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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis

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Military medical Research 2020年第2期7卷 228-238页

作者： Yun-Peng Hou Jia-Lin Wu Chao Tan Yu Chen Rui Guo Yong-Jun Luo department of Military medical Geography Army Medical Service Training BaseArmy Medical UniversityChongqing 400038China

Background:When lowlanders rapidly ascend to altitudes>2500 m,they may develop acute mountain sickness(AMS).The individual susceptibility,ascending velocity,time spent at altitude,activity levels and altitude reached are considered risk factors for ***,it is not clear whether sex is a risk *** results have been *** conducted a meta-analysis to test whether there were sex-based differences in the prevalence of AMS using Lake Louise Scoring ***:Systematic searches were performed in August 2019 in EMBASE,PubMed,and Web of Science for prospective studies with AMS data for men and *** titles and abstracts were independently checked in the primary screening step,and the selected full-text articles were independently assessed in the secondary screening step by the two authors(YPH and JLW)based on pre-defined inclusion *** meta-analysis was performed using by the STATA 14.1 software program.A random-effects model was ***:Eighteen eligible prospective studies were included.A total of 7669 participants(2639[34.4%]women)were *** results showed that there was a statistically significant higher prevalence rate of AMS in women than in men(RR=1.24,95%CI 1.09–1.41),regardless of age or ***,the heterogeneity was significant in the analysis(Tau2=0.0403,Chi2=50.15,df=17;I2=66.1%,P=0.000),it was main caused by different numbers of subjects among the studies(coefficient=–2.17,P=0.049).Besides,the results showed that there was no evidence of significant publication bias in the combined studies on the basis of Egger’s test(bias coefficient=1.48,P=0.052)and Begg’s test(P=0.130).Conclusions:According to this study,the statistically significant finding emerging from this study was that women have a higher prevalence of ***,the authors could not exclude studies where patients were on *** analysis provided a direction for future studies of the relationship of sex and the risk of AMS,such as

关键词： Prevalence Sex differences Acute mountain sickness Risk factors

Association between acute mountain sickness(AMS) and age: a meta-analysis

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Military medical Research 2019年第1期6卷 31-38页

作者： Yu Wu Chi Zhang Yu Chen Yong-Jun Luo department of Military medical Geography Army Medical Service Training Base Army Medical University Battalion 5 of Cadet Brigade Army Medical University Key Laboratory of High Altitude Environmental Medicine of PLA Army Medical University

Background: Acute mountain sickness(AMS) is a potentially lethal condition caused by acute hypoxia after ascending to altitudes higher than 2500 m in a short time. The main symptom of AMS is headache. Numerous risk factors of AMS have been examined, including gender, obesity, ascent rate, age and individual susceptibility. In previous studies, age was considered a predisposing factor for AMS. However, different opinions have been raised in recent years. To clarify the association between AMS and age, we conducted this ***: We obtained observational studies that explored risk factors for AMS by searching PubMed, Embase, China National Knowledge Internet(CNKI), the Wanfang database and CQVIP for articles published before March *** studies included were required to provide the mean age and its standard deviation for subjects with and without AMS, the maximum altitude attained and the mode of ascent. The Lake Louse Score(LLS) or the Chinese AMS score(CAS) was used to judge the severity of AMS symptoms and incidence. Studies were pooled for the analysis by using a random effects model in RevMan 5.0. Meta-regression and subgroup analyses were conducted to identify sources of heterogeneity using Stata 14.2 and RevMan ***: In total, 17 studies were included, and the overall number of subjects with and without AMS was 1810 and3014, respectively. The age ranged from 10 to 76 years. Analysis of the 17 included studies showed that age was not associated with AMS(mean difference(MD)=0.10; 95%CI: —0.38-0.58; P=0.69).Conclusions: This meta-analysis suggests that there is no association between age and the risk of AMS. Race, age,and ascent mode are common sources of heterogeneity, which may provide an analytical orientation for future heterogeneity analyses.

关键词： Meta-analysis Age Acute mountain sickness Individual susceptibility

Nomogram for overall survival in ampullary adenocarcinoma using the surveillance,epidemiology,and end results database and external validation

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World Journal of Clinical Oncology 2025年第2期16卷 36-51页

作者： Jia Yang Zi-Yi Wang Jing Chen Yao Zhang Lei Chen department of Gastroenterology The First Affiliated Hospital of Army Medical UniversityChongqing 400038China department of Epidemiology College of Preventive MedicineArmy Medical UniversityChongqing 400038China

BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal ***,only a few cases have been reported,resulting in limited information on *** To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary *** Data were sourced from the surveillance,epidemiology,and end results stat *** patients in the database were randomized in a 7:3 ratio into training and validation *** Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the *** nomogram was validated with a cohort of patients from the First Affiliated Hospital of the army medical *** For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the *** area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific *** internal and external validation cohorts indicated good consistency of the *** The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.

关键词： Ampullary adenocarcinoma Dynamic nomogram Gastrointestinal tract Surveillance Epidemiology End results database Survival rate

125I Radioactive Particles Drive Protective Autophagy in Hepatocellular Carcinoma by Upregulating ATG9B

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 360-368页

作者： Yunhua Xiao Jing Yuan Chongshuang Yang Junru Xiong Liangyu Deng Qinghua Liang Chuang He Liangshan Li Fengtian He Xuequan Huang department of Nuclear Medicine the First Affiliated Hospital of Army Medical UniversityArmy Medical UniversityChongqingChina department of Radiology Army Medical CenterChongqingChina department of Biochemistry and Molecular Biology College of Basic Medical SciencesArmy Medical UniversityChongqingChina

Background and Aims:125I radioactive particles implantation have demonstrated efficacy in eradicating hepatocellular carcinoma(HCC).However,progressive resistance of HCC to 125I radioactive particles has limited its wide clinical ***:We investigated the cellular responses to 125I radioactive particles treatment and autophagy-related 9B(ATG9B)silencing in HCC cell lines and Hep3B xenografted tumor model using Cell Counting Kit-8 reagent,western blotting,immunofluorescence,flow cytometry,transmission electron microscopy and ***:In this study,we demonstrated that 125I radioactive particles induced cell apoptosis and protective autophagy of HCC in vitro and in *** of autophagy enhanced the radiosensitivity of HCC to 125I radioactive ***,125I radioactive particles induced autophagy by upregulating ATG9B,with increased expression level of LC3B and decreased expression level of ***,ATG9B silencing downregulated LC3B expression and upregulated p62 expression and enhanced radiosensitivity of HCC to 125I radioactive particles in vitro and in ***:Inhibition of ATG9B enhanced the antitumor effects of 125I particle radiation against HCC in vitro and in *** findings suggest that 125I particle radiation plus chloroquine or/and the ATG9B inhibitor may be a novel therapeutic strategy for HCC.

关键词： 125I radioactive particles Hepatocellular carcinoma Autophagy ATG9B

Nanotechnology combining photoacoustic kinetics and chemical kinetics for thrombosis diagnosis and treatment

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Chinese Chemical Letters 2021年第12期32卷 3665-3674页

作者： Hao Tian Lin Lin Zhaojing Ba Fangchao Xue Yanzhao Li Wen Zeng department of Cell Biology Army Medical UniversityChongqing 400038China department of Anatomy Army Medical UniversityChongqing 400038China departments of Neurology Southwest HospitalArmy Medical UniversityChongqing 400038China

Thrombotic disease is a major problem that endangers human health. At present, MRI and CT are commonly used clinically to diagnose thrombosis, and thrombolytic drugs are used for treatment), but the diagnosis time is lagging, the utilization of drugs is low, and the resulting systemic toxicity problems such as side effects lead to poor treatment effects. Nanotechnology combining photoacoustic dynamics and chemical dynamics has shown great application value in tumor targeting, diagnosis, detection and treatment. It has also become a new direction in the diagnosis and treatment of thrombotic diseases, and has created new applications in the field of nanomaterials. This review summarizes the new progress of this combination in the diagnosis and treatment of thrombotic diseases according to the differences in the construction of the nanotherapy system, at the same time, we put forward some new problems and prospects for the integration of thrombosis diagnosis and treatment.

关键词： Nanotechnology Photoacoustic kinetics Chemical kinetics Drug delivery and release Thrombosis disease

Activation of Dopamine D2 Receptors Alleviates Neuronal Hyperexcitability in the Lateral Entorhinal Cortex via Inhibition of HCN Current in a Rat Model of Chronic Inflammatory Pain

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Neuroscience Bulletin 2022年第9期38卷 1041-1056页

作者： Shi-Hao Gao Yong Tao Yang Zhu Hao Huang Lin-Lin Shen Chang-Yue Gao department of Rehabilitation Daping HospitalArmy Medical UniversityChongqing400042China department of Respiratory and Critical Care Medicine Xinqiao HospitalArmy Medical UniversityChongqing400037China army 953 Hospital Army Medical UniversityShigatse857000China

Functional changes in synaptic transmission from the lateral entorhinal cortex to the dentate gyrus(LEC-DG)are considered responsible for the chronification of ***,the underlying alterations in fan cells,which are the predominant neurons in the LEC that project to the DG,remain ***,we investigated possible mechanisms using a rat model of complete Freund’s adjuvant(CFA)-induced inflammatory *** found a substantial increase in hyperpolarization-activated/cyclic nucleotide-gated currents(Ih),which led to the hyperexcitability of LEC fan cells of CFA *** phenomenon was attenuated in CFA slices by activating dopamine D2,but not D1,*** activation of the ventral tegmental area-LEC projection had a D2 receptor-dependent analgesic ***-LEC microinjection of a D2 receptor agonist also suppressed CFA-induced behavioral hypersensitivity,and this effect was attenuated by pre-activation of the *** findings suggest that down-regulating the excitability of LEC fan cells through activation of the dopamine D2 receptor may be a strategy for treating chronic inflammatory pain.

关键词： Inflammatory pain Lateral entorhinal cortex Neuronal hyperexcitability Dopamine D2 receptor HCN current

Getting Lost: Place Cells and Grid Cells in Rodent Models of Alzheimer’s Disease

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Neuroscience Bulletin 2021年第6期37卷 894-897页

作者： Xiaoyang Long Yuan Tao Xi-Chan Chen Bin Deng Jing Cai Sheng-Jia Zhang department of Neurosurgery Xinqiao HospitalArmy Medical UniversityChongqingChina department of Neurology Daping HospitalArmy Medical UniversityChongqingChina

Alzheimer's disease(AD)is a progressive neurodegener-ative disorder and affects 60-80% of all dementia cases in the elderly population *** lost is one of the earliest cognitive symptoms to emerge in AD *** decades-long efforts to identify the molecular mechanisms underlying the pathogenesis of β-amyloid(Aβ)plaques and tau neurofibrillary tangles,no effective therapeutic interventions have been developed for AD so far[1].

关键词： Alzheimer Aβ tau

Lubricating Performance of Rapeseed Oil Under Electromagnetic Field

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China Petroleum Processing & Petrochemical Technology 2018年第1期20卷 85-92页

作者： Jiang Zeqi Liu Ping Fang Jianhua Chen Boshui Gu Kecheng Wu Jiang College of Pharmacy Army Medical University department of Oil Army Logistics University

Considering electromagnetic effect when investigating tribological properties of rapeseed oil is benefical not only to the improvement of green lubrication, but also to the development of tribology theories and practices. In the present paper, the tribological properties of rapeseed oil under different intensity of electromagnetic field and normal loads were evaluated on a modified tribo-tester. The results indicated that the electromagnetic field could improve the anti-wear and friction-reducing property of the rapeseed oil. Furthermore, the influencing mechanisms were discussed from the perspective of electromagnetism according to the analytical results of SEM, EDS and XPS techniques.

关键词： rapeseed oil electromagnetic field anti-wear property friction-reducing performance