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Correlation between Saccharomyces cerevisiae DNA in intestinal mucosal samples and anti-Saccharomyces cerevisiae antibodies in serum of patients with IBD

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World Journal of Gastroenterology 2006年第2期12卷 292-297页

作者： RC Mallant-Hent M Mooij BME von Blomberg RK Linskens AA van Bodegraven PHM Savelkoul Department of Gastroenterology VU University Medical CenterAmsterdamThe Netherlands Department of Medical Microbiology and Infection Control VU University Medical CenterAmsterdamThe Netherlands Department of immunology VU University Medical CenterAmsterdamThe Netherlands Department of Gastroenterology St Anna ZiekenhuisGeldropThe Netherlands

AIM： To investigate the correlation between ASCA and presence of mucosal S. cerevisiae DNA in a population of CD, ulcerative colitis （UC） patients and controls. METHODS： S. cerevisiae-specific primers and a fluorescent probe were designed for a 5＇ exonuclease real time PCR （TaqManTM） assay, which is a homogenous system using a fluorescent-labelled probe for the detection of PCR product in real time. We analyzed the relation of the PCR results with the ASCA findings in a group of 76 inflammatory bowel disease （IBD） patients （31 CD, 45 UC） and 22 healthy controls （HC）. RESULTS： ASCA （IgA or IgG） were positive in 19 （61%） patients with CD, 12 （27%） with UC and none of the HC. PCR amplification was inhibited and excluded from the final results in 10 （22%） UC patients, 7 （22%） CD patients, and 6 （30%） HC. In only 15 of the mucosal samples, S. cerevisiae DNA was detected by real time PCR, including 7 （29%） in CD, 7 （19%） in UC, 1 （6%） in HC. In 4 CD and in 4 UC patients, ASCA and mucosal S. cerevisiae were positive. Hucosal S. cerevisiae was present in combination with negative ASCA IgA and IgG in 3 UC, and 3 CD patients. CONCLUSION： We conclude that since the presence of S. cerevisiae in colonic mucosal biopsy specimens is very rare, ASCA is unlikely to be explained by continuous exposure to S. cerevisiae in the mucosa. Therefore, ASCA formation must occur earlier in life and levels remain relatively stable thereafter in immunological susceptible persons.

关键词： ASCA Saccharomyces cerevisiae mucosa IBD

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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： Manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch Esmée J Grobbee Manon van Engeland Manon C W Spaander Gerrit A Meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

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Frontiers in Biology 2016年第3期11卷 256-259页

作者： M. A. Bottelier A. Schrantee G. van Wingen H. G. Ruhe M. B. de Ruiter L. Reneman Department of Child-andAdolescentPsychiatry Triversum Alkmaar The Netherlands Brain Imaging center Academic Medical Center University of Amsterdam Amsterdam The Netherlands Department of Radiology Academic Medical Center Amsterdam The Netherlands Department of Psychiatry Academic Medical Center Amsterdam The Netherlands Program for Mood and Anxiety Disorders Department of Psychiatry University Medical Center Groningen University of GroningenGroningen The Netherlands

Treatment of adolescents with antidepressants may induce an increased risk for suicidality in this population. The activity of the amygdala during processing of emotional faces with functional Magnetic Resonance Imaging （fMRI） is a well-known measure of emotional dysregulation. Based upon data of our prematurely ended randomized clinical trial with fluoxetine （NTR3103） in anxious and or depressed girls （12-14 years of age） we calculated that with the found effect size of r = 0.66, compared to placebo, only 8 subjects are heeded to demonstrate increased amygdala activity following 16 weeks of treatment with fluoxetine.

关键词： amygdala reactivity SSRI adverse effects anxiety depression

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Cancer drug resistance: a new perspective

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Cancer Drug Resistance 2018年第1期1卷 1-5页

作者： Godefridus J.Peters Laboratory Medical Oncology VU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands

INTRODUCTION Cancer drug resistance has been and unfortunately still is a major problem in cancer *** any therapy(except surgery)that is being used in the treatment of cancer can result in *** there is a large group of patients that will either not respond to the applied therapy(intrinsic resistance)or will become resistant during therapy(acquired resistance).Sometimes patients can become resistant to one specific drug and remain sensitive to other drugs(one-drug resistance);another group of patients may become resistant to one drug and will be resistant to other unrelated drugs as well(multiple drug resistance,MDR).

关键词： drugs Cancer drug

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Is there a hormonal basis for human homosexuality？

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Asian Journal of Andrology 2011年第6期13卷 793-794页

作者： Louis Gooren VU University Medical center Amsterdam 1081HV The Netherlands

In the August 2011 issue of Endocrinology, Dr Balthazart presents a minireview on Hormones and Human Sexual Orientation.1 As in most scientific papers on this issue, the contribution lacks an operational definition ... 详细信息

关键词： Biological sciences Biochemistry Microbiology Virology

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Long noncoding RNA in cardiac aging and disease

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Journal of Molecular Cell Biology 2019年第10期11卷 860-867页

作者： Noelia Lozano-Vidal Diewertje IBink Reinier A.Boon Department of Physiology Amsterdam Cardiovascular SciencesAmsterdam Universitair Medische CentraVrije Universiteit Amsterdam1081 HZAmsterdamthe Netherlands Institute of Cardiovascular Regeneration Goethe UniversityFrankfurt am MainGermany German center for Cardiovascular Research(DZHK) Partner Site Rhein-MainBerlinGermany

Cardiovascular diseases(CVDs)are the main cause of morbidity and mortality in Western society and present an important agerelated *** the constant rise in life expectancy,prevalence ofCVD in the population will likely increase *** therapies,especially in the elderly,are needed to combat *** review is focused on the role of long noncoding RNA(IncRNA)in *** sequencing experiments in the past decade showed that most RNA does not code for protein,but many RNAs function as ***,we summarize the recent findings of IncRNA regulation in the diseased *** potential use of these RNAs as biomarkers of cardiac disease prediction is also discussed.

关键词： long non coding RNA aging cardiovascular disease

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Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 375-385页

作者： Takehiro Noji Satoko Uemura Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano Department of Gastroenterological Surgery II Hokkaido University Faculty of MedicineSapporoJapan Department of Surgery Cancer Center AmsterdamAmsterdam UMCLocation AMC University of AmsterdamAmsterdamthe Netherlands Department of Surgery Erasmus Medical CenterRotterdamthe Netherlands Department of Surgery Memorial Sloan Kettering Cancer CenterNew YorkNYUSA

Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and *** Academic Medical center(amsterdam UMC)and Memorial Sloan Kettering Cancer center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient *** study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido ***:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and ***:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of *** rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,*** ROC analysis demonstrated an AUC value of ***:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is *** POMRS were not applicable in the eastern *** external validation is recommended.

关键词： Perihilar cholangiocarcinoma(PHCC) post operative mortality score post-hepatectomy liver failure score(PHLFS) validation study

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Role of E3 ubiquitin ligases in lung cancer

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World Journal of Clinical Oncology 2013年第3期4卷 58-69页

作者： Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters Department of Medical Oncology VU University Medical Center1081 HV AmsterdamThe Netherlands Department of rheumatology VU University Medical Center1081 HV AmsterdamThe Netherlands

E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S ***,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer ***,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical *** this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung ***,we discuss the processes in which they are involved and evaluate them as potential anti-cancer *** better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients.

关键词： E3 ubiquitin ligases Lung cancer Ubiquitinproteasome system Proteasome inhibitors Bortezomib Apoptosis Gene regulation DNA repair

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Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering

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Bioactive Materials 2022年第3期7卷 221-238页

作者： Mingjing Zhu Wenchao Zhong Wei Cao Qingbin Zhang Gang Wu Department of Temporomandibular Joint Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhouGuangdong510182China Department of Oral and Maxillofacial Surgery/Pathology Amsterdam UMC and Academic Center for Dentistry Amsterdam(ACTA)Vrije Universiteit Amsterdam(VU)Amsterdam Movement Science(AMS)Amsterdamthe Netherlands Department of Oral Cell Biology Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Vrije Universiteit AmsterdamAmsterdam Movement SciencesAmsterdamthe Netherlands

The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature *** provide viable treatment options,tremendous efforts have been made to develop various chondrogenically-functionalized biomaterials for cartilage tissue *** that are derived from and mimic the functions of chondroconductive cartilage extracellular matrix and chondroinductive growth factors,represent a unique group of bioactive agents for chondrogenic *** they can be chemically synthesized,peptides bear better reproducibility,more stable efficacy,higher modifiability and yielding efficiency in comparison with naturally derived biomaterials and recombinant growth *** this review,we summarize the current knowledge in the designs of the chondroinductive/chondroconductive peptides,the underlying molecular mechanisms and their-functionalized biomaterials for cartilage tissue *** also systematically compare their in-vitro and in-vivo efficacies in inducing *** vision is to stimulate the development of novel peptides and their-functionalized biomaterials for cartilage tissue engineering.

关键词： Chondroinductive Chondroconductive Peptide Biomaterial Cartilage tissue engineering

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OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1842-1859页

作者： Chuannan Fan Qian Wang Gerard van der Zon Jiang Ren Cedrick Agaser Roderick C.Slieker Prasanna Vasudevan Iyengar Hailiang Mei Peter ten Dijke Department of Cell and Chemical Biology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Oncode Institute Leiden University Medical CenterLeiden 2300 RCThe Netherlands Department of Biomedical Data Sciences Sequencing Analysis Support CoreLeiden University Medical CenterLeiden 2300 RCThe Netherlands Department of Epidemiology and Data Science Amsterdam Public Health InstituteAmsterdam Cardiovascular Sciences InstituteAmsterdam UMClocation VUmcAmsterdam 1081 HVThe Netherlands

Ovo-like transcriptional repressor 1(OVOL1)is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition(MET).The cytokines transforming growth factor-β(TGF-β)and bone morphogenetic proteins(BMP)control the epithelial–mesenchymal plasticity(EMP)of cancer cells,but whether this occurs through interplay with OVOL1 is not ***,we show that OVOL1 is inversely correlated with the epithelial–mesenchymal transition(EMT)signature,and is an indicator of a favorable prognosis for breast cancer ***1 suppresses EMT.

关键词： invasion breast cancer

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