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Global tissue and serum metabolomics reveals altered tumor biochemical activity in molecular subtypes of hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 13-14页

作者： Xinwei Wang Thaniya Mathuros Ruchirawat Anuradha Budhu Yotsawat Pomyen Jittiporn Chaisaingmongkoll Hien Dang Siritida Rabibhadana Benjarath Pupacdi Marshonna Forgues Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu Auewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Chulabhorn Mahidol The Liver Carcinogenesis Section Laboratory of Human CarcinogenesisCenter for Cancer ResearchNational Cancer InstituteBethesdaMDUSA Chulabhorn Research Institute BangkokThailand Khon Kaen University Khon KaenThailand Chiang mai University Chiang MaiThailand Chulabhorn hospital BangkokThailand Rajavej hospital and Lampang Cancer Center Chiang MaiThailand

Objective:Cancer metabolite profiling(or cancer metabolomics),the global view of the biochemical end products of cellular processes,is a promising approach to identify biomarkers and tumor subgroups,and to understand ... 详细信息

关键词： Global tissue metabolomics

Dry eye rate and its relationship with disease stage in patients with primary hypertension:a cross-sectional study in Vietnam

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： Tran Tat Thang Pham Hong Phuong Nguyen Sa Huynh Nguyen Trung Kien NguyenDuy Toan Nguyen Thi Thu Ha Le Ha Khoa Nguyen Huu Dung Thai Doan Thang Le Viet Thang Nghe An Eye hospital Nghe An 43000Vietnam Nghe An Friendship General hospital Nghe An 43000Vietnam Military hospital 103 Ha Noi 100000Vietnam Vietnam Military Medical University Ha Noi 100000Vietnam Hanoi Medical University Ha Noi 100000Vietnam Bạch mai hospital Ha Noi 100000Vietnam TTH Vinh General hospital Nghe An 100000Vietnam

AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary ***:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control *** Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 *** with OSDI scores<13 and Schirmer Ⅰ values equal to or under 10 mm were diagnosed with ***:The ratio of DE in hypertension patients was higher than in the control group(41.7%versus 18.8%;P<0.001).The proportion of patients with DE increased gradually according to the hypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,P<***,duration of hypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,P<*** age,a long duration of hypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,P<***:DE is a common disorder associated with advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.

关键词： primary hypertension dry eye stage of hypertension plasma creatinine

The rate of patients at high risk for cardiovascular disease with an optimal low-density cholesterol level: a multicenter study from Thailand

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Journal of Geriatric Cardiology 2019年第4期16卷 344-353页

作者： Rungroj Krittayaphong Arintaya Phrommintikul Smonporn Boonyaratvej Rapeephon Kunjara Na Ayudhya Pyatat Tatsanavivat Chulaluk Komoltri Piyamitr Sritara Division of Cardiology Department of MedicineFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Division of Cardiology Department of Internal MedicineFaculty of MedicineChiang Mai UniversityChiang MaiThailand Division of Cardiology Department of MedicineFaculty of MedicineChulalongkorn UniversityBangkokThailand Department of Cardiology Vichaiyut Hospital and Medical CenterBangkokThailand Division of Cardiology Department of MedicineFaculty of MedicineKhon Kaen UniversityKhon KaenThailand Clinical Epidemiology Unit Office for Research and DevelopmentFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Division of Cardiology Department of MedicineFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand

Background Hypercholesterolemia is a major risk factor for cardiovascular events in patients with established atherosclerotic disease (EAD) and in those with multiple risk factors (MRFs). This study aimed to investigate the rate of optimal low-density lipoprotein (LDL) cholesterol level in a multicenter registry of patients at high risk for cardiovascular events. Methods A multicenter registry of EAD and MRF patients was conducted. Demographic data,medical history,cardiovascular risk factors,anthropometric data,laboratory data,and medications were recorded and analyzed. We classified patients according to target LDL levels based on recommendation by the European Society of Cardiology (ESC) 2011 into Group 1 which is EAD and diabetes or chronic kidney disease (CKD)–target LDL below 70 mg/dL,and Group 2 which is MRF without diabetes or CKD–target LDL below 100 mg/dL. The rate of optimal LDL level in patients with Group 1 and Group 2 was analyzed and stratified according to the treatment pattern of lipid-lowering medications. Results A total of 3100 patients were included. Of those,51.7% were male. Average age was 65.8 ± 9.7 years. Average LDL level was 96.3 ± 32.6 mg/dL. A vast majority (92.7%) received statin and 9.3% received ezetimibe. Optimal LDL level was achieved in 20.3% of patients in Group 1 (LDL < 70 mg/dL),and in 46.6% in Group 2 (LDL < 100 mg/dL). The overall rate of optimal LDL control was 23% since 89.6% of study population belongs to Group 1. The rate of optimal LDL was not different between high and low potency statin. Factors that were associated with optimal LDL control were older age,the presence of coronary artery disease or peripheral artery disease. Conclusions The rates of optimal LDL level were unacceptably low in this study population. As such,a strategy to improve LDL control in high-risk population should be implemented.

关键词： Cardiovascular event Established atherosclerotic disease Low-density lipoprotein cholesterol Risk factors Thailand

Pathway analysis of metabolic genes and serum metabolites in HCC reveal aberrations associated with fatty acid and lipid metabolism

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Cancer Biology & Medicine 2018年第S1期15卷 12-13页

作者： Yotsawat Pomyen Anuradha Budhu Jittiporn Chaisaingmongkol Hien Dang Siritida Rabibhadana Benjarath Pupacdi Marshonna Forgues Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Chirayu Auewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang The Liver Carcinogenesis Section Laboratory of Human CarcinogenesisCenter for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Chulabhorn Research Institute BangkokThailand Khon Kaen University Khon KaenThailand Chiang mai University Chiang MaiThailand Chulabhorn hospital BangkokThailand Rajavej hospital and Lampang Cancer Center Chiang MaiThailand National Cancer Institute BangkokThailand

Objective:Hepatocellular carcinoma(HCC)is among the deadliest cancers in *** Thailand Initiative in Genomics and Expression Research for Liver Cancer(TIGER-LC)cohort was established to discover molecular markers that can be used for early detection and diagnosis and to understand possible molecular mechanisms underlying the disease.

关键词： Pathway analysis metabolic

Adverse pregnancy outcomes in women with high pre-pregnancy body mass index

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Open Journal of Obstetrics and Gynecology 2013年第2期3卷 285-291页

作者： Rajin Arora Darin Arora Jayanton Patumanond Clinical Epidemiology Unit Chiang Mai University Chiang Mai Thailand Department of Obstetrics and Gynecology Lampang Regional Hospital Lampang Thailand

Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of these conditions. The objectives of this study were to estimate the prevalence of prepregnancy overweight and obesity and their impacts on adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database along with manual retrieval from medical charts and labor records. Data of all delivery women from 1st February 2011 to 31st August 2012 were collected. When excluded cases with incomplete data and those without PP-BMI, 5420 cases were into analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: The proportion of pregnant women with overweight and obesity were 11.1% and 3.9%. After multiple logistic regression analysis was done, women in obesity group were correlated with having 1, 2 and 3 complications. They were also correlated with preeclampsia, gestational diabetes, cesarean section, higher birth weight group and long neonatal length. Conclusions: This Thai prevalence of obesity in pregnancyshould alarm health care providers to be more prepared, for a future health problem of the country. Many complications that come with obese pregnant women that were reported in western countries also happen in Thai population. Decreasing body weight before conception, giving correct health education, well planned pregnancy;antenatal lifestyle intervention and even gestational weight gain restricttion could help avoiding these uneventful morbidities.

关键词： Pre-Pregnancy Body Mass Index Obesity Pregnancy Prevalence Pregnancy Outcome

Risk of high gestational weight gain on adverse pregnancy outcomes

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 142-147页

Background/Aims: Excessive gestational weight gain was known to be associated with adverse pregnancy outcomes. It increased the complications during pregnancy, delivery and postpartum period. Nevertheless, there are studies reporting the incompliance of pregnant women with recommendations of weight gain. The objectives of this study were to estimate the prevalence of high gestational weight gain and to identify the increased adverse pregnancy outcomes in these women. Methods: This was a cross sectional study. Data were collected retrospectively from hospital electronic database of Lampang Regional hospital (LPH) along with manual retrieval from medical charts and labor records. Data of all pregnant women who delivered at labor room of LPH were collected from 1st February 2011 to 31st August 2012. After preterm and multifetal pregnancies were excluded, 4747 cases were brought to the study. This study used the new weight gain recommendation from the Institute of Medicine and National Research Council to classify pregnant women by pre-pregnancy body mass index. Data were analyzed by univariate and multivariate analysis. Results: The proportions of pregnant women with different level of weight gain were 28.4%, 38.5% and 33.1% for low, normal and high weight gain. After multivariate analysis was done to control the confounders, women with high weight gain were significantly correlated with having preeclampsia, higher birth weight group, cesarean section and long neonatal length with relative risk (RR) and 95% confidence interval (95% CI) of 4.84 (2.31 - 10.16), 3.94 (3.24 - 4.79), 2.12 (1.82 - 2.47) and 2.33 (1.90 - 2.86). Conclusions: There were more than half of pregnant women that were prone to have inappropriate weight gain. Many complications from high weight gain that have been reported from aboard also occurred in Thai pregnant women. This should alert corresponding health institute to establish a new guideline to avoid high gestational weight gain.

关键词： Weight Gain Pregnancy Prevalence Pregnancy Outcome

High pre-delivery body mass index also caused adverse pregnancy outcomes

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Open Journal of Obstetrics and Gynecology 2013年第4期3卷 416-421页

Background/Aims: It is known that high pre-preg-nancybody mass index (BMI) and high gestational weight gain both can cause many adverse pregnancy outcomes. High pre-delivery BMI (PD-BMI), though theoretically could do similar effects, is rarely been studied. The objectives of this study were to show the distribution of PD-BMI of the delivery women and to identify its correlation with adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database of Lampang Regional hospital (LPH) along with manual retrieval from medical charts and labor records. Data of all pregnant women who delivered at labor room were collected from 1st February 2011 to 31st August 2012. After preterm and multifetal pregnancies were excluded, 4999 cases were into the analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: In this group of women, 93.9% were in the PD-BMI range of 20.0 -34.9 kg/m2. After multivariate analysis was used, higher PD-BMI was shown to be correlated with higher cesarean section, neonates weighing ≥3500 gmand long neonatal length with relative risk (RR) and 95% confidence interval (95% CI) of 1.11 (1.09 - 1.13), 1.15 (1.12 - 1.17) and 1.07 (1.05 - 1.09), respectively. Conclusions: High PD-BMI was correlated with multiple adverse pregnancy outcomes. Interestingly, their effect sizes were much smaller comparing to high pre-pregnancy BMI and high gestational weight gain. It confirmed the current recommendations to monitor pre-pregnancy BMI and gestational weight gain to avoid unwanted morbidities.

关键词： Pregnancy Outcome Body Mass Index Delivery

Toilet habits in kindergarten children in a kindergarten in Hanoi

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Health 2013年第11期5卷 1760-1767页

作者： Thi Kim Anh Nguyen Susan JVernon Ann Bengtson Anna-Lena Hellstrom bach mai hospital HanoiVietnam Hanoi Medical University HanoiVietnam Institute of Health and Care Sciences Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden Department of Clinical Medical Sciences Great North Children’s HospitalNewcastle UniversityNewcastle upon TyneUK Queen Silvia Children’s hospital GothenburgSweden

Objective: Describe children’s toilet habits in a kindergarten setting. Subjects: Forty-one children aged 4-5 years, parents and six teachers participated. Method: Open-ended interviews and observations. Results: In school children avoided going to toilet, this could cause incontinence. Related Factors: Inadequate toilet standards and differing cleaning routines as at home. Children were uncomfortable and shy using the toilet, and some children seemed to prefer playing and school work instead of going to the toilet during breaks. Conclusion: Children of 4-5 years of age are sometimes not able to control their bladder and bowel habits in an environment differing to home.

关键词： Children Toilet Habits Interviews Observations

Prevalence of atrial fibrillation in Thai elderly

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Journal of Geriatric Cardiology 2016年第3期13卷 270-273页

作者： Arintaya Phrommintikul Pitsanuwat Detnuntarat Narawudt Prasertwitayakij Wanwarang Wongcharoen Division of Cardiology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand Department of lnternal Medicine Nakornping Hospital Chiang MaL Thailand

Atrial fibrillation （AF） is an important health problem due to its association with serious *** Stroke is one of the most serious complications and is the leading cause of death and disabilities in this population. AF in- creases the risk of embolic stroke five times compared to general population. The prevalence of AF varies from 0.5%-15% depending on studied populations such as age,

关键词： Atrial fibrillation Elderly Prevalence Thailand