Getting Lost: Place Cells and Grid Cells in Rodent Models of Alzheimer’s Disease

作     者：Xiaoyang Long Yuan Tao Xi-Chan Chen Bin Deng Jing Cai Sheng-Jia Zhang Xiaoyang Long;Yuan Tao;Xi-Chan Chen;Bin Deng;Jing Cai;Sheng-Jia Zhang

作者机构：Department of NeurosurgeryXinqiao HospitalArmy Medical UniversityChongqingChina Department of NeurologyDaping HospitalArmy Medical UniversityChongqingChina 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第6期

页      面：894-897页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：This research highlight was supported by the National Natural Science Foundation of China(31872775) the Chongqing Municipality Postdoctoral Fellowship(cstc2019jcyj-bshX0035) 

主　　题：Alzheimer Aβ tau 

摘      要：Alzheimer s disease(AD)is a progressive neurodegener-ative disorder and affects 60-80% of all dementia cases in the elderly population *** lost is one of the earliest cognitive symptoms to emerge in AD *** decades-long efforts to identify the molecular mechanisms underlying the pathogenesis of β-amyloid(Aβ)plaques and tau neurofibrillary tangles,no effective therapeutic interventions have been developed for AD so far[1].