merization and protolysis reactions.

关键词： catalytic oxidation butyl acetate reaction by-product Pd/ZSM-5 VOCs

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Characterization and assessment of volatile organic compounds (VOCs) emissions from typical industries

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Science Bulletin 2013年第7期58卷 724-730页

作者： WANG HaiLin NIE Lie LI Jing WANG YuFei WANG Gang WANG JunHui HAO ZhengPing Department of environmental Nano-materials Research Center for Eco-Environmental SciencesChinese Academy of Sciences Department of Air Pollution Prevention and Control Beijing Municipal Research Institute of Environmental Protection

VOCs play an increasingly important role in affecting air quality and threatening human health in China in recent years,where industry activities show a significant contribution to VOCs *** this article we report our long term study of industrial VOCs emissions of six major industries (vehicle manufacturing,printing,equipment coating,electronic manufacturing,furniture manufacturing and bio-pharming) on the aspects of emission characteristics,environmental impact and health risk assessment,and control challenge analysis with the purpose to obtain in-depth understanding of industry VOCs emissions and offer some original basements for national control and management of industry VOCs *** study shows that all these industries give middle or low emission with total VOCs concentration less than 1000 mg/m3 at each exhaust ***,esters,alcohols,ketones,alkanes,chloroalkanes and alkenes were detected as the major emission components and the most frequently monitored VOCs were benzenes,which varied obviously with different processes and *** environmental impact assessments indicate that vehicle manufacturing and benzenes should be prior controlled with the purpose to reduce air ***,health risk assessments suggest that furniture manufacturing and chloroalkanes should be firstly *** analysis indicates that developing technologies with low cost and high efficiency and establishing and completing specific industry emission standards/regulations are the two key issues in VOCs emission management at present stage.

关键词： VOCs typical industries emission characteristics assessment control analysis

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Temporal-spatial distributions of road silt loadings and fugitive road dust emissions in beijing from 2019 to 2020

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Journal of environmental Sciences 2023年第10期132卷 56-70页

作者： Haibin Wang Lihui Han Tingting Li Song Qu Yuncheng Zhao Shoubin Fan Tong Chen Haoran Cui Junfang Liu Key Laboratory of beijing on Regional Air Pollution Control Faculty of Environment and LifeBeijing University of TechnologyBeijing 100124China beijing municipal research institute of eco-environmental protection Beijing 100037China National Engineering research Center of Urban environmental Pollution Control Beijing 100037China

Road silt loading(sL)is an important parameter in the fugitive road dust(FRD)*** this study,the improved Testing Re-entrained Aerosol Kinetic Emissions from Roads(TRAKER)combined with the AP-42 method was firstly developed to quickly measure and estimate the sLs of paved roads in beijing,*** annual average sLs in beijing was 0.59±0.31 g/m^(2)in 2020,and decreased by 22.4%compared with that in *** seasonal variations of sLs followed the order of spring>winter>summer>autumn in the two *** seasonal mean road sLs on the same type road in the four seasons presented a decline trend from^(2)019 to 2020,especially on the Expressway,decreasing 47.4%-72.7%.The road sLs on the different type roads in the same season followed the order of Major arterial∼Minor arterial∼Branch road>Express road,and Township road∼Country highway>Provincial highway∼National *** emission intensities of PM10 and PM_(2.5)from FRD in beijing in 2020 were lower than those in *** PM10 and PM_(2.5)emission intensities at the four planning areas in the two years all presented the order of the capital functional core area>the urban functional expansion area>the urban development new area>the ecological conservation and development *** annual emissions of PM10 and PM_(2.5)from FRD in beijing in 2020 were 74,886 ton and 18,118 ton,respectively,decreasing by∼33.3%compared with those in 2019.

关键词： Road silt loading Temporal-spatial distribution Emission factor Emission inventory

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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