检索结果-南通市图书馆

Rivers increasingly warmer:Prediction of changes in the thermal regime of rivers in Poland

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Geographical Sciences 2025年第1期35卷 139-174页

作者： Mariusz PTAK Teerachai AMNUAYLOJAROEN Mariusz SOJKA Department of Hydrology and Water Management Adam Mickiewicz University School of energy and Environment University of Phayao Atmospheric Pollution and Climate research Unit School of Energy and Environment University of Phayao Department of Land Improvement Environmental Development and Spatial Management Poznań University of Life Sciences

Emphasis on future environmental changes grows due to climate change, with simulations predicting rising river temperatures globally. For Poland, which has a long history of thermal studies of rivers, such an approach has not been implemented to date. This study used 9 Global Climate Models and tested three machine-learning techniques to predict river temperature changes. Random Forest performed best, with R2=0.88 and lowest error(RMSE:2.25, MAE:1.72). The range of future water temperature changes by the end of the 21st century was based on the Shared Socioeconomic Pathway scenarios SSP2-4.5 and SSP5-8.5. It was determined that by the end of the 21st century, the average temperature will increase by 2.1°C(SSP2-4.5) and 3.7°C(SSP5-8.5). A more detailed analysis, divided by two major basins Vistula and Odra, covered about 90% of Poland's territory. The average temperature increase, according to scenarios SSP2-4.5 and SSP5-8.5 for the Odra basin rivers,is 1.6°C and 3.2°C and for the Vistula basin rivers 2.3°C and 3.8°C, respectively. The Vistula basin's higher warming is due to less groundwater input and continental climate *** findings provide a crucial basis for water management to mitigate warming effects in Poland.

关键词：

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 249-262页

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteractionanalysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Yuan Dong Li Su Sin Man Lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

关键词：

Formation mechanism of deep natural hydrogen in the Sichuan Basin

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年

作者： Xiaomei WANG Kun HE Chunlong YANG Hao XIE Xiaobo WANG Yitong LYU Linfeng XIE Shuichang ZHANG research Institute of Petroleum Exploration & Development PetroChina Key Laboratory of Petroleum Geochemistry China National Petroleum Corporation International center for Isotope Effects research School of Earth Science and Engineering Nanjing University

As a potential renewable and clean energy source,the distribution and exploration prospects of natural hydrogen have garnered widespread ***,the limitations in understanding the formation mechanisms and accumulation patterns of underground natural hydrogen have significantly constrained its efficient exploration and *** study reports H2content and isotopes in natural gas from deep formations in sedimentary basins through geochemical analysis of 58 conventional gas samples from the Sinian to Triassic strata in the central Sichuan *** discovered that H2content in deep natural gas in central Sichuan generally exceeds 0.1%,with a maximum of 1.6%,and hydrogen isotopes (δ2HH2) range from-850‰to-586‰.analysis of the geological conditions,hydrogen generation mechanisms,and isotope fractionation characteristics in the study area confirms that microbial fermentation or in-situ organic matter cracking are not effective pathways for deep *** with helium content and isotope analysis of the natural gas,it is inferred that the volcanic basement in the central Sichuan area is the potential source rock for natural H2in the Sinian to Triassic ***,H2originates from the radiolysis of water and hydrothermal reactions of Fe（II） in the basement ***,a diffusion fractionation model reveals significant isotope fractionation during the migration and accumulation of deep H2into sedimentary reservoirs,which lead to anomalously light δ2HH2in deep natural gas in central *** indicates that the underground natural hydrogen accumulation is in a long-term dynamic process,with simultaneous H2accumulation and dissipation in the gas *** research not only elucidates the formation mechanism of deep H2but also provides insights for the resource potential of natural hydrogen in sedimentary basins.

关键词：

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial center for Engineering and Technology research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

维普期刊数据库

Design high-performance narrowband emitters for blue light-emitting diodes through manipulating resonance structure of aromatic heterocycles

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Yue Yu Lei Xu Wenle Tan Yuyu Pan Jiyin Xiao Bohan Wang Guangjun Tian Yuguang Ma Lei Ying Institute of Polymer Optoelectronic Materials and Devices Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology School of Petrochemical Engineering Shenyang University of Technology Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University

Narrowband light-emitting materials play critical roles in improving the color gamut and energy consumption of electroluminescence. Herein we demonstrated that by regulating the ground state resonance structure form of emitters with polycyclic aromatic heterocycles, the high-energy vibration of the C–C bond can be effectively suppressed, resulting in narrow emission like classical cyanine dyes. The designed compounds consist of twist and planar conformation, while having differences in the orientation of the positioning electron-donating(nitrogen) and electron-accepting(carbonyl) groups in the polycyclic aromatic hydrocarbon skeleton. The resulting compound Ac-Ph-Ac with a dominated zwitterionic resonance structure exhibits a relatively wide electroluminescent profile with the full width at half maximum(FWHM) of 42 nm and moderate device performance. In contrast, the “soliton transition” of 2AcPh based on the cyanine limit character effectively suppresses C–C stretching vibration in the polycyclic aromatic heterocycle skeleton, leading to a narrow electroluminescent profile with FWHM of 30 nm(0.16 eV)associated with an impressively high external quantum efficiency of 28.52%, which is among the highest efficiencies of so far reported non-sensitized organic light-emitting diodes.

关键词：

High-temperature oxidation behavior of CeO_2-SiO_2/Ni-W-P composites

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2009年第5期19卷 1190-1195页

作者：徐瑞东王军丽郭忠诚王华 Faculty of Metallurgy and energy Engineering Kunming University of Science and Technology research center for analysis and Measurement Kunming University of Science and Technology

Ni-W-P matrix composites containing CeO2 and SiO2 nano-particles were prepared on common carbon steel surface by means of pulse electrodeposition,and the high-temperature oxidation behavior was *** results show that when the oxidation time is controlled in 1 h,oxidation kinetics curve between oxidation mass gain rate and oxidation temperature of CeO2-SiO2/Ni-W-P composites accords with the index increasing *** the oxidation temperature is controlled at 300℃,the kinetics curve between oxidation mass gain rate and oxidation time accords with the linear increasing *** composites as-deposited are in the amorphous state and turn into the crystal state at 400℃.The microstructures of oxidation film on the composites will change from the compact state to the loose state with increasing oxidation temperature to 800℃.They are still continuous and compact,and there are no crackle,strip and ***2 and SiO2 nano-particles co-deposited into Ni-W-P alloy can improve the high-temperature oxidation resistance.

关键词：高温氧化行为纳米复合材料 SiO2纳米粒子高温抗氧化性能脉冲电沉积 CeO2 氧化时间温度控制

维普期刊数据库