Lower levels sex hormone-binding globulin independently associated with metabolic syndrome in pre-elderly and elderly men in China

作     者：Xiao-Na Pang Yu Hu Ying Yuan Ji-Ping Shen Xiao-Yun Zha Xuan Sun 

作者机构：Department of Geriatrics Zhongshan Hospital Fudan University 180 Fenglin Road Shanghai China Beckman Coulter Commercial Enterprise China Co. LTD.500 Fu Shan Road Shanghai China 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2013年第10卷第1期

页      面：28-33页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Beckman Coulter Commercial Enterprise (China) Co. LTD. for technical and financial support 

主　　题：Males Metabolic Syndrome Sex hormone–binding globulin Testosterone 

摘      要：Objective To examine the relationship between sex hormone–binding globulin (SHBG) and the metabolic syndrome (MetS) in pre-elderly and elderly men in China. Methods A cross-sectional studywas done among 437men, aged 45 to 94 years old. Early morning fasting sera were assayed for total testosterone (TT), SHBG and other biochemical markers. Free testosterone (FT) was calculated. Results The SHBG level of the MetS group was significantly lower than those without MetS 35.70 (25.18, 47.10) nmol/L vs. 41.90 (31.80, 55.20) nmol/L; P 0.001). As the number of MetS components increases, SHBG and TT levels became lower. SHBG correlated with age, as did TT and most of metabolic components. Body mass index (BMI), high density lipoprotein-cholesterol (HDL-C), triglyceride (TG), and TT remained independently associated with SHBG by multivariate regression analysis. In a logistic regression taking MetS as the dependent variable, SHBG (95% confidence interval (95% CI): 0.975��0.994, P = 0.018) and homeostasis model assessment for insulin resistance (HOMA-IR) (95%CI: 1.535��2.647, P 0.001) were included in the final model. Conclusions Lower SHBG is independently associated with MetS among pre-elderly and elderly men. SHBG may be an independent predictor of MetS, but the mechanism of how SHBG is involved in MetS requires further studied.