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Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State key laboratory of molecular Vaccinology and molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina anhui Province key laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu key laboratory of molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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Ag@ Bi2WO6 Composites with High Visible-Light-Driven Photocatalytic Activities Prepared in UV Light Irradiation

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Chinese Journal of Chemistry 2011年第11期29卷 2345-2349页

作者：周海燕彭银秦述春 anhui key laboratory of functional molecular solids College of Chemistry and Materials Science Anhui Normal University Wuhu Anhui 241000 China

Bi2WO6 microstructures were synthesized through hydrothermal process and Ag@Bi2WO6 composites were synthesized by simple UV light irradiation for 5 rain using Bi2WO6 and AgNO3 as raw materials. Ag@BizWO6 composites were characterized by X-ray powder diffraction （XRD）, field-emission scanning electron microscopy （FE-SEM）, and UV-Vis absorption spectrum （UV-Vis）. Few Ag deposited on the Bi2WO6 leads to an increase in photocatalytic activity, which clearly indicates that the recombination of photogenerated charge carrier between the hybrid orbital of Bi6s and O2p （valence band） to the empty W5d orbital is inhibited greatly in the Ag@Bi2WO6 composite. In addition, a few H2O2 will greatly enhance photocatalytic activity of Ag@BizWO6, and the proper reason is discussed.

关键词： photosynthesis semiconductors photocatalytic mechanism

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Controlled-growth of Zn（OH）F Microbesoms in the Mild Aqueous Solution and Their Photocatalytic Activity

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Chinese Journal of Chemistry 2011年第1期29卷 191-195页

作者： Peng, Yin anhui key laboratory of functional molecular solids College of Chemistry and Materials Science Anhui Normal University Wuhu Anhui 241000 China

Zn（OH）F microbesoms have been synthesized on a large scale by a facile solution-based method using polymer as crystal growth modifier. The obtained products were characterized by X-ray powder diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, and scanning electron microscopy （SEM）. The effects of modifier polyacryla- mide （PAM）, reaction time, concentrations of NaF on the morphology and size of the product were studied. The resuits revealed that the Zn（OH）F microbesom had orthorhombic structures. Experimental conditions had all influence on the shape and size of the final products, but polymer PAM played the key role in formation of the Zn（OH）F microbesom. This novel structures exhibited good UV photocatalytic abilities,

关键词： Zn(OH)F synthesis design photocatalysis

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Cross-scale modulation for aqueous fabrication of monodisperse Cu2−xE(E=S,Se,Te)nanocrystals and supraparticles

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Nano Research 2023年第1期16卷 1448-1458页

作者： Hui Zhu Ge Guo Yunsheng Xia key laboratory of functional molecular solids Ministry of Education College of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241000China

Exploring aqueous nano-fabrication with monodisperse and hierarchical characteristics is fundamentally and technically ***,we discover that inter-particle nano–nano scale interactions profoundly affect the products’morphology ranging from polydisperse→monodisperse to individual→hierarchical ***,we present a“nucleationgrowth-dispersion triple modulation”strategy for fabricating monodisperse Cu2−xE(E=S,Se,Te)nanocrystals(NCs)and supraparticles(SPs).Such full-process and cross-scale control is conducted by two rationally selected ligands(cysteine and citrate molecules),which are responsible for atom/molecule–nano and nano–nano interaction modulations,*** reacts with the cations and forms low reactive(cysteine-Cu+)n coordination polymers,which overcomes the commonly concerned nucleation and particle growth induced ***,by virtue of its strong negative charge modulated NC–NC interactions,decides the products morphology from polydisperse products to monodisperse NCs to monodisperse hierarchical *** findings not only present new insights into aqueous nano-synthesis chemistry but provide an eco-friendly system for versatile and high-quality nano-entity fabrication.

关键词： aqueous fabrication monodisperse Cu2−xE nanocrystals Cu2−xE supraparticles photoacoustic imaging

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Gas template-assisted spray pyrolysis： A facile strategy to produce porous hollow Co3O4 with tunable porosity for high-performance lithium-ion battery anode materials

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Nano Research 2018年第3期11卷 1490-1499页

作者： Haoran Du Kuangfu Huang Min Li Yuanyuan Xia Yixuan Sun Mengkang Yu Baoyou Geng College of Chemistry and Materials Science Anhui Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Laboratory of Molecular-Based Materials Center for Nano-Science and Technology Anhui Normal University Wuhu 241000 China

Porous hollow Co3O4 microspheres have been synthesized from a mixed cobalt nitrate and urea solution through spray pyrolysis followed by calcination at 600 ℃ in air. This porous hollow Co3O4 is assembled by nanoparticles and exhibits variable porosity depending on the amount of gas in the system. In pyrolysis process, urea continuously decomposes into gaseous components, which act as a template to control the porous structure. The amount of gas escaping from precursor droplets can directly influence the porosity of the microspheres and the size of the nanoparticles controlled by the ratio of urea to cobalt nitrate. Electrochemical measurements show that the performance of the porous hollow Co3O4 microspheres is related to the porosity and size of the nanopartides. The sample with optimal porosity delivers a high first charge capacity of 1,417.9 mAh·g^-1 at 0.2C （1C = 890 mA·g^-1）, and superior charge cycle performance of 1,012.7 mAh.g-1 after 100 cycles. In addition, the optimized material displays satisfactory rate performance of 1,012.4 mAh.g-1 at 1C after 50 cycles and 881.3 mAh·g^-1 at 2C after 300 cycles. Superior charge/discharge capacity, excellent rate performance and high yield achieved in this study is promising for the development of high-performance Co3O4 anode materials for lithium-ion batteries.

关键词： Co3O4/gas template tunable porosity spray pyrolysis anode lithium-ion batteries

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Progress of photocatalytic CO_(2)reduction toward multi-carbon products

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Science China Chemistry 2024年第12期67卷 3994-4013页

作者： Jiaojiao Fang Chengyang Zhu Huiling Hu Jiaqi Li Licheng Li Haiyan Zhu Junjie Mao key laboratory of functional molecular solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China

The photocatalytic CO_(2)reduction reaction(CO_(2)RR)represents a promising solution to alleviate environmental and energy issues stemming from CO_(2)emissions while simultaneously enabling the production of high-value multi-carbon ***,the efficient generation of multi-carbon products remains challenging due to high kinetic barriers,sluggish C–C coupling processes,and intricate reaction *** review provides a comprehensive overview of the latest advancements in synthesizing C_(2+)products through CO_(2)photoreduction,highlighting the crucial role of active site design and the C–C coupling ***,we emphasize the correlation between the structure of active sites and the key intermediates of C–C coupling,which is fundamental for achieving deep photoconversion of CO_(2).Finally,we offer a glimpse into future challenges and prospects,outlining potential directions for the development of CO_(2)-to-multicarbon photoconversion,aiming to contribute novel insights to this exciting field.

关键词： CO_(2)reduction photocatalysis multi-carbon products C-C coupling active sites

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Theoretical screening of cooperative N-bridged dual-atom sites for efficient electrocatalytic nitrogen reduction with remolding insight

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Nano Research 2024年第4期17卷 3413-3422页

作者： Huimei Chen Yan Yang Chi Jiao Zhiwen Zhuo Junjie Mao Yan Liu key laboratory of functional molecular solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China

The electrocatalytic nitrogen reduction reaction(e-NRR)is a promising alternative method for the Haber–Bosch ***,it still faces many challenges in searching for high activity,stability,and selectivity catalysts and ascertaining the catalytic mechanism with complete ***,a series of graphene-based N-bridged dual-atom catalysts(M1-N-M2/NC)are systematically investigated via first-principle calculation and a high-throughput screening *** result unveils that N_(2) adsorption on M1-N-M2/NC in bridge-on adsorption mode can effectively break the scaling relationship on single-atom catalysts(SACs).Moreover,V-N-Ru/NC and V-N-Os/NC are systematically screened out as promising e-NRR catalysts,with extremely low limiting potentials of-0.20 and-0.18 V,***,the adsorption site competition between*N_(2) and*H,as well as the competitive twin reactions of hydrogen evolution reaction(HER)on intermediates(N_(n)H_(m))during the e-NRR process,is systematically evaluated to form a remodeling insight for the reactions in mechanism,and the e-NRR of new proposed dual-atom catalysts(DACs)is strategically optimized for its high-efficiency performance potential via our remolding insight in e-NRR *** work provides new ideas and insights for the design and mechanism of e-NRR catalysts and an effective strategy for rapidly screening highly efficient e-NRR catalysts.

关键词： nitrogen reduction dual-atom catalysts high-throughput screening hydrogen evolution reaction density functional theory calculations

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Post-modification of MOF to fabricate single-atom dispersed hollow nanocages catalysts for enhancing CO_(2)conversion

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Nano Research 2023年第7期16卷 8970-8976页

作者： Ruirui Yun Ruiming Xu Changsong Shi Beibei Zhang Tuanhui Li Lei He Tian Sheng Zheng Chen The key laboratory of functional molecular solids Ministry of Education College of chemistry and Materials ScienceAnhui Normal UniversityWuhu 214001China

During the catalytic process,the microenvironment and surface area of the catalyst will affect the catalytic ***,an assisted organic linker coated metal-organic framework(MOF)has been applied,to form Ni/HNC(HNC represents hollow nanocage)for electrocatalytic CO_(2)***,Ni/HNC achieves superb activity with high Faradaic efficiency(FE)of 97.2%at 0.7 V *** hydrogen electrode(RHE)towards CO_(2)conversion to *** contrast to Ni/NPC(afforded from the naked MOF),the Ni/HNC displays higher FE and selectivity on CO rather than H_(2),owing to the large nanocage which extraordinarily facilitates CO_(2)enrichment and the active sites easily *** work provides a general and feasible route to construct high-efficient electrochemical CO_(2)reduction reaction(EC-CO_(2)RR)catalysts via post-modified MOFs.

关键词： post-modification atomically dispersed sites hollow nanocage electrocatalytic CO_(2)reduction

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