Estrogen receptorβexpression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons
作者单位：Division of Medical NutritionDepartment of Biosciences and NutritionKarolinska InstitutetNovum S14186Sweden
会议名称：《中国神经科学学会第四次会员代表大会暨第七届全国学术会议》
会议日期：2007年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
关 键 词：Brain ERβ interneuron calretinin development
摘 要：Our previous studies with ERβ mice demonstrated that ERβis necessary for embryonic development of the brain as early as E14.5 and is involved in neuronal *** early effects of estrogen receptors were unexpected because estradiol synthesis and action in the brain are well documented to occur at *** the presence of ERβin the embryonic brain was not demonstrated it remained possible that the developmental abnormalities in ERβ mice were due to indirect effects of estrogen action on the *** the present study we examined the distribution of ERβin the developing brain and identified a population of ERP-regulated ***βappears in the brain at *** localized in the wall of midbrain,neuromere,hypothalamus,thalamus and basal plate of *** E15.5 and E16.5,ERβexpression increased in the hypothalamus,thalamus and midbrain and appeared in the limbic *** E18.5,ERβexpression was strongly and widely expressed throughout the brain including cerebellum and striatum,while there were very few positive cells in the ventricular *** the paraventricular thalamic nucleus and parafascicular nucleus,most of the calretinin-immunopositive interneurons expressed ERβ.In ERβ mice,calretinin expression was markedly lower than in WT mice in the hippocampus,thalamus and amygdala both at E16.5 and at *** growth factor receptor expression was lower in the cortex of ERβ than WT mice at E15.5,and unlike WT mice,was absent from the superficial marginal *** findings suggest that ERp in the embryonic brain is necessary for the development of calretininimmunoreactive GABAergic intemeurons and for neuronal migration in the cortex through modulating EGFR expression at middle and later embryonic stages.