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Activation of adult endogenous neurogenesis by a hyaluronic acid co.lagen gel co.taining basic fibroblast growth factor promotes remodeling and functional reco.ery of the injured cerebral co.tex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and co.nitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina co.innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reco.struct co.tical layers II to VI in non-neurogenic regions,such as the co.tex,remains *** this study,we implanted a hyaluronic acid co.lagen gel loaded with basic fibroblast growth factor into the motor co.tex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reco.structed the architecture of co.tical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral co.tex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid co.lagen gel co.tical remodeling functional reco.ery migration motor co.tex injury neural circuits neural stem cells newborn neurons proliferation

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Fretting-co.rosion mechanisms of Ti6Al4V against co.rMo in simulated body fluid under various fretting states

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Friction 2024年第12期12卷 2741-2759页

作者： Jian PU Zupei ZHANG Yali ZHANG Xiaogang ZHANG Xinlu YUAN Xiaoyu ZHANG Guoxian ZHANG Wen CUI Shu YANG Zhongmin JIN School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China School of Mechanical Engineering Chengdu UniversityChengdu 610106China beijing akec medical co. Ltd.Beijing 102200China School of Materials Science and Engineering Peking UniversityBeijing 100871China GBA Center for medical Device Evaluation and Inspection NMPAShenzhen 518000China School of Mechanical Engineering University of LeedsLeeds LS29JTUK

Ti6Al4V alloy‒co.rMo alloy pair is co.monly applied for modular head‒neck interfaces for artificial hip ***,the fretting co.rosion damage at this interface seriously restricts its *** work studied the fretting co.rosion of Ti6Al4V‒co.rMo pair in calf serum *** established this material pair’s running co.dition fretting map(RCFM)regarding load and displacement,and revealed the damage mechanism of this material pair in various fretting regimes,namely partial slip regime(PSR),mixed fretting regime(MFR),and gross slip regime(GSR).The damage mechanism of Ti6Al4V alloy was mainly abrasive wear induced by co.rMo alloy and *** wear(material transfer)also existed in *** damage mechanism of co.rMo alloy was mainly abrasive wear induced by metal oxides and triboco.rosion in GSR and MFR,while no apparent damage in ***,a dense co.posite material layer with high hardness was formed in the middle co.tacting area in GSR,which reduced the co.rosion and wear of Ti alloys and exacerbated damage to co.***,the ion co.centration maps for Ti and co.ions were co.structed,which displayed the transition in the amount of released Ti and co.ions under different displacements and loads.

关键词： fretting co.rosion Ti6Al4V alloy co.rMo alloy co.posite material layer damage mechanism metal ion release

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Influence of layer thickness on formation quality,microstructure,mechanical properties,and co.rosion resistance of WE43 magnesium alloy fabricated by laser powder bed fusion

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Journal of Magnesium and Alloys 2024年第4期12卷 1367-1385页

作者： Bangzhao Yin Jinge Liu Bo Peng Mengran Zhou Bingchuan Liu Xiaolin Ma Caimei Wang Peng Wen Yun Tian Yufeng Zheng State Key Laboratory of Tribology in Advanced Equipment Beijing100084China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Institute for Precision Medicine Tsinghua UniversityBeijing102218China Department of Orthopaedics Peking University Third HospitalBeijing 100191China beijing akec medical co. Ltd.Beijing 102200China School of Materials Science and Engineering Peking UniversityBeijing 100871China Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijing 100191China

Laser powder bed fusion(L-PBF)of Mg alloys has provided tremendous opportunities for customized production of aeronautical and medical *** thickness(LT)is of great significance to the L-PBF process but has not been studied for Mg *** this study,WE43 Mg alloy bulk cubes,porous scaffolds,and thin walls with layer thicknesses of 10,20,30,and 40μm were *** required laser energy input increased with increasing layer thickness and was different for the bulk cubes and porous *** tended to occur at the co.nection joints in porous scaffolds for LT40 and co.ld be eliminated by reducing the laser energy *** thin wall parts,a large overhang angle or a small wall thickness resulted in porosity when a large layer thicknesses was used,and the porosity disappeared by reducing the layer thickness or laser energy input.A deeper keyhole penetration was found in all occasions with porosity,explaining the influence of layer thickness,geometrical structure,and laser energy input on the *** the samples achieved a high fusion quality with a relative density of over 99.5%using the optimized laser energy *** increased layer thickness resulted to more precipitation phases,finer grain sizes and decreased grain *** the similar high fusion quality,the tensile strength and elongation of bulk samples were significantly improved from 257 MPa and 1.41%with the 10μm layer to 287 MPa and 15.12%with the 40μm layer,in acco.dance with the microstructural *** effect of layer thickness on the co.pressive properties of porous scaffolds was ***,the co.rosion rate of bulk samples accelerated with increasing the layer thickness,mainly attributed to the increased number of precipitation phases.

关键词： Magnesium alloy WE43 Laser powder bed fusion Layer thickness Process optimization

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High temperature oxidation treated 3D printed anatomical WE43 alloy scaffolds for repairing periarticular bone defects:In vitro and in vivo studies

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Bioactive Materials 2024年第2期32卷 177-189页

作者： Bingchuan Liu Jinge Liu Chaoxin Wang Zhengguang Wang Shuyuan Min Caimei Wang Yufeng Zheng Peng Wen Yun Tian Department of Orthopaedics Peking University Third HospitalBeijing100191China Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijing100191China The State Key Laboratory of Tribology Tsinghua UniversityBeijing100084China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China beijing akec medical co. Ltd.Beijing102200China School of Materials Science and Engineering Peking UniversityBeijing100871China

Reco.struction of subarticular bone defects is an intractable challenge in *** simultaneous repair of cancellous defects,fractures,and cartilage damage is an ideal surgical outco.e.3D printed porous anatomical WE43(magnesium with 4 wt%yttrium and 3 wt%rare earths)scaffolds have many advantages for repairing such bone defects,including good bioco.patibility,appropriate mechanical strength,customizable shape and structure,and *** a previous investigation,we successfully enhanced the co.rosion resistance of WE43 samples via high temperature oxidation(HTO).In the present study,we explored the feasibility and effectiveness of HTO-treated 3D printed porous anatomical WE43 scaffolds for repairing the cancellous bone defects acco.panied by split fractures via in vitro and in vivo *** HTO treatment,a dense oxidation layer mainly co.posed of Y2O3 and Nd2O3 formed on the surface of *** addition,the majority of the grains were equiaxed,with an average grain size of 7.4μ*** and rabbit experiments co.firmed the non-cytotoxicity and bioco.patibility of the HTO-treated WE43 *** the implantation of scaffolds inside bone defects,their porous structures co.ld be maintained for more than 12 weeks without penetration and for more than 6 weeks with *** the postoperative follow-up period for up to 48 weeks,radiographic examinations and histological analysis revealed that abundant bone gradually regenerated along with scaffold degradation,and stable osseointegration formed between new bone and scaffold *** images further demonstrated no evidence of any obvious damage to the cartilage,ligaments,or menisci,co.firming the absence of traumatic ***,finite element analysis and biomechanical tests further verified that the scaffolds was co.ducive to a uniform mechanical *** co.clusion,applying the HTO-treated 3D printed porous anatomical WE43 scaffolds exhibited favorable repa

关键词： Periarticular bone defects 3D printing technology Magnesium alloy High temperature oxidation Osseointegration

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The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study

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Bioactive Materials 2023年第10期28卷 537-548页

作者： Chaoxin Wang Jinge Liu Shuyuan Min Yu Liu Bingchuan Liu Yuanyu Hu Zhengguang Wang Fengbiao Mao Caimei Wang Xiaolin Ma Peng Wen Yufeng Zheng Yun Tian Department of Orthopedics Peking University Third HospitalBeijing100191China Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijing100191China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Institute of Medicine Innovation and Research Peking University Third HospitalBeijing100191China beijing akec medical co. Ltd.Beijing102200China School of Materials Science and Engineering Peking UniversityBeijing100871China

The effects of pore size in additively manufactured biodegradable porous magnesium on the mechanical properties and biodegradation of the scaffolds as well as new bone formation have rarely been reported. In this work, we found that high temperature oxidation improves the co.rosion resistance of magnesium scaffold. And the effects of pore size on the mechanical characteristics and biodegradation of scaffolds, as well as new bone formation, were investigated using magnesium scaffolds with three different pore sizes, namely, 500, 800, and 1400 μm (P500, P800, and P1400). We disco.ered that the mechanical characteristics of the P500 group were much better than those of the other two groups. In vitro and in vivo investigations showed that WE43 magnesium alloy scaffolds supported the survival of mesenchymal stem cells and did not cause any local toxicity. Due to their larger specific surface area, the scaffolds in the P500 group released more magnesium ions within reasonable range and improved the osteogenic differentiation of bone mesenchymal stem cells co.pared with the other two scaffolds. In a rabbit femoral co.dyle defect model, the P500 group demonstrated unique performance in promoting new bone formation, indicating its great potential for use in bone defect regeneration therapy.

关键词： Pore size Additive manufacturing WE43 alloy Magnesium alloy

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Improving co.rosion resistance of additively manufactured WE43 magnesium alloy by high temperature oxidation for biodegradable applications

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Journal of Magnesium and Alloys 2024年第3期12卷 940-953页

作者： Jinge Liu Bangzhao Yin Fei Song Bingchuan Liu Bo Peng Peng Wen Yun Tian Yufeng Zheng Xiaolin Ma Caimei Wang State Key Laboratory of Tribology in Advanced Equipment Beijing100084China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Department of Orthopaedics Beijing Tsinghua Changgung HospitalInstitute for Precision MedicineTsinghua UniversityBeijing102218China Department of Orthopaedics Peking University Third HospitalBeijing 100191China Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijing 100191China School of Materials Science and Engineering Peking UniversityBeijing 100871China beijing akec medical co. Ltd.Beijing 102200China

Laser powder bed fusion(L-PBF)has been employed to additively manufacture WE43 magnesium(Mg)alloy biodegradable implants,but WE43 L-PBF samples exhibit excessively rapid *** this work,dense WE43 L-PBF samples were built with the relativity density reaching 99.9%.High temperature oxidation was performed on the L-PBF samples in circulating air via various heating temperatures and holding *** oxidation and diffusion at the elevated temperature generated a gradient structure co.posed of an oxide layer at the surface,a transition layer in the middle and the *** oxide layer co.sisted of rare earth(RE)oxides,and became dense and thick with increasing the holding *** matrix was co.posed ofα-Mg,RE oxides and Mg_(24)RE_(5) *** precipitates almost disappeared in the transition *** passivation effect was observed in the samples treated by a suitable high temperature *** original L-PBF samples lost 40%weight after 3-day immersion in Hank’s solution,and broke into fragments after 7-day *** casted and solution treated samples lost roughly half of the weight after 28-day *** high temperature oxidation samples,which were heated at 525℃ for 8 h,kept the structural integrity,and lost only 6.88%weight after 28-day *** substantially improved co.rosion resistance was co.tributed to the gradient structure at the *** one hand,the outmost dense layer of RE oxides isolated the co.rosive medium;on the other hand,the transition layer co.siderably inhibited the co.rosion owing to the lack of ***,high temperature oxidation provides an efficient,eco.omic and safe approach to inhibit the co.rosion of WE43 L-PBF samples,and has promising prospects for future clinical applications.

关键词： Laser powder bed fusion Biodegradable magnesium alloy High temperature oxidation co.rosion resistance WE43.

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High-strength mineralized co.lagen artificial bone

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Frontiers of Materials Science 2014年第1期8卷 53-62页

作者： Zhi-Ye QIU Chun-Sheng TAO Helen CUI Chang-Ming WANG Fu-Zhai CUI School of Materials Science and Engineering Tsinghua University Beijing 100084 China beijing AIIgens medical Science & Technology co. Ltd. Beijing 100176 China

Mineralized co.lagen （MC） is a biomimetic material that mimics natural bone matrix in terms of both chemical co.position and microstructure. The biomimetic MC possesses good bioco.patibility and osteogenic activity, and is capable of guiding bone regeneration as being used for bone defect repair. However, mechanical strength of existing MC artificial bone is too low to provide effective support at human load-bearing sites, so it can only be used for the repair at non-load-bearing sites, such as bone defect filling, bone graft augmentation, and so on. In the present study, a high strength MC artificial bone material was developed by using co.lagen as the template for the biomimetic mineralization of the calcium phosphate, and then followed by a co.d co.pression molding process with a certain pressure. The appearance and density of the dense MC were similar to those of natural co.tical bone, and the phase co.position was in co.formity with that of animal＇s co.tical bone demonstrated by XRD. Mechanical properties were tested and results showed that the co.pressive strength was co.parable to human co.tical bone, while the co.pressive modulus was as low as human cancellous bone. Such high strength was able to provide effective mechanical support for bone defect repair at human load-bearing sites, and the low co.pressive modulus can help avoid stress shielding in the application of bone regeneration. Both in vitro cell experiments and in v/vo implantation assay demonstrated good bioco.patibility of the material, and in v/vo stability evaluation indicated that this high-strength MC artificial bone co.ld provide long-term effective mechanical support at human load- bearing sites.

关键词： mineralized co.lagen (MC) high strength biomimeUc mineralization co.dco.pression molding

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A practical synthesis of (-)fosfomycin from its enantiomer

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Chinese Chemical Letters 2008年第11期19卷 1297-1300页

作者： Meng Zhang Zheng Yu Ji Jun Li Da Li Yin beijing co.lab Pharma co. Ltd. Beijing 102600 China Institute of Materia Medica Peking Union Medical College Beijing 100050 China

（＋）-cis-（1S, 2R）-Epoxypropylphosphonic acid, the enantiomer of fosfomycin, which is the industrial side-product in the preparation of the antibiotic fosfomycin, was co.verted into （-）fosfomycin by a seven-step procedure. The esterification of the dihydroxyphosphonic intermediate was the key step. The title co.pound was obtained in good yield and its optical purity was up to the medicine quality standard of Chinese Pharmaco.oeia.

关键词： Fosfomycin Enantiomer Phosphonate

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Stimuli-responsive microcarriers and their application in tissue repair: A review of magnetic and electroactive microcarrier

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Bioactive Materials 2024年第9期39卷 147-162页

作者： LiYang Zhang Mengjiao Ma Junfei Li Kun Qiao Yajie Xie Yudong Zheng School of Material Science and Engineering University of Science and Technology BeijingBeijingChina beijing Wanjie medical Device co. LtdBeijingChina beijing Gereco. Technology co.pany Ltd. BeijingChina

Microcarrier applications have made great advances in tissue engineering in recent years, which can load cells,drugs, and bioactive factors. These microcarriers can be minimally injected into the defect to help reco.struct agood microenvironment for tissue repair. In order to achieve more ideal performance and face more co.plextissue damage, an increasing amount of effort has been focused on microcarriers that can actively respond toexternal stimuli. These microcarriers have the functions of directional movement, targeted enrichment, materialrelease co.trol, and providing signals co.ducive to tissue repair. Given the high co.trollability and designabilityof magnetic and electroactive microcarriers, the research progress of these microcarriers is highlighted in thisreview. Their structure, function and applications, potential tissue repair mechanisms, and challenges are *** summary, through the design with clinical translation ability, meaningful and co.prehensiveexperimental characterization, and in-depth study and application of tissue repair mechanisms, stimuliresponsivemicrocarriers have great potential in tissue repair.

关键词： Stimuli-responsiveness Magnetic microcarrier Electroactive microcarrier Tissue repair

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Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications:Process optimization,in vitro and in vivo investigation

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Bioactive Materials 2022年第10期7卷 301-319页

作者： Jinge Liu Bingchun Liu Shuyuan Min Bangzhao Yin Bo Peng Zishi Yu Caimei Wang Xiaolin Ma Peng Wen Yun Tian Yufeng Zheng The State Key Laboratory of Tribology Tsinghua UniversityBeijing100084China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Department of Orthopaedics Peking University Third HospitalBeijing100191China School of Materials Science and Engineering Peking UniversityBeijing100871China Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijing100191China beijing akec medical co. Ltd.Beijing102200China

Laser powder bed fusion(L-PBF)of magnesium(Mg)alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone ***,one of the key technical difficulties lies in the poor L-PBF process performance of Mg,co.tributed by the high susceptibility to oxidation,vaporization,thermal expansion,and powder attachment *** work investigated the influence of L-PBF energy input and scanning strategy on the formation quality of porous scaffolds by using WE43 powder,and characterized the microstructure,mechanical properties,bioco.patibility,biodegradation and osteogenic effect of the as-built WE43 porous *** the customized energy input and scanning strategy,the relative density of struts reached over 99.5%,and the geometrical error between the designed and the fabricated porosity declined to below 10%.Massive seco.dary phases including intermetallic precipitates and oxides were *** co.pressive strength(4.37-23.49 MPa)and elastic modulus(154.40-873.02 MPa)were co.parable to those of cancellous *** bioco.patibility was observed by in vitro cell viability and in vivo *** biodegradation of as-built porous scaffolds promoted the osteogenic effect,but the structural integrity devastated after 12 h by the immersion tests in Hank’s solution and after 4 weeks by the implantation in rabbits’femur,indicating an excessively rapid degradation rate.

关键词： Additive manufacturing Biodegradable metal Laser powder bed fusion Magnesium alloy Porous scaffold WE43

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