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Synthesis and characterization of reporter molecules embedded core-shell nanoparticles as SERS nanotags

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Journal of Innovative Optical Health Sciences 2021年第4期4卷 94-103页

作者： Chloe Duffield Nana Lyu Yuling Wang Department of Molecular Sciences arc centre of excellence for nanoscale biophotonics Faculty of Science and Engineering Macquarie University SydneyNSW 2109Australia

Surface-enhanced Raman scattering(SERS)spectroscopy is presented as a sensitive and spe-cific molecular tool for clinical diagnosis and prognosis monitoring of various diseases including *** order for clinical application of SERS technique,an ideal method of bulk synthesis of SERS nanoparticles is necessary to obtain sensitive,stable and highly reproducible Raman *** this contribution,we determined the ideal conditions for bulk synthesis of Raman reporter(Ra)molecules embedded silver-gold core-shell nanoparticles(Au@Ra@AgNPs)using hydroquinone as reducing agent of silver *** using UV-Vis spectroscopy,Raman spectroscopy and transmission electron microscopy(TEM),we found that a 2∶1 ratio of silver nitrate to hydroquinone is ideal for a uniform silver coating with a strong and stable Raman *** stability testing of the optimized Au@Ra@AgNPs over a two-week period,these SERS nanotags were found to be stable with minimal signal change *** sta-bility of antibody linked SERS nanotags is also crucial for cancer and disease diagnosis,thus,we further conjugated the as-prepared SERS nanotags with anti-EpCAM antibody,in which the stability of bioconjugated SERS nanotags was tested over eight *** UV-Vis and SERS spectroscopy showed stable absorption and Raman signals on the anti-EpCAM conju-gated SERS nanotags,indicating the great potential of the synthesized SERS nanotags for future applications which require large,reproducible and uniform quantities in order for cancer biomarker diagnosis and monitoring.

关键词： surface-enhanced Raman spectroscopy gold nanoparticles Raman reporter mole-cules SERS nanotags and bioconjugation

Synthesis of strong SiV photoluminescent diamond particles on silica optical fiber by chemical vapor deposition

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Chinese Physics B 2018年第3期27卷 481-486页

作者： Zongchun Yang Yingshuang Mei Chengke Chen Yinlan Ruan Xiaojun Hu College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China arc centre of excellence in nanoscale biophotonics Institute of Photonics and Advanced SensingThe University of AdelaideAdelaideSA 5005Australia

The separated silicon-vacancy(SiV)photoluminescent diamond particles were synthesized on a silica optical fiber by hot filament chemical vapor deposition(HFCVD).The effects of the pre-treated method and chamber pressure on the microstructure and photoluminescence of the diamond particles were *** results show that the diamond particles are homogeneously distributed on the surface of the optical *** the chamber pressure increasing from 1.6 kPa to 3.5 kPa,the shape of the particles transforms from flake to circle,while the diamond particles cannot be deposited on the fiber with the pressure further increased to 4.5 *** samples synthesized under 2.5 kPa chamber pressure are composed of diamond particles with size around 200-400 nm,exhibiting stronger SiV photoluminescence with the width of around 6 nm.

关键词： diamond silicon vacancy photoluminescence optical fiber

A Non-Singular Boundary Element Method for Interactions between Acoustical Field Sources and Structures

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Advances in Applied Mathematics and Mechanics 2023年第4期15卷 831-851页

作者： Qiang Sun Australian Research Council centre of excellence for nanoscale biophotonics School of ScienceRMIT UniversityMelbourneVIC 3001Australia

Localized point sources(monopoles)in an acoustical domain are implemented to a three dimensional non-singular Helmholtz boundary element method in the frequency *** allows for the straightforward use of higher order surface elements on the boundaries of the *** will been shown that the effect of the monopole sources ends up on the right hand side of the resulting matrix *** carefully selected examples are studied,such as point sources near and within a concentric spherical core-shell scatterer(with theoretical verification),near a curved focusing surface and near a multi-scale and multi-domain acoustic lens.

关键词： Acoustic monopoles acoustic lens boundary integral method quadratic elements

SERS Nanotags and Their Applications in Biosensing and Bioimaging

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Journal of Analysis and Testing 2018年第1期2卷 26-44页

作者： Wei Zhang Lianmei Jiang James APiper Yuling Wang Department of Molecular Sciences Macquarie UniversitySydneyNSW 2109Australia arc centre of excellence for nanoscale biophotonics(CNBP) Macquarie UniversitySydneyNSW 2109Australia Department of Physics and Astronomy Macquarie UniversitySydneyNSW 2109Australia

Owing to the unique advantages of surface enhanced Raman scattering(SERS)in high sensitivity,specificity,multiplexing capability and photostability,it has been widely used in many applications,among which SERS biosensing and bioimaging are the focus in recent *** successful applications of SERS for non-invasive biomarker detection and bioimaging under in vitro,in vivo and ex vivo conditions,offer significant clinical information to improve diagnostic and prognostic *** review provides recent developments and applications of SERS,in particular SERS nanotags in biosensing and bioimaging,describing case studies in which different types of biomarkers have been investigated,as well as outlining future challenges that need to be addressed before SERS sees both pathological and clinical use.

关键词： SERS Plasmonic nanostructure Nanotags Biosensing Bioimaging Biomarker

Helmholtz equation and non-singular boundary elements applied to multi-disciplinary physical problems

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Communications in Theoretical Physics 2022年第8期74卷 18-34页

作者： Evert Klaseboer Qiang Sun Institute of High Performance Computing 1 Fusionopolis WaySingapore 138632Singapore Australian Research Council centre of excellence for nanoscale biophotonics School of ScienceRMIT UniversityMelbourneVIC 3001Australia

The famous scientist Hermann von Helmholtz was born 200 years *** complex physical wave phenomena in engineering can effectively be described using one or a set of equations named after him:the Helmholtz *** this has been known for a long time,from a theoretical point of view,the actual numerical implementation has often been hindered by divergence-free and/or curlfree *** is further a need for a numerical method that is accurate,reliable and takes into account radiation conditions at *** classical boundary element method satisfies the last condition,yet one has to deal with singularities in the *** review here how a recently developed singularity-free three-dimensional boundary element framework with superior accuracy can be used to tackle such problems only using one or a few Helmholtz equations with higher order(quadratic)elements which can tackle complex curved *** are given for acoustics(a Helmholtz resonator among others)and electromagnetic scattering.

关键词： acoustics Helmholtz cavity electromagnetics scattering boundary integral method

Resolution and contrast enhancement of laser-scanning multiphoton microscopy using thulium-doped upconversion nanoparticles

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Nano Research 2019年第12期12卷 2933-2940页

作者： Alexey B.Kostyuk Artem D.Vorotnov Andrey V.Ivanov Arthur B.Volovetskiy Aleksandr V.Kruglov Lyudmila M.Sencha Liuen Liang Evgenii L.Guryev Vladimir A.Vodeneev Sergey M.Deyev Yiqing Lu Andrei V.Zvyagin Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod 603950Russia Center of Biomedical Engineering Institute of Molecular MedicineSechenov UniversityMoscow 119991Russia arc centre of excellence"nanoscale biophotonics" Department of Physics and AstronomyMacquarie UniversitySydney 2109Australia Institute ofBioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia

High-contrast optical imagi ng is achievable using phosphoresce nt labels to suppress the short-lived background due to the optical backscatterand autofluoresce ***,the long-lived phosphorescence is generally incompatible with high-speed laser-scan ning imaging ***,we show that upc on versi on nan oparticles of structure NaYF4:Yb co-doped with 8%Tm(8T-UCNP)in combi nation with a commerciallaser-scanning multiphoton microscopy are uniquely suited for labeling biological systems to acquire high-resolution images with the enhancedcon *** comparison with many phosphoresce nt labels,the 8T-UCNP emission lifetime of-15μs affords rapid image ***-order optical nonlinearity of the 8T-UCNP(n=4,as confirmed experimentally and theoretically)afforded pushing the resolution limitattain able with UCNPs to the *** contrast enha nceme nt was achieved by suppressing the backgro und using(i)ban dpassspectral filtering of the narrow emission peak of 8T-UCNP at 455-nm,and(ii)time-gating implemented with a time-correlated single-photon counting system that demonstrated the contrast enhancement of>2.5-fold of polyethyle neimine-coated 8T-UCNPs take n up by huma nbreast adeno carcinoma cells *** a result,discrete 8T-UCNP nan oparticles became clearly observable in the freshly excised splee ntissue of laboratory mice 15-min post in trave nous injectio n of an 8T-UCNP *** dem on strated approach paves the way forhigh-contrast,high-resoluti on,and high-speed multiphot on microscopy in challe nging envir onments of i ntense autofluorescence,exogenous staining,and turbidity,as typically occur in intravital imaging.

关键词： upconversion nanoparticles autofluorescence time-gated imaging scanning microscopy time-correlated single photon counting

New groups of solutions to the Whitham-Broer-Kaup equation

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Applied Mathematics and Mechanics(English Edition) 2020年第11期41卷 1735-1746页

作者： Yaji WANG Hang XU Q.SUN State Key Lab of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Australian Research Council centre of excellence for nanoscale biophotonics School of ScienceRMIT UniversityMelbourneVIC 3001Australia

The Whitham-Broer-Kaup model is widely used to study the tsunami *** classical Whitham-Broer-Kaup equations are re-investigated in detail by the generalized projective Riccati-equation method.20 sets of solutions are obtained of which,to the best of the authors’knowledge,some have not been reported in *** analysis of the planar dynamical systems is then used to show different phase portraits of the traveling wave solutions under various parametric conditions.

关键词： Whitham-Broer-Kaup equation travelling wave bifurcation analysis projective Riccati-equation method

Large-area gold nanohole arrays fabricated by one-step method for surface plasmon resonance biochemical sensing

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Science China(Life Sciences) 2018年第4期61卷 476-482页

作者： Huijie Qi Lihong Niu Jie Zhang Jian Chen Shujie Wang Jingjing Yang Siyi Guo Tom Lawson Bingyang Shi Chunpeng Song State Key Laboratory of Cotton Biology Key Laboratory of Plant Stress Biology School of Life SciencesHenan University Key Laboratory for Special Functional Materials of Ministry of Education Henan University International Joint centre for Biomedical Innovation School of Life Sciences Henan University arc centre of nanoscale biophotonics Macquarie University

Surface plasmon resonance(SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal nanoimprinting in the matrix of IPS(Intermediate Polymer Stamp). No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.

关键词： gold nanohole arrays one-step method nanoimprinting nanosensor biomolccular binding

On-chip structure-switching aptamer-modified magnetic nanobeads for the continuous monitoring of interferon-gamma ex vivo

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Microsystems & Nanoengineering 2019年第1期5卷 281-291页

作者： Guozhen Liu Chaomin Cao Shengnan Ni Shilun Feng Hui Wei Graduate School of Biomedical Engineering ARC Centre of Excellence in Nanoscale Biophotonics(CNBP)Faculty of EngineeringThe University of New South WalesSydneyNSW 2052Australia Australian centre for NanoMedicine UNSW SydneySydneyNSW 2052Australia International Joint Research Center for Intelligent Biosensor Technology and Health College of ChemistryCentral China Normal University430079 WuhanPR China School of Engineering Faculty of Science and EngineeringMacquarie UniversitySydneyNSW 2109Australia

Cytokines are cell signaling molecules that indicate the health status of the *** this study,we developed a microfluidic device integrated with structure-switching aptamers capable of continuously tracking the concentration of the cytokine interferon gamma(IFN-γ)in cell culture medium and blood ***,a ferrocene(Fc)-labeled structure-switching signaling aptamer with a hairpin structure targeting IFN-γwas immobilized on magnetic nanobeads by the strongest noncovalent interactions between streptavidin and *** aptamer-modified magnetic nanobeads were trapped on a customized microfluidic chip by a magnetic field to form the sensing *** binding of IFN-γcould trigger the hairpin structure of the aptamer to unfold,pushing Fc redox molecules away from the sensing interface and consequently switching off the electrochemical *** change in the redox current of Fc was quantitatively related to the concentration of IFN-γin a linear range of 10–500 pg mL^(−1)and with the lowest detection limit of 6 pgmL^(−1).This microfluidic device was specific to IFN-γin the presence of overabundant serum proteins and allowed the continuous monitoring of IFN-γwithout adding exogenous *** provided a universal point-of-care biosensing platform for the real-time detection of a spectrum of analytes.

关键词： beads structure magnetic