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Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus

World Journal of Clinical Cases 2024年第3期12卷 525-537页

作者： Dharmsheel Shrivastav Desh Deepak Singh amity Institute of Biotechnology Amity University RajasthanJaipur 303002India

BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose utilization.Uncontrolled high sugar levels lead to advanced glycation end products(AGEs),which affects several metabolic pathways by its receptor of advanced glycation end products(RAGE)and causes diabetic complication.MiRNAs are small RNA molecules which regulate genes linked to diabetes and affect AGEs pathogenesis,and target tissues,influencing health and disease processes.AIM To explore miRNA roles in T2DM's metabolic pathways for potential therapeutic and diagnostic advancements in diabetes complications.METHODS We systematically searched the electronic database PubMed using keywords.We included free,full-length research articles that evaluate the role of miRNAs in T2DM and its complications,focusing on genetic and molecular disease mechanisms.After assessing the full-length papers of the shortlisted articles,we included 12 research articles.RESULTS Several types of miRNAs are linked in metabolic pathways which are affected by AGE/RAGE axis in T2DM and its complications.miR-96-5p,miR-7-5p,miR-132,has_circ_0071106,miR-143,miR-21,miR-145-5p,and more are associated with various aspects of T2DM,including disease risk,diagnostic markers,complications,and gene regulation.CONCLUSION Targeting the AGE/RAGE axis,with a focus on miRNA regulation,holds promise for managing T2DM and its complications.MiRNAs have therapeutic potential as they can influence the metabolic pathways affected by AGEs and RAGE,potentially reducing inflammation,oxidative stress,and vascular complications.Additionally,miRNAs may serve as early diagnostic biomarkers for T2DM.Further research in this area may lead to innovative therapeutic strategies for diabetes and its associated complications.

关键词： Type 2 diabetes mellitus MicroRNAs Advanced glycation end products Receptor for advanced glycation end products

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Critical Review on Balanites aegyptiaca Delile: Phytoconstituents, Pharmacological Properties and Nanointerventions

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Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： Surendra Kumar Gautam Rakesh Kumar Paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and Pharmacy Central University of Rajasthan university Institute of Pharmaceutical Sciences Panjab University

Balanites aegyptiaca Delile(BA) is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot). It belongs to the family Zygophyllaceae, which is specific to be drought areas of Nigeria, Africa, South Asia and India(rajasthan). In Ayurveda, this traditional medicinal plant is reported for the management of jaundice, syphilis, yellow fever, metabolic disorders, liver, and spleen problems. The main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of mankind. As per the literature survey, various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence, chemical constituents, nano-formulations, commercialized products, and clinical trials. Several remarkable scaffolds and isolated compounds like diosgenin, yamogenin, balanitin1/2, balanitin 3, bal4/5, bal6/7, rutin-3-glycosides, 3,7-diglycosides,(3, 12, 14, 16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been identified. Additionally, this traditional plant has been scientifically proven by in vitro and in vivo. Based on the complete review of this plant, most of the compounds have been isolated from the fruit and kernel part. Additionally, based on the literature, a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological activity. As a spinous desert dates, this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

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Structural,optical and dielectric investigations on RECr_(0.85)Mn_(0.15)O_(3)(RE=Ho,Gd and Pr) nanoparticles

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Journal of Rare Earths 2024年第2期42卷 399-408,I0006页

作者： Komal Kanwar Sonali Pradhan S.Satapathy Yugandhar Bitla Neeraj Panwar Department of Physics Central University of Rajasthan BandarsindrAjmer305817RajasthanIndia Laser Material Section HBNIRaja Ramanna Centre for Advanced TechnologyIndore452013India

We hereby report the room-temperature structural and optical characterization of RECr_(0.85)Mn_(0.15)O_(3)(RECMO,RE=Ho,Gd and Pr) compounds synthesized by the auto-combustion sol-gel route.Their low temperature dielectric properties are also presented.The RECMO compounds crystallize in an orthorhombic Pbnm symmetry with an average grain size range of 51-80 nm.Structural analysis reveals an increase in the structural distortion compared to that of the undoped bulk compounds.Optical measurements exhibit a significant reduction in bandgap values for RECMO nanoparticles when compared with their undoped bulk compounds.Further,from the absorbance measurements various optical parameters such as skin depth,extinction coefficient,refractive index and optical conductivity were also calculated.The dielectric analysis confirms the lower values of the dielectric permittivity and dielectric loss than those of their corresponding bulk compounds.AC conductivity versus frequency and temperature data are fitted according to the Jonscher's power law and Arrhenius law,respectively.The small polaron hopping is responsible for the electric conduction in these compounds.The tunability of the optical and dielectric properties as a result of substitution and particle size reduction makes these materials useful for various potential applications in photocatalysis,optoelectronics and low permittivity dielectrics.

关键词： Rare-earth orthochromites Nanoparticles Optical properties Dispersion parameters Dielectric properties Small polaron hopping

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Effective data transmission through energy-efficient clustering and Fuzzy-Based IDS routing approach in WSNs

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虚拟现实与智能硬件（中英文） 2024年第1期6卷 1-16页

作者： Saziya TABBASSUM Rajesh Kumar PATHAK Research Scholar Department of Computer ScienceOPJS University ChuruSadulpurRajasthan 331303India Vice Chancellor OPJS University ChuruSadulpurRajasthan 331303India

Wireless sensor networks(WSN)gather information and sense information samples in a certain region and communicate these readings to a base station(BS).Energy efficiency is considered a major design issue in the WSNs,and can be addressed using clustering and routing techniques.Information is sent from the source to the BS via routing procedures.However,these routing protocols must ensure that packets are delivered securely,guaranteeing that neither adversaries nor unauthentic individuals have access to the sent information.Secure data transfer is intended to protect the data from illegal access,damage,or disruption.Thus,in the proposed model,secure data transmission is developed in an energy-effective manner.A low-energy adaptive clustering hierarchy(LEACH)is developed to efficiently transfer the data.For the intrusion detection systems(IDS),Fuzzy logic and artificial neural networks(ANNs)are proposed.Initially,the nodes were randomly placed in the network and initialized to gather information.To ensure fair energy dissipation between the nodes,LEACH randomly chooses cluster heads(CHs)and allocates this role to the various nodes based on a round-robin management mechanism.The intrusion-detection procedure was then utilized to determine whether intruders were present in the network.Within the WSN,a Fuzzy interference rule was utilized to distinguish the malicious nodes from legal nodes.Subsequently,an ANN was employed to distinguish the harmful nodes from suspicious nodes.The effectiveness of the proposed approach was validated using metrics that attained 97%accuracy,97%specificity,and 97%sensitivity of 95%.Thus,it was proved that the LEACH and Fuzzy-based IDS approaches are the best choices for securing data transmission in an energy-efficient manner.

关键词： Low energy adaptive clustering hierarchy(LEACH) Intrusion detection system(IDS) Wireless sensor network(WSN) Fuzzy logic and artificial neural network(ANN)

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Medicinal Effects, Phytochemistry,Pharmacology of Euphorbia prostrata and Promising MolecularMechanisms

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Chinese Journal of Integrative Medicine 2024年第2期30卷 181-192页

作者： Nirmala Kumari Yadav Rakesh Yadav Department of Pharmacy Banasthali VidyapithBanasthali(304022)RajasthanIndia Department of Pharmaceutical Sciences Indira Gandhi UniversityMeerpurRewari(122502)HaryanaIndia National Forensic Sciences university Tripura CampusAgartala(799001)TripuraIndia

Euphorbiaceae is a large family of dicotyledonous angiosperms with diverse genera including Euphorbia prostrata(E.prostrata).Current research has provided scientific evidence for traditional uses of E.prostrata against diverse pathological conditions such as anti-hemorrhoidal,anti-inflammatory,analgesic,wound healing,antioxidant,antibacterial,leishmanicidal,antitumor activity,and so on.The phytochemical screening has revealed the presence of glycosides,phytosterols,flavonoids,polyphenols,tannins,and anthraquinones with chemical structures elucidation of their respective compounds.The uniqueness of such multifactorial compounds present in this species endorses it as the potent therapeutic or prophylactic choice for several fatal diseases.Although ethnomedical applications served as a significant citation for pharmacology,the molecular mechanism has not been reviewed yet.The present paper provides a comprehensive review of research outcomes,pharmacology,toxicology,and molecular signaling of phytochemicals of E.prostrata species as a reference for relevant researchers.The study of bioactive compounds in crude extracts and fractions,the demonstration of primary mechanisms of pharmacology,along with the addition of toxicity,and clinical trials,should be conceded in depth.This review underlines the E.prostrata species that can be a promising phytomedicine since we are committed to excavating more intensely into their pharmacological role.

关键词： Euphorbia prostrata Euphorbiaceae phytochemicals ethnomedical applications toxicology molecularmechanism

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Effect of pre-twinning and heat treatment on formability of AZX311 Mg alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 1154-1169页

作者： Mahesh Panchal Lalit Kaushik Min-Seong Kim Ravi Kottan Renganayagalu Shi-Hoon Choi Jaiveer Singh Department of Mechanical Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Department of Metallurgical and Materials Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Energy Materials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang-roSeongbuk-guSeoul 02792Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National University255 Jungang-roSuncheonJeonnam 57922Republic of Korea

In this study,the effects of pre-strain-induced tensile twins(TTWs)and controlled heat treatment on the formability behavior of AZX311 Mg alloy sheets were investigated.A 4%compressive strain was applied to pre-strain the sheets using the in-plane compression(IPC)technique along the rolling direction(RD)to introduce TTWs.The pre-strained(PS)samples were subsequently heat-treated at 250℃,350℃,and 400℃ independently for 1 hr,and are termed as PSA1,PSA2,and PSA3,respectively.Erichsen cupping tests were conducted to assess the formability of the sheet samples under different initial conditions.The results showed that the PS sample heat-treated at 250℃ for 1hr exhibited a decrease in the Erichsen index(IE)compared to the as-rolled sample,whereas PSA2 and PSA3 samples showed an increase in IE values.Microtexture analysis revealed that most of the TTWs generated through pre-twinning were stable at 250℃;however,the twin volume fraction reduced to 41%at 350℃ compared to the PS samples due to enhanced thermal activity at that temperature.Furthermore,PSA2 samples showed severe grain coarsening in some areas of the sample,and the fraction of such grains increased in the PSA3 samples.The stretch formability(IE value)of PSA2 samples showed a 32.3%increase compared to the as-rolled specimens.Additionally,the analysis of the deformed specimen at failure under the Erichsen test indicated that considerable detwinning occurs in the PS and PSA1 samples,whereas dislocation slip activity dominates in the PSA2 and PSA3 samples during stretch forming.Apart from detwinning and dislocation slip,deformation twins were also observed in all samples after the Erichsen test.Thus,this work highlights the importance of texture control and its underlying mechanisms via pre-twinning followed by heat treatment and their impact on the room temperature(RT)stretch formability of AZX311 Mg alloy sheets.

关键词： Mg alloys Pre-twinning Texture Formability EBSD.

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Energy-Efficient Implementation of BCD to Excess-3 Code Converter for Nano-Communication Using QCA Technology

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China Communications 2024年第6期21卷 103-111页

作者： Nuriddin Safoev Angshuman Khan Khudoykulov Zarif Turakulovich Rajeev Arya Department of Cybersecurity&Criminology Tashkent University of Information TechnologiesTashkent 100084Uzbekistan Department of Electronics and Communication Engineering University of Engineering and ManagementJaipurRajasthan 303807India Department of Cryptology Tashkent University of Information TechnologiesTashkent 100084Uzbekistan Department of Electronics and Communication Engineering National Institute of Technology PatnaBihar 800005India

Code converters are essential in digital nano communication;therefore,a low-complexity optimal QCA layout for a BCD to Excess-3 code converter has been proposed in this paper.A QCA clockphase-based design technique was adopted to investigate integration with other complicated circuits.Using a unique XOR gate,the recommended circuit’s cell complexity has been decreased.The findings produced using the QCADesigner-2.0.3,a reliable simulation tool,prove the effectiveness of the current structure over earlier designs by considering the number of cells deployed,the area occupied,and the latency as design metrics.In addition,the popular tool QCAPro was used to estimate the energy dissipation of the proposed design.The proposed technique reduces the occupied space by∼40%,improves cell complexity by∼20%,and reduces energy dissipation by∼1.8 times(atγ=1.5EK)compared to the current scalable designs.This paper also studied the suggested structure’s energy dissipation and compared it to existing works for a better performance evaluation.

关键词： BCD code converter Excess-3 nano communication QCA circuits

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Enhanced photoluminescence from CdS nanocrystals encapsulated by PVP and SHMP

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Optoelectronics Letters 2022年第5期18卷 257-262页

作者： Vikas Lahariya Saral Kumar Gupta Department of Physics Amity School of Applied SciencesAmity UniversityHaryana122413India Department of Physics Banasthali VidyapeethRajasthanIndia

The effects of the stabilizing agent on the structural and luminescence properties of cadmium sulfide(CdS)nanocrystals have been investigated.Samples were prepared by chemical precipitation method using sodium hexametaphosphate(SHMP)and polyvinyl pyrrolidone(PVP).The structural and optical properties have been studied by X-ray diffraction(XRD),ultraviolet-visible(UV-Vis)absorption,photoluminescence(PL)and Fourier transform infrared(FTIR)spectroscopy.XRD patterns confirm the presence of cubic zinc blend crystal structure with space group F-43m.The results show the variation in crystallite size with change in surfactant.Blue shift in absorption edge as compared to bulk CdS is found.PL results represent broad and very intense red emission with smaller particle size due to modification of surface emitting states with surfactant.

关键词： spectroscopy surfactant absorption

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose MPerez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion university of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),Dist.Barabanki,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus:A narrative review of randomized control trials

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World Journal of Diabetes 2023年第6期14卷 919-929页

作者： Dharmsheel Shrivastav Pradeep Kumar Dabla Jitender Sharma Aroop Viswas Rashid Mir amity Institute of Biotechnology Amity University RajasthanJaipur 303002India Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Department of Medical Lab Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491Saudi Arabia

BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose utilization.Imbalance in generation and elimination of free radicals generate oxidative stress which modulates glucose metabolism and insulin regulation,resulting in the occurrence and progression of diabetes and associated complications.Antioxidant supplements in T2DM can be seen as a potential preventive and effective therapeutic strategy.AIM To compare randomized controlled trials(RCTs)in which antioxidants have been shown to have a therapeutic effect in T2DM patients.METHODS We systematically searched the electronic database PubMed by keywords.RCTs evaluating the effect of antioxidant therapy on glycaemic control as well as oxidant and antioxidant status as primary outcomes were included.The outcomes considered were:A reduction in blood glucose;changes in oxidative stress and antioxidant markers.Full-length papers of the shortlisted articles were assessed for the eligibility criteria and 17 RCTs were included.RESULTS The administration of fixed-dose antioxidants significantly reduces fasting blood sugar and glycated hemoglobin and is associated with decreased malondialdehyde,advanced oxidation protein products,and increased total antioxidant capacity.CONCLUSION Antioxidant supplements can be a beneficial approach for the treatment of T2DM.

关键词： Diabetes Antioxidants Oxidative stress Malondialdehyde Polyphenols Antioxidant therapy

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