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Lower levels sex hormone-binding globulin independently associated with metabolic syndrome in pre-elderly and elderly men in china

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Journal of Geriatric Cardiology 2013年第1期10卷 28-33页

作者： Xiao-Na Pang Yu Hu Ying Yuan Ji-Ping Shen Xiao-Yun Zha Xuan Sun Department of Geriatrics Zhongshan Hospital Fudan University 180 Fenglin Road Shanghai China beckman coulter commercial enterprise china co. ltd. 500 Fu Shan Road Shanghai China

Objective To examine the relationship between sex hormone–binding globulin (SHBG) and the metabolic syndrome (MetS) in pre-elderly and elderly men in china. Methods A cross-sectional studywas done among 437men, aged 45 to 94 years old. Early morning fasting sera were assayed for total testosterone (TT), SHBG and other biochemical markers. Free testosterone (FT) was calculated. Results The SHBG level of the MetS group was significantly lower than those without MetS 35.70 (25.18, 47.10) nmol/L vs. 41.90 (31.80, 55.20) nmol/L; P co.ponents increases, SHBG and TT levels became lower. SHBG co.related with age, as did TT and most of metabolic co.ponents. Body mass index (BMI), high density lipoprotein-cholesterol (HDL-C), triglyceride (TG), and TT remained independently associated with SHBG by multivariate regression analysis. In a logistic regression taking MetS as the dependent variable, SHBG (95% co.fidence interval (95% CI): 0.975��0.994, P = 0.018) and homeostasis model assessment for insulin resistance (HOMA-IR) (95%CI: 1.535��2.647, P co.clusions Lower SHBG is independently associated with MetS among pre-elderly and elderly men. SHBG may be an independent predictor of MetS, but the mechanism of how SHBG is involved in MetS requires further studied.

关键词： Males Metabolic Syndrome Sex hormone–binding globulin Testosterone

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Research on Moflo XDP high speed cell sorting techniques and parameter optimization

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Journal of Chinese Pharmaceutical Sciences 2020年第5期29卷 355-363页

作者： Yufang Sun Chen Zheng Bo Xu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China beckman coulter commercial enterprise(china)co. LTDBeijing 100004China

This article aims to discuss strategies to operate Moflo XDP high-speed sorting equipment for cell sorting and optimize the instrument to run in the best operating *** fluorescent microspheres to quickly calibrate the position of the main liquid flow and the laser beam,adjust the amplitude and frequency acco.ding to different size CytoNozzles to find the best breakoff point,and adjust the four-way side flow to achieve the stable maintaining of the equipment,so as to quickly sort sample at *** absence of air bubbles in the sheath liquid barrel and the liquid path is the key to achieving a stable sorting-maintaining in the sorting *** accurate calculation of the breakoff point and drop delay is the key to improve sorting efficiency and cell activity.

关键词： Cell sort Bubble Maintaining CV optimization

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