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Superparamagnetic iron oxide nanoparticle regulates microbiota-gut-inner ear axis for hearing protection

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National Science Review 2024年第6期11卷 273-284页

作者： Zhanhang Guo Yunhao Wu Bo Chen Mengdie Kong Peng Xie Yan Li Dongfang Liu Renjie Chai Ning Gu Jiangsu Key Laboratory for biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast University Medical Science and Technology Innovation Center Shandong First Medical University &Shandong Academy of Medical Sciences State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast University Institute of Materials Science and Devices School of Materials Science and Engineering Suzhou University of Science and Technology Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &Interventional Radiology & Vascular Surgery Department of Radiology Medical School Zhongda Hospital Southeast University Co-Innovation Center of Neuroregeneration Nantong University School of Medical Technology Institute of Engineering MedicineBeijing Institute of Technology Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Southeast university Shenzhen research institute Cardiovascular Disease Research Center Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Medical School Nanjing University

Noise-induced hearing loss(NIHL) is a highly prevalent form of sensorineural hearing damage that has significant negative effects on individuals of all ages and there are no effective drugs approved by the US Food and Drug Administration. In this study, we unveil the potential of superparamagnetic iron oxide nanoparticle assembly(SPIOCA) to reshape the dysbiosis of gut microbiota for treating NIHL. This modulation inhibits intestinal inflammation and oxidative stress responses, protecting the integrity of the intestinal barrier. Consequently, it reduces the transportation of pathogens and inflammatory factors from the bloodstream to the cochlea. Additionally, gut microbiota-modulated SPIOCA-induced metabolic reprogramming in the gut–inner ear axis mainly depends on the regulation of the sphingolipid metabolic pathway, which further contributes to the restoration of hearing function. Our study confirms the role of the microbiota–gut–inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL and other microbiota dysbiosis-related diseases.

关键词： superparamagnetic iron oxide nanoparticle hearing loss gut microbiota inflammation sphingolipid metabolism microbiota–gut–inner ear axis

Effects of TiN film coating on electrochemical behaviors of nanotube formed Ti-xHf alloys

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中国有色金属学会会刊：英文版 2009年第4期19卷 857-861页

作者： Kang LEE Won-Gi KIM Joo-Young CHO Sang-Won EUN Han-Cheol CHOE Department of Dental Materials & Research Center of Nano-Interface Activation for biomaterials College of DentistryChosun University Department of Applied advanced Materials Korea Polytechnic Ⅴ Colleges

Ti-xHf(x=10%,20%,30% and 40%,mass fraction) alloys were prepared by arc melting,and the microstructure was controlled for 24 h at 1 000 ℃ in argon *** formation of nanotube was conducted by anodizing on Ti-Hf alloys in 1.0 mol/L H3PO4 electrolytes with small amounts of NaF at room *** then TiN coatings were coated by DC-sputtering on the anodized *** and nanotube morphology of the alloys were examined by field emission scanning electron microscopy(FE-SEM) and X-ray diffractometry(XRD).The corrosion properties of the specimens were examined through potentiodynamic test(potential range from -1 500 to 2 000 mV) in 0.9 % NaCl solution by *** microstructure shows the acicular phase and α' phase with Hf *** amorphous oxide surface is transformed to crystalline anatase *** coated nanotube surface has a good corrosion resistance.

关键词：氮化钛涂层合金制备纳米管电化学行为薄膜包衣 0.9%NaCl溶液扫描电子显微镜微观结构

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The effects of deformation parameters and cooling rates on the aging behavior of AZ80+0.4%Ce

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Journal of Magnesium and Alloys 2024年第2期12卷 639-658页

作者： Yongbiao Yang Jinxuan Guo Cuiying Wang Ting Yan Zhang Wenxuan Jiang Zhimin Zhang Qiang Wang Guojun Li Jun Wang College of Materials Science and Engineering North University of ChinaLane 3Xueyuan RoadTaiyuanShanxiChina030051 State Key Laboratory of advanced Stainless Steel Materials Taiyuan Iron Steel(Group)Co.Ltd.Taiyuan 030003China Technology Center Shanxi Taigang Stainless Steel Co.Ltd.Taiyuan 030003China

The extruded AZ80+0.4%Ce magnesium alloy was twisted in the temperature range of 300-380℃by using a Gleeble 3500 thermal simulation test machine with a torsion *** deformed cylindrical specimens were cooled at a cooling rate of 10℃/s or 0.1℃/s,respectively,and aged at 170℃.The microstructure analysis results showed that the grain size decreased with increasing specimen radial position from center(SRPC),and that the strong initial basal texture of the extruded magnesium alloy was *** continuous and discontinuous dynamic recrystallization mechanisms were involved in contributing to the grain refinement for all specimens *** a novel extension twinning induced dynamic recrystallization mechanism was proposed for specimen deformed at 300℃.For the specimens deformed at 300℃and 340℃followed by a slow cooling rate(0.1℃/s),precipitates of various shapes(β-Mg_(17)Al_(12)),with the dominant precipitates being on the grains boundaries,appeared on the surface *** specimen deformed at 380℃,lamellar precipitates(LPS)in the interiors of the grains were *** aging,the LPS still dominated for specimens twisted at 380℃;however,the LPS gradually decreased with decreasing deformation temperatures from 380℃to 300℃.Dynamically precipitatedβ,especially those decorating the grain boundaries,changed the competition pictures for the LPS and precipitates of other shapes after ***,LPS dominated the areas for the center section of the specimens after aging regardless of deformation *** temperature deformation with high SRPC followed by rapid cooling rate increased the micro hardness of the alloy after aging due to refined grain,reduced precipitates size,decreased lamellar spacing as well as strain hardening.

关键词： AZ80+0.4%Ce magnesium alloy Hot torsion Deformation parameters Cooling rate Aging Micro hardness

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Development of D_α band symmetrical visible optical diagnostic for boundary reconstruction on EAST tokamak

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Plasma Science and Technology 2024年第2期26卷 44-53页

作者：陈明沈飊 Shinichiro KADO 郭笔豪陈大龙蔡福瑞肖炳甲 Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031People's Republic of China Science Island Branch Graduate School of University of Science and Technology of ChinaHefei 230026People's Republic of China Institute of advanced Energy Kyoto UniversityUji 611-0011Japan Graduate School of Energy Science Kyoto UniversityUji 611-0011Japan

To investigate the potential of utilizing visible spectral imaging for controlling the plasma boundary shape during stable operation of plasma in future tokamak, a D_α band symmetric visible light diagnostic system was designed and implemented on the Experimental advanced Superconducting Tokamak(EAST). This system leverages two symmetric optics for joint plasma imaging. The optical system exhibits a spatial resolution less than 2 mm at the poloidal cross-section, distortion within the field of view below 10%, and relative illumination of 91%.The high-quality images obtained enable clear observation of both the plasma boundary position and the characteristics of components within the vacuum vessel. Following system calibration and coordinate transformation, the image coordinate boundary features are mapped to the tokamak coordinate system. Utilizing this system, the plasma boundary was reconstructed, and the resulting representation showed alignment with the EFIT(Equilibrium Fitting) results. This underscores the system's superior performance in boundary reconstruction applications and provides a diagnostic foundation for boundary shape control based on visible spectral imaging.

关键词： visible optical diagnostic plasma boundary reconstruction EAST

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Photosynthetic co-culture system of algae and human umbilical vein endothelial cells:The effect on alleviating hypoxia and hypoxia/reoxygenation injury

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Biosurface and Biotribology 2024年第2期10卷 76-88页

作者： Donghu Lin Yuanyuan Chen Xinyu Tao Xin Che Shiyu Li Shiyu Cheng Shuxin Qu Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Laboratory of advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina School of Life Science and Engineering Southwest Jiaotong UniversityChengduSichuanChina

It is a developed photosynthetic co-culture system to alleviate the hypoxia and hypoxia/reoxygenation(H/R)-injured human umbilical vein endothelial cells(HUVECs).The algae,Chlorella vulgaris,were encapsulated to slow their growth while not affecting the photosynthetic oxygen-producing capacity by Layer-by-layer(LbL)using gelatin and sodium alginate as the positive and negative charges materials,***,the photosynthetic co-culture system of HUVECs and self-oxygenating alginate hydrogel(Algae-gel)was constructed in which the optimal ratios between algae and HUVECs were 5:1 and 20:1 for a 2D or 3D co-cultured manner,*** indicated that the 3D cocultured manner of HUVECs needed more O_(2) by the production of algae than it did in a 2D co-cultured *** co-cultured Algae-gel could alleviate hypoxia and the oxidative stress injury of hypoxia and hypoxia/reoxygenation(H/R)-treated HUVECs in the proliferation,intracellular ROS and cellular migratory *** addition,the Algaegel could downregulate the expression of hypoxia-inducible factors 1α(HIF-1α)and vascular endothelial growth factor(VEGF)of hypoxia and H/R-injured HUVECs due to the improvement of hypoxia and H/R *** photosynthetic co-culture system could offer a promising approach for repairing hypoxia and H/R-injured cells or tissue by providing safe and stable O_(2).

关键词： biomaterials biomedical application bionic design regenerative medicine self-assembly tissue engineering

MOF-derived Fe based catalysts for efficiently advanced Oxidation Processes: From single atoms to diatomic and nanoparticles

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Progress in Natural Science:Materials International 2023年第4期33卷 534-543页

作者： Xinyi Yang Jiewen Qin Zhichao Dai Yunqiang Sun Hongmei Liu Xiuwen Zheng Zunfu Hu School of Chemistry and Chemical Engineering Linyi University Key Laboratory of advanced biomaterials and Nanomedicine in Universities of Shandong School of Physics and Electronic Engineering Linyi University Qilu Normal University

Sub-nanometer catalysts have drawn great attention based on their superior catalytic activity and extensive application in advanced oxidation processes(AOPs). Nonetheless, the precise regulation of the coordination environment and exploration of the peroxymonosulfate(PMS) activation mechanism remain the focus of ***, we report the preparation of Fe catalysts with diverse sizes, including single atoms(SAs), double atoms(DAs), and nanoparticles(NPs) via adjusting the precursor. Sub-nanometric Fe catalysts exhibit a higher catalytic activity for Bisphenol A(BPA) degradation. It is confirmed that the catalytic activity of the Fe diatomic catalysts(Fe2–N/C) is 2.5 times that of the Fe single-atom catalysts(Fe1–N/C) and 8.3 times that of the Fe-nanoparticleloaded catalysts(FeNP–N/C). Broad pH adaptation ranges and reusability have also been proved. Based on experimental verification and density functional theory, non-free radical pathways dominate the degradation process of BPA, while free radical pathways are in an auxiliary position, accompanied by electron transfer *** is found that the synergistic effect of Fe2–N6sites and pyridinic N adsorption centers contribute to the ultra-high catalytic activity of Fe2–N/C. This work opens up an efficient way for single atom catalysts-based advanced oxidation processes for the efficient removal of refractory organic pollutants.

关键词： Fe diatomic catalysts advanced oxidation processes Non-free radical pathways Double reaction sites High efficiency degradation

Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance

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Nano Research 2020年第11期13卷 2958-2966页

作者： Shiyang Shen Li Zhang Mengru Li Zhizi Feng Huixia Li Xiao Xu Shiqi Lin Ping Li Can Zhang Xiaojun Xu Ran Mo State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Advanced Pharmaceuticals and BiomaterialsChina Pharmaceutical UniversityNanjing210009China

Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 *** lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin ***,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory *** nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)*** obtained cNC displays significantly higher stability than *** moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA ***-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse ***-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice.

关键词： small interfering RNA(siRNA)delivery collaborative assembly nanomedicine insulin resistance diabetes

Foregut tuberculosis:Too close but miles apart

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World Journal of Clinical Cases 2024年第32期12卷 6517-6525页

作者： Yumna Shahid Muhammad Aarish Anis Shahab Abid Department of Medicine Section of GastroenterologyAga Khan University HospitalKarachi 74800Pakistan Medical College Aga Khan University HospitalKarachi 74800Pakistan

The worldwide burden of tuberculosis(TB)has increased and it can involve virtually any organ of the *** TB accounts for about 2%of the cases of TB *** ileocecal region is the most commonly affected site,and the foregut is rarely *** reported incidence is approximately 0.5%.Esophageal TB presents with dysphagia,weight loss,and hematemesis in rare *** TB usually manifests with symptoms such as nausea,vomiting,weight loss,and sometimes with gastric outlet *** may reveal shallow ulcers in stomach and duodenal deformity when underlying TB is suspected,therefore histopathology plays pivotal *** computed tomography,duodenal TB typically manifests as duodenal strictures predominantly,accompanied by extrinsic compression,and occasionally as intraluminal *** their diagnosis can easily be missed if proper biopsies are not taken and samples are not sent for GeneXpert testing,TB polymerase chain reaction investigation and histopathological *** being in close proximity to the lungs,the esophagus and stomach are rare sites of *** reasons could be low gastric pH and acidity which does not let mycobacterium *** there are various case reports of TB involving the *** have summarized the rare cases of foregut TB in different sections and highlighted the importance of esophagogastroduodenoscopy,histopathology and advanced techniques like endoscopic ultrasound in establishing the diagnosis.

关键词： Foregut Tuberculosis Gastroduodenal Esophagogastroduodenoscopy Mycobacterium Caseating granulomas

The structure,formation,and effect of plasma protein layer on the blood contact materials:A review

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Biosurface and Biotribology 2022年第1期8卷 1-14页

作者： Xiao Chen Jiang Chen Nan Huang Institute of biomaterials and Surface Engineering Key Lab.for Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengduChina

Understanding material-protein interactions is the basis for regulating material-blood interactions,which is a common topic of interest for medical material *** recent years,researchers have conducted extensive studies on(1)the structural charac-teristics of the plasma protein adsorption layer on the material surface,including the evolution of the protein adsorption layer and its typical binary structure.(2)Influence factors of the protein adsorption layer formation include protein factors(e.g.,isoelectric point,structural stability),material factors(e.g.,wettability,surface charge,morphology,size),and environmental factors.(3)Effects of some common plasma proteins in the protein adsorption layer on material-blood ***,we review the important research results in this field,hoping to provide a reference for future development of advanced blood contact materials.

关键词： blood contact material protein adsorption protein adsorption layer protein conformation plasma protein Vroman effect