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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine acupuncture and moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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Protective mechanisms of Tuina therapy against lipopolysaccharide-induced fever in young rabbits based on untargeted metabolomics analysis

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Journal of Traditional Chinese Medicine 2023年第4期43卷 725-733页

作者： LIU Di ZHANG Yingqi YU Tianyuan LIU Zhifeng JIAO Yi WANG Hourong XU Yajing GUAN Qian CHEN Lulu HU Hui School of acupuncture-moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102401China Department of acupuncture-moxibustion Beijing Massage HospitalBeijing 100035China Department of acupuncture-moxibustion Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To investigate the effect of Tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant ***:Twenty-four infant New Zealand rabbits were selected and randomly divided into three groups:saline,model,and *** fever model was established by injecting LPS intravenously through the ear margin vein in the model group and Tuina group,*** modeling was considered successful when the anal temperature increased by 0.5℃or above within 1 *** the Tuina group,six Tuina techniques(i.e.,opening Tianmen/the heaven gate,pushing Kangong/the superciliary arch,kneading Taiyang and the prominent bone behind the ears,clearing Tianheshui,spine pinching)that alleviate fever were performed on the young rabbits 1 h after the modeling,whereas the model and saline groups were not given Tuina treatment,with the real-time anal temperature monitored during the *** plasma was taken 3 h after the modeling for liquid chromatography-mass spectrometry(LC-MS)untargeted metabolomics ***:Our results showed a fever-reducing effects of Tuina therapy on lipopolysaccharide-induced fever in young rabbits,as indicated by a significantly lower anal temperature,maximum rise in body temperature,and body response index at 2 and 3 h after modeling in the Tuina group compared to the model group,with reductions in the PGE2 expression observed in the blood and *** differential metabolites including riboflavin,nicotinamide N-oxide,porphobilinogen,5-hydroxyindoleacetic acid,gamma-aminobutyric acid,and lysoPC(16:1(9Z)/0:0)were found following the Tuina *** primarily involves glycine-serinethreonine,arginine-proline,porphyrin-chlorophyll,pyrimidine,primary bile acid biosynthesis,and cyanoamino acid metabolic ***:Tuina therapy has proven to be effective in reducing body temperature and down-regulating PGE2 expression in LPS-induced febrile young rabbits,with its mechanism of fever-reducing action poss

关键词： fever pediatrics metabolomics Lipopolysaccharides riboflavin glycine Tuina therapy

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Effects of nape acupuncture combined with swallowing rehabilitation on dysphagia in pseudobulbar palsy

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Journal of Traditional Chinese Medicine 2018年第1期38卷 117-124页

作者： Liu Xiaoping Chen Feiyu Chu Jiamei Bao Yehua Department of acupuncture-moxibustion and Rehabilitation Hangzhou Hospital of Traditional Chinese Medicine

OBJECTIVE: To evaluate the therapeutic effects of nape acupuncture combined with rehabilitative swallowing training for dysphagia caused by pseudobulbar palsy, and to compare it with rehabilitative swallowing training alone, and to observe the improvement in quality of life after the ***: One hundred patients were randomly divided into two groups: the rehabilitative swallowing training group(control group, n = 50) and the nape acupuncture combined with rehabilitative swallowing training group(experimental group,n = 50). Each group had 8 weeks' therapy, 5 times a week. Patients in the control group received rehabilitative swallowing training, while those in the experimental group received nape acupuncture therapy based on swallowing rehabilitation. The out-comes were assessed by the repetitive saliva-swallowing test(RSST), water swallow test(WST), standardized swallowing assessment(SSA), and a swallow quality-of-life questionnaire(SWAL-QOL). Correlations of onset age, onset frequency and lesion location with the efficacy of the acupuncture treatment were also ***: The scores for RSST, WST, and SSA in both groups were lower than before the therapy(P acupuncture was not correlated with location(P > 0.05), but was related to onset age(P acupuncture combined with rehabilitative swallowing training has an effect on dysphagia caused by pseudobulbar palsy and improves quality of life.

关键词： Deglutition disorders Pseudobulbar palsy Quality of life Age of onset Nape acupunc- ture Rehabilitative swallowing training

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Effect of acupuncture at Renying(ST 9) on gene expression profile of hypothalamus in spontaneously hypertensive rats

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Journal of Traditional Chinese Medicine 2018年第2期38卷 227-241页

作者： Guo Yan Lu Juan Liang Jingrong Zhao Ruili Xu Jing Zhang Wei Park Kibeum Zhu Shipeng Chen Huan Ma Liangxiao Department of acupuncture and moxibustion First Hospital Affiliated to Tianjin College of Traditional Chinese Medicine College of acupuncture-moxibustion and Tuina Beijing University of Chinese Medicine College of acupuncture-moxibustion and Tuina Second School of Clinical Medical of Nanjing University of Traditional Chinese Medicine Department of acupuncture and moxibustion Jiangsu Province Hospital

OBJECTIVE: To investigate changes in gene expression profiles in the hypothalamus related to the effects of acupuncture at the Renying(ST 9) acupoint in spontaneously hypertensive(SH) ***: We randomly divided 18 SH rats into Renying(ST 9) group and model control group, 9 body weight-matched Wistar-Kyoto rats were used as blank controls. acupuncture was performed manually for 20-min daily over 28 d in the Renying(ST 9) group. Rat Gene 2.0 array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction(RT-PCR) ***: The different groups exhibited differential gene expression: compared with the blank control group, 48 genes were up-regulated and 91 genes were down-regulated in the model group;compared with the model group, 79 genes were up-regulated and 80 genes were down-regulated in Renying(ST 9) group. The RT-PCR results of the key genes including Chi3 l1, Ephx2, Klk1, 5-HT1 A and Cbs were consistent with that of gene chip ***: acupuncture at Renying(ST 9)could significantly lower the blood pressure of SH rats and affect their hypothalamic gene expression profile. Genes associated with the contraction of vascular smooth muscle and the regulation of inflammation, neurotransmitters may be involved in acupuncture's antihypertensive mechanism.

关键词： Essential hypertension Point ST 9(Re-nying) Oligonucleotide array sequence analysis Hypothalamus

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Effect of scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on neutrophil-to-lymphocyte ratio and quality of life in patients with non-small-cell lung cancer: A randomized,controlled trial

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Journal of Traditional Chinese Medicine 2018年第3期38卷 439-446页

作者： Zhang Mengxue Guan Ling Wang Lili Li Ying Department of acupuncture and moxibustion Chinese People's Liberation Army General Hospital

OBJECTIVE: To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on the neutrophil-to-lymphocyte ratio(NLR) and quality of life in patients with non-small-cell lung cancer(NSCLC).METHODS: Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) every day for 6 weeks, while group B received no intervention(control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 ***: Five participants dropped out, leaving afinal total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B(P moxibustion by heat-stimulating the acupoints Zusanli(ST 36) and Feishu(BL13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.

关键词： Carcinoma non-small-cell lung Scar-ring moxibustion Point ST36 (Zusanli) Point BL13(Feishu) Immunity Neutrophils Lymphocytes Quality of life Randomized controlled trial

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acupuncture at heterotopic acupoints enhances jejunal motility in constipated and diarrheic rats

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World Journal of Gastroenterology 2014年第48期20卷 18271-18283页

作者： Qing-Guang Qin Xin-Yan Gao Kun Liu Xiao-Chun Yu Liang Li Hai-Ping Wang Bing Zhu Department of Physiology Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Department of acupuncture and moxibustion Henan Orthopedics Hospital Institute of acupuncture and moxibustion China Academy of Chinese Medical Sciences Shanxi University of Traditional Chinese Medicine

AIM: To investigate the effect and mechanism of acupuncture at heterotopic acupoints on jejunal motility, particularly in pathological conditions.

关键词： acupuncture Heterotopic acupoint LI11 ST37 BL25 Jejunal motility Constipation Diarrhea C fibers Muscarinic receptors

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Effect of herb-partitioned moxibustion on dopamine levels and dopamine receptor 1 expression in the colon and central nervous system in rats with Crohn’s disease

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Journal of Traditional Chinese Medicine 2019年第3期39卷 356-363页

作者： Lu Yuan Zheng Handan Lü Tingting Ma Zhe Wu Huangan Xu Manwen Weng Zhijun Feng Hui Zhang Fang Ding Guanghong Wu Luyi Liu Huirong Department of Mechanics and Engineering Science Fudan University Shanghai 200433China Shanghai Research Institute of acupuncture and Meridian Shanghai 200030 China Department of acupuncture and moxibustion Huashan Hospital Shanghai 200040 China Department of acupuncture and moxibustion and Tuina Guanghua Hospital Shanghai 200052 China

OBJECTIVE:To observe the effect of herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints in rats with Crohn's disease,and explore the underlying mechanism from dopamine (DA) and dopamine receptor 1 (D1 R) in the colon,spinal dorsal horn and ***:The rats were randomly divided into the normal,model (CD),herb-partitioned moxibustion (Mox) and mesalazine (Mesa) *** in the colons was scored and observed by hematoxylin and eosin *** and D1R protein expression in the colonic mucosa were detected by *** concentrations of DA and D1R in the spinal dorsal horn and hypothalamus were measured by enzyme-linked immunosorbent assay,and D1R mRNA expression was evaluated by quantitative real-time polymerase chain ***:In the colon,compared with the normal group,DA,D1 R protein expressions and D1 R mRNA expression were significantly higher in the model group,while decreased in the Mox group and the Mesa *** the spinal dorsal horn and hypothalamus,compared with the normal group,the concentrations of DA and D1 R,and the D1R mRNA expressions were significantly higher in the model group,and decreased in the Mox group and the Mesa ***:Herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints relieved ulceration in CD rats,the underlying mechanism maybe relative with the regulation of DA and D1R in the colon,spinal dorsal horn and hypothalamus by moxibustion.

关键词： Crohn disease Dopamine Receptors,dopamine Neuropeptides Point ST25 (Tianshu) Point CV6 (Qihai) Herb-partitioned moxibustion

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Efficacy and safety of electroacupuncture for insomnia:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第4期22卷 459-472页

作者： Han-yu Xu Lin-na Wu Yuan Zhang Te Ba Xiao-feng Zhao acupuncture and moxibustion Department First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for Chinese Medicine acupuncture and moxibustion Tianjin 300193China

Background:Electroacupuncture is often used to treat ***:To evaluate the efficacy and safety of electroacupuncture for *** strategy:Databases including PubMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Literature Database,China National Knowledge Infrastructure,Wanfang Data and VIP Fulltext e-Journals Database were searched up to January 15,*** criteria:Randomized clinical trials were included if they compared the clinical efficacy and safety of electroacupuncture with sham acupuncture,no treatment or usual care (UC) and general *** extraction and analysis:The full texts of the studies were reviewed to remove ineligible *** extracted data included authors,publication year,diagnostic criteria,sample size,population characteristics,interventions and *** above steps were performed independently by two reviewers and the data were cross ***15.0 software was used to analyze the extracted outcome *** continuous data (Pittsburgh Sleep Quality Index[PSQI]score and Insomnia Severity Index score),weighted mean difference (WMD) was calculated and 95% confidence interval (CI) was reported when the same scale was *** dichotomous variables (clinical response rate and adverse events),a meta-analysis was performed using risk ratio (RR) as the effect ***:Thirty-one trials with 2226 subjects were *** meta-analysis suggested that electroacupuncture was more effective in improving insomnia compared with the control group (sham acupuncture,no treatment,UC and general acupuncture)(RR=1.21;95 CI:[1.16,1.27]),significantly reducing the PSQI score in insomnia patients after treatment and at follow-up (WMD=-3.23;95%CI:[-4.29,-2.17];Pacupuncture and no treatment or ***=1.48;95%CI:[0.91,2.40];P=0.117).In addition,the regression results revealed t

关键词： Electroacupuncture Insomnia Systematic review Meta-analysis

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Effects of acupuncture on functional gastrointestinal disorders:special effects,coeffects,synergistic effects in terms of single or compatible acupoints

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Journal of Traditional Chinese Medicine 2023年第2期43卷 397-408页

作者： ZHAO Jun LI Xia ZHENG Hui YE Kun WANG Xin WANG Xuefei SUN Runquan LI Zhigang School of acupuncture-moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Chengdu University of Traditional Chinese Medicine Chengdu 610075China Department of acupuncture and moxibustion The Sixth Medical Center of PLA General HospitalBeijing 100048China Department of acupuncture and moxibustion Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China

OBJECTIVE:To investigate how the“special effect”/“coeffect”/“synergistic effect”can achieve a positive result using an“acupuncture prescription”for functional gastrointestinal disorders(FGIDs)in clinical practice,based on the characteristics of single/compatible acupoints and acupuncture ***:According to the search strategy,we searched six electronic bibliographic databases and provided a summary for this ***:A large body of evidence has shown that acupuncture has positive effects in the treatment of ***,the“prescription”intervention involved different single acupoints,compatible acupoints and acupoints based on expert ***:The core acupoints,including Tianshu(ST25),Zusanli(ST36),and Shangjuxu(ST37),emphasize the application of special acupoints,meridian points and nerve segments,and the two-way regulatory effect found in this study is often used as the basis of acupoint selection and acupoint prescription for acupuncture treatment of FGIDs.

关键词： acupuncture gastrointestinal diseases acupuncture points special effects co-effects synergistic effects

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Molecular Mechanism of Electroacupuncture Regulating Cerebral Arterial Contractile Protein in Rats with Cerebral Infarction Based on MLCK Pathway

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Chinese Journal of Integrative Medicine 2023年第1期29卷 61-68页

作者： LI Jing ZHANG Min HE Ying DU Yuan-hao ZHANG Xue-zhu Rainer Georgi Bernhard Kolberg Xu Yan-long Institute of acupuncture and moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin300193China Max Planck Institute for Medical Research Heidelberg69120Germany Uniklinik Mannheim Mannheim68167Germany Department of acupuncture and moxibustion Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou730050China

Objective To explore the effect of electroacupuncture(EA)intervention on the vasoconstriction of cerebral artery smooth muscle cells after cerebral *** Male Wistar rats were randomly divided into 3 groups by a random number table:the model group(n=24),the EA group(n=24),and the normal group(n=6).The model and the EA groups were divided into different time subgroups at 0.5,1,3,and 6 h after middle cerebral artery occlusion(MCAO),with 6 rats in each *** model was established using intraluminal suture occlusion *** EA group was given EA treatment at acupoint Shuigou(GV 26)instantly after MCAO for 20 *** contents of cerebrovascular smooth muscle MLCK,the 3 subunits of myosin light chain phosphatase(MLCP)MYPT1,PP1c-δand M20,as well as myosin-ATPase activity were detected using immunohistochemistry and Western *** The overall expression level of the MYPT1 and PP1c-δin the model group was significantly higher(P0.05),and the other subgroups were still significantly higher than the normal group(P<0.01).After EA intervention,the expression level of each subgroup was significantly lower than the corresponding model *** was a significant difference between the 0.5 and 1 h subgroups(P<0.01),while a difference was also observed between the 3 and 6 h subgroups(P<0.05).The dynamic change rule gradually increased with the prolongation of infarction time within 6 h after *** EA intervention can inhibit contraction of cerebral vascular smooth muscle cells and regulate smooth muscle relaxation by regulating MLCK pathway.

关键词： infarction vasomotor MLCK pathway Shuigou(GV 26) electroacupuncture

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