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Common bean SNP alleles and candidate genes affecting photosynthesis under contrasting water regimes

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Horticulture Research 2021年第1期8卷 110-123页

作者： Susana Trindade Leitao Maria Catarina Bicho Priscila Pereira Maria Joao Paulo Marcos Malosetti Susana de Sousa Araujo Fred van Eeuwijk Maria Carlota Vaz Patto Instituto de Tecnologia Quimica e Biológica Antonio Xavier Universidade Nova de LisboaOeirasPortugal Wageningen University&Research WageningenThe Netherlands Present address:Instituto Superior de Agronomia Universidade de LisboaLisboaPortugal Present address:Nunhems Vegetable Seeds NunhemThe Netherlands Present address:association blc3-technology and innovation campus Centre Bio R&D UnitOliveira do HospitalLisboaPortugal

Water deficit is a major worldwide constraint to common bean(Phaseolus vulgaris L.)production,being photosynthesis one of the most affected physiological *** gain insights into the genetic basis of the photosynthetic response of common bean under water-limited conditions,a collection of 158 Portuguese accessions was grown under both well-watered and water-deficit *** gas-exchange parameters were measured and photosynthetic pigments *** same collection was genotyped using SNP arrays,and SNP-trait associations tested considering a linear mixed model accounting for the genetic relatedness among accessions.A total of 133 SNP-trait associations were identified for net CO 2 assimilation rate,transpiration rate,stomatal conductance,and chlorophylls a and b,carotenes,and xanthophyll *** of these associations were detected under water-deficit and 43 under well-watered conditions,with only two associations common to both *** candidate genes revealed that stomatal regulation,protein translocation across membranes,redox mechanisms,hormone,and osmotic stress signaling were the most relevant processes involved in common bean response to water-limited *** candidates are now preferential targets for common bean water-deficit-tolerance ***,new sources of water-deficit tolerance of Andean,Mesoamerican,and admixed origin were detected as accessions valuable for breeding,and not yet explored.

关键词： breeding water assimilation

MicroRNAs expression dynamics reveal post-transcriptional mechanisms regulating seed development in Phaseolus vulgaris L.

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Horticulture Research 2021年第1期8卷 195-211页

作者： Jose Ricardo Parreira Michela Cappuccio Alma Balestrazzi Pedro Fevereiro Susana de Sousa Araujo Instituto de Tecnologia Quimica e Biologica Antonio Xavier Universidade Nova de LisboaAvenida da Republica2780-157 OeirasPortugal Department of Biology and Biotechnology“L.Spallanzani” University of Paviavia Ferrata 927100 PaviaItaly InnovPlantProtect Collaborative Laboratory Estrada de Gil Vaz7351-901 ElvasPortugal Present address:association blc3-technology and innovation campus Centre Bio R&D UnitRua Nossa Senhora da Conceicao 2Lagares da Beira3405-155 Oliveira do HospitalPortugal

The knowledge on post-transcriptional regulation mechanisms implicated in seed development(SD)is still limited,particularly in one of the most consumed grain legumes,Phaseolus vulgaris *** explore for the first time the miRNA expression dynamics in *** developing ***-two known and 39 new miRNAs were found expressed in *** developing *** of the miRNAs identified were more abundant at 10 and 40 days after anthesis,suggesting that late embryogenesis/early filling and desiccation were SD stages in which miRNA action is more *** analysis and target prediction identified targets for 77 expressed *** several known miRNAs were predicted to target HD-ZIP,ARF,SPL,and NF-Y transcription factors families,most of the predicted targets for new miRNAs encode for functional ***-targets expression profiles evidenced that these miRNAs could tune distinct seed developmental *** more accumulated at early SD stages were implicated in regulating the end of embryogenesis,postponing the seed maturation program,storage compound synthesis and *** more accumulated at late SD stages could be implicated in seed quiescence,desiccation tolerance,and longevity with still uncovered roles in *** miRNAs herein described represent novel *** resources with potential application in future biotechnological approaches to modulate the expression of genes implicated in legume seed traits with impact in horticultural production systems.

关键词： mechanisms dynamics regulating

Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi Jiang Jingqi Chen Institute of Science and technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

Extended Evolutionary Fast Learn-to-Walk Approach for Four-Legged Robots

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Journal of Bionic Engineering 2007年第4期4卷 255-263页

作者： Muh. Anshar Mary-Anne Williams innovation and technology Research Laboratory Faculty of Information Technology University of Technology Sydney City Campus 15 Broadway Ultimo NSW 2007 Australia

Robot locomotion is an active research area. In this paper we focus on the locomotion of quadruped robots. An effective walking gait of quadruped robots is mainly concerned with two key aspects, namely speed and stability. The large search space of potential parameter settings for leg joints means that hand tuning is not feasible in general. As a result walking parameters are typically determined using machine learning techniques. A major shortcoming of using machine learning techniques is the significant wear and tear of robots since many parameter combinations need to be evaluated before an optimal solution is found. This paper proposes a direct walking gait learning approach, which is specifically designed to reduce wear and tear of robot motors, joints and other hardware. In essence we provide an effective learning mechanism that leads to a solution in a faster convergence time than previous algorithms. The results demonstrate that the new learning algorithm obtains a faster convergence to the best solutions in a short run. This approach is significant in obtaining faster walking gaits which will be useful for a wide range of applications where speed and stability are important. Future work will extend our methods so that the faster convergence algorithm can be applied to a two legged humanoid and lead to less wear and tear whilst still developing a fast and stable gait.

关键词： legged-robots locomotion learning genetic convergence walking gaits

Trends in the Prevalence of Cognitive Impairment Among Older Adults Aged 65 to 105 Years—China,2002–2018

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China CDC weekly 2022年第42期4卷 945-949页

作者： Xiaojin Yan Shiqi Lin Jiajia Li Hao Cheng Xiangguo Liu Lijun Pei Institute of Population Research Peking UniversityBeijingChina National Academy of innovation Strategy China Association for Science and TechnologyBeijingChina

Introduction:This study aims to analyze trends and subgroup differences in the prevalence of cognitive impairment among older Chinese adults aged 65–105 years from 2002 to ***:Data were drawn from six waves of the Chinese Longitudinal Healthy Longevity Survey(CLHLS).Cognitive function was measured using the Chinese version of the Mini-Mental State Examination(CMMSE).Cognitive impairment was determined by the total CMMSE score and educational attainment of *** generalized estimating equation(GEE)models with a logistic link and binominal distribution were performed to assess the secular trend in the ***:The prevalence of cognitive impairment among older adults aged 65–105 years decreased from 3.44%[95%confidence interval(CI):3.15%–3.73%]in 2002 to 2.41%(95%CI:2.17%–2.65%)in 2018 in *** prevalence was slightly higher in women than in men in 2002(3.71%vs.3.13%,P3%reduction in the odds of the prevalence of cognitive impairment[odds ratio(OR)=0.97;95%CI:0.97–0.97;P<0.05].Conclusions:The prevalence of cognitive impairment among Chinese older adults aged 65–105 years declined slowly from 2002 to *** gender,urban-rural,age,and regional differences in the prevalence of cognitive impairment changed over time.

关键词： slowly nominal successive

User association in Heterogeneous Network with Dual Connectivity and Constrained Backhaul

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China Communications 2016年第2期13卷 11-20页

作者： WU Zhouyun XIE Weiliang YANG Fengyi BI Qi technology innovation Center China Telecom Corporation Limited

A novel user association model for heterogeneous network(Het Net) with dual connectivity(DC) and constrained backhaul is proposed in this paper, where not only the best combination of serving macro cell and small cell for each user to associate is selected but also the optimal traffi c split between the macro cell and small cell is determined to enhance both radio resource effi ciency and backhaul capacity utilization. To solve this optimization problem, an intuitive algorithm based on iteratively solving two sub-problems is proposed. One sub-problem is a binary integer programming problem and a corresponding greedy algorithm is proposed, while the other sub-problem is a simple linear programming problem and can be easily solved. Numerical results show that the proposed model and algorithm can achieve better radio resource effi ciency and backhaul capacity utilization compared with user association in Het Net without DC, which validate the capacity enhancement potentials of radio resource coordination in Het Net with DC.

关键词： user association dual connectivity traffic split constrained backhaul

Closed-form dynamics of a hexarot parallel manipulator by means of the principle of virtual work

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Acta Mechanica Sinica 2018年第5期34卷 883-895页

作者： Siamak Pedrammehr Saeid Nahavandi Hamid Abdi Institute for Intelligent Systems Research and innovation Deakin UniversityWaurn Ponds CampusGeelongVIC 3217Australia

In this research,a systematic approach to solving the inverse dynamics of hexarot manipulators is addressed using the methodology of virtual *** the first time,a closed form of the mathematical formulation of the standard dynamic model is presented for this class of *** efficient algorithm for solving this closed-form dynamic model of the mechanism is developed and it is used to simulate the dynamics of the system for different *** of the proposed model is performed using SimMechanics and it is shown that the results of the proposed mathematical model match with the results obtained by the SimMechanics model.

关键词： Parallel mechanism Hexarot Simulator Dynamics Virtual work principle