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Effect of hydrogen intervention on refractory wounds after radiotherapy:A case report

World Journal of Clinical Cases 2022年第21期10卷 7545-7552页

作者： Peng-Xiang Zhao Rui-Liu Luo Zheng Dang You-Bin Wang Xu-Juan Zhang Zi-Yi Liu Xiao-Hu Wen Meng-Yu Liu Ming-Zi Zhang Yao Mawulikplimi Adzavon Xue-Mei Ma Faculty of Environment and Life science Beijing International Science and TechnologyCooperation Base of Antivirus DrugBeijing University of TechnologyBeijing 100124China Department of Plastic Surgery Peking Union Medical College HospitalBeijing 100032China

BACKGROUND Patients with keloids who receive radiotherapy(RT)after surgery can develop refractory wounds that cannot be healed by the patient's own repair *** chronic wounds are uneven and complex due to persistent abscess and *** external intervention,they can easily result in local tissue necrosis or,in severe cases,large area tissue resection,amputation,and even *** SUMMARY This article describes the use of hydrogen to treat a 42-year-old female patient with a chronic wound on her left *** patient had a skin graft that involved implanting a dilator under the skin of her left shoulder,and then transferring excess skin from her shoulder onto scar tissue on her *** skin grafting was followed by two rounds of RT,after which the shoulder wound had difficulty *** six months,the patient was treated with 2 h of hydrogen inhalation(HI)therapy per day,in addition to application of sterile gauze on the wound and periodic *** also performed one deep,large,sharp debridement to enlarge the wound *** wound healed completely within 6 mo of beginning the HI *** After HI therapy,the patient showed superior progress in reepithelialization and wound repair,with eventual wound closure in 6 mo,in comparison with the previous failures of hyperbaric oxygen and recombinant bovine basic fibroblast growth factor *** work showed that HI therapy could be a new strategy for wound healing that is cleaner,more convenient,and less expensive than other therapies,as well as easily accessible for further application in clinical wound care.

关键词： Hydrogen Inhalation therapy Wound healing Reepithelialization Refractory wounds Case report

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Association analysis of BclI with benign lymphoepithelial lesions of the lacrimal gland and glucocorticoids resistance

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international Journal of Ophthalmology(English edition) 2023年第11期16卷 1734-1745页

作者： Xu-Juan Zhang Peng-Xiang Zhao Ming-Shen Ma Hao Wu Rui Liu Hui Wang Meng-Yu Liu Fei Xie Xue-Mei Ma Faculty of Environment and Life Beijing University of TechnologyBeijing 100124China beijing international science and technology cooperation base of antivirus drug Beijing 100124China beijing Tongren Hospital Capital Medical UniversityBeijing 100730China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi international Joint Research Center for Oral Diseases Department of General Dentistry and EmergencySchool of StomatologyAir Force MedicalXi’an 710032Shaanxi ProvinceChina

AIM:To evaluate the relationship between gene polymorphism(BclI,ER22/23EK,N363S)and the occurrence,progression and sensitivity to glucocorticoid of lacrimal gland benign lymphoepithelial lesion(LGBLEL).METHODS:Clinical peripheral blood samples of 52 LGBLEL patients and 10 normal volunteers were collected for DNA extraction and polymerase chain reaction sequencing to analyze single nucleotide polymorphism(SNP)*** lacrimal tissues of LGBLEL were surgically removed and made into paraffin sections for subsequent hematoxylin-eosin(HE)and Masson staining *** duration of disease and hormone use of LGBLEL patients from diagnosis to surgery were also *** Meta-analysis follows PRISMA guidelines to conducted a systematic review of human studies investigating the relationship between the NR3C1 BclI polymorphism and glucocorticoids(GCs)***:There was no association between ER22/23EK or N363S and the occurrence of LGBLEL or GCs sensitivity(P>0.05);BclI GC genotype was closely related to GCs resistance(P=0.03)as is the minor allele C(P=0.0017).The HE staining and Masson staining showed that the GC genotype of BclI remarkably slowed down the disease progression and reduced fibrosis(P<0.05),especially for GCs-dependent patients(P<0.0001).Meta-analysis showed that BclI was not significantly associated with GCs ***:The LGBLEL patients who carry the NR3C1 BclI allele C may be more sensitive to GCs and associated with lower fibrosis and slower disease *** results may guide the clinical treatment strategy for the LGBLEL patients.

关键词： lacrimal gland benign lymphoepithelial lesion Bcll single nucleotide polymorphisms glucocorticoids resistance fibrosis

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Gut liver brain axis in diseases:the implications for therapeutic interventions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： Mengyao Yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Tianjin Key Laboratory for Modern drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

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Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao Ge Yuanyuan Wei Lulu He Aiguo Wu Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of sciences Beijing 100049China Advanced Energy science and technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

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Electro-catazone treatment of an ozone-resistant drug:Effect of sintering temperature on TiO_(2) nanoflower catalyst on porous Ti gas diffuser anodes

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Chinese Chemical Letters 2021年第10期32卷 3221-3225页

作者： Xinyang Li Yannan Li Hao Zhang Zhen Shen Shuang Cheng Guicheng Liu Hong Yao beijing international Scientific and Technological cooperation base of Water Pollution Control Techniques for Antibiotics and Resistance Genes Beijing Key Laboratory of Aqueous Typical Pollutants Control and Water Quality SafeguardDepartment of Municipal and Environmental EngineeringSchool of Civil EngineeringBeijing Jiaotong UniversityBeijing 100044China Department of Physics Dongguk UniversitySeoul 04620Republic of Korea

Electrochemical heterogeneous catalytic ozonation(E-catazone) is a promising and advanced oxidation technology that uses a titanium dioxide nanoflower(TiO_(2-NF))-coated porous Ti gas diffuser as an anode *** previous study has highlighted that the importance of the TiO_(2-NF)coating layer in enhancing*OH production and rapidly degrading O_(3)-resistant *** is well known that the properties of TiO_(2-NF)are closely related to its sintering ***,to date,related research has not been conducted in E-catazone ***,this study evaluated the effect of the sintering temperature on the degradation of the O_(3)-resistant drug para-chlorobenzoic acid(p-CBA) using both experimental and kinetic modeling and revealed its influence *** results indicated that the TiO_(2-NF)sintering temperature could influence p-CBA degradation and*OH ***_(2-NF)prepared at 450 C showcased the highest p-CBA removal efficiency(98.5% in 5 min) at a rate of 0.82 min^(-1),and an*OH exposure of 8.41 x 10^(-10) mol L^(-1) *** modeling results and interface characterization data revealed that the sintering temperature could alter the TiO_(2) crystallized phase and the content of surfaceadsorbed oxygen,thus affecting the two key limiting reactions in the E-catazone *** is,≡TiO_(2) surface reacted with H_(2) O to form TiO_(2)-(OH)_(2),which then heterogeneously catalyzed O_(3) to form ****,E-catazone with a TiO_(2-NF)anode prepared at 450°C generated the highest surface reaction rate(5.00 x 10^(-1) s^(-1) and 4.00 x 10^(-3) L mol^(-1) s^(-1),respectively),owing to its higher anatase content and adsorbed ***,a rapid O_(3)-TiO_(2) reaction was achieved,resulting in an enhanced*OH formation and a highly effective p-CBA ***,this study provides novel baseline data to improve the application of E-catazone technology.

关键词： Electrochemical Ozonation Sintering temperature Crystallized phase Interface reactions

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Bio-characteristic profiling related to clinic:A new technology platform for quality evaluation of Chinese materia medica

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TMR Modern Herbal Medicine 2019年第4期2卷 215-224页

作者： Li-Na Wen Ai-Ting Wang Na Guo Yumei Han Can Yan Dan Yan beijing Shijitan Hospital Capital Medical University Beijing China beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational drug Use Beijing China international cooperation & Co-construction Laboratory of Bio-characteristic Profiling for Evaluation of Rational drug Use Beijing China. Experimental Research Center China Academy of Chinese Medical Sciences Beijing China. beijing Physical Examination Center Beijing China. Guangzhou University of Chinese Medicine Guangzhou China.

Quality evaluation is a bottleneck restricting the modernization and internationalization of Chinese materia medica (CMM). Due to characteristics of multi-component, multi-efficacy, multi-target, the existing quality evaluation system still cannot fully meet quality control needs of CMM. Hence, the author put forward “Bio-characteristic profiling related to clinic, BPRC” academic concept, meanwhile, fully take the advantage of analysis method with clinical monitoring superiority or profiling characteristics, build up “BPRC” new technology platform, in order to realize “real-time, dynamic and full-range monitoring” new technologies of CMM quality evaluation system and promote the further development of CMM industry.

关键词： Bio-characteristic profiling related to clinic Correlation efficacy Quality evaluation of Chinese materia medica

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Intermolecular through-space charge transfer enabled by bicomponent assembly for ultrasensitive detection of synthetic cannabinoid JWH-018

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Aggregate 2023年第4期4卷 128-137页

作者： Chaogan Liu Fangfang Xiao Yushu Li Da Lei Yuan Liu Xiaowei Ma Chengzhi Gu Xincun Dou State Key Laboratory Incubation base for Green Processing of Chemical Engineering School of Chemistry and Chemical EngineeringShihezi UniversityShiheziChina Xinjiang Key Laboratory of Explosives Safety science Xinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesUrumqiChina Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina

Launching the intermolecular through-space charge transfer(TSCT)from a bicomponent assembly for photophysical property manipulation is of great significance in fluorescence probe ***,we demonstrate the elaborate control of droplet evaporation dynamics for intermolecular TSCT can facilitate the ultrasensitive detection of JWH-018,a representative synthetic *** by diverse intermolecular interactions,the probe,and JWH-018 assemble in a closely stacked manner to emit strong fluorescence at 477 nm,ascribing to the intermolecular TSCT at the S2 *** strategy realizes an ultra-low limit of detection of 11 nmol/mL and great selectivity towards *** practicability is further verified by constructing a sensing chip for JWH-018 aerosol detection,which facilitates the on-site drug abuser screening with the naked ***,the proposed assembly-enabled TSCT is expected to find a variety of applications for optoelectronic materials design and photophysical mechanism-dominated molecular recognition.

关键词： bicomponent assembly fluorescent sensing intermolecular interaction

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Clinical metabolic analysis combined with traceability of biosynthetic pathway:a new approach to quality marker of Chinese materia medica

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TMR Modern Herbal Medicine 2019年第1期2卷 3-10页

作者： Zhi-Rui Yang Ai-Ting Wang Juan Liu Xin-Yu Yang Xiao-Fang Wang Lei Zhang Na Guo Jia-Chen Zi Cheng Peng Shu-Xun Yan Dan Yan beijing Shijitan Hospital Capital Medical UniversityBeijingChina beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational drug Use BeijingChina international cooperation&Joint Laboratory of Bio-characteristic Profiling for Evaluation of Rational drug Use BeijingChina Experimental Research Center China Academy of Chinese Medical SciencesBeijingChina JiNan University GuangzhouChina Chengdu University of Traditional Chinese Medicine ChengduChina The first affiliated hospital Henan University of China MedicineZhengzhouChina

Quality marker(Q-marker)of Chinese materia medica(CMM)plays an important role in quality control of CMM ***,its research strategy and technique remain *** on the fact that quality standard of CMM should be associated with clinical efficacy,taking Jinqi Jiangtang tablet treating type 2 diabetes as an example,the Q-marker related to activity via the reverse analysis of drug metabolism in clinic and traceability of botanic biosynthetic pathways is discovered and ***,we proposed a new research strategy of Q-marker of CMM with"Discovery of clinical active constituents as guidance,Reverse analysis of metabolic transformations as link,and Traceability of biosynthesis pathways as key",to improve quality control of CMM products.

关键词： Chinese materia medica Quality marker Clinical metabolic analysis Biosynthetic pathway Jinqi Jiangtang Tablet Type 2 diabetes

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A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids

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Plant Communications 2024年第1期5卷 231-244页

作者： Wei Zhou Can Wang Xiaolong Hao Fei Chen Qikai Huang Tingyao Liu Jiang Xu Shuai Guo Baosheng Liao Zhixiang Liu Yue Feng Yao Wang Pan Liao Jiayu Xue Min Shi Itay Maoz Guoyin Kai Zhejiang Provincial international S&T cooperation base for Active Ingredients of Medicinal and Edible Plants and Health Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and TransformationSchool of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Sanya Nanfan Research Institute from Hainan University Hainan Yazhou Bay Seed LaboratorySanya 572025China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Department of Postharvest science Agricultural Research OrganizationVolcani CenterP.O.Box 15159HaMaccabim Road 68Rishon LeZion 7505101Israel

Tropane alkaloids(TAs),which are anticholinergic agents,are an essential class of natural compounds,and there is a growing demand for TAs with anesthetic,analgesic,and spasmolytic *** acutan-gulus(Solanaceae)is a TA-producing plant that was used as an anesthetic in ancient *** this study,we assembled a high-quality,chromosome-scale genome of *** with a contig N50 of 7.4 Mb.A recent whole-genome duplication occurred in *** after its divergence from other Solanaceae species,which resulted in the duplication of ADC1 and UGT genes involved in TA *** catalytic activities of H6H enzymes were determined for three Solanaceae *** the basis of evolution and co-expressed genes,AaWRKY11 was selected for further analyses,which revealed that its encoded tran-scription factor promotes TA biosynthesis by activating AaH6H1 *** provide useful insights into genome evolution related to TA biosynthesis and have potential implications for genetic manipulation of TA-producing plants.

关键词： Anisodus acutangulus tropane alkaloid biosynthesis hyoscyamine 6 b-hydroxylase AaWRKY11

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Genome of the Giant Panda Roundworm Illuminates Its Host Shift and Parasitic Adaptation

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 366-381页

作者： Yue Xie Sen Wang Shuangyang Wu Shenghan Gao Qingshu Meng Chengdong Wang Jingchao Lan Li Luo Xuan Zhou Jing Xu Xiaobin Gu Ran He Zijiang Yang Xuerong Peng Songnian Hu Guangyou Yang Department of Parasitology College of Veterinary MedicineSichuan Agricultural UniversityChengdu 611130China Agricultural Genomics Institute Chinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Oncology and Pathology Karolinska InstitutetStockholm 17164Sweden Department of Urology Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Chengdu Research base of Giant Panda Breeding Chengdu 610081China Institute of Animal Genetics and Breeding College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Department of Civil and Environmental Engineering University of MarylandCollege ParkMD 20740USA Department of Chemistry College of Life and Basic ScienceSichuan Agricultural UniversityChengdu 611130China University of Chinese Academy of sciences Beijing 100049China

Baylisascaris schroederi,a roundworm(ascaridoid)parasite specific to the bamboofeeding giant panda(Ailuropoda melanoleuca),represents a leading cause of mortality in wild giant panda ***,we present a 293-megabase chromosome-level genome assembly of *** to infer its biology,including host *** genomics revealed an evolutionary trajectory accompanied by host-shift events in ascaridoid parasite lineages after host separations,suggesting their potential for transmission and rapid adaptation to new *** and anatomical lines of evidence,including expansion and positive selection of genes related to the cuticle and basal metabolisms,indicate that *** undergoes specific adaptations to survive in the sharp-edged bamboo-enriched gut of giant pandas by structurally increasing its cuticle thickness and efficiently utilizing host nutrients through gut ***,we characterized the secretome of *** and predicted potential drug and vaccine targets for new control ***,this genome resource provides new insights into the host adaptation of *** to the giant panda as well as the host-shift events in ascaridoid parasite *** findings on the unique biology of *** will also aid in the development of prevention and treatment measures to protect giant panda populations from roundworm parasitism.

关键词： Giant panda Baylisascaris genome Host shift Parasitism evolution Host adaptation

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