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终末期肾衰竭患者动脉粥样硬化性心血管疾病的危险因素

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中华内科杂志 2004年第12期43卷 948-950页

作者：姚强钱家麒 Bengt Lindholm Peter Stenvinkel 上海第二医科大学附属仁济医院肾脏科 200001 Divisions of baxter novum and Renal Medicine Karolinska University Hospital HuddingeKarolinska InstitutetStockholmSweden Divisions

终末期肾衰竭（ESRD）患者比一般人群具有更高的临床心血管疾病（CVD）和左室肥大患病率，尤其是接受肾脏替代治疗（RRT）的ESRD患者，高度处于过早死亡的危险。事实上，ESRD患者死于营养不良、炎症和动脉粥样硬化综合征的人数与死于转... 详细信息

终末期肾衰竭（ESRD）患者比一般人群具有更高的临床心血管疾病（CVD）和左室肥大患病率，尤其是接受肾脏替代治疗（RRT）的ESRD患者，高度处于过早死亡的危险。事实上，ESRD患者死于营养不良、炎症和动脉粥样硬化综合征的人数与死于转移性肿瘤的人数相当。引起尿毒症患者CVD发病明显增高的原因尚不完全明了，特别是逆流行病学现象的出现，使人们对传统的CVD危险因素如高胆固醇、高血压、肥胖等在ESRD人群中的作用产生了困惑。本文将着重讨论在ESRD这一CVD高发人群中，非传统的危险因素（表1）在动脉粥样性CVD进展中的影响。

关键词：终末期肾衰竭动脉粥样硬化心血管疾病危险因素流行病学

终末期肾衰竭患者血清胎球蛋白A水平改变与临床预后的关系

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中华肾脏病杂志 2005年第2期21卷 72-75页

作者：王开钱家麒 Peter Stenvinkel Bengt Lindholm 200001 上海第二医科大学附属仁济医院肾脏科 Divisions of Renal Medicine and baxter novum Department of Clinical Science Karolinska University Hospital Huddinge Stockholm Sweden

目的探讨终末期肾衰竭(ESRD)患者在透析前以及透析年后血清胎球蛋白1A浓度的改变以及其与临床表现及预后之间的关系。方法,247例透析前ESRD患者接受血清胎球蛋白A及有关生化检查,其中131例在透析1年后再次检测。此外,用B超检测颈动脉斑... 详细信息

目的探讨终末期肾衰竭(ESRD)患者在透析前以及透析年后血清胎球蛋白1A浓度的改变以及其与临床表现及预后之间的关系。方法,247例透析前ESRD患者接受血清胎球蛋白A及有关生化检查,其中131例在透析1年后再次检测。此外,用B超检测颈动脉斑块。患者随访期中位数为29.6(范12.1￣42.0)个围月。70例健康人入选对照组。结果ESRD患者血胎球蛋白A水平较正常对照组明显降低(P<0.05)。透析前血胎球蛋白A水平与血白蛋白(P<0.01)、IL鄄6(P<0.05)、血钙磷乘积(P<0.05),尤其是与血磷水平(P<0.05)相关。炎症、营养不良患者血胎球蛋白水平较低(AP<0.05)。颈动脉有斑块的患者血胎球蛋白浓度较无斑块者明显降低(AP<0.01)。透析1年后胎球蛋白A血浓度较治疗前相比明显降低(131例,P<0.01)。62%患者经过1年的肾脏替代治疗后胎球蛋白A水平较治疗前相比明显下降。无论是在治疗前还是在治疗1年后,随访中存活的患者胎球蛋白水平显著地高于死亡者(AP<0.05)。结论ESRD患者低胎球蛋白A水平与营养不良、炎症、动脉粥样硬化以及病死率相关,经肾脏替代治疗后胎球蛋白A水平仍持续下降。胎球蛋白A水平是ESRD患者预后的一个重要独立因素。

关键词：终末期肾衰竭血清胎球蛋白A 预后动脉粥样硬化营养不良

Recent advances in estrogen-signaling and new sites for pharmacological interventions

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Recent advances in estrogen-signaling and new sites for phar...

Dementia studies in Chinese populations

第十五届国际药理学大会

作者： Jan-Ake Gustafsson Department of Biosciences and Nutrition novum Karolinska Institutet Stockholm

＜正＞ Both in vitro and in vivo. ERβ acts as an antiproliferative principle in several tissues, e g the prostate where ERβ is antiproliferative. proapoptotic and prodifferentiative. An ERβ agonist developed by Eli Lilly shows all of the anticipated biological effects on the prostate, namely reduced cellular proliferation and increased apoptosis, leading to a diminished size of both mouse and rat prostate. This opens up hitherto unthought-of pharmaceutical possibilities in treating prostate disorders in humans, including both benign prostatic hyperplasia and prostate carcinoma. It now appears quite clear that ERβ also exerts an antiproliferative effect on human breast cancer cells both in vitro and in vivo;there seems to be sufficient indications for a pharmaceutical potential of ERβ agonists in treatment of breast cancer. A similar case can be made for use of ERβ agonists in treatment of colon cancer. Furthermore. ERβ is of major importance in estrogenic regulation of the immune system. Wyeth-Ayerst has reported extremely encouraging results of ERβ agonists in treatment of rodent models of inflammatory bowel disease （IBD）. rheumatoid arthritis and endometriosis.

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Neuroscience Bulletin 2014年第2期30卷 207-216页

作者： Jin-Jing Pei Maria Stella T. Giron Jianping Jia Hui-Xin Wang Department of Neurology Xuan Wu Hospital Capital Medical University Beijing 100053 China KI-Alzheimer's Disease Research Center Department of Neurobiology Care Sciences and Society Karolinska InstitutetNovum 141 86 Stockholm Sweden Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and StockholmUniversity G~vlegatan 16 113 30 Stockholm Sweden

Variations in the prevalence of dementia in different ethnic groups have been reported worldwide, and a number of reviews have provided a picture of epidemiological studies in dementia research. However, little is known about epidemiological studies in Chinese populations. In this review, we searched PubMed and the Web of Science for original research articles published in English up to July 2013 on the prevalence, incidence, risk factors, and prognosis of dementia in Chinese populations worldwide. Except for the prevalence, we included only population-based follow-up studies. We identified 25 studies in elderly Chinese residents in China's Mainland, Hong Kong, Taiwan, and Singapore, and found a higher prevalence of dementia in China's Mainland than in the other locations, which may be due to that the studies from China's Mainland are more recent than those from other locations. A notable increase in incidence was observed when dementia cases were diagnosed using 10/66 diagnostic criteria compared to other criteria. Studies on risk factors for dementia were limited and mostly from China's Mainland. Age, gender, education, smoking, and alcohol consumption were related to the risk of dementia in Chinese populations. Only two prognostic studies were identified, and age, gender, and residential area were related to the prognosis of dementia. In conclusion, the prevalence, incidence, and risk factors for dementia found in Chinese populations were comparable to other ethnic groups, but no conclusive results on prognosis were found. The differences in prevalence and incidence were influenced by the diagnostic criteria and the time of study. Longitudinal population-based studies on the incidence, risk factors, and prognosis of dementia in Chinese populations are required.

关键词： dementia epidemiology risk factors prognosis prevalence incidence

Estrogen receptorβexpression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons

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UV Photoproduct Levels in Melanocytic Nevi and Surrounding Epidermis in Human Skin in situ

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Margaret WARNER Jan-Ake GUSTAFSSON Division of Medical Nutrition Department of Biosciences and NutritionKarolinska InstitutetNovum S14186Sweden

Our previous studies with ERβ mice demonstrated that ERβis necessary for embryonic development of the brain as early as E14.5 and is involved in neuronal *** early effects of estrogen receptors were unexpected because estradiol synthesis and action in the brain are well documented to occur at *** the presence of ERβin the embryonic brain was not demonstrated it remained possible that the developmental abnormalities in ERβ mice were due to indirect effects of estrogen action on the *** the present study we examined the distribution of ERβin the developing brain and identified a population of ERP-regulated ***βappears in the brain at *** localized in the wall of midbrain,neuromere,hypothalamus,thalamus and basal plate of *** E15.5 and E16.5,ERβexpression increased in the hypothalamus,thalamus and midbrain and appeared in the limbic *** E18.5,ERβexpression was strongly and widely expressed throughout the brain including cerebellum and striatum,while there were very few positive cells in the ventricular *** the paraventricular thalamic nucleus and parafascicular nucleus,most of the calretinin-immunopositive interneurons expressed ERβ.In ERβ mice,calretinin expression was markedly lower than in WT mice in the hippocampus,thalamus and amygdala both at E16.5 and at *** growth factor receptor expression was lower in the cortex of ERβ than WT mice at E15.5,and unlike WT mice,was absent from the superficial marginal *** findings suggest that ERp in the embryonic brain is necessary for the development of calretininimmunoreactive GABAergic intemeurons and for neuronal migration in the cortex through modulating EGFR expression at middle and later embryonic stages.

关键词： Brain ERβ interneuron calretinin development

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UV Photoproduct Levels in Melanocytic Nevi and Surrounding E...

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

Asian-Pacific Conference of Tumor Biology 2001

作者： ChunyanZhao KariHemminki ErnaSnellman ChristerT.Jansen Department of Biosciences at novum Karolinska Institute 14157 Huddinge Sweden Department of Biosciences at novum Karolinska Institute 14157 Huddinge Sweden Department of Dermatology Paijat-Hame Central HospitalFIN 15850 LahtiFinland Department of Dermatology University of Turku20520 TurkuFinland

＜正＞Melanocytic nevi are localized benign proliferations of *** development of nevi and cuta-neous malignant melanoma（CMM）has been linked to sun *** risk factors for CMM includesun exposure,pigmentary traits,and a family history of *** damage induced by ultravioletradiation（UVR）is considered to have a direct role in the initiation of skin *** mein products in-duced by UV are dipyrimidine lesions:cyclobutane pyrimidine dimers（CPD）and 6-4 pyrimidine-pyrimidone *** study compares the induction of photoproducts in nevi and in surrounding

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Frontiers of Medicine 2008年第3期2卷 235-238页

作者： Rong LIU Ji ZENG Xinwen ZHOU Jinjing PEI Jianzhi WANG Department of Pathophysiology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Karolinska Institutet KI-Alzheimer Disease Research Center(KI-ADRC)NovumHuddingeSweden Clinical Laboratory of Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The aim of this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307)phosphor-ylation,protein phosphatase 2A(PP2A)activity,and on tau *** Src siRNA was transfected into cultured mouse neuroblastoma N2a cells to inhibit the expression of Src protein,and the phosphorylation levels of PP2A Y307 and tau at different sites,as well as PP2A activity were detected at different time points after siRNA *** hours after siRNA transfec-tion,the protein level of Src was dramatically decreased,with decreased PP2A Y307 ***,the total PP2A protein level was also decreased,together with a decreased PP2A *** was hyperpho-sphorylated at the Ser198/199/202 *** factors may be involved in the cellular regulation of PP2A *** Src expression could induce inactivation of PP2A and tau hyperphosphorylation.

关键词： Src kinase protein phosphatase 2A tau pro-tein Alzheimer’s disease

MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction

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Protein & Cell 2016年第12期7卷 916-920页

作者： Han Feng Sheng Wang Ling Guo Avinash S. Punekar Rudolf Ladenstein Da-Cheng Wang Wei Liu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Molecular Biophysics of the Ministry of Educa- tion College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Institute of Immunology The Third Military Medical University Chongqing 400038 China Department of Biosciences and Nutrition Karolinska Institutet NOVUM 14183 Huddinge Sweden

Dear Editor, Heat shock factors （HSFs） constitute a transcription factor family playing regulatory roles in maintaining cellular protein homeostasis or mediating cell differentiation and develop- ment （Akerfelt et al., 2010, Bjork and Sistonen 2010, Westerheide et al., 2012）. Some human diseases such as cancer and neurodegeneration are often linked with mal- function of HSFs （Dai et al., 2007, Neef et al., 2011, Scherz- Shouval et al., 2014）. The human HSF family consists four members： HSF1-4, which exhibit tissue-specific expression profiles and possess unique but overlapping functions. HSF1 is the major regulator of the heat shock response.

关键词： Minor Groove Major Groove Significant Conformational Change Sumo Modification Attenuation Phase

Skin Cancer Detection Using Temperature Variation Analysis

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Engineering（科研） 2013年第10期5卷 18-21页

作者： Ahmed M. Nasr Moustafa Hamed Hamid Muhammed Moustapha Hassan Clinical Research Center novum Karolinska University Hospital Huddinge Stockholm Sweden Division of Informatics Logistics and Management School of Technology and Health STH Royal Institute of Technology KTH Stockholm Sweden

In the medical field, new technologies are incorporated for the sole purpose of enhancing the quality of life for the patients and even for the normal healthy people. Infrared technology is one of the technologies that have some applications in both the medical and biological fields. In this work, the thermal infrared (IR) measurement is used to investigate the potential of skin cancer detection. IR enjoys non-invasive and non-contact advantages as well as favorable cost, apparently. It is also very well developed regarding the technological and methodological aspects. IR per se is an electro-metric radiation that all objects emit when their temperature is above the absolute zero. And the human body is not different in this regard. The IR range extends, ideally, to cover wavelengths from 800 nanometer to few hundred micrometer. Cancer, in modern life, has grown tangibly due to many factors, such as life expectancies increase, personal habits and ultraviolet radiation exposures among others. Moreover, the significant enhancement of technologies has helped identifying more types of cancers than before. The sole purpose of this work is to investigate further IR technology methods and applications not yet matured in skin cancer detection to enhance the detection ability with higher safety level.

关键词： Infrared Skin Cancer Melanoma Thermal Detection