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Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity

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World Journal of Nephrology 2022年第2期11卷 39-57页

作者： Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis Allan Collins Peter Kotanko Global Medical Office Fresenius Medical CareBad Homburg 61352Germany Department of Nephrology Montpellier UniversityMontpellier 34000France Department of Internal Medicine Maastricht UniversityMaastricht 6229 HXNetherlands Centre for Kidney Research and Innovation Academic Unit for Translational Medical SciencesSchool of MedicineUniversity of NottinghamDerby DE223DTUnited Kingdom Global Research Development Fresenius Medical CareSchweinfurt 97424Germany University of Nottingham Nottingham NG72RDUnited Kingdom Renal Research Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10065United States

The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many ***,intermittent renal replacement therapy is also a source of recurrent stress for *** thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease *** cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular *** unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects.

关键词： End stage kidney disease Cardiovascular mortality Dialytic morbidity Circulatory stress Biologic storm Dialysis sickness Personalized medicine

股-腘动脉病变行定向经皮腔内斑块旋切术后的长期效果

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 48-48页

作者： Zeller T. Rastan A. Sixt S. 郭俊 Department of Angiology Herz-Zentrum Bad KrozingenBad KrozingenGermany Dr.

目的:本研究旨在评价使用Silverhawk器械对股-动脉病变行定向经皮腔内斑块旋切术后的长期效果。背景:考虑到股-动脉内支架断裂的报道。

关键词：斑块旋切长期效果皮腔腘动脉动脉病再狭窄球囊血管成形术靶病变血运重建闭塞性旋切术

Efficacy of Detoxsan~? powder on diarrhea caused by gastrointestinal neuroendocrine tumors

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World Journal of Gastroenterology 2019年第17期25卷 2133-2143页

作者： Thomas Langbein Wilfried Dathe Anika Deuerling Richard P Baum Theranostics Center for Molecular Radiotherapy and Molecular Imaging Zentralklinik Bad Berka Scientific Managment Heck Bio-Pharma GmbH

BACKGROUND Patients with neuroendocrine tumors(NETs) of the gastrointestinal tract suffer frequently from chronic diarrhea. A well characterized medical advice containing zeolite(Detoxsan~? powder) was applied to patients suffered from therapyrefractory diarrhea either by its frequency or by watery stool, despite receiving standard pharmacotherapy according to the guidelines for carcinoid syndrome and comorbidities. Detoxsan~? powder acts as an adsorbent and might reduce significantly symptoms of diarrhea in patients suffering from *** To overcome the therapy-refractory diarrhea of patients with NETs by the zeolite containing medical advice Detoxsan~? *** A total of 20 patients(12 female and 8 male) suffering from diarrhea either by its frequency or from watery stool caused by NETs were included. In each patient,the diagnosis had been confirmed by histology and somatostatin receptors expression proven by positron emission tomography/computed tomography using Ga-68-labeled somatostatin analogs. All patients received standard-of-care pharmacotherapy and were additionally given Detoxsan~? powder as an extemporaneous drug containing 90% natural Cuban zeolite and 10% magnesium aspartate. Recommended daily dosage ranges between 3 g once to three times per day. Each day dose and bowel movements were documented by the patients themselves in a pre-defined table. Additionally to the bowel movements quantitative determinations of serotonin, urea, creatinine and single ions were performed within the serum of the patients by commercially available equipment used as a matter of routine in the *** All patients enrolled in this pilot study did not only suffer from NETs, but also from comorbidities and treatment-resistant diarrhea. There was insufficient control of diarrhea, most probably due to the secretion of hormones like serotonin produced by the slowly growing and highly differentiated NETs. All patients only took Detoxsan~? powder as an antidiarrhea

关键词： Neuroendocrine tumor Diarrhea Carcinoid syndrome Treatment Clinoptilolite Mordenite Zeolite

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主动脉手术中颈动脉插管术的应用

世界核心医学期刊文摘(心脏病学分册) 2007年第5期 62-62页

作者： Urbanski P.P. Lenos A. Lindemann Y. 黄浙勇 Department of Cardiovascular Surgery Cardiovascular Clinic Bad Neustadt Bad Neustadt Germany Dr.

目的:颈动脉插管术在本临床中心最早应用于急性主动脉夹层的手术,现已成为需停循环下实施手术时的标准方法。本研究通过观察100例患者主动脉手术后结果,评价颈动脉插管术的效能。方法:2002年7月至2005年10月期间,100例主动脉手术患者采... 详细信息

目的:颈动脉插管术在本临床中心最早应用于急性主动脉夹层的手术,现已成为需停循环下实施手术时的标准方法。本研究通过观察100例患者主动脉手术后结果,评价颈动脉插管术的效能。方法:2002年7月至2005年10月期间,100例主动脉手术患者采用了颈动

关键词：插管术颈动脉主动脉手术

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静脉断流术治疗肝硬化食道静脉曲张出血

德国医学 1996年第4期13卷 192-193页

作者： K.-J.Paquet A.Lazar 朱学海郝连杰 DEPARTMENT FUR CHIRURGIE GEFAΒ-UND VISZERALCHIRURGIEHEINZ-KALK-KRANKENHAUSAM GRADIERBAUD-97688 BAD KISSINGENGERMANY 同济医科大学附属同济医院

肝硬化者50%～60%会发生食道静脉曲张,其中1/3将致大出血,出血的危险性随静脉曲张程度加剧和肝功能恶化而增加。用保守疗法洽疗出血其死亡率达20%～50%。出血时要用最简捷的急救止血法,除使用降低门脉压的药物和气囊填压法外。

关键词：肝硬化食管静脉曲张出血静脉断流术

联机血液滤过透析和无醋酸盐生物滤过的前瞻性交叉研究

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中华肾脏病杂志 2001年第6期17卷 388-393页

作者：丁峰 Peter Ahrenholz Joerg Vienken 顾勇林善锬复旦大学附属华山医院肾内科上海200040 BioArtProducts GmbH.Rostock Fresenius Medical Care Bad Homburg

目的通过前瞻性、随机、交叉试验比较联机血液滤过透析（联机ＨＤＦ）和无醋酸盐生物滤过（ＡＦＢ）治疗尿毒症的疗效。方法１２例维持性透析患者分别采用联机ＨＤＦ（包括前稀释和后稀释两种模式）和ＡＦＢ治疗．每１２周为交叉期。结... 详细信息

目的通过前瞻性、随机、交叉试验比较联机血液滤过透析（联机ＨＤＦ）和无醋酸盐生物滤过（ＡＦＢ）治疗尿毒症的疗效。方法１２例维持性透析患者分别采用联机ＨＤＦ（包括前稀释和后稀释两种模式）和ＡＦＢ治疗．每１２周为交叉期。结果两种治疗方法效果均满意。透前血钠。总钙和离子钙、氯、碳酸氢根、尿素无明显变化；联机ＨＤＦ组血钾有轻度上升；各组血磷、β２－微球蛋白均较透前有下降趋势；ＡＦＢ组透后血钾水平较联机ＨＤＦ组低，而碳酸氢根水平较高。动脉血气监测显示．透析中ＡＦＢ组ＰＯ２下降幅度和ＰＣＯ２上升幅度均低于联机ＨＤＦ组。和ＡＦＢ相比，联机ＨＤＦ司达到较高的一室和二室Ｋｔ／Ｖ值、较高的尿素和β２－微球蛋白有效清除率、较少的透析间期症状分数。ＡＦＢ组患者透前平均动脉压低于联机ＨＤＦ组，透祈中血压下降幅度也低于联机ＨＤＦ组；各组对骨代谢指标的影响无明显差异，血铝水平均下降到透前的１／３左右。前８周各组均发现血浆白蛋白水平下降．随后略有回升，但在研究期末仍低于初始值。结论联机ＨＤＦ和ＡＦＢ均属当今最佳的血液净化疗法之一。联机ＨＤＦ有较高的大、中小分子量毒素清除率．较少的透析间期症状。ＡＦＢ时透析中血气和血流动力学的影响较小。

关键词：血液透析滤过醋酸盐肾脏替代疗法尿毒症

使用全新机器人引导的肝脏肿瘤影像导引下微波热消融术:初步经验

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国际医学放射学杂志 2015年第2期 200-200页

作者： E.C.Mbalisike T.J.Vogl S.Zangos K.Eichler P.Balakrishnan J.Paul 郭凌飞 Institute for Diagnostic and Interventional Radiology Klinikum Bad Salzungen Lindigalle 3 36433 Bad Salzungen Germany

摘要目的评估并比较机器人引导与手动操作方法在影像引导下行微波热消融中的程序精确性、操作时间、程序性能和影像质量的差异。方法本研究于2013年6月—2013

关键词：微波电磁波机器人人工智能

RBM20 mutations in left ventricular non-compaction cardiomyopathy

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Pediatric Investigation 2020年第1期4卷 61-63页

作者： Anna Gaertner Barbel Klauke Andreas Brodehl Hendrik Milting Heart and Diabetes Center NRW University Hospital of the Ruhr-University BochumClinic of Thoracic and Cardiovascular SurgeryErich and Hanna Klessmann Institute for Cardiovascular Research and DevelopmentGeorgstrasse 11D-32545 Bad OeynhausenGermany

Cardiomyopathies are among the most prevalent causes of premature death in the Western world.A significant amount of cardiomyopathies has a genetic ***,mutations in more than 170 genes associated with different cardio... 详细信息

关键词： involvement ventricular cardiomyopathy

COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors

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Signal Transduction and Targeted Therapy 2022年第1期7卷 270-281页

作者： Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhouChina Division of Vascular Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina Medical Research Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina Department of Obstetrics and Gynecology Guangzhou Women and Children Medical CenterGuangzhou Medical UniversityGuangzhouChina Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Department of Immunology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Guangzhou Center for Disease Control and Prevention GuangzhouChina Wuhan Metware Biotechnology Co. LtdWuhanChina Department of Biomedical Sciences New York Institute of TechnologyCollege of Osteopathic MedicineOld WestburyNYUSA Max Planck Institute for Heart and Lung Research and Cardiopulmonary Institute(CPI) Bad NauheimGermany Department of Molecular Diagnostics Sun Yat-sen Cancer CenterSun Yat-sen UniversityGuangzhouChina School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhenChina State Key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhouChina The Sixth Affiliated Hospital of Sun Yat-sen University GuangzhouChina Department of Endocrinology Sun Yat-Sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Guangzhou Regenerative Medicine and Health-Guangdong Laboratory(GRMH-GDL) Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina Key Laboratory of Regenerative Biology of the Chinese Academy of

Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear *** this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie *** nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid ***,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin *** together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications.

关键词： metabolism mechanism resistance