The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

作     者：Caiyun Liu Haixin Yu Zhengchao Li Shulian Chen Xiaoyin Li Xuyi Chen Bo Chen Caiyun Liu;Haixin Yu;Zhengchao Li;Shulian Chen;Xiaoyin Li;Xuyi Chen;Bo Chen

作者机构：School of Acupuncture&Moxibustion and TuinaTianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupucture ScienceTianjin University of Traditional Chinese MedicineTianjinChina Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Binhai New Area Hospital of TCMTianjinChina Fourth Teaching Hospital of Tianjin University of TCMTianjinChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第1期

页      面：22-28页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the Key Projects of the National Natural Science Foundation of China,No.11932013(to XC) Key Military Logistics Research Projects,No.B WJ21J002(to XC) the Key projects of the Special Zone for National Defence Innovation,No.21-163-12-ZT006002-13(to XC) the National Nature Science Foundation of China No.82272255(to XC) the National Defense Science and Technology Outstanding Youth Science Fund Program,No.2021-JCIQ-ZQ-035(to XC) the Scientific Research Innovation Team Project of Armed Police Characteristic Medical Center,No.KYCXTD0104(to ZL) the National Natural Science Foundation of China Youth Fund,No.82004467(to BC) 

主　　题：artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor 

摘      要：Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system *** present,no effective clinical treatment *** one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord ***,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord *** hibernation is a futureoriented disruptive technology for human life *** involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adaptto the external cold environment,and reduce the physiological resistance to cold ***,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia *** review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation *** summarizes the relevant research on hypothermia and hibernation for organ and nerve *** studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central *** also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine *** review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial *** present,artificial hibernation technology is not mature,and research fa ces various *** rtheless,the effort is wo rthwhi