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Absorption and biotransformation of four compounds in the Guizhi decoction in the gastrointestinal tracts of rats

Journal of Traditional Chinese medicine 2019年第3期39卷 332-338页

作者： Gao Huan Zhang Lishi Song Jiannan Bai Dong College of pharmacy Shaanxi University of Chinese Medicine Xianyang 712046 China Institute of basic Theory of Traditional Chinese medicine China Academy of Chinese Medical Sciences Beijing 100700 China

OBJECTIVE:To study the absorption and biotransformation of liquiritin,cinnamic acid,paeoniflorin,and glycyrrhizic acid in the Guizhi decoction (GZD) in the gastrointestinal tracts of ***:A simple and reliable high-performance liquid chromatography method was established and validated for the analysis of the four components of GZD simultaneously in the gastrointestinal tracts of *** were randomly divided into in situ gastrointestinal loop model,in vitro anaerobic culture model,and blank control *** rats were fasted for 12 h and anesthetized using 20% ***,the abdominal cavity of each rat was opened,and the stomach,duodenum,jejunum,ileum,cecum,and colon were *** the in situ gastrointestinal loop model group,2.5 mL of GZD (1.0 g crude drug/mL,37 ℃)were injected into the gastrointestinal *** abdominal incision was covered with warm,wet cotton,and animals were maintained at 25 ℃.Then,we collected the gastrointestinal tract content after 1.5 *** the in vitro anaerobic culture model group,the gastrointestinal tract contents of rats were collected and then cultured in 2.5 mL of GZD in an anaerobic environment at 25 ℃ for 24 *** the blank control group,rats received the same volume of a normal saline solution instead of *** performance liquid chromatography was used to detect the liquiritin,cinnamic acid,paeoniflorin,and glycyrrhizic acid concentrations in each group and calculate the absorption and biotransformation rates of each ***:Cinnamic acid (low polarity) was more easily absorbed by each gastrointestinal part than the higher-polarity ***,the absorption rate in the cecum was higher than that in other *** four compounds,cinnamic acid,liquiritin,paeoniflorin,and glycyrrhizic acid,were transformed completely within 24 h in the cecum and colon,whereas they were hardly transformed in the stomach,excluding glycyrrhizic *** addition,all ingredients had higher biotransformati

关键词： Absorption Cinnamates Glycyrrhizic acid Biotransformation Chromatography,high pressure liquid Guizhi decoction

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Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance

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World Journal of Diabetes 2024年第6期15卷 1291-1298页

作者： Xiao-Ming Liu Shi-Qing Yuan Ying Ning Shi-Jia Nie Xu-Qiong Wang Hong-Yi Jia Xiu-Li Zheng Department of basic medicine School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of clinical medicine Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Lingguizhugan(LGZG)decoction is a widely used classic Chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal *** To assess the therapeutic effect of LGZG decoction on HFD-induced IR and explore the potential underlying *** To establish an IR rat model,a 12-wk HFD was administered,followed by a 4-wk treatment with *** determination of IR status was achieved through the use of biochemical tests and oral glucose tolerance *** a targeted metabolomics platform to analyze changes in serum metabolites,quantitative real-time PCR(qRT-PCR)was used to assess the gene expression of the ribosomal protein S6 kinase beta 1(S6K1).RESULTS In IR rats,LGZG decreased body weight and indices of hepatic *** effectively controlled blood glucose and food intake while protecting islet *** analysis revealed significant differences between the HFD and HFDLGZG *** intervention reduced branched-chain amino acid *** of IR-related metabolites such as tryptophan,alanine,taurine,and asparagine decreased *** may be linked to amino acids due to the contemporaneous increase in S6K1 expression,as shown by *** Our study strongly suggests that LGZG decoction reduces HFD-induced *** may activate S6K1 via metabolic *** findings lay the groundwork for the potential of LGZG as an IR treatment.

关键词： Lingguizhugan decoction High-fat diet-induced insulin resistance Amino acid metabolism S6K1

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Statistical Identification of Syndromes Feature and Structure of Disease of Western medicine Based on General Latent Structure Model

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Chinese Journal of Integrative medicine 2012年第11期18卷 850-861页

作者：杨伟易丹辉谢雁鸣田峰 School of Statistics Renmin University of China Institute of basic Research in clinical medicine China Academy of Chinese Medical Sciences

Syndrome differentiation is the character of Chinese medicine （CM）. Disease differentiation is the principle of Western medicine （WM）. Identifying basic syndromes feature and structure of disease of WM is an important avenue for prevention and treatment of integrated Chinese and Western medicine. The idea here is first to divide all patients suffering from a disease of WM into several groups in the light of the stage of the disease, and secondly to identify basic syndromes feature in a distinct stage, and finally to achieve the purpose of syndrome differentiation. Syndrome differentiation is simply taken as a classifier that classifies patients into distinct classes primarily based on overall observation of their symptoms. Previous clustering methods are unable to cope with the complexity of CM. We therefore show a new multi-dimensional clustering method in the form of general latent structure （GLS） model, which is a suitable statistical learning technique of latent class analysis. In this paper, we learn an optimal GLS model which reflects much better model quality compared with other latent class models from the osteoporosis patient of community women （OPCW） real data including 40 65 year old women whose bone mineral density （BMD） is less than mean2.0 standard deviation （M 2.0SD）. Further, we illustrate a case analysis of statistical identification of CM syndromes feature and structure of OPCW from qualitative and quantitative contents through the GLS model. Our analysis has discovered natural clusters and structures that correspond well to CM basic syndrome and factors of osteoporosis patients （OP）. The GLS model suggests the possibility of establishing objective and quantitative diagnosis standards for syndrome differentiation on OPCW. Hence, for the future it can provide a reference for the similar study from the perspective of a combination of disease differentiation and syndrome differentiation.

关键词： latent structure analysis general latent structure model multi-dimensional cluster Bayesiannetworks integrative medicine

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Appraisal of the Quality and Contents of clinical Practice Guidelines for Hypertension Management in Chinese medicine: A Systematic Review

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Chinese Journal of Integrative medicine 2018年第7期24卷 545-550页

作者： YUWEN Ya HAN Xue-jie WENG Wei-liang ZHAO Xue-yao LIU Yu-qi LI Wei-qiang LIU Da-sheng WANG Yan-ping LU Ai-ping Institute of basic Research in clinical medicine China Academy of Chinese Medical Sciences Institute of clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical Sciences Chinese medicine College Ningxia Medical University School of Chinese medicine Hong Kong Baptist University

Objective： To evaluate the quality and consistency of recommendations in the clinical practice guidelines（CPGs） for hypertension in Chinese medicine（CM）. Methods： CM CPGs were identified from 5 electronic databases and hand searches through related handbooks published from January 1990 to December 2013. Three reviewers independently appraised the CPGs based on the Appraisal of Guidelines for Research and Evaluation（AGREE Ⅱ） instrument, and compared the CPGs＇ recommendations on CM syndrome pattern classification and treatment. Results： Five CM CPGs for hypertension were included. The quality score of the evidence-based（EB） guideline was higher than those of the consensus-based with no explicit consideration of evidence-based（CB-EB） and the consensus-based（CB） guidelines. Three out of five patterns in the CPGs were recommended by the EB guideline. Tianma Gouteng Formula（天麻钩藤复方） in the EB guideline was recommended mostly for hypertension patients with pattern of ascendant hyperactivity of Gan（Liver）-yang and pattern of yin deficiency with yang hyperactivity in the CPGs. Acupuncture and massage were recommended for Grade Ⅰ and Grade Ⅱ hypertension with severe symptoms weakening the quality of life in the EB guideline. For Grade Ⅰ and Grade Ⅱ hypertension, CM could be used alone, while for Grade Ⅲ hypertension, they should be used in combination with Western medicines. Conclusion： The quality of EB guideline was higher than those of CB and CB-EB CPGs in CM for hypertension and CM should be prescribed alone or combined with Western medicines based on the grade of hypertension.

关键词： hypertension Chinese medicine clinical practice guideline systematic review syndrome pattern

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Influenza vaccination in acute coronary syndromes patients in Thailand： the cost-effectiveness analysis of the prevention for cardiovascular events and pneumonia

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Journal of Geriatric Cardiology 2018年第6期15卷 413-421页

作者： Apirak Sribhutom Arintaya Phrommintikul Wanwarang Wongcharoen Usa Chaikledkaew Suntara Eakanunkul Apichard Sukonthasam Program in clinical Epidemiology Faculty of Medicine Chiang Mai University Thailand Department of pharmacy Practice School of Pharmaceutical Sciences University of Phayao Thailand Cardiology Division Department of Internal Medicine Faculty of Medicine Chiang Mai University Thailand Social and Administrative pharmacy Excellence Research Unit (SAPER) Department of Pharmacy Faculty of Pharmacy Mahidol University Thailand Department of Pharmaceutical Sciences Faculty of Pharmacy Chiang Mai University Thailand

Background Influenza vaccination has been clinically shown to reduce adverse cardiovascular outcomes in acute coronary syndrome （ACS） patients, but the economic perspectives can provide important data to make informed decisions. This study aimed to perform the economic evaluation of lifelong annual influenza vaccination for cardiovascular events and well-established pneumonia prevention. Methods Lifetime costs, life-expectancy, and quality-adjusted live years （QALYs） were estimated beyond one-year cycle length of a six-health states Markov model condition on whether a hospitalization for ACS, stroke, heart failure, pneumonia, no hospitalizations occurred, or death. The comparison of three age-groups of 40-49, 50-65, and 〉 65 years scenario was performed. Incremental cost-effectiveness ratio （ICER） and net monetary benefit （NMB） were presented as a societal perspective in 2016. The model robustness was determined by one-way and prob- abilistic sensitivity analyses. Results The influenza vaccination was cost-effective in all age-groups, by dominant ICERs （lower cost with higher effectiveness） which was completely lower than acceptable willingness-to-pay threshold of Thailand [160,000 THB （4,466.8 USD） per QALYs], with a great incremental value of NMB. Especially, the 50-year-old-and- above scenario was shown as the most benefit at 129,092 THB （3,603.9 USD） for each patient. Conclusions The annually additional influenza vaccination to standard treatment in ACS was cost-effective in all age-groups, which should be considered in clinical practice and health-policy making process.

关键词： Acute coronary syndrome Cost-effectiveness Heart failure Influenza vaccine Pneumonia Stroke

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Methological Quality of Systematic Reviews and Meta-Analyses on Acupuncture for Stroke: A Review of Review

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Chinese Journal of Integrative medicine 2017年第11期23卷 871-877页

作者： CHEN Xin-lin MO Chuan-wei LU Li-ya GAO Ri-yang XU Qian WU Min-feng ZHOU Qian-yi HU Yue ZHOU Xuan LI Xian-tao College of basic Medical Science Guangzhou University of Chinese Medicine Public Health Institute of Health and Wellbeing University of Glasgow First clinical College Guangzhou University of Chinese Medicine

Objective： To assess the methodological quality of systematic reviews and meta-analyses regarding acupuncture intervention for stroke and the primary studies within them. Methods： Two researchers searched Pub Med, Cumulative index to Nursing and Allied Health Literature, Embase, ISI Web of Knowledge, Cochrane, Allied and Complementary medicine, Ovid Medline, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang and Traditional Chinese Medical Database to identify systematic reviews and meta-analyses about acupuncture for stroke published from the inception to December 2016. Review characteristics and the criteria for assessing the primary studies within reviews were extracted. The methodological quality of the reviews was assessed using adapted Oxman and Guyatt Scale. The methodological quality of primary studies was also assessed. Results： Thirty-two eligible reviews were identified, 15 in English and 17 in Chinese. The English reviews were scored higher than the Chinese reviews（P=0.025）, especially in criteria for avoiding bias and the scope of search. All reviews used the quality criteria to evaluate the methodological quality of primary studies, but some criteria were not comprehensive. The primary studies, in particular the Chinese reviews, had problems with randomization, allocation concealment, blinding, dropouts and withdrawals, intent-to-treat analysis and adverse events. Conclusions： Important methodological flaws were found in Chinese systematic reviews and primary studies. It was necessary to improve the methodological quality and reporting quality of both the systematic reviews published in China and primary studies on acupuncture for stroke.

关键词： systematic review meta-analyses stroke acupuncture review of review methodological quality

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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

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Journal of Integrative medicine 2024年第2期22卷 137-162页

作者： Bizhar Ahmed Tayeb Ikhwan Yuda Kusuma Alaa A.M.Osman Renáta Minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of clinical pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of clinical pharmacy and pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub Med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

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Overview of the microbiota in the gut-liver axis in viral B and C hepatitis

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World Journal of Gastroenterology 2021年第43期27卷 7446-7461页

作者： Maria Adriana Neag Andrei Otto Mitre Adrian Catinean Anca Dana Buzoianu Department of Pharmacology Toxicology and Clinical PharmacologyIuliu Hatieganu University of Medicine and Pharmacy of Cluj-NapocaCluj-Napoca 400337Romania Faculty of medicine Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-NapocaCluj-Napoca 400012Romania Department of Internal medicine Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-NapocaCluj-Napoca 400006Romania

Viral B and C hepatitis are a major current health issue,both diseases having a chronic damaging effect on the liver and its *** liver disease can lead to even more severe and life-threatening conditions,such as liver cirrhosis and hepatocellular *** years have uncovered an important interplay between the liver and the gut microbiome:the gut-liver *** B and C infections often cause alterations in the gut microbiota by lowering the levels of‘protective’gut microorganisms and,by doing so,hinder the microbiota ability to boost the immune *** aimed at restoring the gut microbiota balance may provide a valuable addition to current practice therapies and may help limit the chronic changes observed in the liver of hepatitis B and C *** review aims to summarize the current knowledge on the anatofunctional axis between the gut and liver and to highlight the influence that hepatitis B and C viruses have on the microbiota balance,as well as the influence of treatments aimed at restoring the gut microbiota on infected livers and disease progression.

关键词： Viral B hepatitis Viral C hepatitis Gut-liver axis Immunomodulation Lipopolysaccharides Short-chain fatty acids

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Traditional Chinese medicine in the treatment of recurrent respiratory tract infections in children:an overview of systematic reviews and Meta-analyses

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Journal of Traditional Chinese medicine 2024年第5期44卷 871-884页

作者： DENG Yasheng HAN Siyin XI Lanhua HUANG Hui LIANG Tianwei ZHENG Yiqing FAN Yanping LIN Jiang School of basic Medical Sciences Guangxi University of Chinese MedicineNanning 530200China School of basic Medical Sciences Guangxi University of Chinese MedicineGuangxi Key Laboratory of Marine DrugsNanning 530200China Department of pharmacy Hainan Traditional Chinese Medicine HospitalHaikou 570203China

OBJECTIVE:To evaluate and summarise the evidence from published Meta-analyses/systematic reviews(MAs/SRs)of Traditional Chinese medicine(TCM)in the treatment of recurrent respiratory tract infections(RRTIs)and to provide a scientific basis for the clinical treatment of RRTIs with ***:Studies were retrieved from Chinese and English databases including the China National Knowledge Infrastructure,Wanfang database,China Science and Technology Journal Database,SinoM ed,PubM ed,Web of Science,the Cochrane Library and EMbase from their establishment date to March *** studies were screened,extracted,and evaluated for quality by two researchers *** a measurement tool to assess systematic reviews(AMSTAR)2 scale was used for methodological quality evaluation,as well as the preferred reporting items for systematic reviews and Meta-analyses(PRISMA)2020 statement for report quality evaluation,the risk of bias in systematic reviews(ROBIS)tool for risk of bias,and the grading of recommendations,assessment,development and evaluation(GRADE)quality assessment tool for evidence ***:Twenty MAs/SRs studies were included,including analyses of 274 original studies involving 38335 patients with *** AMSTAR 2 scale evaluation results showed that 19 studies were of very low quality and one of moderate *** ROBIS evaluation results showed that 11 MAs/SRs were at high risk and nine at low risk of *** PRISMA 2020 report quality showed the included studies had scores between 23.5 and 35.5,among them one with high quality,17 with moderate quality and two with low *** GRADE system results showed that among 126 outcome indicators,only 17 had moderate quality of evidence,27 had low quality,82 had very low quality,and none had high ***:The MAs/SRs methodological quality of using TCM for treatment RRTIs is generally poor,the quality of reports as well as of evidence is generally low,and the risk of bias is high;therefo

关键词： respiratory tract infections child medicine Chinese traditional Meta-analysis systematic review randomized controlled trial

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Leukocyte-derived biomimetic nanoparticulate drug delivery systems for cancer therapy

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Acta Pharmaceutica Sinica B 2018年第1期8卷 4-13页

作者： Yukun Huang Xiaoling Gao Jun Chen Key Laboratory of Smart Drug Delivery Ministry of Education School of Pharmacy Fudan University Department of Pharmacology and Chemical Biology Faculty of Basic Medicine Shanghai Jiao Tong University School of Medicine

Precise drug delivery to tumors with low system toxicity is one of the most important and challenging tasks for pharmaceutical researchers. Despite progress in the field of nanotherapeutics, the use of artificially synthesized nanocarriers still faces several challenges, including rapid clearance from blood circulation and limited capability of overcoming multiple physiological barriers, which hamper the clinical application of nanoparticle-based therapies. Since leukocytes(including monocytes/macrophages,neutrophils, dendritic cells and lymphocytes) target tumors and can migrate across physiological barriers,leukocytes are increasing utilized as carriers to transfer nanoparticles to tumors. In this review we specifically focus on the molecular and cellular mechanisms of leukocytes that can be exploited as a vehicle to deliver nanoparticles to tumors and summarize the latest research on how leukocytes can be harnessed to improve therapeutic end-points. We also discuss the challenges and opportunities of this leukocyte-derived nanoparticle drug delivery system.

关键词： Leukocytes Tumor Biomimetic carrier Nanoparticulate drug delivery systems Nanotherapeutics Cancer therapy

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