检索结果-南通市图书馆

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina school of pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui school of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China school Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First school of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China school of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Improving the prediction accuracy of soil nutrient classification by optimizing extreme learning machine parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Information Processing in Agriculture 2020年第1期7卷 72-82页

作者： M.S.Suchithra Maya L.Pai Department of Computer Science and IT Amrita School of Arts and SciencesKochiAmrita Vishwa Vidyapeetham682024India

The soil,Soul of Infinite Life,is the entity responsible for sustaining life on *** spite of significant advances in the service sector,agriculture remains the major provider of employment and source of revenue in *** testing is a valuable tool for evaluating the available nutrient status of soil and helps to determine the proper amount of nutrients to be added to a given soil based on its fertility and crop *** the current study,the soil test report values are used to classify several significant soil features like village wise soil fertility indices of Available Phosphorus(P),Available Potassium(K),Organic Carbon(OC)and Boron(B),as well as the parameter Soil Reaction(pH).The classification and prediction of the village wise soil parameters aids in reducing wasteful expenditure on fertilizer inputs,increase profitability,save the time of chemical soil analysis experts,improves soil health and environmental *** five classification problems are solved using the fast learning classification technique known as Extreme Learning Machine(ELM)with different activation functions like gaussian radial basis,sine-squared,hyperbolic tangent,triangular basis,and hard *** the performance analysis of ELMs with diverse activation functions for these soil parameter classifications,the gaussian radial basis function attains the maximum performance for four out of five problems,which goes above 80%in most of the accuracy rate calculations in every problem,followed by hyperbolic tangent,hard limit,triangular basis,and ***,the performance of the final classification problem,*** pH classification,gives moderate values with the gaussian radial basis and best performance(near 90%),with the hyperbolic tangent.

关键词： Extreme learning machine Activation functions Soil fertility indices Soil pH Classification Prediction

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Olfactory receptors in neural regeneration in the central nervous system

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Mental Illness Disorder Diagnosis Using Emotion Variation Detection from Continuous English Speech

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2021年第12期69卷 3217-3238页

作者： S.Lalitha Deepa Gupta Mohammed Zakariah Yousef Ajami Alotaibi Department of Electronics&Communication Engineering Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluruIndia Department of Computer Science&Engineering Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluruIndia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversitySaudi Arabia

Automatic recognition of human emotions in a continuous dialog model remains challenging where a speaker’s utterance includes several sentences that may not always carry a single *** work with standalone speech emotion recognition(SER)systems proposed for continuous speech only has been *** the recent decade,various effective SER systems have been proposed for discrete speech,i.e.,short speech *** would be more helpful if these systems could also recognize emotions from continuous ***,if these systems are applied directly to test emotions from continuous speech,emotion recognition performance would not be similar to that achieved for discrete speech due to the mismatch between training data(from training speech)and testing data(from continuous speech).The problem may possibly be resolved if an existing SER system for discrete speech is ***,in this work the author’s existing effective SER system for multilingual and mixed-lingual discrete speech is enhanced by enriching the cepstral speech feature set with bi-spectral speech features and a unique functional set of Mel frequency cepstral coefficient features derived from a sine filter *** augmentation is applied to combat skewness of the SER system toward certain *** using random forest is *** enhanced SER system is used to predict emotions from continuous speech with a uniform segmentation *** to data scarcity,several audio samples of discrete speech from the SAVEE database that has recordings in a universal language,i.e.,English,are concatenated resulting in multi-emotional speech ***,fear,sad,and neutral emotions,which are vital during the initial investigation of mentally disordered individuals,are selected to build six categories of multi-emotional *** results demonstrate the suitability of the proposed method for recognizing emotions from continuous speech as well as from discrete speech.

关键词： Continuous speech cepstral bi-spectral multi-emotional discrete emotion filter bank mental illness

AN EFFICIENT 3-DIMENSIONAL DISCRETE WAVELET TRANSFORM ARCHITECTURE FOR VIDEO PROCESSING APPLICATION

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Electronics(China) 2012年第6期29卷 534-540页

作者： Ganapathi Hegde Pukhraj Vaya Department of ECE Amrita Vishwa Vidyapeetham Amrita School of Engineering

This paper presents an optimized 3-D Discrete Wavelet Transform (3-DDWT) architecture. 1-DDWT employed for the design of 3-DDWT architecture uses reduced lifting scheme approach. Further the architecture is optimized by applying block enabling technique, scaling, and rounding of the filter coefficients. The proposed architecture uses biorthogonal (9/7) wavelet filter. The architecture is modeled using Verilog HDL, simulated using ModelSim, synthesized using Xilinx ISE and finally implemented on Virtex-5 FPGA. The proposed 3-DDWT architecture has slice register utilization of 5%, operating frequency of 396 MHz and a power consumption of 0.45 W.

关键词： 3-D Discrete Wavelet Transform (3-DDWT) Lifting scheme Pipelining Video coding Low power

Design of area and power efficient Radix-4 DIT FFT butterfly unit using floating point fused arithmetic

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2016年第7期23卷 1669-1681页

作者： Prabhu E Mangalam H Karthick S Department of Electronics and Communication Engineering Amrita School of EngineeringCoimbatore Amrita Vishwa Vidyapeetham Amrita University Department of Electronics and Communication Engineering Sri Krishna College of Engineering and Technology Department of Electronics and Communication Engineering Bannari Amman Institute of Technology

In this work, power efficient butterfly unit based FFT architecture is presented. The butterfly unit is designed using floating-point fused arithmetic units. The fused arithmetic units include two-term dot product unit and add-subtract unit. In these arithmetic units, operations are performed over complex data values. A modified fused floating-point two-term dot product and an enhanced model for the Radix-4 FFT butterfly unit are proposed. The modified fused two-term dot product is designed using Radix-16 booth multiplier. Radix-16 booth multiplier will reduce the switching activities compared to Radix-8 booth multiplier in existing system and also will reduce the area required. The proposed architecture is implemented efficiently for Radix-4 decimation in time(DIT) FFT butterfly with the two floating-point fused arithmetic units. The proposed enhanced architecture is synthesized, implemented, placed and routed on a FPGA device using Xilinx ISE tool. It is observed that the Radix-4 DIT fused floating-point FFT butterfly requires 50.17% less space and 12.16% reduced power compared to the existing methods and the proposed enhanced model requires 49.82% less space on the FPGA device compared to the proposed design. Also, reduced power consumption is addressed by utilizing the reusability technique, which results in 11.42% of power reduction of the enhanced model compared to the proposed design.

关键词： floating-point arithmetic floating-point fused dot product Radix-16 booth multiplier Radix-4 FFT butterfly fast fouriertransform decimation in time

A Deep Convolutional Architectural Framework for Radiograph Image Processing at Bit Plane Level for Gender&Age Assessment

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2020年第2期62卷 679-694页

作者： N.Shobha Rani M.Chandrajith B.R.Pushpa B.J.Bipin Nair Department of Computer Science Amrita School of Arts and SciencesMysuruAmrita Vishwa VidyapeethamIndia Maharaja Institute of Technology MysuruIndia

Assessing the age of an individual via bones serves as a fool proof method in true determination of individual *** attempts are reported in the past for assessment of chronological age of an individual based on variety of discriminative features found in wrist radiograph *** permutation and combination of these features realized satisfactory accuracies for a set of limited *** this paper,assessment of gender for individuals of chronological age between 1-17 years is performed using left hand wrist radiograph images.A fully automated approach is proposed for removal of noise persisted due to non-uniform illumination during the process of radiograph acquisition *** to this a computational technique for extraction of wrist region is proposed using operations on specific bit planes of image.A framework called GeNet of deep convolutional neural network is applied for classification of extracted wrist regions into male and *** experimentations are conducted on the datasets of Radiological Society of North America(RSNA)of about 12442 *** of preprocessing and segmentation techniques resulted into a correlation of about 99.09%.Performance of GeNet is evaluated on the extracted wrist regions resulting into an accuracy of 82.18%.

关键词： Bit plane processing automated segmentation deep convolutional network