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Use of self-organizing suppression and q-Gaussian mutation in artificial immune systems

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International Journal of Intelligent Computing and Cybernetics 2013年第3期6卷 296-322页

作者： Helder Ken Shimo Renato Tinòs Department of Computing and Mathematics University of Sa˜o PauloSa˜o PauloBrazil

Purpose-The purpose of this paper is to propose two operators for diversity and mutation control in artificial immune systems(AISs).Design/methodology/approach-The proposed operators are applied in substitution to the suppression and mutation operators used in *** proposed mechanisms were tested in the opt-aiNet,a continuous optimization algorithm inspired in the theories of *** traditional opt-aiNet uses a suppression operator based on the immune network principles to remove similar cells and add random ones to control the diversity of the *** procedure is computationally expensive,as the Euclidean distances between every possible pair of candidate solutions must be *** work proposes a self-organizing suppression mechanism inspired by the self-organizing criticality(SOC)phenomenon,which is less dependent on parameter *** work also proposes the use of the q-Gaussian mutation,which allows controlling the form of the mutation distribution during the optimization *** algorithms were tested in a well-known benchmark for continuous optimization and in a bioinformatics problem:the rigid docking of ***-The proposed suppression operator presented some limitations in unimodal functions,but some interesting results were found in some highly multimodal *** proposed q-Gaussian mutation presented good performance in most of the test cases of the benchmark,and also in the docking ***/value-First,the self-organizing suppression operator was able to reduce the complexity of the suppression stage in the ***,the use of q-Gaussian mutation in AISs presented better compromise between exploitation and exploration of the search space and,as a consequence,a better performance when compared to the traditional Gaussian mutation.

关键词： Artificial immune system Evolutionary computation Self-adjusting systems

Linking the Gawler Craton and Mount Isa Province through hydrothermal systems in the Peake and Denison Domain,northeastern Gawler Craton

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Geoscience Frontiers 2023年第5期14卷 108-125页

作者： Mitchell J.Bockmann Justin L.Payne Martin Hand Laura J.Morrissey Antonio P.Belperio Department of Earth Sciences University of AdelaideAdelaideSAAustralia Mineral Exploration Cooperative Research Centre University of AdelaideAdelaideSAAustralia Unisa STEM University of South AustraliaAdelaideSAAustralia Mineral Exploration Cooperative Research Centre Future Industries InstituteUniversity of South AustraliaAdelaideSAAustralia Demetallica Ltd NorwoodSAAustralia

Tectonic reconstructions of Proterozoic Australia commonly place the Peake and Denison Domain of the northeastern Gawler Craton at the interface between the North and South Australian cratons prior to the reconfiguration of Australia’s main tectonic components in the ***,this reconstruction is largely based on palaeomagnetic data as the geological correlations between these regions are currently limited,particularly during the *** early Mesoproterozoic period is significant as it corresponds to major IOCG mineralization in the eastern Gawler Craton between 1600 Ma and 1575 Ma,and IOCG mineralization in the Mount Isa Province largely between 1550 Ma and 1490 ***,determining the relationship of the Peake and Denison Domain to the Gawler Craton and Mount Isa Province during this period is essential to evaluating mineral prospectivity in the northeastern Gawler *** U–Pb LA-ICP-MS geochronology on zircon and titanite improves our understanding of the tectonothermal and hydrothermal history the Peake and Denison Domain during the latePalaeoproterozoic,early-Mesoproterozoic and the Cambrian–Ordovician *** formed within largely calc-silicate alteration assemblages indicates the Peake and Denison Domain has a protracted history of hydrothermal activity,recording events at c.1565 Ma,1530–1515 Ma,c.1500 Ma,c.1465 Ma and c.490 *** highly calcic nature of the c.1565–1500 Ma alteration in the Peake and Denison Domain shares strong similarities in age and character to the regional calcic-sodic alteration recorded in the Mount Isa *** suggest the two regions were influenced by similar hydrothermal systems during the early Mesoproterozoic,supporting reconstruction models that place the Peake and Denison Domain near the Mount Isa Province during the *** highlights the prospectivity of the Peake and Denison Domain for Isan-style IOCG mineralization,but requires consideration of the post-

关键词： Peake and Denison Gawler Craton Mount Isa IOCG Tectonic reconstruction Titanite

Brachioradialis tendon transfer and palmaris longus tendon graft for thumb avulsion:A case report and review of literature

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World Journal of Clinical Cases 2025年第4期13卷 48-55页

作者： Pierre Curings Sonia Ramos-Pascual Kinga Michalewska Nicolas Gibert Lionel Erhard Mo saffarini AlexisNogier Department of Hand Surgery Clinique TrenelSainte-Colombe 69560France Medical Research ReSurg SANyon 1260VaudSwitzerland Department of Hand Surgery Hand and Upper Limb Surgical InstituteVilleurbanne 69100France Department of Orthopaedics Clinique TrenelSainte-Colombe 69560France

BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous *** treatments include direct tendon suture or tendon transfer,most commonly from the ring *** optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon *** SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a *** patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and *** patient was treated with two stage thumb *** first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon *** second intervention consisted of PL tendon graft and BR tendon ***-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 *** Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.

关键词： Brachioradialis tendon transfer Flexor pollicis longus Palmaris longus tendon graft Replantation Thumb amputation Thumb avulsion Case report

Laser ablation(in situ)Lu-Hf dating of magmatic fluorite and hydrothermal fluorite-bearing veins

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Geoscience Frontiers 2023年第6期14卷 142-154页

作者： Stijn Glorie Jacob Mulder Martin Hand Adrian Fabris Alexander Simpson sarah Gilbert Department of Earth Sciences University of AdelaideSA 5005Australia Geological Survey of South Australia Department for Energy and MiningAdelaideSA 5005Australia Adelaide Microscopy University of AdelaideSA 5005Australia

Fluorite(CaF_(2))is a common hydrothermal mineral,which precipitates from fluorine-rich fluids with an exceptional capacity to transport metals and Rare Earth Elements(REEs).Hence,the ability to date fluorite has important implications for understanding the timing of metal transport in hydrothermal *** we present,for the first time,fluorite Lu-Hf dates from fluorite-carbonate veins from the Olympic Cu-Au Province in South *** fluorite dates were obtained in situ using the recently developed LA-ICP-MS/MS Lu-Hf dating method.A fluorite-calcite age of 1588±19 Ma was obtained for the Torrens Dam prospect,consistent with the timing of the formation of the nearby Olympic Dam iron-oxide copper gold Breccia *** in the overlying Neoproterozoic successions were dated at 502±14 Ma,indicating a temporal link between Cu-sulphide remobilisation and the Delamerian ***,we present a multi-session reproducible date for magmatic fluorite from a monzogranite in the Pilbara Craton(Lu-Hf age of 2866±19 Ma).This age is consistent with a garnet Lu-Hf age from the same sample(2850±12 Ma)and holds potential to be developed into a secondary reference material for future fluorite Lu-Hf dating.

关键词： Reaction-cell ICP-MS In-situ geochronology Fluorite-calcite veins Iron oxide copper-gold Critical mineral exploration Rare Earth Elements

Classifying rockburst with confidence:A novel conformal prediction approach

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International Journal of Mining Science and Technology 2024年第1期34卷 51-64页

作者： Bemah Ibrahim Isaac Ahenkorah University of South Australia UniSA STEMSA 5000Australia

The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation *** literature reports various successful applications of machine learning(ML)models for rockburst assessment;however,a significant question remains unanswered:How reliable are these models,and at what confidence level are classifications made?Typically,ML models output single rockburst grade even in the face of intricate and out-of-distribution samples,without any associated confidence *** the susceptibility of ML models to errors,it becomes imperative to quantify their uncertainty to prevent consequential *** address this issue,we propose a conformal prediction(CP)framework built on traditional ML models(extreme gradient boosting and random forest)to generate valid classifications of rockburst while producing a measure of confidence for its *** proposed framework guarantees marginal coverage and,in most cases,conditional coverage on the test *** CP was evaluated on a rockburst case in the sanshandao Gold Mine in China,where it achieved high coverage and efficiency at applicable confidence ***,the CP identified several“confident”classifications from the traditional ML model as unreliable,necessitating expert verification for informed *** proposed framework improves the reliability and accuracy of rockburst assessments,with the potential to bolster user confidence.

关键词： Rockburst Machine learning Uncertainty quantification Conformal prediction

A maintenance driven scheduling cockpit for integrated production and maintenance operation schedule

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Advances in Manufacturing 2022年第2期10卷 205-219页

作者： Mario Arena Valentina Di Pasquale Raffaele lannone salvatore Miranda Stefano Riemma Department of Industrial Engineering University of SalernoFiscianoSAItaly

The production and maintenance functions have objectives that are often in contrast and it is essential for management to ensure that their activities are carried out synergistically,to ensure the maximum efficiency of the production plant as well as the minimization of management *** current evolution of ICT technologies and maintenance strategies in the industrial field is making possible a greater integration between production and *** work addresses this challenge by combining theknowledge of the data collected from physical assets for predictive maintenance management with the possibility of dynamic simulate the future behaviour of the manufacturing system through a digital twin for optimal management of maintenance *** paper,indeed,presents a supporting digital cockpit for production and maintenance integrated *** proposes an innovative approach to manage health data from machines being in any production system and provides support to compare the information about their remaining useful life(RUL)with the respective production *** maintenancedriven schedulingcockpit(MDSC)offers,indeed,a supporting decision tool for the maintenance strategy to be implemented that can help production and maintenance managers in the optimal scheduling of preventive maintenance interventions based on RUL *** simulation is performed by varying the production schedule with the maintenance tasks involvement;opportune decisions are taken evaluating the total costs related to the simulated strategy and the impact on the production schedule.

关键词： Industry 4.0-Maintenance task Production schedule Predictive maintenance Integrated plan

Analysis of spontaneous adverse drug reactions to echinacea, valerian,black cohosh and ginkgo in Australia from 2000 to 2015

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Journal of Integrative Medicine 2019年第5期17卷 338-343页

作者： Claire L.Hoban Roger W.Byard Ian F.Musgrave Discipline of Pharmacology The University of AdelaideAdelaideSA 5005Australia Discipline of Anatomy and Pathology The University of AdelaideAdelaideSA 5005Australia

Objective: Assessing adverse drug reactions(ADRs) is a proven method to estimate the safety of medicines. The ADRs to herbal medicines in Australia(and by inference, the safety of herbal medicines in Australia) remain unknown. This study examines spontaneous ADR cases to four of the most popular herbs in Australia from 2000 to 2015: echinacea(Echinacea purpurea), valerian(Valeriana officinalis), black cohosh(Actaea racemosa) and ginkgo(Ginkgo biloba).Methods: ADRs of echinacea, valerian, black cohosh and ginkgo reported to the Australian Therapeutic Goods Administration(TGA) between 2000 and 2015 were obtained from the TGA database. Data were collated and analysed according to age, sex, severity, type of ADR and body system affected. Statistics were calculated using Graph Pad Prism ***: Most ADRs were mild or moderate. However, every herbal medicine was associated with lifethreatening ADRs. In each life-threatening case, the herbal medicine was taken concomitantly with prescription medications. Black cohosh was associated with a significant number of severe ADRs(30.3% of the total), with 39.4% of these ADRs being associated with abnormal hepatic function, hepatitis or ***: This study highlights the lack of public awareness with regard to herb–drug interactions,since most of the severe ADRs involved a herb–drug interaction.

关键词： Herbal medicine Adverse drug reaction Actaea racemosa Echinacea purpurea Ginkgo biloba Valeriana officinalis

Brain metastasis in advanced colorectal cancer： results from the South Australian metastatic colorectal cancer (samCRC) registry

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Cancer Biology & Medicine 2017年第4期14卷 371-376页

作者： Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers David Roder Amanda R. Townsend Department of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Department of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Department of Surgery Flinders Medical Center Bedford Park SA 5042 Australia Department of Surgery The Queen Elizabeth Hospital Adelaide SA 5011 Australia Department of Surgery University of South Australia Adelaide SA 5005 Australia Department of Surgery Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Radiation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the *** reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(samCRC)was analyzed to assess the number of patients presenting with brain metastasis during their *** to small numbers,a descriptive analysis is ***:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were *** the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain *** median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the samCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 ***:Brain metastasis is a rare outcome in advanced *** within the registry tended to be female,young in age,and harbored with higher rates of KRAS *** routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease.

关键词： Brain metastasis colorectal cancer survival surveillance

Synthetic fluorescent probes to apprehend calcium signalling in lipid droplet accumulation in microalgae——an updated review

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Science China Chemistry 2020年第3期63卷 308-324页

作者： AHM Mohsinul Reza Javad Tavakoli Yabin Zhou Jianguang Qin Youhong Tang College of Science and Engineering Flinders UniversityAdelaideSA 5001Australia Institute for NanoScale Science and Technology College of Science and EngineeringFlinders UniversityAdelaideSA 5001Australia

Lipid bodies are dynamic organelles of photosynthetic microalgae that can be used as the third generation resources for biofuel *** of lipids can be influenced by different signalling *** of these processes can provide useful information about the fate and associated roles of lipid molecules in different biological *** photosynthetic organisms,however,studies of calcium ediated lipid biosynthesis is bottlenecked due to the limitation of proper and efficient technologies,which also include visualisation ***,most studies to visualise lipid droplets in vivo have used traditional dyes,and proper visualisation of lipid drops is hindered by dye-specific *** hurdle could be overcome by using recently developed aggregation-induced emission *** review reveals current knowledge gaps in the studies of lipid drops and calcium ions in microalgae,as calcium signaling is important secondary messenger to detect a wide variety of environmental stimuli in plant and animal *** obtain insight into the mechanisms of these processes,the merits and demerits of currently available visualisation techniques for lipid drops and calcium are also ***,opportunities and possibilities are proposed to recommend further improvement of techniques for detecting the role of calcium during lipid formation in microalgae for biofuel production.

关键词： aggregation-induced emission calcium lipid droplets microalgae traditional fluorophores