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Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery

Chinese Medical Journal 2022年第9期135卷 1087-1095页

作者： Xiaoming Yan Fangzhao Yin Cuiping Xu Tao Yu Xiaonan Li Wei Wang Xi Zhang Kai Ma Guojun Zhang beijing institute of Functional Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China beijing institute of brain disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijing 100069China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong 510005China

Background:The combination of high-frequency oscillations(HFOs)with single-mode imaging methods has been proved useful in identifying epileptogenic zones,whereas few studies have examined HFOs combined with multimodal imaging methods.The aim of this study was to evaluate the prognostic value of ripples,an HFO subtype with a frequency of 80 to 200 Hz is combined with multimodal imaging methods in predicting epilepsy surgery outcome.Methods:HFOs were analyzed in 21 consecutive medically refractory epilepsy patients who underwent epilepsy surgery.All patients underwent positron emission tomography(PET)and deep electrode implantation for stereo-electroencephalography(SEEG);11 patients underwent magnetoencephalography(MEG).Sensitivity,specificity,positive predictive value,negative predictive value,and accuracy in predicting surgical outcome were calculated for ripples combined with PET,MEG,both PET and MEG,and PET combined with MEG.Kaplan-Meier survival analyses were conducted in each group to estimate prognostic value.Results:The study included 13 men and 8 women.Accuracy for ripples,PET,and MEG alone in predicting surgical outcome was 42.9%,42.9%,and 81.8%,respectively.Accuracy for ripples combined with PET and MEG was the highest.Resection of regions identified by ripples,MEG dipoles,and combined PET findings was significantly associated with better surgical outcome(P<0.05).Conclusions:Intracranial electrodes are essential to detect regions which generate ripples and to remove these areas which indicate good surgical outcome for medically intractable epilepsy.With the assistance of presurgical noninvasive imaging examinations,PET and MEG,for example,the SEEG electrodes would identify epileptogenic regions more effectively.

关键词： High-frequency oscillations Ripples PET MEG Epileptogenic zone

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Interactions between remote ischemic conditioning and post-stroke sleep regulation

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Frontiers of Medicine 2021年第6期15卷 867-876页

作者： Xian Wang Xunming Ji beijing institute of brain disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijing100069China beijing Key Laboratory of Hypoxia Conditioning Translational Medicine Beijing100069China

Sleep disturbances are common in patients with stroke,and sleep quality has a critical role in the onset and outcome of stroke.Poor sleep exacerbates neurological injury,impedes nerve regeneration,and elicits serious complications.Thus,exploring a therapy suitable for patients with stroke and sleep disturbances is imperative.As a multi-targeted nonpharmacological intervention,remote ischemic conditioning can reduce the ischemic size of the brain,improve the functional outcome of stroke,and increase sleep duration.Preclinical/clinical evidence showed that this method can inhibit the inflammatory response,mediate the signal transductions of adenosine,activate the efferents of the vagal nerve,and reset the circadian clocks,all of which are involved in sleep regulation.In particular,cytokines tumor necrosis factorα(TNFα)and adenosine are sleep factors,and electrical vagal nerve stimulation can improve insomnia.On the basis of the common mechanisms of remote ischemic conditioning and sleep regulation,a causal relationship was proposed between remote ischemic conditioning and post-stroke sleep quality.

关键词： remote ischemic conditioning sleep regulation stroke

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Response to magnesium sulfate and adrenocorticotropic hormone combination therapy for infantile spasms with failed first-line treatments

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Pediatric Investigation 2023年第1期7卷 29-35页

作者： Qiuhong Wang Wen He Yangyang Wang Liying Liu Mengna Zhang Xiaoyan Yang Liping Zou Department of Pediatrics Chinese PLA General HospitalThe First Medical Center of Chinese PLA General HospitalBeijingChina Department of Pediatrics Beijing Institute for Brain DisordersCenter for Brain Disorders ResearchCapital Medical UniversityBeijingChina

Importance:Infantile spasm(IS)is a kind of refractory epilepsy.The first-line treatments for IS are adrenocorticotropic hormone(ACTH),oral corticosteroids,and vigabatrin.Objective:This study aimed to evaluate the efficacy of magnesium sulfate and ACTH(MgSO_(4)+ACTH)combination therapy in patients with IS who failed first-line treatments.Methods:In this retrospective study,the clinical data of patients with IS who failed first-line treatments were collected in the Chinese PLA General Hospital.Patients received MgSO_(4)+ACTH combination therapy after first-line treatments failed.The course of treatments was 2 weeks.The therapeutic dose of ACTH and MgSO_(4)was 2.5 U·kg^(-1)·d^(-1)and 0.25 g·kg^(-1)·d^(-1),respectively.Results:A total of 229 patients with IS who failed the first-line treatments were collected.At the end of the MgSO_(4)+ACTH combination treatment,the seizure-free rate was 48.5%(111/229),and the resolution of hypsarrhythmia on electroencephalogram(EEG)was 72.1%(165/229).About 21.4%(49/229)of patients showed side effects,including infectious diseases,hypokalemia,and diarrhea.Interpretation:For patients with IS who failed first-line treatments,in terms of the seizure-free rate and resolution of hypsarrhythmia on EEG,MgSO_(4)+ACTH combination therapy can be considered.

关键词： Infantile spasms Magnesium sulfate Adrenocorticotropic hormone Treatment Efficacy

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cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus

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Neuroscience Bulletin 2022年第10期38卷 1153-1169页

作者： Jiayin Zheng Yue Wang Yue Liu Song Han Ying Zhang Yanlin Luo Yi Yan Junfa Li Li Zhao Department of Neurobiology and Center of Stroke Beijing Institute for Brain DisordersCapital Medical UniversityBeijing100069China The National Clinical Research Center for Mental disorders&beijing Key Laboratory of Mental disorders Beijing Anding HospitalCapital Medical UniversityBeijing100088China Advanced Innovation Center for Human brain Protection Capital Medical UniversityBeijing100088China

Type 1 diabetes mellitus(T1DM)-induced cognitive dysfunction is common,but its underlying mechanisms are still poorly understood.In this study,we found that knockout of conventional protein kinase C(cPKC)γsignificantly increased the phosphorylation of Tau at Ser214 and neurofibrillary tangles,but did not affect the activities of GSK-3βand PP2A in the hippocampal neurons of T1DM mice.cPKCγdeficiency significantly decreased the level of autophagy in the hippocampal neurons of T1DM mice.Activation of autophagy greatly alleviated the cognitive impairment induced by cPKCγdeficiency in T1DM mice.Moreover,cPKCγdeficiency reduced the AMPK phosphorylation levels and increased the phosphorylation levels of mTOR in vivo and in vitro.The high glucose-induced Tau phosphorylation at Ser214 was further increased by the autophagy inhibitor and was significantly decreased by an mTOR inhibitor.In conclusion,these results indicated that cPKCγpromotes autophagy through the AMPK/mTOR signaling pathway,thus reducing the level of phosphorylated Tau at Ser214 and neurofibrillary tangles.

关键词： Conventional protein kinase C(cPKC)γ Tau Phosphorylated Tau Autophagy AMPK/mTOR signaling pathway

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brain-Computer Interfaces in disorders of Consciousness

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Neuroscience Bulletin 2023年第2期39卷 348-352页

作者： Qiheng He Jianghong He Yi Yang Jizong Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Chinese institute for brain Research Beijing 100010China beijing institute of brain disorders Beijing 100069China China National Clinical Research Center for Neurological Diseases Beijing 100070China

The development of brain-computer interfaces(BCIs)has established a new communication channel between the brain and external devices for information transmission that requires no muscular signals[1].BCIs have been preliminarily studied to improve motor functions in patients with severe motor disabilities,especially lock-in syndrome.At present,the application of BCIs has been extensively validated.

关键词： communication Interfaces channel

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Effect of haemodynamics on the risk of ischaemic stroke in patients with severe vertebral artery stenosis

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Stroke & Vascular Neurology 2022年第3期7卷 200-208页

作者： Qing Li Yinghua Zhou Yingqi Xing Jie Yang Yang Hua Department of Vascular Ultrasonography Xuanwu Hospital Capital Medical UniversityBeijingChina beijing Diagnostic Center of Vascular Ultrasound Xuanwu Hospital Capital Medical UniversityBeijingChina Center of Vascular Ultrasonography Beijing Institute of Brain DisordersCollaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijingChina

Objectives Endovascular treatment strategies to optimise individualised care for patients with vertebral artery(VA)stenosis need to be revisited.This study aimed to investigate the relationship between net VA flow volume(NVAFV)and the risk of posterior circulation infarction(PCI)in a high-risk patient population.Methods We screened 1239 patients with extracranial VA stenosis,of whom 321 patients with severe VA V1 segment stenosis(≥70%)were enrolled in our study.We restratified the patients based on NVAFV and contralateral VA stenosis grades to analyse the proportion of each PCI mechanism-large artery atherosclerosis and branch artery occlusive disease.Furthermore,we estimated the incidence of recurrent ischaemic stroke between groups with different NVAFV over a follow-up period of 2 years.Results NVAFV was lower in the PCI group.Multiple logistic regression analysis showed that NVAFV is an independent risk factor for PCI and that the OR for PCI for the lowest NVAFV(<112.8 mL/min)was 4.19(1.76 to 9.95,p=0.001).In patients with severe carotid artery disease,the OR for the lowest NVAFV was 14.03(3.18 to 61.92,p<0.001).The lower NVAFV group had a higher incidence of recurrent ischaemic stroke events than the higher NVAFV group(HR 2.978,95%CIs 1.414 to 6.272).Conclusion Our study demonstrated that NVAFV,as estimated by colour duplex ultrasonography,was associated with the incidence of PCI and subsequent ischaemic events and that a high-risk population could be identified for further posterior circulation revascularisation.

关键词： patients stenosis vertebral

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Y-shaped branched ventriculo-peritoneal shunt for adult multiloculated hydrocephalus

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Chinese Medical Journal 2022年第8期135卷 980-982页

作者： Xiaohui Ren Chuanwei Yang Xiangrong Li Yong Cui Yonggang Wang Dali Sui Zhongli Jiang Song Lin Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing Neurosurgical InstituteChina National Clinical Research Center for Neurological DiseasesCenter of Brain TumorBeijing Institute for Brain DisordersBeijing Key Brain Tumor LaboratoryBeijing 100070China School of Neurosurgery Capital Medical UniversityBeijing 100069China

Multiloculated hydrocephalus(MLH)due to neurosurgical manipulation,hemorrhage,infection,or tumors is uncommon in adults and cannot be easily resolved by endoscopic fenestration or unilateral ventriculo-peritoneal shunt(VPS)and no consensus on surgical strategy for MLH has yet been reported.The goal of treatment is to restore communication between trapped ventricular compartments,[1]and current treatment methods include microsurgical fenestration of separate entrapments by endoscopy or craniotomy,shunt surgery with multiple catheters placed in trapped compartments,or combinations of these modalities.

关键词： shunt peritoneal manipulation

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低温自体血靶向回输对于非人灵长类脑卒中模型的神经保护作用

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Science Bulletin 2023年第14期68卷 1556-1566,M0004页

作者：陈健徐率立 Hangil Lee 吴隆飞何小夺赵文博张默马艳辉丁玉川付永娟吴川杰李明姜缪文程化坤李胜利马挺吉训明吴迪 Department of Neurosurgery Xuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China China-America institute of Neuroscience Xuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China Department of Neurological Surgery Wayne State University School of MedicineDetroit MI 46801USA Department of Neurology Xuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Anesthesiology Xuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China Department of Pathology Xuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China beijing Key Laboratory of Hypoxia Conditioning Translational Medicine Beijing 100053China Interdisciplinary Innovation institute of Medicine and Engineering Beijing Advanced Innovation Center for Big Data-Based Precision MedicineSchool of Biological Science andMedical EngineeringBeihang UniversityBeijing 100083China Department of Neurosurgery Heilongjiang Provincial HospitalHarbin 1500036China Department of Laboratory Animal Science Capital Medical UniversityBeijing 100069China

近几十年来,虽然研究已经证明治疗性低温在啮齿类动物脑卒中模型中有神经保护作用,但其临床转化却未能成功.可能的原因是不同物种之间的生物学差异以及转化研究中治疗性低温诱导难以有效实施.本研究介绍了一种基于非人灵长类动物缺血再... 详细信息

近几十年来,虽然研究已经证明治疗性低温在啮齿类动物脑卒中模型中有神经保护作用,但其临床转化却未能成功.可能的原因是不同物种之间的生物学差异以及转化研究中治疗性低温诱导难以有效实施.本研究介绍了一种基于非人灵长类动物缺血再灌注模型的选择性治疗性低温疗法,即将自体血于体外循环中冷却,在血管再通后立即通过微导管向缺血区域回输低温自体血.低温自体血将目标脑区迅速冷却至34℃以下,而核心温度可以维持在36℃左右.低温自体血回输减少了梗死面积,保留了白质完整性,改善了神经功能且未引发低温相关并发症.本研究结果表明,在非人灵长类动物脑卒中模型中,通过冷自体输血诱导治疗性低温是一种可行、快速和安全的方法.这提示低温自体血靶向回输是一种具有临床转化潜力的新型低温脑保护疗法.

关键词：自体血非人灵长类动物缺血区域血管再通神经保护作用自体输血微导管核心温度

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Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection

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Virologica Sinica 2024年第2期39卷 251-263页

作者： Wei Yang Chong-Yang Tang Dong-Ying Fan Yi-Song Wang Pei-Gang Wang Jing An Guo-Ming Luan beijing Key Laboratory of Epilepsy Sanbo Brain HospitalCapital Medical UniversityBeijing100093China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing100093China Department of Neurosurgery Epilepsy CenterSanbo Brain HospitalCapital Medical UniversityBeijing100093China Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Chinese institute for brain Research Beijing102206China

Viral encephalitis continues to be a significant public health concern.In our previous study,we discovered a lower expression of antiviral factors,such as IFN-β,STING and IFI16,in the brain tissues of patients with Rasmussen's encephalitis(RE),a rare chronic neurological disorder often occurred in children,characterized by unihemispheric brain atrophy.Furthermore,a higher cumulative viral score of human herpes viruses(HHVs)was also found to have a significant positive correlation with the unihemispheric atrophy in RE.Type I IFNs(IFN-I)signaling is essential for innate anti-infection response by binding to IFN-α/βreceptor(IFNAR).In this study,we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1(HSV-1)via periocular injection to investigate the relationship between IFN-I signaling and HHVs-induced brain lesions.While all mice exhibited typical viral encephalitis lesions in their brains,HSV-induced epilepsy was only observed in A6 mice.The gene expression matrix,functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced epilepsy.Additionally,ten key genes with the highest scores were identified.Taken together,these findings indicate that intact IFN-I signaling can effectively limit HHVs induced neural symptoms and brain lesions,thereby confirming the positive correlation between IFN-I signaling repression and brain atrophy in RE and other HHVs encephalitis.

关键词： IFN-I signaling Human herpes viruses(HHVs) Rasmussen's encephalitis(RE)

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Mice 3D testicular organoid system as a novel tool to study Zika virus pathogenesis

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Virologica Sinica 2023年第1期38卷 66-74页

作者： Wei Yang Chen Zhang Yan-Hua Wu Li-Bo Liu Zi-Da Zhen Dong-Ying Fan Zheng-Ran Song Jia-Tong Chang Pei-Gang Wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Department of Neurosurgery Capital Medical University Sanbo Brain HospitalBeijing100093China Center of Epilepsy Beijing Institute for Brain DisordersBeijing100093China

Zika virus(ZIKV)poses a serious threat to global public health due to its close relationship with neurological and male reproductive damage.However,deficiency of human testicular samples hinders the in-depth research on ZIKV-induced male reproductive system injury.Organoids are relatively simple in vitro models,which could mimic the pathological changes of corresponding organs.In this study,we constructed a 3D testicular organoid model using primary testicular cells from adult BALB/c mice.Similar to the testis,this organoid system has a blood-testis barrier(BTB)-like structure and could synthesize testosterone.ZIKV tropism of testicular cells and ZIKV-induced pathological changes in testicular organoid was also similar to that in mammalian testis.Therefore,our results provide a simple and reproducible in vitro testicular model for the investigations of ZIKV-induced testicular injury.

关键词： Organoid 3D cell culture Testicular organoid model Zika virus(ZIKV)

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