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Next Decade of Telecommunications Artificial Intelligence

CAai Artificial Intelligence Research 2022年第1期1卷 28-53页

作者： Ye Ouyang Lilei Wang aidong Yang Tongqing Gao Leping Wei Yaqin zhang Asiainfo Technologies(China)Ltd. Beijing 100193China China Mobile Communications Group Co. Ltd.Beijing 100032China China Telecom Group Corporation Beijing 100033China Institute for ai Industry Research Tsinghua UniversityBeijing 100084China

It has been an exciting journey since the mobile communications and artificial intelligence(ai)were conceived in 1983 and *** both fields evolved independently and profoundly changed communications and computing industries,the rapid convergence of 5th generation mobile communication technology(5G)and ai is beginning to significantly transform the core communication infrastructure,network management,and vertical *** paper first outlined the individual roadmaps of mobile communications and ai in the early stage,with a concentration to review the era from 3rd generation mobile communication technology(3G)to 5G when ai and mobile communications started to *** regard to telecommunications ai,the progress of ai in the ecosystem of mobile communications was further introduced in detail,including network infrastructure,network operation and management,business operation and management,intelligent applications towards business supporting system(BSS)&operation supporting system(OSS)convergence,verticals and private networks,*** the classifications of ai in telecommunication ecosystems were summarized along with its evolution paths specified by various international telecommunications standardization *** the next decade,the prospective roadmap of telecommunications ai was *** line with 3rd generation partnership project(3GPP)and International Telecommunication Union Radiocommunication Sector(ITU-R)timeline of 5G&6th generation mobile communication technology(6G),the network intelligence following 3GPP and open radio access network(O-RAN)routes,experience and intent-based network management and operation,network ai signaling system,intelligent middle-office based BSS,intelligent customer experience management and policy control driven by BSS&OSS convergence,evolution from service level agreement(SLA)to experience level agreement(ELA),and intelligent private network for verticals were further *** paper is co

关键词： artificial intelligence(ai) mobile communication 5th generation(5G) general purpose technology(GPT) network intelligence intent-based network network ai signaling system

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Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development

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Protein & Cell 2020年第12期11卷 921-927页

作者： Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan bin Li Xiaoyan Mao Jing Fu Zhihua zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang Institute of Pediatrics Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and metabolismMinistry of Science and technology and Institutes of Biomedical SciencesState Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200032China Center of Assisted Reproduction Shanghai East hospitalTongji UniversityShanghai 200120China The Reproductive Medical Center of Xiangya Hospital Central South UniversityChangsha 41008China Reproductive Medicine Center Shaanxi Maternal and Child Care Service CenterXi'an 710069China NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research) Fudan UniversityShanghai 200032China Reproductive Medicine Center Shanghai Ninth HospitalShanghai Jiao Tong UniversityShanghai 200011China Shanghai Ji ai Genetics and IVF Institute Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Key Laboratory of Molecular Virology Immuno logy In stitute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Bio-X Center Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesFudan UniversityShanghai 200438China Zhuhai Fudan Innovation Institute Zhuhai 519000China Shanghai Center for Women and Children's Health Shanghai 200062China

Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely *** recent years,"missing"Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated.

关键词： female maturation arrest

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Effects of Cryopreservation on Human Sperm Glycocalyx

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Reproductive and Developmental Medicine 2017年第4期1卷 233-238页

作者： Yan-Cheng Wu ai-Jie Xin Hui Lu Hua Diao Li Cheng Yi-Hua Gu bin Wu Sheng-Ce Tao Zheng Li Hui-Juan Shi Yong-Lian zhang Department of Applied Biology State Key Laboratory of Bioreactor EngineeringSchool of BiotechnologyEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases Shanghai Ji Ai Genetics and IVF InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Department of Allergy Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China Department of Reproductive Pharmacology NPFPC Key Laboratory of Contraceptives and DevicesShanghai Institute of Planned Parenthood ResearchShanghai 200032China Shanghai Center for Systems Biomedicine Shanghai Jiao Tong UniversityShanghai 201100China Department of Andrology Urologic Medical CenterShanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Background:To study the effects of cryopreservation on human sperm ***:The lectin binding profilings of sperm after freeze-thaw were compared by lectin ***:CryoSperm^(TM) and direct fumigation were confirmed to be the optimized cryoprotectant and method by comparing the sperm recovery *** 91 lectins,33 lectins were significantly changed after sperm *** them,9 lectins greatly decreased and 24 lectins mainly *** binding signals of MAA,PSA,ABA,and aiA were verified by FACS,and the results were consistent with that of lectin ***:Sperm glycocalyx had significant changes after *** sialic acid,playing an important role in protecting sperm,was greatly lost,which exposed the inner ***,the glycocalyx damage due to the cryopreservation might be one of the reasons for low sperm fertility.

关键词： Cryopreservation Damage Glycocalyx Lectin Microarray Sperm

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Protist 10,000 Genomes Project

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The Innovation 2020年第3期1卷 68-69页

作者： Wei Miao Lirong Song Sang Ba Longxian zhang Guiquan Guan zhang zhang Kang Ning National Aquatic Biological Resource Center Institute of HydrobiologyChinese Academy of SciencesWuhanChina Laboratory of Wetland and Catchments Ecology in Tibetan Plateau Faculty of Natural SciencesTibet UniversityLhasaChina College of Veterinary Medicine Henan Agricultural UniversityZhengzhouChina State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhouChina National Genomics Data Center Beijing Institute of GenomicsChinese Academy of SciencesChina National Center for BioinformationBeijingChina Key Laboratory of Molecular Biophysics of the Ministry of Education Hubei Key Laboratory of Bioinformatics and Molecular-imagingCenter of AI BiologyDepartment of Bioinformatics and Systems BiologyCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanChina

Protists are a highly diverse group of microscopic eukaryotic organisms that are not fungi,animals,or *** some of the microbes first visualized and described by Anton van Leeuwenhoek using themicroscope in the seventeenth *** that,the description and cataloging of these diverse microbial eukaryotes was pursued by microbiologists throughout the following centuries.1 So far,more than 60,000 protist species have been recorded in the NCBI taxonomy system,but many have yet to be *** have long been considered important models in fundamental biological studies,such as cell biology,genetics,ecology and evolution toxicology,and applied fields,including biofuels,nutritional supplements and aquaculture feed production,environmental monitoring and pollution treatment,protozoan parasitic disease treatment and prevention,as well as agriculture.

关键词： prevention taxonomy pollution

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Machine Learning Based Cybersecurity Threat Detection for Secure IoT Assisted Cloud Environment

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Computer Systems Science & Engineering 2023年第10期47卷 855-871页

作者： Z.Faizal Khan Saeed M.Alshahrani Abdulrahman Alghamdi Someah Alangari Nouf Ibrahim Altamami Khalid A.Alissa Sana Alazwari Mesfer Al Duhayyim Fahd N.Al-Wesabi Department of Computer Engineering College of Computing and Information TechnologyShaqra UniversityShaqraSaudi Arabia Department of Computer Science College of Computing and Information TechnologyShaqra UniversityShaqraSaudi Arabia Department of Computer Science College of Science and Humanities DawadmiShaqra UniversityShaqraSaudi Arabia Department of Mathematics College of EducationShaqra UniversityShaqraSaudi Arabia Saudi Aramco Cybersecurity Chair Networks and Communications DepartmentCollege of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif P.O.Box 11099Taif21944Saudi Arabia Department of Computer Science College of Sciences and Humanities-AflajPrince Sattam bin Abdulaziz UniversityAlaflaj16828Saudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia

The Internet of Things(IoT)is determine enormous economic openings for industries and allow stimulating innovation which obtain between domains in childcare for eldercare,in health service to energy,and in developed to *** develops a difficult problem in IoT platform whereas the presence of cyber-attack requires that *** progress of automatic devices for cyber-attack classifier and detection employing Artificial Intelligence(ai)andMachine Learning(ML)devices are crucial fact to realize security in IoT *** can be required for minimizing the issues of security based on IoT devices ***,this research proposal establishes novel mayfly optimized with Regularized Extreme Learning Machine technique called as MFO-RELM model for Cybersecurity Threat classification and detection fromthe cloud and IoT *** proposed MFORELM model provides the effective detection of cybersecurity threat which occur in the cloud and IoT *** accomplish this,the MFO-RELM technique pre-processed the actual cloud and IoT data as to meaningful ***,the proposed models will receive the pre-processing data and carry out the classifier *** boosting the efficiency of the proposed models,theMFOtechnique was utilized to *** experiential outcome of the proposed technique was tested utilizing the standard CICIDS 2017 dataset,and the outcomes are examined under distinct aspects.

关键词： Mayfly optimization machine learning artificial intelligence cybersecurity threat detection

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Mesenchymal stromal cell biotherapy for Parkinson’s disease premotor symptoms

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Chinese Neurosurgical Journal 2023年第4期9卷 300-314页

作者： Jinmei Sun Wei zhang Zheng Zachory Wei Xiaopeng Song Liu Jian Feng Jiang Shuanglin Wang Haibo Li Yongbo zhang Houzhen Tuo The CtrLyin Group Clinical Diagnosis and Treatment Center for Parkinson’s Disease Beijing Friendship HospitalBeijingChina Laboratories of Biological Therapeutic Medical Technology Department of NeurologyBeijing Friendship Hospital Center for Neurological DisordersCapital Medical UniversityBeijingChina National Clinical Research Center for Digestive Diseases Beijing Friendship HospitalNeuroscience InstituteBeijingChina Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Beijing Tropical Medicine Research Institute BeijingChina McLean Imaging Center McLean HospitalHarvard Medical SchoolBelmontMAUSA Neuroscience Research Institute Peking UniversityBeijingChina Casstar Zhongguancun No.1 Global Key&Core Technology(AI)Innovation CenterBeijingChina Department of Critical Care Medicine Airport Hospital of Tianjin Medical University General HospitalTianjinChina Department of Cardiovascular Thoracic Surgery Tianjin Medical University General HospitalTianjinChina Department of Biochemistry and Cell Biology Geisel School of MedicineDartmouth CollegeHanoverNHUSA 不详

Parkinson’s disease(PD)is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms(NMS)such as anxiety,cognitive dysfunction,depression,hyposmia,and sleep *** is presented in at least one-fifth of the patients with *** the histological information being investigated,stem cells are shown to provide neurotrophic supports and cellular replacement in the damaging brain areas under PD *** change of progressive PD includes degeneration and loss of dopaminergic neurons in the substantia nigra of the *** current stem cell beneficial effect addresses dopamine boost for the striatal neurons and gliovascular mechanisms as competing for validated PD drug *** addition,there are clinical interventions for improving the patient’s NMS and targeting their autonomic dysfunction,dementia,mood disorders,or sleep *** our and many others’research using brain injury models,multipotent mesenchymal stromal cells demonstrate an additional and unique ability to alleviate depressive-like behaviors,independent of an accelerated motor *** delivery of the stem cells is discussed for it is extensively tested in rodent animal models of neurological and psychiatric *** this review,we attempt to discuss the repairing potentials of transplanted cells into parkinsonism pathological regions of motor deficits and focus on preventive and treatment *** new approaches in the PD biological therapy,it is believed that it can as well benefit patients against PD-NMS.

关键词： Cell therapy Cognitive impairment Depression Neuronal survival and differentiation Parkinson's disease

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Nationwide survey analysis of esophagogastric varices in portal hypertension based on endoscopic management in China

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Portal Hypertension & Cirrhosis 2024年第3期3卷 129-138页

作者： Xing Wang bing Hu Yiling Li Weichun Lin Zhijie Feng Yanjing Gao Zhining Fan Feng Ji bingrong Liu Jinhai Wang Wenhui zhang Tong Dang Hong Xu Derun Kong Lili Yuan Liangbi Xu Shengjuan Hu Liangzhi Wen Ping Yao Yunxiao Liang Xiaodong Zhou Huiling Xiang Xiaowei Liu Xiaoquan Huang Yinglei Miao Xiaoliang Zhu De‐An Tian Feihu Bai Jitao Song Ligang Chen Yangzhen Bian Ba Yingcai Ma Yifei Huang bin Wu Xiaolong Qi CHESS‐Endoscopyconsortium Department of Gastroenterology The Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouGuangdongChina Guangdong Province Engineering and Technology Research Center of Digestive Endoscopy GuangzhouGuangdongChina Department of Gastroenterology and Hepatology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Gastroenterology Qilu Hospital of Shandong UniversityJinanShandongChina Department of Digestive Endoscopy The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiangChina Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Beijing Daxing District People's HospitalBeijingChina Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeBaotouInner MongoliaChina Department of Gastroenterology The First Hospital of Jilin UniversityChangchunJilinChina Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Digestive Endoscopy The Second Hospital of Shanxi Medical UniversityTaiyuanShanxiChina Digestive Endoscopy Center The Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhouChina Department of Gastroenterology People's Hospital of Ningxia Hui Autonomous RegionNingxia Medical UniversityYinchuanNingxiaChina Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqingChina Department of Gastroenterology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Gastroente

aims:The endoscopic treatment of esophagogastric varices is challenging,and the nationwide application of endoscopic therapies for various types of esophagogastric varices and different clinical scenarios remains *** study investigated the use of endoscopic therapy for portal hypertension in ***:This study used a questionnaire survey initiated by the Liver Health Consortium in China to investigate the use of endoscopic therapies for portal *** were released online from January 30,2023 to February 28,2023 and filled out by chief physicians or senior instructors responsible for endoscopic therapies in participating hospitals across 31 provinces(autonomous regions and municipalities)in *** of guideline adherence between primary and referral medical centers were performed using the chi‐square test or Fisher's exact ***:In total,836 hospitals participated in the *** primary and secondary prophylaxis of esophagogastric variceal bleeding(EGVB),adherence to the national guidelines was 72.5%(606/836)and 39.2%(328/836),*** differences were observed in the rate of adherence between the primary and referral centers for primary(79.9%[111/139]vs.71.0%[495/697],p=0.033)and secondary prophylaxis(27.3%[38/139]vs.41.6%[290/697],p=0.002).Of the hospitals,78.2%(654/836)preferred endoscopic therapies for acute EGVB,and the timing of endoscopy was usually within 12 h(48.5%,317/654)and 12-24 h(36.9%,241/654)after *** therapy was more likely to be the first choice of treatment for acute EGVB in referral centers than in primary centers(82.6%[576/697]vs.56.1%[78/139],pbined with sclerotherapy(48.2%[403/836]and 29.9%[250/836],respectively);however,substantial hospitals preferred clip-assisted therapies(12.4%[104/836]and 2

关键词： endoscopy esophagogastric varices guideline adherence portal hypertension questionnaire survey

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Forecasts on CMB lensing observations with AliCPT-1

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Science China(Physics,Mechanics & Astronomy) 2022年第10期65卷 115-129页

作者： Jinyi Liu Zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh bin Yue Pengjie zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le zhang Zi-Rui zhang Wen Zhao bin Hu Hong Li Xinmin zhang Department of Astronomy Beijing Normal UniversityBeijing 100875China Department of Astronomy School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai 200240China Division of Astronomy and Astrophysics Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China D´epartement de Physique Th´eorique et CAP Universit´e de Gen`eveGen`eve CH-1211Switzerland CNRS-UCB International Research Laboratory Centre Pierre Bin´etruyCPB-IN2P3Berkeley IRL2007USA Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Optoelectronics Engineering Anhui UniversityHefei 230039China School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China Peng Cheng Laboratory Shenzhen 518000China Theoretical devision Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Ali CPT-1 is the first Chinese cosmic microwave background(CMB) experiment aiming for the high-precision measurement of CMB B-mode polarization. The telescope, currently under deployment in Tibet, will observe in two frequency bands centered at 90 and 150 GHz. We forecast the CMB lensing reconstruction, lensing-galaxy, and lensing-cosmic infrared background(CIB) cross-correlation signal-to-noise ratio(SNR) for Ali CPT-1. We consider two stages with different integrated observation times, namely “4 module*yr”(first stage) and “48 module*yr”(final stage). For lensing reconstruction, we use three different quadratic estimators, namely temperature-only, polarization-only and minimum-variance(MV) estimators, using curved sky geometry. We take into account the impacts of inhomogeneous hit counts and mean-field bias due to incomplete sky *** the first stage, our results show that the 150 GHz channel can measure the lensing signals at 15σ significance with the MV estimator. In the final stage, the measurement significance will increase to 31σ. We also combine the two frequency data in the harmonic domain to optimize the SNR. Our results show that the coadding procedure can significantly reduce the reconstruction bias in the high multiple range. Owning to the high quality of the polarization data in the final stage of Ali CPT-1, the EB estimator will dominate the lensing reconstruction in this stage. We also estimate the SNR of cross-correlations between Ali CPT-1 CMB lensing and other tracers of the large scale structure of the universe. For its cross-correlation with Dark Energy Spectroscopic Instrument(DESI) galaxies/quasars, we report the cross-correlation SNR = 10-20 for the four redshift bins at 0.05 < z < 2.1. In the first stage, the total SNR is approximately 32. In the final stage, the lensing-galaxy cross-correlation can reach SNR = 52. For lensing-CIB cross-correlation, in the first stage, the cross-correlations between Ali CPT-1 lensing and Planck CIB 353

关键词： background radiation cosmic cosmology gravitational lenses and luminous ares

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长江草鱼群体MHC Class II B的多态性和进化分析

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淡水渔业 2010年第5期 14-21页

作者：张燕姚延丹段辛斌陈大庆曾令兵汪登强张燕 ZHANG Yan(华中农业大学水产学院武汉430070 中国水产科学研究院长江水产研究所湖北荆州434000 中国水产科学院淡水渔业研究中心江苏无锡214081) 姚延丹 YAO Yan-dan(中国水产科学研究院长江水产研究所湖北荆州434000 上海海洋大学上海200090) 段辛斌陈大庆曾令兵汪登强DUAN Xin-binCHEN Da-qingZENG Ling-bingWANG Deng-qiang(中国水产科学研究院长江水产研究所湖北荆州434000)

克隆及测序草鱼(Ctenopharyngodon idella)长江3个群体的主要组织相容性复合体(MHC)Class II B基因编码β1和β2区的第2和第3个外显子及两个外显子之间的内含子,分析了草鱼MHC的进化模式和种群遗传结构.结果显示:实验共定义了34个等位基... 详细信息

克隆及测序草鱼(Ctenopharyngodon idella)长江3个群体的主要组织相容性复合体(MHC)Class II B基因编码β1和β2区的第2和第3个外显子及两个外显子之间的内含子,分析了草鱼MHC的进化模式和种群遗传结构.结果显示:实验共定义了34个等位基因,每条序列包括长为130～136 bp的第2个外显子,长为218 bp的第3个外显子以及长81～371 bp的内含子.序列分析揭示,第2个外显子有106个核苷酸变异位点(78%)和40个氨基酸变异位点(88%),而第3个外显子有100个核苷酸变异位点(45%)和41个氨基酸变异位点(56%),β1变异要大于β2区.用β1和β2区序列分别构建的邻接(NJ)系统树均显示5个具有高支持率的谱系,结合序列变异特点和内含子长度,推测草鱼至少存在5个MHC Class II座位.分别计算β1的肽结合位点(PBR)、非肽结合位点及β2的非同义替换率(dN)和同义替换率(dS),PBR的dN/dS为2.03(P<0.05),非肽结合位点和β2则小于1,表明草鱼MHC受到歧化选择作用.根据等位基因在群体中的分布频率作分子方差分析(AMOVA),得出FST为0.37%,提示长江草鱼MHC没有遗传分化.

关键词：草鱼(Ctenopharyngodon idella) 主要组织相容性复合体(MHC) 遗传变异进化模式

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Nature：研究鉴定出侵袭性胰腺癌细胞及其弱点

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现代生物医学进展 2017年第14期17卷 I0002-I0003页

作者： Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda Univ Texas MD Anderson Canc Ctr Dept Genom Med Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Inst Appl Canc Sci Houston TX 77030 USA European Inst Oncol I-20141 Milan Italy Sun Yat Sen Univ Ctr Canc State Key Lab Oncol South China Guangzhou 510060 Guangdong Peoples R China Univ Cattolica Sacro Cuore Ist Patol Gen I-00168 Rome Italy Baylor Coll Med Grad Program Struct & Computat Biol & Mol Biophys Houston TX 77030 USA Johns Hopkins Univ Sol Goldman Pancreat Canc Res Ctr Dept Pathol Baltimore MD 21287 USA Univ Texas MD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Translat Mol Pathol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Leukemia Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Off Technol Commercializat Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Canc Syst Imaging Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Canc Biol Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Expt Therapeut Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr ORBIT Platform Houston TX 77030 USA Univ Texas MD Anderson Canc Ctr Dept Surg Oncol Houston TX 77030 USA Friedrich Alexander Univ Erlangen Nuremberg Univ Hosp Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Sheikh Ahmed Bin Zayed Nahyan Ctr Pancreat Canc R D-91054 Erlangen Germany St Jude Childrens Res Hosp Ctr Comprehens Canc Memphis TN 77027 USA St Jude Childrens Res Hosp Dept Oncol Memphis TN 77027 USA C4 Therapeut Cambridge MA 02142 USA Univ Texas Syst Inst Hlth Transformat Austin TX 78701 USA

在一项新的研究中，来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为... 详细信息

在一项新的研究中，来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型，并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。

关键词：胰腺癌癌细胞侵袭性鉴定异种移植研究人员细胞类型细胞转化

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