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Efficacy of a Biorevitalizing-Filler Solution on All Skin Aspects: 10 Years Approach through <i>in Vitro</i>Studies and Clinical Trials

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第1期11卷 18-37页

作者： Sophie Robin Férial Fanian Carol Courderot-Masuyer Michel Tordjman Frederic Braccini Sylvie Boisnic Valérie Philippon Anne Grand Vincent Catherine Salomon Michel Manfait Philippe Humbert Philippe Piccerelle Bioexigence SAS Besan&#231 on France Laboratoires Fill-Med Paris France aesthetic doctor Paris France aesthetic Surgeon Nice France Gredeco SARL Paris France Laboratoires Multaler Argenteuil France Reims University Pharmaceutical Faculty Reims France University of Bourgogne-Franche Comté Besan&#231 on France IMBE UMR CNRS 7263 IRD 237 University of Aix-Marseille Pharmaceutical Faculty Marseille France

Introduction: Skin aging is the result of many cellular dysfunctions over time particularly the fibroblasts and the keratinocytes. These dysfunctions could be decelerated by the preventive effects of some skin treatments such as Intradermal injections. NCTF 135HA has a polycomponent formulation designed to improve the efficacy of non-cross linked hyaluronic acid (as a micro-filler) on fibroblasts function. Although NCTF 135HA has been used by aesthetic practitioners since 20 years, we have analyzed all in vitro, ex vivo and in vivo studies during past 10 years in order to summarized its anti-aging effect. Methods: In these series of studies, the known effects of HA have been evaluated with this boosted formula. Collagen I synthesis, antiglycation effect and contractile forces developed by fibroblasts were studied. Fibroblasts and keratinocytes proliferations were evaluated in monolayer cells culture. The filling effect thanks to NCTF 135HA injection was ex vivo performed by fringe projection and the protective effect of NCTF 135HA against solar irradiation was performed ex vivo to study proliferation rate, elastin and collagen expression. Two clinical trials were performed on women to evaluate the anti-aging effect of NCTF 135HA injection. Hydration, firmness, radiance, wrinkles size, pore size, thickness and density of the dermis were analyzed. Results: Collagen I, anti-AGE products, cell proliferation and contractile forces were significantly increased with NCTF 135HA in culture medium. Ex vivo studies showed that NCTF 135HA increased, cells proliferation rate, elastin and collagen production. In addition, the filling effect of the NCTF 135HA is significantly superior to placebo. The first clinical trial shows that NCTF 135HA injection significantly increased tonicity, hydration and radiance of the skin and significantly decreased wrinkle score. The second clinical trial demonstrat

关键词： Mesotherapy Skin Rejuvenation NCTF 135HA® Hyaluronic Acid Skin Bio-revitalization Skin Booster

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Hyaluronic acid in calves defects correction

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Plastic and aesthetic Research 2014年第1期1卷 62-64页

作者： Lorenzo Rosset Mario Goisis School of Medicine University of Turin10043 OrbassanoItaly doctor’s Equipe via Carducci 1920123 MilanItaly

Aim:Since the advent of fillers,new techniques are continuously developed for different *** this study,we evaluated the use of hyaluronic acid for calf ***:A total of 42 patients were enrolled in this *** of them underwent augmentation procedure in our centers under local anesthesia,the operations were completed within 1 h with a prompt correction of the ***:Thirty-nine patients were satisfied with the treatment(93%),while three had complications,local infection,and lumps,that were resolved quickly(7%).Conclusion:Macrofillers can be injected into the calf to correct any *** advantages include short duration of treatment;the procedure performed under local anesthesia and limited side-effects that resolve *** study suggests the use of biocompatible macrofillers for the augmentation of not only calves,but also for augmentation of breast and buttocks.

关键词： Acid augmentation calves hyaluronic remodeling

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The Comparison and Research Between Chinese and South Korean Preschool Music Education

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International Journal of Technology Management 2015年第7期 89-91页

作者： Zhangrui jihuihui art college ofshandong university weihai doctor lecturer 264209weihai0 art college ofshandong university weihai master lecturer 264209weihai

It＇ s quite necessary for children＇ s intelligence development and good aesthetic orientation development to get preschool music education. As the current society is in diversified development, to continuously promote Chinese educational development, we need to actively communicate and study with foreign education; reference the advantages of foreign education ;and make up for the deficiency of Chinese education. The purpose of this thesis is to give some references to Chinese music education by finding the culture differences in music between China and South Korean through the comparative studys in preschool music education between these two countries.

关键词： China and South Korea preschool education music education comparison.

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Consensus on Treatment of Acne Scars in China(2021)

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International Journal of Dermatology and Venereology 2022年第3期5卷 121-131页

作者：无 Sen Yang Zhong Lu Tong Lin Guo-Yu Zhou Min Yao Yi Liu Rong-Ya Yang Zhi-Fei Liu Yuan-Hong Li Dong-Ni Li Xiao-Dong Chen Shu-Xian Yan Lin Gao Qiu-Ning Sun Hong Cai Yan-Hua Liang Rong Xiao Xiao-Ming Jia Jin Chen Jing-Long Cai Cai-Xia Tu Laser Cosmetology Group Medical Aesthetics and Cosmetology Branch of Chinese Medical Association Cosmetic Laser Group Chinese Society of Dermatology Laser Group Cosmetic and Plastic Surgeon Branch of Chinese Medical Doctor Association Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China Department of Cosmetic Laser Surgery Hospital of DermatologyChinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Oral and Maxillofacial-Head Neck Oncology Department of Laser and Aesthetic MedicineShanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Plastic Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Dermatology Chinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Dermatology The Seventh Medical Center of PLA General Hospital(PLA Army General Hospital)Beijing 100700China Department of Plastic Surgery Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Dermatology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China Department of Plastic and Reconstructive Surgery Guangdong Second Provincial General HospitalGuangzhouGuangdong 510317China Department of Dermatology Affiliated Hospital of Nantong UniversityNantongJiangsu 226006China Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Dermatology The Air Force General Hospital of PLABeijing 100142China Department of Dermatology Cosmetology and VenereologyShenzhen HospitalSouther

Acne scars are caused by inflammatory reactions,infections,and improper handling of acne *** scars have a high incidence and are difficult to *** are many methods currently used to treat acne scars,including medications,photoelectric technology,surgery,filling,chemical peeling,traditional Chinese medicine,biotherapy,and microneedle therapy,and many new methods are constantly ***,there are still many issues,such as the lack of high-quality clinical studies,non-uniform treatment methods,and unsatisfactory therapeutic *** selection of appropriate methods for the comprehensive treatment of different types of acne scars at different stages in clinical practice remains challenging and is a research topic of great *** the perspective of evidence-based medicine,this consensus aims to provide a reference for the treatment of acne scars in clinical practice.

关键词： acne vulgaris cicatrix practice guideline therapy

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