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Exploring the heavy air pollution in beijing in the fourth quarter of 2015： assessment of environmental benefits for red alerts

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Frontiers of Earth Science 2018年第2期12卷 361-372页

作者： Teng NIE Lei NIE Zhen ZHOU Zhanshan WANG Yifeng XUE Jiajia GAO Xiaoqing WU Shoubin FAN Linglong CHENG National Engineering research center of Urban Environmental Pollution Control Beijing Municipal Research Institute of Environmental Protection Beijing 100037 China beijing municipal Environmental Monitoring center Beijing 100048 China Department of Air Pollution Control Beijing Municipal Institute of Labour Protection Beijing 100054 China

In recent years, beijing has experienced severeair pollution which has caused widespread public *** to the same period in 2014, the first threequarters of 2015 exhibited significantly improved airquality. However, the air quality sharply declined in thefourth quarter of 2015, especially in November andDecember. During that time, beijing issued the first redalert for severe air pollution in history. In total, 2 red alerts,3 orange alerts, 3 yellow alerts, and 3 blue alerts wereissued based on the adoption of relatively temporaryemergency control measures to mitigate air pollution. Thisstudy explored the reasons for these variations in airquality and assessed the effectiveness of emergency alertsin addressing severe air pollution. A synthetic analysis ofemission variations and meteorological conditions wasperformed to better understand these extreme air pollutionepisodes in the fourth quarter of 2015. The results showedthat compared to those in the same period in 2014, thedaily average emissions of air pollutants decreased in thefourth quarter of 2015. However, the emission levels ofprimary pollutants were still relatively high, which was themain intrinsic cause of haze episodes, and unfavorablemeteorological conditions represented important externalfactors. Emergency control measures for heavy airpollution were implemented during this red alert period,decreasing the emissions of primary air pollutants byapproximately 36% and the PMa.5 concentration by 11%-21%.

关键词： heavy air pollution red alert emissions

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MicroRNA expression in the hippocampal CA1 region under deep hypothermic circulatory arrest

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Neural Regeneration research 2019年第11期14卷 2003-2010页

作者： Xiao-Hua Wang Dong-Xu Yao Xiu-Shu Luan Yu Wang Hai-Xia Liu Bei Liu Yang Liu Lei Zhao Xun-Ming Ji Tian-Long Wang Department of Anesthesiology Xuanwu HospitalCapital Medical UniversityBeijingChina Institute of geriatrics BeijingChina National Clinical research center for geriatric Disorders BeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Cerebrovascular research center Xuanwu HospitalCapital Medical UniversityBeijingChina

Using deep hypothermic circulatory arrest, thoracic aorta diseases and complex heart diseases can be subjected to corrective procedures. However, mechanisms underlying brain protection during deep hypothermic circulatory arrest are unclear. After piglet models underwent 60 minutes of deep hypothermic circulatory arrest at 14°C, expression of microRNAs(miRNAs) was analyzed in the hippocampus by microarray. Subsequently, TargetScan 6.2, RNA22 v2.0, miRWalk 2.0, and miRanda were used to predict potential targets, and gene ontology enrichment analysis was carried out to identify functional pathways involved. Quantitative reverse transcription-polymerase chain reaction was conducted to verify miRNA changes. Deep hypothermic circulatory arrest altered the expression of 35 miRNAs. Twenty-two miRNAs were significantly downregulated and thirteen miRNAs were significantly upregulated in the hippocampus after deep hypothermic circulatory arrest. Six out of eight targets among the differentially expressed miRNAs were enriched for neuronal projection(cyclin dependent kinase, CDK16 and SLC1 A2), central nervous system development(FOXO3, TYRO3, and SLC1 A2), ion transmembrane transporter activity(ATP2 B2 and SLC1 A2), and interleukin-6 receptor binding(IL6 R)– these are the key functional pathways involved in cerebral protection during deep hypothermic circulatory arrest. Quantitative reverse transcription-polymerase chain reaction confirmed the results of microarray analysis. Our experimental results illustrate a new role for transcriptional regulation in deep hypothermic circulatory arrest, and provide significant insight for the development of miRNAs to treat brain injuries. All procedures were approved by the Animal Care Committee of Xuanwu Hospital, Capital medical University, China on March 1, 2017(approval No. XW-INI-AD2017-0112).

关键词： nerve regeneration cerebral protection deep hypothermic circulatory arrest gene ontology enrichment analysis microRNA hippocampus post-transcriptional expression microarray bioinformatics neural regeneration

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Dynamic emission characteristics and control strategies of air pollutants from motor vehicles in downtown beijing,China

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Journal of Environmental Sciences 2024年第2期136卷 637-646页

作者： Yan Shen Tongran Wu Aiping Lian Jie Gao Fei Peng Guohua Song Xuefang Wu Yangyang Cui Xinyu Liu Yunfei Wan Jing Yan Yifeng Xue National Engineering research center of Urban Environmental Pollution Control Beijing Municipal Research Institute of Eco-Environmental ProtectionBeijing 100037China beijing municipal Ecology and Environment Bureau Beijing 100048China beijing Jiaotong University Beijing 100091China

This study combined the real-time monitoring and investigation of traffic flows to comprehensively analyze the road traffic flow and vehicle structure in downtown beijing.A dynamic emission inventory of motor vehicle air pollutants in downtown beijing in 2021 was established,and the impact of these emissions on air quality was simulated and quantified,and different emission reduction control scenarios were proposed to evaluate their environmental improvement effects and explore measures to mitigate the impact of pollution *** results show that the high traffic flow and the structure of the motor vehicle emissions in downtown beijing are the main causes of severe motor vehicle *** data shows that traffic flow in central beijing is dominated by small passenger vehicles,while the vehicle mix is better than in other regions,with 72.0%of vehicles meeting"National V"or higher emission ***,to achieve higher air quality goals,further reducing vehicle emissions is *** on dynamic traffic flow,the average daily emissions of nitrogen oxides(NOX),particulate matters(PM_(2.5))and volatile organic compounds(VOC)from motor vehicles in central beijing are 17.7 tons,0.6 tons and 14.0 tons,respectively,accounting for 23.0%of the city’s average daily motor vehicle *** a zero-emission zone for motor vehicles were implemented in central beijing,the annual average emission level of pollutants will be reduced by 10.4%to 21.0%.The designation of ultra-low emission zones for motor vehicles could be effective in improving the air quality in the center of beijing.

关键词： Motor vehicle Air pollutant Emission characteristics Control strategy beijing

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science center for Stem Cells School of Life Sciences and TechnologyTongji University Translational medical center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University research Institute of Intelligent Computing Zhejiang Lab Shanghai research Institute for Intelligent Autonomous Systems center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical research center for geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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Composition of Ophiopogon Polysaccharide,Notoginseng Total Saponins and Rhizoma Coptid is Alkaloids Inhibits Myocardial Apoptosis in Diabetic Atherosclerosis Rabbits

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Chinese Journal of Integrative Medicine 2020年第5期26卷 353-360页

作者： JIN Zhao-hui GAO Pu LIU Zheng-tang JIN Bing SONG Guang-yi XIANG Tian-yuan geriatric research center Xiyuan HospitalChina Academy of Chinese Medicine SciencesBeijing(100091)China Liaoning Basic medical research Institute Shenyang(110005)China

Objective: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids(CONR) on myocardial apoptosis of diabetic atherosclerosis(DA) rabbits Methods: Sixty male New Zealand white rabbits were randomly divided into 6 groups [control group, model group, CONR high-dose group(450 mg/kg), CONR medium-dose group(150 mg/kg), CONR low-dose group(50 mg/kg), and simvastatin group] by using a completely random method, 10 in each group. DA model was established by intravenously injected alloxan combined with high-fat diet and abdominal aortic balloon injury. After mediation for 10 weeks, fasting blood glucose(FBG), glycosylated hemoglobin(GHB), glycosylated serum protein(GSP), fructoseamine(FRA), aldose reductase(AR), advanced glycation end products(AGEs) in serum were measured by enzyme linked immunosorbent assay(ELISA) method;the expression of receptor of AGEs(RAGE) in myocardial tissue were observed by immunohistochemical method;and p-Jun N-terminal kinase(p-JNK), caspase-3, B-cell lymphoma-2(bcl-2) protein expression in myocardial tissue were measured by Western blotting. The myocardial apoptosis was detected by Td T-mediated d UTPnick-end labeling(TUNEL) method, and apoptosis index(AI) was calculated. Results: Compared with the control group, serum FBG, GHB, GSP, FRA, AR, AGEs and the expression of myocardium RAGE, p-JNK, caspase-3 proteins, as well as apoptosis index(AI) were significantly increased and bcl-2 protein was significantly decreased in the model group(P<0.01). Compared with the model group, the levels of serum FBG, GHB, GSP, FRA and AR showed a significant decline in CONR high-and medium-dose groups(P<0.01). FBG and GHB showed a significant decline in CONR low-dose group(P<0.01). Compared with the model group, the expression of serum AGEs and myocardium RAGE, p-JNK and caspase-3 protein as well as AI were significantly decreased and bcl-2 protein was significantly up-regulated in all treatme

关键词： ophiopogon polysaccharide notoginseng total saponins Rhizoma Coptidis alkaloids advanced glycation end products p-C-N-Jun teminal kinase diabetic atherosclerosis myocardial apoptosis

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Metabolic syndrome,ApoE genotype,and cognitive dysfunction in an elderly population:A single-center,case-control study

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World Journal of Clinical Cases 2021年第5期9卷 1005-1015页

作者： Jie-Yu Wang Li Zhang Jia Liu Wei Yang Li-Na Ma Department of geriatrics Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric MedicineBeijing 100053China

BACKGROUND Metabolic syndrome(MetS)is related to poor cognitive ***,the results of previous studies were inconsistent,and whether the ApoEε4 allele modifies the association remains *** To elucidate the relationships among MetS,ApoEε4,and cognitive dysfunction in an elderly population in *** One hundred elderly patients with MetS and 102 age-and gender-matched controls were included in the *** clinical characteristics and biochemical index for glucose and lipid metabolism were *** distribution of ApoEε4 was assessed with PCR restriction fragment length polymorphism *** function was evaluated by mini-mental status examination at the 1-year follow-up *** Compared with controls,MetS patients had worse cognitive function and decreased ability to participate in activities of daily life(P=0.001 and 0.046,respectively).Patients with cognitive dysfunction had higher prevalence of MetS(62.1%vs 36.4%,P<0.001)and were more likely to carry the ApoEε4 allele(22.3%vs 10.1%,P=0.019).Multivariate logistic regression analyses showed that diagnosis with MetS,severe insulin resistance,status as an ApoEε4 carrier,higher systolic blood pressure,and larger waist circumference were risk factors for cognitive dysfunction(P<0.05).Repeated-measures analysis of variance,performed with data collected at the 1-year follow-up,revealed continuous influences of MetS and ApoEε4 on the deterioration of cognitive function(time×team,P<0.001 for both).CONCLUSION Diagnosis of MetS and ApoEε4 carrier status were persistently associated with cognitive dysfunction among an elderly population in China.

关键词： Metabolic syndrome ApoEε4 Cognitive dysfunction Elderly Genotype Case-control study

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Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation

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Journal of geriatric Cardiology 2023年第11期20卷 788-800页

作者： Shan-Shan LIU Hong-Yang GUO Jian ZHU Jin-Ling MA Sai-Zhe LIU Kun-Lun HE Su-Yan BIAN Department of Cardiology the Second Medical CenterNational Clinical Research Center of Geriatric DiseaseBeijing Key Laboratory of Chronic Heart Failure Precision MedicineChinese PLA General HospitalBeijingChina Department of Cardiology the Six Medical CenterChinese PLA General HospitalBeijingChina medical Big Data research center Medical Innovation Research DepartmentBeijing Key Laboratory of Chronic Heart Failure Precision MedicineChinese PLA General HospitalBeijingChina

BACKGROUND Catheter-based pulmonary vein isolation(PVI) is an effective and well-established intervention for symptomatic paroxysmal atrial fibrillation(PAF). Nevertheless, late recurrences of atrial fibrillation(LRAF) occurring during 3 to 12months are common, and the underlying mechanisms remain elusive. Circular RNAs(circ RNAs) in atrial tissue have been linked to the pathophysiological mechanisms and progression of PAF in a few studies. However, their expression patterns in peripheral blood and regulatory function in LRAF are not *** In the present study, the expression profile of circulating circ RNAs in three paired nonvalvular PAF patients with or without LRAF was investigated by high-throughput sequencing and validated by quantitative real-time polymerase chain reaction(q RT-PCR). Bioinformatics analyses, including Gene Ontology(GO), Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis, and circ RNA/mi RNA regulatory network, were performed to predict the functions and potential regulatory roles of differentially expressed(DE) circ *** A total of 12,834 circ RNAs, comprising 5,491 down-regulated and 7,343 up-regulated circ RNAs, were found to be DE in blood smaples from the two groups in peripheral blood between LRAF and non-recurrence control individuals. The most enriched GO categories in terms of molecular function, biological process, and cellular component features were catalytic activity,cellular metabolic process, and intracellular part, respectively. The KEGG enrichment study revealed that the most important metabolic process controlled by DE circ RNAs is endocytosis. In the circ RNA/micro RNAs interaction network, four up-regulated circ RNAs(hsa_circ_0002665, hsa_circ_0001953, hsa_circ_0003831, and hsa_circ_0040533) and one down-regulated circ RNA(hsa_circ_0041103) were predicted to play potential regulatory roles in the pathogenesis of *** This investigation discovered the expression pattern of circulating c

关键词： atrial fibrillation paroxysmal

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Evaluation of characteristics of left-sided colorectal perfusion in elderly patients by angiography

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World Journal of Gastroenterology 2020年第24期26卷 3484-3494页

作者： Chao Zhang Ang Li Tao Luo Yu Li Fei Li Jia Li Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Gastroenteropancreatic center National Clinical Research Center for Geriatric DiseasesBeijing 100053China

BACKGROUND Handling of the inferior mesenteric artery(IMA)and maintaining anastomotic perfusion are important in radical resection of left-sided colorectal ***,the branching of this artery and the drainage patterns of this vein vary among individuals,and the characteristics and perfusion region of this artery in elderly patients remain *** To evaluate the characteristics and perfusion region of the IMA in elderly patients using *** We enrolled 154 patients(>65 years old)who underwent digital subtraction angiography of the *** characteristics,bifurcation,and distribution of the IMA and termination of the anastomotic perfusion of the left colon and rectum were examined using digital subtraction *** arterial arches and the IMA hemoperfusion region were also *** regions were cross-referenced with clinical and anatomical features by the univariate *** Of 154 patients,25(16.2%)had IMA *** left colic artery arose independently from the IMA in 44.2%of patients,shared a trunk with the sigmoid artery in 35.1%,shared an opening with the sigmoid and superior rectal arteries in 16.9%,and was absent in 5.1%.The IMA perfusion region stopped at the splenic flexure in 50(32.5%)*** collateral circulation existed in the colonic perfusion region,including the marginal artery(Drummond’s artery),the ascending branch of the left colonic artery to supply the transverse colon,and the arc of Riolan with a frequency of 100%,22.7%,and 1.9%,*** IMA perfusion region was independently associated with the comorbidity of atherosclerosis,IMA atherosclerotic lesion,branching pattern,collateral circulation,and marginal artery *** The IMA and its branches are prone to arteriosclerosis,and IMA perfusion may be interrupted at the splenic flexure in elderly *** applicability and precision of preoperative angiography for evaluating the IMA branching and perfusion pat

关键词： Anatomy Digital subtraction angiography Elderly Inferior mesenteric artery Left-sided colorectum

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Diagnostic Efficacy of^(18)F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma

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Biomedical and Environmental Sciences 2023年第6期36卷 510-516页

作者： GUO Bo QIN Ran GU Zhen Yang LI Yan Fen GAO Lei HUANG Wen Rong Department of Hematology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Hematology The Fifth Medical CenterChinese PLA General HospitalBeijing 100071China Department of medical Engineering Medical Supplies Center of PLA General HospitalBeijing 100039China

Objective Diffuse large B-cell lymphoma(DLBCL)is often associated with bone marrow infiltration,and 2-deoxy-2-(18F)fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)has potential diagnostic significance for bone marrow infiltration in *** A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were *** marrow biopsy and^(18)F-FDG PET/CT examinations were performed at the time of initial *** tests were used to evaluate the agreement of^(18)F-FDG PET/CT with the gold standard,and the imaging features of DLBCL bone marrow infiltration on PET/CT were *** The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy(P=0.302)or between the two bone marrow biopsies(P=0.826).The sensitivity,specificity,and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923(95%CI,0.759-0.979),0.934(95%CI,0.855-0.972),and 0.857,***^(18)F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow ***/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.

关键词： Diffuse large B-cell lymphoma Bone marrow infiltration Positron emission computed tomography(PET/CT) Bone marrow biopsy Diagnostic efficacy

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