Severe graft-versus-host disease post allogeneic hematopoietic stem cell transplantation due to loss of HLA heterozygosity in recipient lymphocytes after full graft rejection

作     者：Song Xue Lili Miao Zimu Gong Wenqiu Huang Yongping Zhang Fuhong Liu Jingbo Wang 

作者机构：Department of HematologyAerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijingChina Beijing Bo Fu Rui Gene Diagnostics Co.LtdBeijingChina Cancer CenterHouston Methodist HospitalHoustonTexasUSA 

出 版 物：《Cancer Innovation》 (肿瘤创新（英文）)

年 卷 期：2023年第2卷第4期

页      面：312-317页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：chimerism germcelltumors graft-versus-host disease heterozygosity stemcell transplantation 

摘      要：Germ cell tumors complicated by hematological malignancy(HM)are a rare clinical *** hematopoietic stem cell transplantation(allo-HSCT)is a potentially effective therapy,but graft-versus-host disease(GVHD)is a life-threatening *** report a case of a 13-year-old female patient diagnosed with germ cell tumors followed by acute lymphoblastic *** chemotherapy,she received allo-HSCT and her chimerism rate decreased rapidly to near zero by 6 months without evidence of HM ***,she developed severe,multiorgan GVHD-like *** analysis revealed the pathogenesis of GVHD to be loss of HLA heterozygosity in recipient hematopoietic cells.