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Melatonin promotes the development of the secondary hair follicles by regulating circMPP5

Journal of animal Science and Biotechnology 2023年第4期14卷 1696-1712页

作者： Xiaogao Diao Lingyun Yao Tao Duan Jiaxin Qin Liwen He Wei Zhang Department of animal nutrition and Feed Science State Key Laboratory of Animal NutritionCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background The quality and yield of cashmere fibre are closely related to the differentiation and development of secondary hair follicles in the skin of cashmere *** higher the density of secondary hair follicles,the higher the quality and yield of cashmere from the *** of secondary hair follicles commences in the embryonic stage of life and is completed 6 months after *** experimental results from our laboratory showed that melatonin(MT)treatment of goat kids after their birth could increase the density of secondary hair follicles and,thus,improve the subsequent yield and quality of *** changes in the secondary hair follicles resulted from increases in levels of antioxidant and expression of anti-apoptotic protein,and from a reduction in *** present study was conducted to explore the molecular mechanism of MT-induced secondary hair follicle differentiation and development by using whole-genome *** MT had no adverse effect on the growth performance of cashmere kids but significantly improved the character of the secondary hair follicles and the quality of cashmere,and this dominant effect continued to the second *** promotes the proliferation of secondary hair follicle cells at an early *** formation of secondary hair follicles in the MT group was earlier than that in the control group in the second *** genome-wide data results involved KEGG analysis of 1044 DEmRNAs,91 DElncRNAs,1054 DEcircRNAs,and 61 DEmiRNAs which revealed that the mitogen-activated protein kinase(MAPK)signaling pathway is involved in the development of secondary hair follicles,with key genes(FGF2,FGF21,FGFR3,MAPK3(ERK1))being up-regulated and *** also found that the circMPP5 could sponged miR-211 and regulate the expression of *** We conclude that MT achieves its effects by regulating the MAPK pathway through the circMPP5 sponged the miR-211,regulating the expression of MAPK3,to induce

关键词： Cashmere MAPK Melatonin miR-211 Secondary hair follicle

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Restricted feeding regimens improve white striping associated muscular defects in broiler chickens

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animal nutrition 2023年第1期12卷 128-137页

作者： Hammed Ayansola Yanhui Luo Yan Wan Xiaoxiao Yu Jiaqi Lei Kewei Yu Chaoyong Liao Yuming Guo Bingkun Zhang Bo Wang State Key Laboratory of animal nutrition Department of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China

The current study investigated the effects of intermittent feeding(IF)and fasting strategies at different times post–hatch on muscle growth and white striping(WS)breast *** the first trial,32 one-day-old Abor Acre broilers were fed ad libitum(AL)for 3 d post–hatch and then randomly allotted into 4 feeding strategies including AL,1h-IF group(1 h IF,4 times feeding/d,1 h each time),1.5h-IF(1.5 h IF,4 times feeding/d,1.5 h each time),and fasting(1d acute fasting,6 d free access to feed)groups and fed for 7 *** angiogenic genes including VEGFA,VEGFR1,and VEGFR2,and myogenic genes including MYOG and MYOD were upregulated(Pdownregulated MYF5 expression(P0.05).In the second trial,384 one-day-old birds were fed AL for 1 wk and then randomly allotted to the above 4 feeding strategies starting at 8 d of age until 42 d of ***,IF and fasting strategies upregulated the expression of angiogenic and myogenic genes(P0.05).Fasting and 1h-IF reduced the expression of adipogenic genes ZNF423 and PDGFRα(P<0.05).Moreover,IF and fasting strategies reduced fibrosis in breast muscle and reduced skeletal muscle-specific E3 ubiquitin ligases(TRIM63 and MAFBX)(P<0.05).Fasting significantly reduced CASPASE-3 in breast muscle(P<0.05).In conclusion,IF starting in the first week decreases SC *** to AL,IF or fasting promotes muscular angiogenesis,increases SC number

关键词： Broiler chickens Intermittent feeding Angiogenesis Satellite cells White striping

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Alginate oligosaccharide-induced intestinal morphology, barrier function and epithelium apoptosis modifications have beneficial effects on the growth performance of weaned pigs

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Journal of animal Science and Biotechnology 2018年第4期9卷 937-948页

作者： Jin Wan Jiao Zhang Daiwen Chen Bing Yu Xiangbing Mao Ping Zheng Jie Yu Junqiu Luo Jun He Institute of animal nutrition Sichuan Agricultural University

Background: Alginate oligosaccharide(AOS), produced from alginate by alginate lyase-mediated depolymerisation, is a potential substitute for antibiotics and possesses growth-enhancing effects. Nevertheless, the mechanisms by which AOS regulates porcine growth remain to be elucidated. Therefore, we investigated the AOS-mediated changes in the growth performance of weaned pigs by determining the intestinal morphology, barrier function,as well as epithelium ***: Twenty-four weaned pigs were distributed into two groups(n = 12) and received either a basal diet(control group) or the same diet supplemented with 100 mg/kg AOS. On d 15, D-xylose(0.1 g/kg body weight)was orally administrated to eight randomly selected pigs per treatment, and their serum and intestinal mucosa samples were collected 1 h ***: Our results showed that inclusion of AOS in the diet for 2 wk increased(P down-regulated(P < 0.05) the B-cell lymphoma-2-associated X protein(BAX), cysteinyl aspartate-specific proteinase-3(caspase-3) and caspase-9 transcriptional levels in the small ***: In summary, this study provides evidence that supplemental AOS beneficially affects the growth performance of weaned pigs, which may result from the improved intestinal morphology and barrier function,as well as the inhibited enterocyte death, through reducing apoptosis via mitochondria-dependent apoptosis.

关键词： Alginate oligosaccharide Barrier function Cell apoptosis Intestinal morphology Weaned pigs

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Production performance and plasma metabolite concentrations of broiler chickens fed low crude protein diets differing in Thr and Gly

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animal nutrition 2021年第2期7卷 472-480页

作者： Laura Star Sophie Tesseraud Marije van Tol Ilaria Minussi Etienne Corrent William Lambert Schothorst Feed Research Meerkoetenweg 268218 NA Lelystadthe Netherlands INRAE BOAUniversitéde Tours37380 NouzillyFrance Orffa Additives B.V. Vierlinghstraat 514251 LC Werkendamthe Netherlands ajinomoto animal nutrition Europe 32 rue Guersant75017 ParisFrance

The aim of the study was to test the interaction between Thr and Gly in low crude protein(CP)diets in 7 to 28 d broilers on production performance and plasma metabolites.A total of 2,040 broilers were allocated to 17 treatments.A positive control(PC)diet(20.5%CP)was formulated to be adequate in dietary Thr and Gly.A negative control(NC)diet(18.5%CP,deficient in Thr and Gly)was supplemented with crystalline L-Thr and Gly to obtain a 4 Thr×4 Gly *** Thr was tested at an apparent faecal digestibility(AFD)Thr-to-Lys ratio,which was 55%,58%,61%or 64%,and dietary Gly was tested at an AFD(Gly+Ser)-to-Lys ratio,which was 135%,142%,149%or 156%.Plasma samples were collected at 28 *** low CP diet,formulated at 64%Thr and 156%Gly,resulted in a higher body weight gain(BWG)(P<0.01)and similar feed conversion ratio(FCR)as the high CP treatment(PC).FCR was improved(P<0.001)by L-Thr *** response to dietary Thr was significant for feed intake(FI),BWG and FCR(P<0.01).A near-significant interaction for Thr×Gly was observed for FI and BWG(Plinear=0.091 and P=0.074,respectively).Gly did not affect production *** interaction between Thr×Gly on plasma free AA level was observed(P<0.05).Free AA concentration in plasma linearly decreased with increase in AFD Thr-to-Lys ratio,and increased with increase in AFD(Gly+Ser)-to-Lys *** uric acid concentration was higher in PC than in all of the other diets,and plasma triglyceride concentration was decreased by L-Thr supplementation,but not by *** conclusion,Gly was not limiting for growth at low dietary CP level unless Thr was deficient,showing that adequate amounts of Thr in broiler diets can overcome marginal supply of Gly and Ser and allow reduction of dietary CP from 20.5%to 18.5%for broilers from 7 to 28 d of age.

关键词： Broiler Threonine Glycine Low protein Performance Plasma metabolite

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Transcriptome analysis of the effect of pyrroloquinoline quinone disodium（PQQ·Na2） on reproductive performance in sows during gestation and lactation

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Journal of animal Science and Biotechnology 2019年第4期10卷 1022-1036页

作者： Boru Zhang Chenxi Wang Wei Yang Hongyun Zhang Qingwei Meng Baoming Shi Anshan Shan Institute of animal nutrition Northeast Agricultural University

Background: Pyrroloquinoline quinone(PQQ), which is a water soluble, thermo-stable triglyceride-quinone, is widely distributed in nature and characterized as a mammalian vitamin-like redox cofactor. The objective of this study was to investigate the effects of pyrroloquinoline quinone disodium(PQQ·Na2) on reproductive performance in ***: Dietary supplementation with PQQ·Na2 significantly increased the total number of piglets born, the number of piglets born alive and the born alive litter weight. It also increased the antioxidant status in the placenta, plasma and milk. The concentration of NO was significantly increased in the plasma and placenta. RNA-seq analysis showed that462 unigenes were differentially expressed between the control(Con) treatment and PQQ treatment *** these unigenes, 199 were upregulated, while 263 unigenes were downregulated. The assigned functions of the unigenes covered a broad range of GO categories. Reproduction(27, 7.03%) and the reproduction process(27, 7.03%) were assigned to the biological process category. By matching DEGs to the KEGG database, we identified 29 ***: In conclusion, dietary supplementation with PQQ·Na2 in gestating and lactating sows had positive effects on their reproductive performance.

关键词： Oxidative stress Pyrroloquinoline quinone Pyrroloquinoline quinone disodium Reproductive performance,RNA-seq Sow

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Modified halloysite nanotubes reduce the toxic effects of zearalenone in gestating sows on growth and muscle development of their offsprings

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Journal of animal Science and Biotechnology 2016年第4期7卷 570-578页

作者： Rui Gao Qingwei Meng Jianan Li Min Liu Yuanyuan Zhang Chongpeng Bi Anshan Shan Institute of animal nutrition Northeast Agricultural University

Background： Zearalenone （ZEN） is an estrogenic mycotoxin that is primarily produced by Fusarium fungi and has been proven to affect the reproductive capacity of many species to varying degrees. The present experiment was designed to study the maternal persistent effects of zearalenone toxicity in gestating sows on growth and muscle development of their offsprings, and the alleviation of zearalenone toxicity by modified halloysite nanotubes （MHNTs）. Methods： Eighteen sows were fed with one of three dietary treatments that included the following：（1） a control diet, （2） a contaminated grain diet （with 50 % moldy corn, 2.77 mg/kg ZEN）, and （3） a contaminated grain diet （with 50 % moldy corn, 2.76 mg/kg ZEN）＋ 1% MHNTs. Each sow was exclusively fed its experimental diets from 35 to 70 d of gestation at a total of 2 kg daily. Muscle samples were collected from six piglets per treatment at birth, weaning and finishing. Results： The results showed that feeding the sows with the ZEN-contaminated diets from 35 to 70 d of gestation decreased the ADG, ADFI and G：F of their offsprings （P 〈 0.05）. The muscle fiber numbers in the newborn, weaning and growing-finishing pigs and the muscle fiber diameters at birth and weaning were also decreased by maternal ZEN exposure （P 〈 0.05）. The expressions of IGF-I, IGF-II, Myf-5 and Mstn at birth and IGF-II, Pax7, Myf-5 and MyoD1 at weaning were altered by feeding gestating sows with ZEN-contaminated diets （P 〈 0.05）. The MHNTs reduced most of the ZEN-induced toxic effects： the ADG and ADFI on growth performance, the muscle fiber numbers at weaning and finishing and the muscle fiber diameters at weaning （P 〈 0.05）. The expression levels of IGF-II and Mstn in newborn piglets and IGF-II and Myf-5 in weaning piglets were also prevented by adding 1% MHNTs （P 〈 0.05）. Conclusions： The present study demonstrated that the offsprings of sows fed with ZEN-contaminated diets from 35 to 70 day of gestation exhibited weakening on growth performance, p

关键词： Growth MHNTs Muscle development Offsprings Sows Zearalenone

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Solid state fermentation of rapeseed cake with Aspergillus niger for degrading glucosinolates and upgrading nutritional value

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Journal of animal Science and Biotechnology 2015年第3期6卷 340-346页

作者： Changyou Shi Jun He Jie Yu Bing Yu Zhiqing Huang Xiangbing Mao Ping Zheng Daiwen Chen animal nutrition Institute Sichuan Agricultural University

Background： Rapeseed cake is a good source of protein for animal feed but its utilization is limited due to the presence of anti-nutritional substances, such as glucosinolates （GIs）, phytic acid, tannins etc. In the present study, a solid state fermentation （SSF） using Aspergillus niger was carried out with the purpose of degrading glucosinolates and improving the nutritional quality of rapeseed cake （RSC）. The effects of medium composition and incubation conditions on the GIs content in fermented rapeseed cake （FRSC） were investigated, and chemical composition and amino acid in vitro digestibility of RSC substrate fermented under optimal conditions were determined. Results： After 72 h of incubation at 34℃, a 76.89% decrease in GIs of RSC was obtained in solid medium containing 70% RSC, 30% wheat bran at optimal moisture content 60% （w/w）. Compared to unfermented RSC, trichloroacetic acid soluble protein （TCA-SP）, crude protein and ether extract contents of the FRSC were increased （P〈 0.05） 103.71, 23.02 and 23.54%, respectively. As expected, the contents of NDF and phytic acid declined （P〈 0.05） by 9.12 and 44.60%, respectively. Total amino acids （TAA） and essential amino acids （EAA） contents as well as AA in vitro digestibility of FRSC were improved significantly （P 〈 0.05）. Moreover, the enzyme activity of endoglucanase, xylanase, acid protease and phytase were increased （P 〈 0.05） during SSF. Conclusions： Our results indicate that the solid state fermentation offers an effective approach to improving the quality of proteins sources such as rapeseed cake.

关键词： Aspergillus niger Glucosinolates nutritional value Rapeseed cake Solid state fermentation

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Yeast-Derived β-1,3-Glucan Substrate Significantly Increased the Diversity of Methanogens During In vitro Fermentation of Porcine Colonic Digesta

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Journal of Integrative Agriculture 2013年第12期12卷 2229-2234页

作者： LUO Yu-heng LI Hua LUO Jun-qiu ZHANG Ke-ying Key Laboratory for animal Disease-Resistance nutrition of Sichuan Province and China Ministry of Education/Institute of animal nutrition Sichuan Agricultural University

The β-1,3-glucan from yeast has been extensively examined for its immuno-enhancing effects in ***,investigation on the relationship among β-glucan,gut microbiota and immune-modulating effects remains limited particularly in *** the critical roles of gut methanogens in the microbial fermentation,energy metabolism and disease resistance,we investigated the phylogenetic diversity of methanogens from fermented cultures of porcine colonic digesta with（G） or without（N） yeast β-glucan based on sequences of the archaeal 16S rRNA gene.A total of 145 sequences in the G library were assigned into 8 operational taxonomic units（OTUs） with the majority of sequences（114/145） related to strains Methanobrevibacter millerae or Methanobrevibacter gottschalkii with high identities ranging from 97.9 to 98.6%,followed by 23 sequences to Methanobrevibacter ruminantium,2 sequences to Methanobrevibacter smithii and one sequence to Methanobrevibacter *** 142 sequences in the N library were assigned to 2 OTUs with most sequences（127/142） related to strains *** or *** with sequence identities ranging from 97.9 to 98.5%,and 15 sequences related to *** with 97.9% *** diversity index showed that the G library exhibited significantly higher archaeal diversity（P0.05） and Libshuff analysis indicated the differences in the community structure between the two libraries were significant（P0.0001）.In conclusion,the current study provides evidence that addition of yeast β-glucan significantly increased the diversity of methanogens in in vitro fermented porcine colonic digesta.

关键词： β-glucan methanogen diversity pig colonic digesta in vitro

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Infusion of short chain fatty acids in the ileum improves the carcass traits,meat quality and lipid metabolism of growing pigs

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animal nutrition 2021年第1期7卷 94-100页

作者： Anran Jiao Hui Diao Bing Yu Jun He Jie Yu Ping Zheng Yuheng Luo Junqiu Luo Quyuan Wang Huifen Wang Xiangbing Mao Daiwen Chen Institute of animal nutrition Sichuan Agricultural UniversityKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationKey Laboratory of Animal Disease-resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey Laboratory of Animal Disease-resistant Nutrition of Sichuan ProvinceYa'an625014China

Short chain fatty acids(SCFA)are the main products of indigestible carbohydrates undergoing bacterial fermentation in the hindgut,which are related to some physiological *** study was designed to investigate the effects of SCFA infusion by ileum on the carcass traits,meat quality and lipid meta-bolism of growing *** a 28-day study,24 growing barrows fitted with a T-cannula in distal ileum were divided into 4 treatments:1)Control,2)antibiotics(AB),3)AB+300 mL of SCFA1 solution(ABS1),4)AB+300 mL of SCFA2 solution(ABS2).The concentrations of acetate,propionate and butyrate in SCFA1 solution were respectively 61.84,18.62 and 12.55 mmol/L,and in SCFA2 were respectively 40.08,15.41 and 9.78 mmol/L The results showed that the SCFA infusion increased the average daily feed intake and average daily gain of pigs(Pdorsi area(Pdorsi(P=0.059),and reduced serum concentrations of triglyceride,total cholesterol and urea nitrogen(Pdorsi(Pdominal fat(Pdominal fat(P<0.05),and the mRNA expressions of free fatty acid receptor 2,glucose-6-phosphatase and phosphoenolpyruvate carboxykinase 1 in the colon(P<0.05).These results suggested that SCFA administration in the ileum could improve the carcass traits and meat quality of growing pigs,which was possibly due to the fact that SCFA modulated lipid metabolism.

关键词： Short chain fatty acid Carcass trait Meat quality Lipid metabolism Growing pig

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Novel metabolic and physiological functions of branched chain amino acids: a review

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Journal of animal Science and Biotechnology 2017年第3期8卷 501-512页

作者： Shihai Zhang Xiangfang Zeng Man Ren Xiangbing Mao Shiyan Qiao State Key Laboratory of animal nutrition College of Animal Science and Technology China Agricultural University College of animal Science South China Agricultural University College of animal Science Anhui Science & Technology University animal nutrition Institute Key Laboratory of Animal Disease-Resistance NutritionMinistry of Education Sichuan Agricultural University

It is widely known that branched chain amino acids（BCAA） are not only elementary components for building muscle tissue but also participate in increasing protein synthesis in animals and humans. BCAA（isoleucine, leucine and valine） regulate many key signaling pathways, the most classic of which is the activation of the m TOR signaling pathway. This signaling pathway connects many diverse physiological and metabolic roles. Recent years have witnessed many striking developments in determining the novel functions of BCAA including：（1） Insufficient or excessive levels of BCAA in the diet enhances lipolysis.（2） BCAA, especially isoleucine, play a major role in enhancing glucose consumption and utilization by up-regulating intestinal and muscular glucose transporters.（3）Supplementation of leucine in the diet enhances meat quality in finishing pigs.（4） BCAA are beneficial for mammary health, milk quality and embryo growth.（5） BCAA enhance intestinal development, intestinal amino acid transportation and mucin production.（6） BCAA participate in up-regulating innate and adaptive immune *** addition, abnormally elevated BCAA levels in the blood（decreased BCAA catabolism） are a good biomarker for the early detection of obesity, diabetes and other metabolic diseases. This review will provide some insights into these novel metabolic and physiological functions of BCAA.

关键词： Amino acid transporters Glucose transporters Gut health Immunity Lipolysis Mammary health Meat quality Milk production

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