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Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired aplastic anemia

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Frontiers of Medicine 2021年第5期15卷 718-727页

作者： Hongchen Liu Xiaoli Zheng Chengtao Zhang Jiajun Xie Beibei Gao Jing Shao Yan Yang Hengxiang Wang Jinsong Yan Department of Hematology Liaoning Medical Center for Hematopoietic Stem Cell TransplantationDalian Key Laboratory of HematologyLiaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational MedicineDiamond Bay Institute of Hematologythe Second Hospital of Dalian Medical UniversityDalian 116027China Department of Hematology Air Force Medical CenterPLABeijing 100142China Department of Environmental Health and Toxicology Liaoning Medical Center for Hematopoietic Stem Cell TransplantationLiaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational MedicineSchool of Public HealthDalian Medical UniversityDalian 116044China

Severe aplastic anemia II(SAA-II)progresses from non-severe aplastic anemia(NSAA).The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation(haplo-BMT)in patients lacking a human leukocyte antigen(HLA)-matched *** study aimed to investigate the efficacy of haplo-BMT for patients with ***-two patients were included and followed up,and FLU/BU/CY/ATG was used as conditioning *** these patients,21 were successfully engrafted,19 of whom survived after *** patients experienced grade II–IV aGvHD,including two with grade III–IV *** patients experienced chronic GvHD,among whom four were mild and two were *** patients experienced infections during *** was diagnosed with post-transplant lymphoproliferative disorder and one with probable EBV disease,and both recovered after rituximab ***-BMT achieved 3-year overall survival and disease-free survival rate of 86.4%±0.73%after a median follow-up of 42 months,indicating its effectiveness as a salvage *** promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with SAA-II lacking HLA-matched donors.

关键词： severe aplastic anemia non-severe acquired aplastic anemia haploidentical bone marrow transplantation outcomes

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Development of a helicon-wave excited plasma facility with high magnetic field for plasma-wall interactions studies

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Plasma Science and Technology 2018年第8期20卷 112-118页

作者： Guilu ZHANG Tianyuan HUANG Chenggang JIN Xuemei WU Lanjian ZHUGE Hantao JI College of Physics Optoelectronics and Energy ＆ Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215006People＇s Republic of China Key Laboratory of Modern Optical Technologies（Soochow University） Education of Ministry ＆ Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province ＆ Jiangsu Key Laboratory of Thin FilmsSoochow UniversitySuzhou 215006People＇s Republic of China Analysis and Testing Center Soochow UniversitySuzhou 215123People＇s Republic of China princeton Plasma Physics Laboratory PrincetonNew Jersey 08543United States of America State Key Laboratory for Strength and Vibration of Mechanical Structures Xi＇an Jiaotong UniversityXi＇an 710049People＇s Republic of China

The high magnetic field helicon experiment system is a helicon wave plasma（HWP）source device in a high axial magnetic field（B0）developed for plasma–wall interactions studies for fusion *** HWP was realized at low pressure（5×10^-3-10 Pa）and a RF（radio frequency,13.56 MHz）power（maximum power of 2 k W）using an internal right helical antenna（5 cm in diameter by 18 cm long）with a maximum B0of 6300 *** HWP with electron density～10^18–10^20m^-3 and electron temperature～4–7 e V was produced at high B0 of 5100 G,with an RF power of 1500 *** Ar^＋ion flux of 7.8×10^23m^-2s^-1 with a bright blue core plasma was obtained at a high B0 of 2700 G and an RF power of 1500 W without *** energy and mass spectrometer studies indicate that Ar^＋ ion-beams of 40.1 eV are formed,which are supersonic（～3.1cs）.The effect of Ar HWP discharge cleaning on the wall conditioning are investigated by using the mass *** the consequent plasma parameters will result in favorable wall conditioning with a removal rate of 1.1×10^24N2/m^2 h.

关键词： helicon wave plasma high magnetic field wall conditioning

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Striatopallidal adenosine A2A Receptors in the Nucleus Accumbens Control Instrumental Learning through Pavlovian–Instrumental Transfer

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Striatopallidal adenosine A2A Receptors in the Nucleus Accum...

低温自体血靶向回输对于非人灵长类脑卒中模型的神经保护作用（英文）

中国神经科学学会第十二届全国学术会议

作者： Yan Li Zhilan Pu Mozhi Chen Yan He Yang Ruan Linshan Huang Jiang-Fan Chen Department of Neurology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University The Institute of Molecular Medicine School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Department of Neurology Boston University School of Medicine Boston Massachusetts United States of America

The adenosine receptor（A2AR） in the nucleus accumbens（NAc） exerts control of motor, reward and motivational and learning behaviors, but its specific contribution to striatum-dependent instrumental learning is unknown. This is in part due to lack of methods to transiently control the A2AR activity in "time-locked" manner with physiological reward critical for instrumental learning. In the present study, we employed our newly developed rhodopsin-A2AR chimeras（opto A2AR） to temporally activate A2AR by light in "time-locked" manner with reward delivery, to determine the A2AR modulatory effect on instrumental learning. We demonstrated that transient light activation of opto A2AR signaling in the NAc neurons in ‘time-locked’ manner with the reward delivery was sufficient to reduce the animal’s sensitivity to outcome devaluation, displaying habitual actions in contrast to goal-directed behavior in the control group Furthermore, focal knockdown of A2ARs in NAc by Cre-flox strategy promoted goaldirected behavior in contrast to habitual actions. Since the NAc plays a critical role in the motivational aspect of instrumental behavior and NAc A2ARs play an important role in motivation/effort-related choice behaviors, we employed opto A2AR approach coupled with a Pavlovian-to-instrumental transfer（PIT） paradigm to critically determine whether striatopallidal A2AR signaling in NAc can influence instrumental learning by motivational processes via PIT. Following instrumental（morning） and Pavlovian（afternoon） conditioning, both wild-type mice and mice with A2AR knockdown in NAc increased lever pressing rate and elevated nose poking ratio, respectively. On the 10 th day, we performed a transfer test and found that mice with A2AR knockdown in the NAc showed much higher transfer efficiency than the control group. Thus, the A2AR in the NAc modulates instrumental behavior through the influence of the Pavlovian cue on instrumental behavior.

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Science Bulletin 2023年第14期 1556-1566页

作者：陈健徐率立 Hangil Lee 吴隆飞何小夺赵文博张默马艳辉丁玉川付永娟吴川杰李明姜缪文程化坤李胜利马挺吉训明吴迪 Department of Neurosurgery Xuanwu Hospital Beijing Institute of Brain Disorders Capital Medical University China-america Institute of Neuroscience Xuanwu Hospital Beijing Institute of Brain Disorders Capital Medical University Department of Neurological Surgery Wayne State University School of Medicine Department of Neurology Xuanwu Hospital Beijing Institute of Brain Disorders Capital Medical University Department of Radiology Xuanwu Hospital Capital Medical University Department of Anesthesiology Xuanwu Hospital Beijing Institute of Brain Disorders Capital Medical University Department of Pathology Xuanwu Hospital Beijing Institute of Brain Disorders Capital Medical University Beijing Key Laboratory of Hypoxia conditioning Translational Medicine Interdisciplinary Innovation Institute of Medicine and Engineering Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Biological Science and Medical Engineering Beihang University Department of Neurosurgery Heilongjiang Provincial Hospital Department of Laboratory Animal Science Capital Medical University

近几十年来,虽然研究已经证明治疗性低温在啮齿类动物脑卒中模型中有神经保护作用,但其临床转化却未能成功.可能的原因是不同物种之间的生物学差异以及转化研究中治疗性低温诱导难以有效实施.本研究介绍了一种基于非人灵长类动物缺血再...

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Performance Model Analysis of Armenian Premier League Soccer Players Using Global Positioning System Technology and Comparison between European Championship

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Journal of Sports Science 2019年第2期7卷 39-45页

作者： Riccardo Izzo Ciro Hosseini Varde’i Vito Azzone Department of Biomolecular Sciences School of Health and Sport ScienceUniversity of Urbino Carlo BoUrbinoPU 61029Italy Strength and conditioning Coach Italian National Team U-21 Club ItaliaFIGC

The aim of this research was to analyze the PPM of Armenian Premier League using 25 GPS 10 Hz(K-Sport,Montelabbate,Italy),in order to compare data from literature from major European *** total 25 matches were analyzed from one team militant in Armenian Premier League(10 wins,10 loses and 5 draws),33 different players(age 24.3±4.2,height 1.76±4.2 and weight 74±3.5)and in total 270 performances(10.8 for matches).Matches were divided in First Half(T1),Second Half(T2),Second Half Substitution(T2 Sub),Full Match,Full Match Substitution(Full Match Sub)and Total Match(Total)that include all the players detected during a ***,all matches were divided even by quarters 0-15,15-30,30-45,45-60,60-75 and 75-90,only players that played all match were included in this analyses,in order to check the performance decreasing during the *** data were added in an Excel Spreadsheet in order to build a database,to organize and better analyze data,cataloging events for data,results,and role of *** data from Armenian Premier League in comparison with literature data from European and Italian Championship show that in every parameter,the Armenian Premier League is under the *** is obviously related to the non-high level of the Armenian football that is in fact placed at the 106°place of the FIFA ranking(update 7 June 2019).Physical data represent an indicator of performance but also of the qualitative level of the league and of individual *** this reason,the use of the match analysis can be decisive to verify the PPM,in order to better evaluate the championships,teams,and players,in order to build an easier search and discovery of talents.

关键词： Match analysis performance model GPS comparison European championship

The Complex Irradiation Facility at DLR-Bremen

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材料科学与工程（中英文A版） 2014年第1期4卷 1-9页

作者： Thomas Renger Maciej Sznajder Andreas Witzke Ulrich Geppert DLR Institute for Space Systems System Conditioning Bremen 28359 Germany DLR Institute for Space Systems University of Bremen Bremen 28359 Germany University of Zielona Gora Kepler Institute of Astronomy Zielona Gora 65-265 Poland

All material exposed to interplanetary space conditions are subject to degradation processes. For obvious reasons there is a great interest to study these processes for materials that are used in satellite construction. However, also the influence of particle and electromagnetic radiation on the weathering of extraterrestrial rocks and on organic and biological tissues is the research topic of various scientific disciplines. To strengthen the comprehensive and systematic investigation of degradation processes a new laboratory, the complex irradiation facility (CIF), has been designed, set up, tested, and put into operation at the DLR-Institute of Space Systems in Bremen (Germany). The CIF allows the simultaneous irradiation with three light sources and with a dual beam irradiation system for the bombardment of materials with electrons and protons having energies up to 100 keV. It is eminently suitable to perform a large variety of irradiation procedures that are similar to those which appear at different distances to the Sun. This paper is devoted to potential users in order to inform them about the capabilities of the CIF.

关键词：辐照装置空间系统梅有材料降解过程空间条件卫星工程生物组织

Impact of prophylactic/preemptive donor lymphocyte infusion and intensified conditioning for relapsed/refractory leukemia:a real-world study

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Science China(Life Sciences) 2020年第10期63卷 1552-1564页

作者： Yu Wang Qi-Fa Liu De-Pei Wu Jing-Bo Wang Xi Zhang Heng-Xiang Wang Feng Gao Shun-Qing Wang Zi-Min Sun Jian Ouyang Kai-Lin Xu Su-Jun Gao Lan-Ping Xu Chen-Hua Yan Xiao-Jun Huang Department of Hematology Peking University People’s HospitalPeking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Hematology Aero Center Space HospitalBeijing 100049China Department of Hematology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Department of Hematology Air Force General HospitalPLABeijing 100142China Department of Hematology the Affiliated Hospital of North China University Science and TechnologyTangshan 063210China Department of Hematology Guangzhou First People’s HospitalGuangzhou 510180China Department of Hematology Anhui Provincial HospitalHefei 230001China Department of Hematology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Hematology the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000China Department of Hematology the First Affiliated Hospital of Jilin UniversityChangchun 130021China Peking-Tsinghua Center for Life Sciences Beijing 100871China Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences2019RU029Beijing 100730China Collaborative Innovation Center of Hematology Beijing 100044China

Prophylactic/preemptive donor lymphocyte infusion(p/pDLI)and intensified conditioning have shown promising results in experimental studies of refractory/relapsed acute leukemia(RRAL),but real-world data remain *** conducted a multicenter,population-based analysis of 932 consecutive *** three-year leukemia-free survival(LFS)rates were 56%for patients receiving both p/pDLI and intensified myeloablative conditioning(MAC)(intenseMAC)and 30%for those who received neither therapy per landmark *** analyses were run separately for acute myeloid leukemia(AML)and acute lymphoblastic leukemia(ALL),and p/pDLI treatment was linked to significantly higher LFS than non-DLI for both AML and ALL patients without increasing the nonrelapse *** was associated with significantly lower relapse and higher LFS than nonintensified MAC despite higher nonrelapse mortality rates in ALL,while there was no impact of intenseMAC observed in AML.p/pDLI achieved superior outcomes in both matched-sibling donor(MSD)and haploidentical donor transplantation,while intenseMAC only influenced MSD *** suggest that RRAL patients receiving“total therapy”by way of p/pDLI and intensified conditioning treatment have an improved chance for LFS,with p/pDLI being safer with a more extensive impact relative to *** with RRAL can tolerate both interventions and achieve a reasonable outcome.

关键词： donor lymphocyte infusion intensified conditioning refractory/relapsed leukemia haploidentical prophylactic

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