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Developing a multi-method approach to identifying e-scooter hazard hotspots

Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 667-680页

作者： Michael Hardinghaus Simon Nieland Rebekka Oostendorp Jan Weschke German Aerospace center(DLR)Institute of Transport research Berlin 12489Germany

In recent years,e-scooters have been introduced in many European *** several places we have witnessed a rapid uptake of this new mode of transport mainly as a result of public sharing schemes.A number of incidents,injuries and even fatalities have given rise to questions regarding the safety of these *** questions are being researched mainly using official crash data and data specifying injuries and hospital *** now,the research has focused on investigating typical injury patterns and estimating risk *** little is known about exactly where conflicts and crashes *** of hazard hotspots is crucial when investigating risk levels and improving safety for all road ***,this paper develops an approach to investigating locations with potentially dangerous interactions within the active mobility system in the city of *** approach consists of explorative expert interviews,an online poll,and quantitative *** the latter we combine three ***,we research crash hotspots using official ***,we use data based on acceleration sensors from cyclists'smartphones to find locations of sudden ***,we use trip data from the operators of escooter sharing *** information gathered is used in a conclusive expert workshop to identify hazard *** show that many of the conflicts with pedestrians are caused by parked ***,e-scooter trips are concentrated in the inner city and along specific *** moving traffic,various data sources are used to identify hotspots at intersections and in areas between *** present research lays the foundation for important further studies to investigate interactions at hotspots in detail by determining nine specific locations in the city of Berlin.

关键词： E-scooter Accidents Crashes Active mobility Micromobility Road safety

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Quantitative analysis on resistant forces at oil-surfactant-rock interfaces with dynamic wettability characterization

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Energy Geoscience 2024年第3期5卷 305-312页

作者： Qiaoyu Ge Tao Ma Guanli Xu Zengmin Lun Science and Technology Experimental research center Petroleum Exploration and Production Research InstituteSINOPECBeijingChina

Adhesion of oil at rock surface plays an important role in the liberation of oil from micro-/nano-pores,especially for heavy oil that has extremely high *** molecular dynamics simulation is widely used to study the interfacial interaction for some specific oil-water-rock systems,experimental measurements provide more realistic and reliable *** this work,we propose a dynamic wettability characterization method to indirectly measure resistant forces at oil-surfactant-rock interfaces,including frictional force,wettability hysteresis force,and viscous force,which are parallel with the oil-solid *** adhesive force,which is normal to the oil-solid interface is calculated through measurement of work of *** results show that work of adhesion instead of contact angle can better describe the adhesion of oil at solid *** effect of surfactant concentration on work of adhesion is different for water-wet and oil-wet ***,average viscous forces are calculated through force analysis on oil drops moving along solid surface in different surfactant *** is found that viscous force has a magnitude comparable to the frictional force during the movement,while the wettability hysteresis force is *** the other hand,the adhesive force calculated from the work of adhesion is also comparable to the viscous ***,both the resistant forces parallel with and normal to the oil-solid interface should be minimized for the liberation of oil from rock *** work proposes a simple method to evaluate the wetting capability of different surfactants and measure the adhesive force between heavy oil and rock surfaces indirectly,which provides insight into the adhesion of heavy oil at rock surface and would be valuable for the development of surfactant-based oil recovery methods.

关键词： Work of adhesion Wettability characterization Adhesive force Viscous force Surfactant

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Cellular precision modulation of JAK1:tailoring therapies for allergic lung inflammation

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2843-2844页

作者： Xiaocheng Yan Siegfried Ussar research Unit Adipocytes&Metabolism(ADM) Helmholtz Diabetes CenterHelmholtz Zentrum MünchenGerman Research Center for Environmental Health GmbH85764 NeuherbergGermany German center for Diabetes research(DZD) 85764 NeuherbergGermany

In a recent publication published in Cell,Tamari et *** a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors show that sensory neuromodulation could be an important therapeutic avenue for the treatment of lung *** is now well established that the number of patients suffering from allergic disorders,like those suffering from obesity and the metabolic syndrome,is rapidly increasing world-wide,accelerating the burden on individual health and healthcare ***,basic and clinical researchers urgently need to develop novel therapeutics and approaches to limit or prevent disease development or progression.

关键词： JAK1 allergic lung

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Combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and Steel research International 2024年第1期31卷 195-203页

作者： Zhi-gang Que Jin-ming Shi Xian-bin Ai Institute of Energy research Jiangxi Academy of ScienceNanchang330096JiangxiChina Jiangxi Carbon Neutralization research center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOCs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOCs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the CHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming CO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of CO_(2)and H_(2)*** oxidations of C_(6)H_(5)O,CO,and C_(5)H_(4)O intermediates to CO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter Combustion Simulation Temperature Oxygen

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Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu Qi Pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-Qi Wang Bing-Hai Lou Jun He Cui-Yun Lei Lin Cong Hao-Qiang Liu Xue-Feng Wang Chun Ran Citrus research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

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Regression Method for Rail Fastener Tightness Based on center-Line Projection Distance Feature and Neural Network

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 356-371页

作者： Yuanhang Wang Duxin Liu Sheng Guo Yifan Wu Jing Liu Wei Li Hongjie Wang Robotics research center School of MechanicalElectronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China China Construction Industrial&Energy Engineering Group Co. Ltd.Nanjing 210023China

In the railway system,fasteners have the functions of damping,maintaining the track distance,and adjusting the track ***,routine maintenance and inspection of fasteners are important to ensure the safe operation of track ***,assessment methods for fastener tightness include manual observation,acoustic wave detection,and image *** are limitations such as low accuracy and efficiency,easy interference and misjudgment,and a lack of accurate,stable,and fast detection *** at the small deformation characteristics and large elastic change of fasteners from full loosening to full tightening,this study proposes high-precision surface-structured light technology for fastener detection and fastener deformation feature extraction based on the center-line projection distance and a fastener tightness regression method based on neural ***,the method uses a 3D camera to obtain a fastener point cloud and then segments the elastic rod area based on the iterative closest point algorithm *** component analysis is used to calculate the normal vector of the segmented elastic rod surface and extract the point on the centerline of the elastic *** point is projected onto the upper surface of the bolt to calculate the projection ***,the mapping relationship between the projection distance sequence and fastener tightness is established,and the influence of each parameter on the fastener tightness prediction is ***,by setting up a fastener detection scene in the track experimental base,collecting data,and completing the algorithm verification,the results showed that the deviation between the fastener tightness regression value obtained after the algorithm processing and the actual measured value RMSE was 0.2196 mm,which significantly improved the effect compared with other tightness detection methods,and realized an effective fastener tightness regression.

关键词： Railway system Fasteners Tightness inspection Neural network regression 3D point cloud processing

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Removal of rubidium from brine by an integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide

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Chinese Journal of Chemical Engineering 2024年第5期69卷 112-121页

作者： Huanxi Xu Peihua Lin Pei-Jun Liu Hai-Gang Liu Hui-Bin Guo Chao-Xiang Wu Ming Fang Xu Zhang Guan-Ping Jin Anhui Province Engineering research center of Flexible and Intelligent Materials School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China Chemical Design and research Institute Co. LTD of Qinghai ProvinceQinghai Engineering and Technology Research Center of Fine ChemicalXining 810008China

A novel integrated film of sulfonated polysulfone/graphene/potassium copper ferricyanide(KCuFC/SPSG)was used for selectively extracting rubidium ion(Rb^(+))from *** form KCuFC/SPSG,the precursor film of sulfonated polysulfone/graphene(SPSG)was synthesized by phase conversion process,which was alternately immersed in 0.1 mol·L^(-1)CuSO_(4)/K_(4)[Fe(CN)_(6)]by in-situ adsorption coupled co-precipitation *** data such as nuclear magnetic resonance spectrometer,Fourier transform infrared spectroscope,X-ray photoelectron spectroscope,X-ray diffraction,scanning electron microscope,and energy dispersive spectroscopy all verified that abundant KCuFC were uniformly located on the *** resulting KCuFC/SPSG was used in film separation *** the solution was fed into the system,the Rb^(+)could be selectively adsorption by KCuFC/*** the saturation adsorption,0.5 mol·L^(-1)NH_(4)Cl/HCl was fed into the film cell,Rb^(+)could be quickly desorbed by ion-exchange between Rb^(+)and NH_(4)^(+)in the lattice of *** purpose of separating and recovering Rb^(+)from the brine can be achieved after the repeated *** effects of pH,adsorption time,and interferential ions on the adsorption capacity of Rb^(+)were investigated by batch *** adsorption behavior fits the pseudo-second order kinetic process,while KCuFC has a higher adsorption capacity(Langmuir maximum sorption 165.4 mg·g^(-1)).In addition,KCuFC/SPSG shows excellent selectivity for Rb^(+)even in complex brine ***/SPSG could maintain 93.5%extraction efficiency after five adsorption/desorption cycles.

关键词： Rubidium extraction Potassium copper ferricyanide Sulfonated polysulfone Graphene oxide Adsorption

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Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma Jing-Sheng Lu Xiang-Xin Cao Yan-Wei Cheng Gang Wang Zi-Qian Zhang Bo-Cheng Chen Ning Lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine center of Engineering and Technology

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance, toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***, Zn-based MOF-zeolitic imidazole framework-90(ZIF-90) was selected as the drug delivery carrier, with the cancer therapeutic drug mercaptopurine(6-MP) and glucose oxidase(GOD) as the drug models, hyaluronic acid(HA) was used for protection and targeted delivery, which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA). This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome. Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity, which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Cancer treatment Combination therapy Drug delivery Metal-organic framework Reduced toxicity

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Application of nanoscale metal–organic frameworks in tumor immunotherapy

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Rare Metals 2024年第10期43卷 4867-4883页

作者： Xiao-Xuan Zeng Jing-Sheng Lu Dong-Wei Ma Yu-Ting Huang Ling Chen Gang Wang Qing Chen Ning Lin College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine center of Engineering and Technology

Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy in tumor immunotherapy, combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy, photodynamic therapy/immunotherapy, sonodynamic therapy/immunotherapy and so on. Nanoscale metal–organic frameworks(nMOFs) are widely used for drug delivery because of their rich and variable composition, high drug loading capacity and good biodegradability. Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies. This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers, supplementary agents and drug carriers, respectively, with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.

关键词： Drug delivery system Immunotherapy Metal–organic frameworks Tumor

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Optimizing Sorghum Productivity Using Balanced Fertilizers on Dryland

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1403-1420页

作者： Samijan Samijan Endah Nurwahyuni Sri Minarsih Agus Supriyo Sodiq Jauhari Yulis Hindarwati Meinarti Norma Setiapermas Raden Heru Praptana Endah Winarni Vina Eka Aristya research center for Food Crops Research Organization for Agriculture and FoodNational Research and Innovation Agency(BRIN)Cibinong Science CenterJl.Raya Jakarta-Bogor Km.46Bogor16911Indonesia

Sorghum is theﬁfth most required cereal crop *** bicolor has the advantage of being adaptive to both lowland and dryland,with drought-tolerant and wide *** low nutrient availability in dryland requires additional effective fertilizers to increase sorghum *** research aimed to assess the appli-cation of organic,inorganic,and biofertilizers for sorghum productivity on *** in Central Java,Indonesia as dryland sorghum areas,from November 2022 to February *** experiment cooperates with the farmers in a split-plot design,the main plot was two varieties and subplots of four *** enhanced sorghum yield(21.38%–36.06%)with combined fertilizer was greater than the existing *** con-trol does not rely on inorganic fertilizers but also on applying *** sorghum farming economic value farming indicated that combinations of fertilizer treatments and varieties provide beneﬁts of USD 929.81–1955.81 with a revenue-cost ratio(R/C)value>*** is an essential food commodity that faces the threat of the global crisis and an unfavorable *** study indicated balanced fertilizers could provide sufﬁ-cient nutrients to the soil and increase nutrient absorption availability for sorghum growth and *** fertilization increases the uptake of N,P,and K nutrients correlates with an increase in yield of 21.38%–36.06%.

关键词： Biofertilizer dryland adaptability economic value sorghum potential yield

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