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Comparison of a simplified skin pointer device compared with a skeletal marker for knee rotation laxity: A cadaveric study using a rotation-meter

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World Journal of Orthopedics 2018年第6期9卷 85-91页

作者： Ken Lee Puah Andy Khye Soon Yew Siaw Meng Chou Denny Tijauw Tjoen Lie Department of Orthopaedic Surgery Singapore General Hospital Singapore General Hospital School of Mechanical and aerospace Engineering College of Engineering Nanyang Technological University

AIM To compare the measurements of knee rotation laxity by non-invasive skin pointer with a knee rotation jig in cadaveric knees against a skeletally mounted marker. METHODS Six pairs of cadaveric legs were mounted on a knee rotation jig. One Kirscher wire was driven into the tibial tubercle as a bone marker and a skin pointer was attached. Rotational forces of 3, 6 and 9 nm applied at 0°, 30°, 45°, 60° and 90° of knee flexion were analysed using the Pearson correlation coefficient and paired t-test. RESULTS Total rotation recorded with the skin pointer significantly correlated with the bone marker at 3 nm at 0°(skin pointer 23.9 ± 26.0° vs bone marker 16.3 ± 17.3°, r = 0.92; P = 0.0), 30°(41.7 ± 15.5° vs 33.1 ± 14.7°, r = 0.63; P = 0.037), 45°(49.0 ± 17.0° vs 40.3 ± 11.2°, r = 0.81; P = 0.002), 60°(45.7 ± 17.5° vs 34.7 ± 9.5°, r = 0.86; P = 0.001) and 90°(29.2 ± 10.9° vs 21.2 ± 6.8°, r = 0.69; P = 0.019) of knee flexion and 6 nm at 0°(51.1 ± 37.7° vs 38.6 ± 30.1°, r = 0.90; P = 0.0), 30°(64.6 ± 21.6° vs 54.3 ± 15.1°, r = 0.73; P = 0.011), 45°(67.7 ± 20.6° vs 55.5 ± 9.5°, r = 0.65; P = 0.029), 60°(62.9 ± 22.4° vs 45.8 ± 13.1°,r = 0.65; P = 0.031) and 90°(43.6 ± 17.6° vs 31.0 ± 6.3°, r = 0.62; P = 0.043) of knee flexion and at 9 nm at 0°(69.7 ± 40.0° vs 55.6 ± 30.6°, r = 0.86; P = 0.001) and 60°(74.5 ± 27.6° vs 57.1 ± 11.5°, r = 0.77; P = 0.006). No statistically significant correlation with 9 nm at 30°(79.2 ± 25.1° vs 66.9 ± 15.4°, r = 0.59; P = 0.055), 45°(80.7 ± 24.7° vs 65.5 ± 11.2°, r = 0.51; P = 0.11) and 90°(54.7 ± 21.1° vs 39.4 ± 8.2°, r = 0.55; P = 0.079). We recognize that 9 nm of torque may be not tolerated in vivo due to pain. Knee rotation was at its maximum at 45° of knee flexion and increased with increasing *** The skin pointer and knee rotation jig can be a reliable and simple means of quantifying knee rotational laxity with future clinical application.

关键词： Rotatometer Rottometer Knee Laxity Cruciate Biomechanics Measurement

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Naoxintong dose effects on inflammatory factor expression in the rat brain following focal cerebral ischemia

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Neural Regeneration Research 2008年第10期3卷 1111-1115页

作者： Xiangjian Zhang Li Xu Zuoran Chen Shuchao Hu Liying Zhang Haiyan Li Ruichun Liu Department of Neurology the Second Hospital of Hebei Medical University Shijiazhuang Department of Neurology Bejing Aerospace General Hospital Beijing 100076 China Department of Neurology Beijing Daxing Hospital of Capital University Beijing 102600 China Department of Neurology Beijing Shijingshan Hospital Beijing 100043 China Department of Neurology Beijing Shijitan Hospital Beijing 100038 China

BACKGROUND： Certain components of tetramethylpyrazine, a traditional Chinese medicine, exhibit protective effects against brain injury. OBJECTIVE： To investigate the effects of different Naoxintong doses on expression of nuclear factor-kappa B （ kB）, interleukin-6, tumor necrosis factor-α, and complement 3 in rats following focal cerebral ischemia. DESIGN, TIME AND SETTING： The randomized experiment was performed at the Laboratory of Neurology, Second hospital of Hebei Medical University from June 2004 to June 2006. MATERIALS： A total of 150 adult, healthy, male, Sprague Dawley rats, weighing 280-320g, were selected. Naoxintong powder （mainly comprising szechwan lovage rhizome, milkvetch root, danshen root, and radix angelicae sinensis） was obtained from Buchang Pharmacy Co., Ltd. in Xianyang City of Shanxi Province of China, lot number 040608. METHODS： The rats were randomly assigned into sham operation, saline, high-dose Naoxintong, moderate-dose Naoxintong, and low-dose Naoxintong groups, with 30 rats in each group. Rat models of middle cerebral artery occlusion were established using the suture method, with the exception of the sham operation group. Rats in the high-dose, moderate-dose and low-dose Naoxintong groups received 4, 2, and 1 g/kg Naoxintong respectively, by gavage. Rats in the saline group were treated with 1 mL saline by gavage All rats were administered by gavage at 5 and 23 hours following surgery, and subsequently, once per day. MAIN OUTCOME MEASURES： At 6, 24, 48, 72 hours, and 7 days following model establishment, brain water content was measured. Histopathological changes in brain tissues were detected using hematoxylin-eosin staining. Expression of nuclear factor- kB, interleukin-6, tumor necrosis factor- α, and complement 3 was examined by immunohistochemistry. RESULTS： A total of 150 rats were included in the final analysis with no loss. Brain water content was significantly increased in the ischemic hemisphere of rats from the saline, as w

关键词： brain ischemia complement 3 interleukin-6 Naoxintong nuclear factor-kB rat tumor necrosis factor-α

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Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 805-811页

作者： Qian Zhang Hong-Song Li Rong Li Jun-Hui Du Cong Jiao Center of Clinical aerospace Medicine School of Aerospace MedicineKey Laboratory of Aerospace Medicine of Ministry of EducationAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi'an Medical UniversityXi'an 710077Shaanxi ProvinceChina Department of Ophthalmology Xi’an Ninth Hospital Affiliated to Medical College of Xi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

AIM:To observe the role and mechanism of autophagy in retinal pigment epithelial cell(RPE)damaged by high glucose,so as to offer a new idea for the treatment of diabetic retinopathy(DR).METHODS:ARPE-19,a human RPE cell line cultured in vitro was divided into the normal control(NC),autophagy inhibitor 3-methyladenine(3-MA),high-glucose(HG),and HG+3-MA *** viability was detected by CCK-8 assay and the apoptosis rate was measured by flow *** protein expressions of apoptosis markers,including Bax,Bcl-2,and Caspase-3,as well as autophagy marker including microtubule-related protein 1 light chain 3(LC3),p62,and mechanistic target of rapamycin(m TOR)were detected by Western *** flux was detected by transfection with Ad-m Cherry-GFP-LC3 ***:Under high glucose conditions,the viability of ARPE-19 was decreased,and the apoptosis rate increased,the protein expressions of Bax,Caspase-3,and LC3-II/LC3-I were all increased and the expressions of Bcl-2,p62 and p-m TOR decreased,and autophagic flux was increased compared with that of the *** with 3-MA reversed all these changes caused by high ***:The current study demonstrates the mechanisms of cell damage of ARPE-19 through high glucose/m TOR/autophagy/apoptosis pathway,and new strategies for DR may be developed based on autophagy regulation to manage cell death of RPE cells.

关键词： diabetic retinopathy retinal pigment epithelial cell apoptosis autophagy the mechanistic target of rapamycin(mTOR)

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RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis

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Virologica Sinica 2023年第5期38卷 741-754页

作者： Yue Si Haijun Zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang Zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv Xijing Zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin Zhang Hongwei Ma Department of Microbiology School of Basic MedicineAir Force Medical UniversityXi'an710032China Department of Neurology Xijing HospitalAir Force Medical UniversityXi'an710032China Center of Clinical aerospace Medicine School of Aerospace MedicineKey Laboratory of Aerospace Medicine of Ministry of EducationAir Force Medical UniversityXi'an710032China Department of Anesthesiology&Critical Care Medicine Xijing HospitalAir Force Medical UniversityXi'an710032China The College of Life Sciences and Medicine Northwest UniversityXi'an710069China

Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)***,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains ***,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 ***-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral ***3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I ***,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV ***3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune ***,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase ***,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV.

关键词： Hantaan virus(HTNV) RIPK3 Interferons IFN-stimulated genes STAT1 Innate immune response

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Numerical study on dynamic mechanism of brain volume and shear deformation under blast loading

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Acta Mechanica Sinica 2019年第5期35卷 1104-1119页

作者： Zhijie Li Zhibo Du Xiaochuan You Zhanli Liu Jian Cheng Chengcheng Luo Dongyang Chu Shaowu Ning Yue Kang Ce Yang Zhuo Zhuang School of aerospace Engineering Tsinghua UniversityBeijing 100084China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Daping hospital Army Medical UniversityChongqing 400038China

Blast-induced traumatic brain injury(b-TBI)is a kind of significant injury to soldiers in the current military ***,the mechanism of b-TBI has not been well understood,and even there are some contradictory *** is crucial to reveal the dynamic mechanism of brain volume and shear deformations under blast loading for better understanding of *** this paper,the numerical simulation method is adopted to carry out comprehensive and in-depth researches on this issue for the first *** on the coupled Eulerian-Lagrangian method,the fluid-structure coupling model of the blast wave and human head is developed to simulate two situations,namely the head subjected to the frontal and lateral *** simulation results are analyzed to obtain the underlying dynamic mechanisms of brain *** brain volume deformation is dominated by the local bending vibration of the skull,and the corresponding frequency for the forehead skull under the frontal impact and the lateral skull faced to the lateral impact is as high as 8 kHz and 5 kHz,*** leads to the high-frequency fluctuation of brain pressure and the large pressure gradient along the skull,totally different from the dynamic response of brain under head *** the brain shear deformation mainly depends on the relative tangential displacement between the skull and brain and the anatomical structure of inner skull,being not related to the brain pressure and its *** further comparing the medical statistics,it is inferred that diffuse axonal injury and brain contusion,the two most common types of b-TBI,are mainly attributed to brain shear *** the von Mises stress can be adopted as the indicator for these two brain *** study can provide theoretical guidance for the diagnosis of b-TBI and the development of protective equipment.

关键词： Blast-induced traumatic brain injury Numerical head model Fluid-structure coupling model Diffuse axonal injury Brain contusion

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Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression

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World Journal of Gastroenterology 2014年第11期20卷 3011-3017页

作者： Sang Hwa Lee Sung-Im Do Hyun-Soo Kim Department of Pathology Aerospace Medicine Research CenterAerospace Medical CenterRepublic of Korea Air ForceChungcheongbuk-do 363-849South Korea Department of Pathology Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea

AIM: To investigate the effect of hypoxia or hyperoxia on the progression of hepatic fibrosis and to examine the role of transforming growth factor-β (TGF-β) in the livers of rats exposed to hypoxic or hyperoxic con... 详细信息

关键词： Hepatic fibrosis, Cirrhosis, Hypoxia, Hyperoxia, Transforming growth factor-β

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Severe graft-versus-host disease post allogeneic hematopoietic stem cell transplantation due to loss of HLA heterozygosity in recipient lymphocytes after full graft rejection

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Cancer Innovation 2023年第4期2卷 312-317页

作者： Song Xue Lili Miao Zimu Gong Wenqiu Huang Yongping Zhang Fuhong Liu Jingbo Wang Department of Hematology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijingChina Beijing Bo Fu Rui Gene Diagnostics Co. LtdBeijingChina Cancer Center Houston Methodist HospitalHoustonTexasUSA

Germ cell tumors complicated by hematological malignancy(HM)are a rare clinical *** hematopoietic stem cell transplantation(allo-HSCT)is a potentially effective therapy,but graft-versus-host disease(GVHD)is a life-threatening *** report a case of a 13-year-old female patient diagnosed with germ cell tumors followed by acute lymphoblastic *** chemotherapy,she received allo-HSCT and her chimerism rate decreased rapidly to near zero by 6 months without evidence of HM ***,she developed severe,multiorgan GVHD-like *** analysis revealed the pathogenesis of GVHD to be loss of HLA heterozygosity in recipient hematopoietic cells.

关键词： chimerism germcelltumors graft-versus-host disease heterozygosity stemcell transplantation

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Fibrous Fractionation of Cocoa Pod Husks Alkali Extraction

Fibrous Fractionation of Cocoa Pod Husks Alkali Extraction

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中国营养学会第十五届全国营养科学大会

作者： Jia Wang aerospace Center hospital aerospace Center hospital (ASCH)

Cellulose, hemicellulose and lignin from cocoa pod husks were fractionated by alkali solution by using 0.5 mol/L 1.0 mol/L 1.5 mol/L concentration of NaOH for 3 hours in total. The raw materials were pretreated by 1-Cycle and 2-Cycle to obtain cellulose hemicellulose and lignin. The effects of three different concentration extraction solutions and two extraction methods on cellulose yield were compared and chemical and physical properties including water retention capacity, oil retention capacity were analyzed. In this paper, the high yield(52.8%-90.5%) of the total dietary fiber was extracted by alkali extraction. The relatively high total dietary fiber(> 50%) content of cacao pod husks indicates good dietary fiber potential. The hemicellulose(7%-15.8%) extracted in 2-Cycles was less than the hemicellulose extracted in 1-Cycle(7.6%-13.7%). The chemical and physical properties including water retention capacity and oil retention capacity were also characterized. Describe the monosaccharides composition of hemicellulose extracted by 1-Cycles. Results showed that the WRC(4.37 g-6.80 g/g) of hemicellulose increased as the concentration of the alkaline solution increased during the extraction process. Conversely, as the concentration of the alkaline solution increased, the ORC decreased(from 6.30 g to 3.76 g). Hemicellulose extracted by 1.5 mol/L NaOH showed shear thinning property, while hemicellulose extracted by 0.5 M NaOH observed more Newtonian fluid property. Methods Alkali extraction previously is shown as a promising method for the separation. 5 g of the dry mill sample was and mixed with 200 mls of three different concentrations of alkali solutions(0.5 mol/L NaOH, 1.0 mol/L NaOH and 1.5 mol/L NaOH) and stirred at 200 rpm, 50 °C. The project designed two extraction methods. 1-Cycle: extraction once. 200 ml NaOH was added in one portion, and extracted at 50 °C, 200 rpm for 3 hours, and then the next step centrifugation was carried out. 2-Cycle: extracted twice. F

关键词： cocoa pod husks dietary fiber hemicellulose chemical composition alkali extraction rheological properties

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Early changes to the extracellular space in the hippocampus under simulated microgravity conditions

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Science China(Life Sciences) 2022年第3期65卷 604-617页

作者： Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang Jiabin Lu Department of Radiology Peking University Third HospitalBeijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Department of Neurology Aerospace Center HospitalPeking University Aerospace Clinical CollegeBeijing 100039China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China NHC Key Laboratory of Medical Immunology Department of ImmunologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Radiology Aerospace Center HospitalPeking University Aerospace Clinical CollegeBeijing 100039China

The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains *** this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 *** tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both *** diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 *** alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 *** findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS.

关键词： brain extracellular space interstitial fluid interstitial system tracer-based magnetic resonance imaging simulated microgravity hindlimb-unloading

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Cholesterol modulating the orientation of His17 in hepatitis C virus p7 (5a) viroporin--A molecular dynamic simulation study

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Chinese Chemical Letters 2018年第5期29卷 719-723页

作者： Yuebin Zhang Xiangda Peng Hong Ren Huiying Chu Yan Li Guohui Li State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China aerospace Center hospital Bering 100049 China

Protein p7 of HCV is a 63 amino acid channel forming membrane protein essential for the progression ofviral infection and the sensitivity of this channel to small-molecule inhibitors renders p7 a potentialtarget for novel therapies against HCV infection. Previous biochemical experiments suggested that theHis17 of p7 is a pore-lining residue and solvated-exposed to participate in channel gating. However, arecent NMR structural identification of the p7 hexamer in dodecylphosphocholine （DPC） micellesindicated that the His17 is embedded into the protein matrix. In this work, we performed moleculardynamic simulations to bridge the controversial observations. Our results illustrated that byincorporating the cholesterol into DOPC membranes to mimic an actual membrane-like composition,the orientation of His17 in the hexameric bundles spontaneously access to the central pore region,indicating a versatile property of the p7 viroporin conformation that could be voluntarily influenced byits surrounding environments.

关键词： Hepatitis C virus p7 Viroporin Cholesterol Molecular dynamic simulation Conformational transition

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