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Efficacy and safety of electroacupuncture for insomnia:A systematic review and meta-analysis

Journal of Integrative Medicine 2024年第4期22卷 459-472页

作者： Han-yu Xu Lin-na Wu Yuan Zhang Te Ba Xiao-feng Zhao acupuncture and Moxibustion Department First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for Chinese Medicine acupuncture and Moxibustion Tianjin 300193China

Background:Electroacupuncture is often used to treat ***:To evaluate the efficacy and safety of electroacupuncture for *** strategy:Databases including PubMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Literature Database,China National Knowledge Infrastructure,Wanfang Data and VIP Fulltext e-Journals Database were searched up to January 15,*** criteria:Randomized clinical trials were included if they compared the clinical efficacy and safety of electroacupuncture with sham acupuncture,no treatment or usual care (UC) and general *** extraction and analysis:The full texts of the studies were reviewed to remove ineligible *** extracted data included authors,publication year,diagnostic criteria,sample size,population characteristics,interventions and *** above steps were performed independently by two reviewers and the data were cross ***15.0 software was used to analyze the extracted outcome *** continuous data (Pittsburgh Sleep Quality Index[PSQI]score and Insomnia Severity Index score),weighted mean difference (WMD) was calculated and 95% confidence interval (CI) was reported when the same scale was *** dichotomous variables (clinical response rate and adverse events),a meta-analysis was performed using risk ratio (RR) as the effect ***:Thirty-one trials with 2226 subjects were *** meta-analysis suggested that electroacupuncture was more effective in improving insomnia compared with the control group (sham acupuncture,no treatment,UC and general acupuncture)(RR=1.21;95 CI:[1.16,1.27]),significantly reducing the PSQI score in insomnia patients after treatment and at follow-up (WMD=-3.23;95%CI:[-4.29,-2.17];Pacupuncture and no treatment or ***=1.48;95%CI:[0.91,2.40];P=0.117).In addition,the regression results revealed t

关键词： Electroacupuncture Insomnia Systematic review Meta-analysis

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The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

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Neural Regeneration Research 2024年第1期19卷 22-28页

作者： Caiyun Liu Haixin Yu Zhengchao Li Shulian Chen Xiaoyin Li Xuyi Chen Bo Chen school of acupuncture&Moxibustion and tuina Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupucture Science Tianjin University of Traditional Chinese MedicineTianjinChina Characteristic Medical Center of Chinese People’s Armed Police Force TianjinChina Binhai New Area hospital of TCM TianjinChina Fourth teaching hospital of Tianjin University of TCM TianjinChina

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system *** present,no effective clinical treatment *** one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord ***,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord *** hibernation is a futureoriented disruptive technology for human life *** involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold ***,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia *** review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation *** summarizes the relevant research on hypothermia and hibernation for organ and nerve *** studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central *** also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine *** review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial *** present,artificial hibernation technology is not mature,and research fa ces various *** rtheless,the effort is wo rthwhi

关键词： artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor

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Acute Metabolic Complications of Diabetes in the Oueme-Plateau Provincial teaching hospital: Epidemiological, Clinical, Paraclinical and Evolutionary Aspects

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Open Journal of Internal Medicine 2024年第1期14卷 83-92页

作者： Finangnon Armand Wanvoegbe Comlan Jules Gninkoun Hubert Dedjan Kouessi Anthelme Agbodande Van Carrel Yongolo Prosper Singbo Elisé Boko Manchouhoud Alalade Adele Cakpo Ingrid Thomas Angele Azon Kouanou Internal Medicine Department Oueme-Plateau Provincial Teaching Hospital Porto-Novo Benin Endocrinology Department Hubert Koutoukou Maga National Teaching Hospital Cotonou Benin Endocrinology Department Oueme-Plateau Provincial Teaching Hospital Porto-Novo Benin Internal Medicine Department Hubert Koutoukou Maga National Teaching Hospital Cotonou Benin

Introduction: Diabetes mellitus, a metabolic disease, is now an important public health problem across the world. Our aim was to study the epidemiological, clinical, paraclinical, and evolutionary aspects of acute metabolic complications (AMC) of diabetes in the endocrinology department of the Oueme-Plateau Provincial teaching hospital. Methods: This was a descriptive cross-sectional study with data collection based on the medical records of patients presenting with acute metabolic complications of diabetes in the endocrinology department of the Oueme-Plateau Provincial teaching hospital during the 3 years study period (from January 2020 to December 2022). Results: Over 788 patients hospitalized during the study period, 157 had an acute metabolic complication of diabetes, which is a hospital prevalence of 19.9%. Among these 157 cases, 140 were suitable for analysis and therefore constituted our study sample. The mean age of the patients was 49.9 ± 14.7 years, with 19 as minimum and 90 years as maximum. Most of them were women (52.4%). Hypertensive diabetics accounted for 54.9% of cases. Ketoacidosis was the most common complication (62.1%), followed by hyperosmolar hyperglycemic syndrome (23.6%) and hypoglycemia (14.3%). Infection (69.3%) and therapeutic noncompliance (22.9%) were the most common triggers. The average length period of their hospital stay was 7.1 ± 5.1 days, and the outcome was satisfactory in 87.9% of the cases. Unfortunately, there were 3.6% deaths during hospitalization. Conclusion: Acute metabolic complications of diabetes were dominated by ketoacidosis. Infection was the dominant factor in decompensation. Therapeutic education of diabetic patients as well as clinical and biological monitoring must be more stringent and rigorous.

关键词： Acute Metabolic Complications Diabetes Ketoacidosis Porto-Novo

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Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2024年第3期19卷 619-628页

作者： Jun Chang Yujiao Li Xiaoqian Shan Xi Chen Xuhe Yan Jianwei Liu Lan Zhao First teaching hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine acupuncture and Moxibustion TianjinChina Tianjin University of Traditional Chinese Medicine TianjinChina

Recent studies have demonstrated that neuroplasticity,such as synaptic plasticity and neurogenesis,exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer’s ***,promoting neuroplasticity may represent an effective strategy with which Alzheimer’s disease can be *** to their significant ability to self-renew,differentiate,and migrate,neural stem cells play an essential role in reversing synaptic and neuronal damage,reducing the pathology of Alzheimer’s disease,including amyloid-β,tau protein,and neuroinflammation,and secreting neurotrophic factors and growth factors that are related to *** events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the mammalian ***,neural stem cells are considered to represent a potential regenerative therapy with which to improve Alzheimer’s disease and other neurodegenerative *** this review,we discuss how neural stem cells regulate neuroplasticity and optimize their effects to enhance their potential for treating Alzheimer’s disease in the clinic.

关键词： Alzheimer’s disease amyloid-β cell therapy extracellular vesicle neural stem cell synaptic plasticity tau

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Effects of anterior sciatic nerve acupuncture on lower limb paralysis after cerebral infarction:study protocol for a randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第1期44卷 205-211页

作者： LI Menghan WANG Yu RAN Dawei YANG Xinming DENG Shizhe SHI Lei MENG Zhihong Department of acupuncture First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for Chinese Medicine acupuncture and Moxibustion Tianjin 300193China Graduate department Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Massage and Rehabilitation Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

Stroke is the main cause of disability in the middle and old ***,especially lower limb paralysis,often leads to the loss of self-care ability and a series of secondary *** main method to improve hemiplegic limb movement is exercise therapy,but there are still many patients with disabilities after rehabilitation *** one of the non-pharmacological therapies for stroke,acupuncture has been recognized to improve motor function in ***,we propose a new method,anterior sciatic nerve acupuncture,which can stimulate both the femoral nerve and the sciatic *** designed this study to determine the effect of this method on lower limb motor *** participants recruited with hemiplegia after cerebral infarction will be randomly assigned to the test group or control group in a 1:1 *** control group will receive Xingnao Kaiqiao acupuncture,and the test group will receive anterior sciatic nerve acupuncture on this *** participants will get acupuncture treatment once a day,6 times a week for 2 *** primary outcome is Fugl-Meyer Assessment of Lower Extremity and the secondary outcomes are Modified Ashworth Scale and Modified Barthel *** will be collected before treatment,1week after treatment,and 2 weeks after treatment,and then statistical analysis will be *** study can preliminarily verify the effect of anterior sciatic nerve acupuncture on improving lower limb motor function in patients with cerebral infarction,which may provide an alternative approach for clinical treatment of hemiplegia.

关键词： anterior sciatic nerve acupuncture paralysis cerebral infarction Xingnao Kaiqiao clinical protocols

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Post Episiotomy Morbidity among Parturient in Alex Ekwueme Federal University teaching hospital Abakaliki, Ebonyi State

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1144-1160页

作者： John Chinedu Obasi Ayodele Adegbite Olaleye Boniface N. Ejikeme John O. Egede Charles Nwambeke Edene Enemma Christian Enemma Victor Onuchukwu Emmanuel Onyekelu Nathan C. Ekpe Wendy Oliobi Emmanuel C. Uwakwe Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital AbakalikiNigeria

Background: Episiotomy is a very common obstetric surgery, and it could be associated with serious complications. However, these complications largely are not noticed due to the shift of attention from mother to baby, after a successful delivery. Objective: To identify the morbidities associated with episiotomies and factors associated with such morbidities. Method: This was a questionnaire based cross sectional descriptive study among women who attended the Obstetric Department of Alex Ekwueme Federal University teaching hospital Abakaliki Ebonyi State, between 1st July and 31st Nov, 2023. The study population consisted of parturients who had episiotomies in their previous confinements, attending either the antenatal clinic or the postnatal clinic at Alex Ekwueme Federal University teaching hospital Abakaliki Ebonyi State. Results: Macrosomia was the most common indication of episiotomy at a rate of 31.6%. The majority of episiotomies were performed on the parturients in their first confinement at a rate of 64.5% and the majority of repairs were performed by the Registrar at a rate of 65.0%. Informed consent was obtained from 45.79% of parturients while 54.21% were not informed before the episiotomy was administered. Only 55.3% of the parturient received analgesia before episiotomy was administered. The majority of the parturients had their episiotomy repaired between 10 - 15 minutes at a rate of 40.3%. Postoperative pain at the rate of 44.5% was the most common complication and dyspareunia as a form of sexual complication was the commonest at a rate of 31.3%. Conclusion: The parturient needs to be properly counselled before administration of episiotomy and adequate analgesia should be given, as episiotomy is a surgical procedure. Proper training of health workers on both the technique of administering and repairing episiotomy is important. Restrictive use of routine episiotomy in primigravidae is advised to reduce the rate of episiotomy.

关键词： Episiotomy Vulva Pains Primigravidae Morbidities Analgesia

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Cuproptosis:A potential therapeutic target in clear cell renal cell carcinoma

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Chinese Medical Journal 2024年第11期137卷 1378-1380页

作者： Yuetong Zhao Jie Li Xiaojie Lu Shuang Wu Yunze Xing Yaxuan Fang Bo Yang Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of Nephrology National Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China

To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological *** ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in *** studies have shown that intracellular copper accumulation can cause oxidative stress and disrupt cellular function.[1]Different from apoptosis,autophagy,pyroptosis,and ferroptosis,cuproptosis is a newly discovered type of cell death in 2022.[2]It is mediated by protein lipoylation with ferredoxin 1(FDX1)in *** most common pathological type of kidney cancer in adults is clear cell renal cell carcinoma(ccRCC),which accounts for 70-80%of all cases of renal cell carcinoma(RCC).[3]Currently,surgical resection is the preferred treatment for RCC,as radiotherapy,chemotherapy,and immunotherapy have shown limited effectiveness in treating ***,cuproptosis induction may offer a new approach for ccRCC treatment.

关键词： metabolism chemotherapy potential

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Acceptability of Caesarean Section among Pregnant Women Seeking Antenatal Care at Women and Newborn hospital-University teaching hospitals, Lusaka Zambia

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 721-743页

作者： Huhenya Sharon Chongo Maureen Masumo Namayipo Nankamba Lusaka College of Nursing and Midwifery University Teaching Hospital Lusaka Zambia Department of Midwifery Women and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia

Caesarean section remains one of the most common obstetric and major operations performed on women during pregnancy and has contributed to improving maternal and foetal health. Consequently, significant mortality and morbidity from pregnancy and labour-related causes can be eliminated by a timely caesarean section. The acceptance of the life-saving procedure remains unsatisfactory in most sub-Saharan nations. The study aimed to assess the acceptability of caesarean section and associated factors among pregnant women seeking antenatal care at Women and Newborn hospital-University teaching hospitals in Lusaka Zambia. The study utilised a quantitative cross-sectional analytical study design involving 420 pregnant women selected using systematic random sampling at Women and Newborn hospital-University teaching hospitals Lusaka Zambia. Data was obtained using an Interview schedule and analysed using R software version 4.3.2. Chi-square, Fisher’s exact test, Wilcoxon rank sum test and binary logistic regression for statistical analysis at a 5% level of significance. The study found that the acceptability of Caesarean section as a mode of delivery was low (29%) among respondents at Women and Newborn hospital-University teaching hospitals. This was influenced by marital status (P = 0.002), socioeconomic status (P = 0.050), parity (P = 0.004), gestation age (P = 0.008), previous history of caesarean section (P = 0.003), knowledge (P hospital-University teaching hospitals, despite its potential benefits for maternal and neonatal health. Socio-demographic and maternal characteristics, knowledge, attitude, perception, and socio-cultural beliefs play a major role in determining acceptability. Therefore, efforts to enhance acceptability should focus on improving knowledge, enhancing positive perceptions and attitudes, an

关键词： Caesareans Section Acceptability Knowledge Attitude Perception

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Endoscopic Internal Urethrotomy in the Treatment of Male Urethral Stenosis in the Urology-Andrology Department of KARA teaching hospital (Togo)

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Open Journal of Urology 2024年第1期14卷 20-26页

作者： Musapudi Éric Mbuya Komi Hola Sikpa Edoe Viyome Sewa Messan Semefa Agbedey Gnimdou Botcho Kodjo Tengue Tchilabalo Matchonna Kpatcha Urology and Andrology Department Kara Teaching Hospital Kara Togo Urology and Andrology Department Hubert Koutoukou Maga National Teaching Hospital Cotonou Benin Surgery Department University Clinics of Lubumbashi Lubumbashi DRC Aneho Prefectural hospital Center Aneho Togo Urology and Andrology Department Kpalime Prefectural Hospital Center Kpalime Togo Urology and Andrology Department Sokodé Regional Hospital Center Sokodé Togo Urology and Andrology Department Sylvanus Olympio Teaching Hospital Lomé Togo

Introduction: Endoscopic internal urethrotomy (EIU) is a method for stricture opening using transurethral incision by direct visualisation of the urethral channel, resulting in a widening of the urinary canal with the aim of improving the quality of bladder emptying. The aim of the study was to evaluate the indication and results of EIU in the treatment of stenosis of the male urethra in the Urology-Andrology Department of Kara teaching hospital. Methodology: This was a cross-sectional descriptive study with retrospective data collection in the Urology-Andrology department of Kara teaching hospital. It involved 21 records of patients with urethral stenosis treated by endoscopic internal urethrotomy (EIU) in the said department during the period from January 2021 to September 2023. The following variables were evaluated: age, circumstance of discovery, site, length, number, etiology of the urethral stenosis and evolution of the patients. Results: The mean age of the patients was 59.2 ± 11.7 years. Infectious etiology of stenosis was predominant with 10 patients (47.6%) followed by trauma with 5 cases (23.8%). The bulbar urethra was the most frequently observed site, with 11 cases (52.4%). The length was mostly less than 2 cm in 12 patients (57.1%). Stenosis was unique in 14 patients (66.7%). The mean postoperative follow-up time was 3.2 months. The result was immediately better in 11 patients (52.4%) and it was poor in 8 patients (38.1%) who required maintenance dilation sessions.

关键词： Internal Urethrotomy Urethral Stenosis Kara Togo

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Evaluation of Antibiotic Prescribing in the Pediatric Department of Gabriel Touréteaching hospital, Bamako, Mali

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Open Journal of Pediatrics 2024年第3期14卷 645-656页

作者： Pierre Togo Hawa Konaré Mariam Maïga Karamoko Sacko Djénéba Konaté Abdoul Karim Doumbia Adama Dembélé Oumar Coulibaly Aminata Sangaré Mohamed Elmouloud Cissé Fousseyni Traoré Belco Maïga Ibrahim Ahamadou Aminata Doumbia Lala N’Drany Sidibé Amadou Touré Yacouba Aba Coulibaly Kalirou Traoré Tati Simaga Souleymane Sagara Leyla Bagna Maïga Bory Traoré Abdoul Aziz Diakité Fatoumata Dicko Mariam Sylla Sounkalo Dao Boubacar Togo Paediatric Department Gabriel Tour&#233 Teaching Hospital Bamako Mali Pediatric Department Distric VI Reference Health Center Bamako Mali Infectious Diseases Department Point G Teaching Hospital Bamako Mali

Objectives: The main objective was to evaluate antibiotic prescribing in the Department of Pediatrics at Gabriel Touré teaching hospital. Methods: This was a prospective descriptive study conducted from September 1 to November 31, 2018, in the Department of Pediatrics at Gabriel Touré teaching hospital. All children aged 0 to 15 years hospitalized for any pathology during the study period and having received at least one antibiotic had been included. Results: We collected 445 children’s records out of 1032 admissions during the study period, representing a hospital frequency of 43.1%. The sex ratio was 1.3%. The 2 - 5 age group accounted for 48.1%. Fever was the reason for consultation in 45.6% of cases. Patients’ general condition was altered in 60% of cases. The fathers were blue-collar workers in 65.4% and the mothers housewives in 85%, and had no education in 42.9% and 64.5% respectively. Hepatomegaly was present in 18.2%, splenomegaly in 9.6% and peripheral adenopathy in 3.1%. The site of infection was pulmonary in 37.6% and ENT in 9.2%. Bacterial infection was assumed on admission in 54% of cases, and meningitis in 57.7%. The discharge diagnosis was malaria in 54.6%, severe acute malnutrition in 18.6% and meningitis in 6.7%. The death rate was 3.8%. Neutrophilic leukocytosis was present in 47.3% of patients. CRP was positive in 85% of patients. Blood cultures taken in 27.6% of patients were positive in 5. CSF analysis in 30% of patients showed elevated leukocytes in 6.5%. No cultures were positive. Antibiotic prescription was justified by infectious hypotheses in 43.1% of patients. β-lactam antibiotics were prescribed in 98.6%. Antibiotic therapy was not adapted to national/international recommendations in 68.3% of cases, and was not justified in 16.3% of cases on D5 of hospitalization. Conclusion: Antibiotic use was justified in more than half of patients, but remained inadequate in almost two-thirds of cases, in line with national and international recommend

关键词： Antibiotic Prescription hospitalization Child

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