低温自体血靶向回输对于非人灵长类脑卒中模型的神经保护作用

作     者：陈健 徐率立 Hangil Lee 吴隆飞 何小夺 赵文博 张默 马艳辉 丁玉川 付永娟 吴川杰 李明 姜缪文 程化坤 李胜利 马挺 吉训明 吴迪 Jian Chen;Shuaili Xu;Hangil Lee;Longfei Wu;Xiaoduo He;Wenbo Zhao;Mo Zhang;Yanhui Ma;Yuchuan Ding;Yongjuan Fu;Chuanjie Wu;Ming Li;Miuwen Jiang;Huakun Cheng;Shengli Li;Ting Ma;Xunming Ji;Di Wu

作者机构：Department of NeurosurgeryXuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China China-America Institute of NeuroscienceXuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China Department of Neurological SurgeryWayne State University School of MedicineDetroit MI 46801USA Department of NeurologyXuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China Department of RadiologyXuanwu HospitalCapital Medical UniversityBeijing 100053China Department of AnesthesiologyXuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China Department of PathologyXuanwu HospitalBeijing Institute of Brain DisordersCapital Medical UniversityBeijing 100053China Beijing Key Laboratory of Hypoxia Conditioning Translational MedicineBeijing 100053China Interdisciplinary Innovation Institute of Medicine and EngineeringBeijing Advanced Innovation Center for Big Data-Based Precision MedicineSchool of Biological Science andMedical EngineeringBeihang UniversityBeijing 100083China Department of NeurosurgeryHeilongjiang Provincial HospitalHarbin 1500036China Department of Laboratory Animal ScienceCapital Medical UniversityBeijing 100069China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2023年第68卷第14期

页      面：1556-1566,M0004页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82027802,82171304,82071466,81771260,81871022,82071468,and 82201618) “Sail Plan”Key Medical Specialty(ZYLX202139) “Mission”Talent Project of Beijing Municipal Administration of Hospitals(SML20150802) Beijing Municipal Science and Technology Project(Z181100001918026) Technological Innovation and Service Capability Construction Project From Beijing Municipal Commission of Education(11000023T000002157177) 

主　　题：自体血 非人灵长类动物 缺血区域 血管再通 神经保护作用 自体输血 微导管 核心温度 

摘      要：近几十年来,虽然研究已经证明治疗性低温在啮齿类动物脑卒中模型中有神经保护作用,但其临床转化却未能成功.可能的原因是不同物种之间的生物学差异以及转化研究中治疗性低温诱导难以有效实施.本研究介绍了一种基于非人灵长类动物缺血再灌注模型的选择性治疗性低温疗法,即将自体血于体外循环中冷却,在血管再通后立即通过微导管向缺血区域回输低温自体血.低温自体血将目标脑区迅速冷却至34℃以下,而核心温度可以维持在36℃左右.低温自体血回输减少了梗死面积,保留了白质完整性,改善了神经功能且未引发低温相关并发症.本研究结果表明,在非人灵长类动物脑卒中模型中,通过冷自体输血诱导治疗性低温是一种可行、快速和安全的方法.这提示低温自体血靶向回输是一种具有临床转化潜力的新型低温脑保护疗法.