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Diagnosis of Crohn's disease in India where tuberculosis is widely prevalent

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World Journal of Gastroenterology 2008年第5期14卷 741-746页

作者： Deepak N Amarapurkar Nikhil D Patel Priyamvada S Rane Department of Gastroenterology Bombay Hospital & Medical Research Centre Mumbai 400025 India

AIM:To define the parameters that positively predict diagnosis of Crohn's disease (CD) and differentiate it from gastrointestinal tuberculosis (GITB). METHODS:This prospective study over 3 years was carried out in the consecutive Indian patients with definite diagnosis of CD and equal numbers of patients with definite diagnosis of GITB. Demographic, clinical, laboratory, morphological and histological features were noted in all the patients. Serological tests such as p-anca, c-anca, IgA ASCA and IgG ASCA, were performed. Endoscopic biopsy and/or surgical tissue specimens were subjected to smear and culture for acid-fast bacilli (AFB) and tissue polymerase chain reaction for tuberculosis (TB PCR). Diagnosis of CD and GITB was based on the standard criteria. Data were analyzed using univariate Chi-square test and multiple logistic regression (MLR). RESULTS:The study is comprised of 26 patients with CD (age 36.6 ± 8.6 year, male:female, 16:10) and 26 patients with GITB (age 37.2 ± 9.6 year, male:female, 15:11). The following clinical variables between the two groups (CD vs TB) were significant in univariate analysis:duration of symptoms (58.1 ± 9.8 vs 7.2 ± 3.4 mo), diarrhoea (69.2% vs 34.6%), bleeding per rectum (30.7% vs 3.8%), fever (23.1% vs 69.2%), ascites (7.7% vs 34.6%) and extra-intestinal manifestations of inflammatory bowel disease (61.5% vs 23.1%). Of these, all except ascites and extra-colonic manifestations were found statistically significant by MLR. Accuracy of predicting CD was 84.62% based on the fever, bleeding P/R, diarrhoea and duration of symptoms while it was 63.4% when histology was reported as inflammatory bowel disease and 42.3% when there was recurrence of disease after surgery. Accuracy of predicting GITB was 73.1% when there was co-existing pulmonary lesions and/or abdominal lymphadenopathy;75% when tuberculosis was reported in histology;63.4% when granuloma was found in histology;82.6% when TB PCR was positive;and 61.5% when smear and/ or c

关键词： Crohn's disease Gastrointestinal tuberculosis Differential diagnosis Inflammatory bowel disease Anti-neutrophil cytoplasmic antibody Anti-Saccharomyces Cerevisiae antibody Tissue polymerase chain reaction Mycobacterium Tuberculosis Acid-fact bacilli

The management of the long head of the biceps in rotator cuff repair:A comparative study of high *** tenodesis

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Journal of Sport and Health Science 2023年第5期12卷 613-618页

作者： Edoardo Franceschetti Edoardo Giovannetti de Sanctis Alessio Palumbo Michele Paciotti Luca La Verde Nicola Maffulli Francesco Franceschi Department of Orthopaedic and Trauma Surgery Campus Biomedico University of RomeVia Alvaro del Portillo 20000100 RomeItaly Department of Orthopaedics and Traumatology Catholic UniversityAgostino Gemelli Hospital00100 RomeItaly anca Surgical Center Via Francesco Maidalchini 20Roma00152RomeItaly Department of Musculoskeletal Disorders Via Salvador Allende4384081 BaronissiSalernoItaly centre for Sports and Exercise Medicine Barts and The London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondon E14DGEnglandUK School of Pharmacy and Bioengineering Keele University School of MedicineThornburrow DriveStoke on Trent ST4EnglandUK

Background:Tenodesis of the long head of the biceps(LHB)is commonly undertaken during arthroscopic rotator cuff *** assessed the clinical and structural outcomes after high arthroscopic tenodesis(HAT)or mini-open subpectoral tenodesis(ST).We hypothesized that the clinical and structural results after HAT and ST are ***:We included 40 patients with rotator cuff tear and LHB *** patients(7 women and 13 men;mean age:57.9 years;range:56-63 years)were treated using HAT,and 20 patients(8 women and 12 men;mean age:58.5 years;range:55-64 years)were treated using *** evaluation was performed preoperatively and at 6 weeks,6 months,and 1 year after surgery,using the Constant Murley Score and Simple Shoulder Test scores;the LHB was evaluated using the LHB score.A Visual Analogue Scale was administered to all patients preoperatively and 2 days after ***:The postoperative total and pain subscale’s Constant scores were significantly higher in the ST ***,2 LHB score values were significantly different between the *** postoperative LHB total score in the ST and HAT groups averaged 86.9±4.1(mean±SD)points and 73.3±6.4 points,*** Pain/Cramps subscale in the ST and HAT groups averaged 47.1±5.9 and 33.2±4.6 points,*** 2 groups showed no difference in Visual Analogue Scale values(5.5 in the HAT group;5.8 in the ST group)*** patient in the HAT group reported a secondary onset of Popeye ***:Both high arthroscopic and mini-open ST of the LHB tendon produced reliably good functional results,but the ST group was associated with better postoperative clinical outcomes.

关键词： Long head of the biceps Shoulder Shoulder arthroscopy Subpectoral TenodesisTagedEnd

anca-Associated Vasculitides—An Update

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Health 2014年第14期6卷 1767-1779页

作者： Johanna Kegel Torsten Kirsch Department of Nephrology and Hypertension Centre for Internal Medicine Hannover Medical School Hannover Germany

Anti-neutrophil cytoplasmic antibody (anca)-associated vasculitides are characterized by destruction of small vessels, granulomatous inflammation of the respiratory tract and necrotizing glomerulonephritis. This review describes the clinical diagnosis and therapy as well as the patho-physiology of anca-associated vasculitides with a specific focus on the interplay of ancas with activated neutrophils and the deleterious pathophysiological consequences of neutrophil-endothelium interaction.

关键词： Vasculitis Anti-Neutrophil Cytoplasmic Antibodies Neutrophils

Knights in Action： Lectin Receptor-Like Kinases in Plant Development and Stress Responses

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Molecular Plant 2013年第5期6卷 1405-1418页

作者： Neha Vaid anca Macovei Narendra Tuteja Plant Molecular Biology Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg New Delhi 110067 India

The Receptor-Like Kinase （RLK） is a vast protein family with over 600 genes in Arabidopsis and 1100 in rice. The Lectin RLK （LecRLK） family is believed to play crucial roles in saccharide signaling as well as stress perception. All the LecRLKs possess three domains： an N-terminal lectin domain, an intermediate transmembrane domain, and a C-terminal kinase domain. On the basis of lectin domain variability, LecRLKs have been subgrouped into three subclasses： L-, G-, and C-type LecRLKs. While the previous studies on LecRLKs were dedicated to classification, comparative structural analysis and expression analysis by promoter-based studies, most of the recent studies on LecRLKs have laid special emphasis on the potential of this gene family in regulating biotic/abiotic stress and developmental pathways in plants, thus mak- ing the prospects of studying the LecRLK-mediated regulatory mechanism exceptionally promising. In this review, we have described in detail the LecRLK gene family with respect to a historical, evolutionary, and structural point of view. Furthermore, we have laid emphasis on the LecRLKs roles in development, stress conditions, and hormonal response. We have also discussed the exciting research prospects offered by the current knowledge on the LecRLK gene family. The multitude of the LecRLK gene family members and their functional diversity mark these genes as both interesting and worthy candidates for further analysis, especially in the field of crop improvement.

关键词： classification hormone signaling Lectin Receptor-Like Kinase membrane protein plant development RLKfamily stress.

Molecular dynamics of pre-germinative metabolism in primed eggplant(Solanum melongena L.)seeds

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Horticulture Research 2020年第1期7卷 1599-1610页

作者： Chiara Forti Valentino Ottobrino Laura Bassolino Laura Toppino Giuseppe Leonardo Rotino Andrea Pagano anca Macovei Alma Balestrazzi Department of Biology and Biotechnology‘Lazzaro Spallanzani’ University of PaviaPaviaItaly CREA-Research centre for Genomics and Bioinformatics Montanaso LombardoLOItaly CREA-Research centre for Cereal and Industrial Crops BolognaItaly Institute of Plant Genetics Polish Academy of SciencesPoznanPoland

Seed priming,a pre-sowing technique that enhances the antioxidant/DNA repair activities during the pre-germinative metabolism,still retains empirical *** explore for the first time the molecular dynamics of pre-germinative metabolism in primed eggplant(Solanum melongena L.)seeds in order to identify hallmarks(expression patterns of antioxidant/DNA repair genes combined with free radical profiles)useful to discriminate between high-and lowquality *** hydropriming protocol hereby developed anticipated(or even rescued)germination,when applied to lots with variable ***(reactive oxygen species)raised during hydropriming and dropped after *** of antioxidant/DNA repair genes was observed during hydropriming and the subsequent *** of SmOGG1(8-oxoguanine glycosylase/lyase)gene detected in primed seeds at 2 h of imbibition appeared as a promising *** the basis of these results,the investigation was restricted within the first 2 h of imbibition,to verify whether the molecular landscape was reproducible in different lots.A complex pattern of antioxidant/DNA repair gene expression emerged,reflecting the preponderance of seed lot-specific *** the low-quality eggplant seeds subjected to hydropriming showed enhanced ROS levels,both in the dry and imbibed state,and this might be a useful signature to discriminate among *** plasticity of eggplant pre-germinative metabolism stimulated by priming imposes a plethora of heterogeneous molecular responses that might delay the search for quality ***,the information hereby gained could be translated to eggplant wild relatives to speed-up their use in breeding programs or other agronomical applications.

关键词： metabolism dynamics gained

Evaluating pediatric ureteropelvic junction obstruction:Dynamic magnetic resonance urography vs renal scintigraphy 99mtechnetium mercaptoacetyltriglycine

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World Journal of Radiology 2024年第3期16卷 49-57页

作者： Yousuf Al-Shaqsi Matthieu Peycelon Annabel Paye-Jaouen Elisabeth Carricaburu anca Tanase Christine Grapin-Dagorno Alaa El-Ghoneimi Department of Pediatric Surgery Sultan Qaboos University HospitalMuscat 123Oman Service de Chirurgie Viscérale et Urologie Pédiatrique Hôpital Universitaire Robert-DebréAssistance-Publique Hôpitaux de ParisParis 75019France centre de Références Maladies Rares Malformations Rares des Voies Urinaires(MARVU)Paris 97019France Facultéde Médecine Universitéde ParisParis 75006France Service d’Imagerie Pédiatrique Hôpital Universitaire Robert-DebréAssistance-Publique Hôpitaux de ParisParis 75019France UniversitéParis 13 Sorbonne Paris CitéParis 75013France

BACKGROUND Ureteropelvic junction obstruction(UPJO)is a common congenital urinary tract disorder in *** can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to symptomatic *** To evaluate the discrepancy between dynamic contrast-enhanced magnetic resonance urography(dMRU)and scintigraphy 99m-technetium mercaptoacetyltriglycine(MAG-3)for the functional evaluation of *** Between 2016 and 2020,126 patients with UPJO underwent surgery at Robert Debré*** these,83 received a prenatal diagnosis,and 43 were diagnosed during *** of the 126 patients underwent surgery based on the clinical situation and postnatal ultrasound findings without undergoing functional imaging *** renal function was evaluated preoperatively using scintigraphy MAG-3(n=28),dMRU(n=53),or both(n=40).In this study,we included patients who underwent surgery for UPJO and scintigraphy MAG-3+dMRU but excluded those who underwent only scintigraphy MAG-3 or *** patients were divided into groups A(10%discrepancy).We examined the discrepancy in split renal function between the two modalities and investigated the possible risk *** The split renal function between the two kidneys was compared in 40 patients(28 boys and 12 girls)using scintigraphy MAG-3 and *** renal function,as determined using both modalities,showed a difference of10%in 9 *** of the relative renal function using dMRU revealed an excellent correlation coefficient with renal scintigraphy MAG-3 for both *** Our findings demonstrated that dMRU is equivalent to scintigraphy MAG-3 for evaluating split renal function in patients with UPJO.

关键词： Uteropelvic junction obstruction Scintigraphy 99m-technetium mercaptoacetyltriglycine Magnetic resonance imaging Dynamic contrast-enhanced magnetic resonance urography

Calculous Eosinophilic Cholecystitis in Immunocompetent Patient

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Surgical Science 2022年第9期13卷 443-447页

作者： Mohamed Abughararah Haytham Alabbas Saud Almuhammad Department of Surgery Section of Hepatobiliary King Faisal Specialist Hospital and Research Centre Jeddah Saudi Arabia

We report a case of calculous eosinophilic cholecystitis (EC) without symptoms suggesting the presence of Eosinophilic Granulomatosis with Polyangiitis (EGPA). A 68 years old male immunocompetent, presented to the Emergency Department (ED), with a picture of acute calculous cholecystitis. Upon his presentation, laboratory investigations showed no leukocytosis nor elevation of eosinophils count in blood serum, however, neutrophils count in serum was found to be high (76%, normal range up to 70%), then two days later patient underwent laparoscopic cholecystectomy. His final histopathology showed a picture of Eosinophilic Cholecystitis, post-operative detailed history, laboratory test including Antinuclear Antibody (ANA), Antineutrophil cytoplasmic Antibody (anca), immunoglobulin, and chest X-ray ruled out the possibility of the systemic disease (EGPA, Churg Strauss syndrome), and confirmed that the eosinophilia was localized to the gallbladder, which caused the picture of acute cholecystitis, and was treated sufficiently with the laparoscopic cholecystectomy.

关键词： Cholecystitis Eosinophilic Granulomatosis Polyangiitis Churg Strauss Syndrome

Relapsing polychondritis with p-anca associated vasculitis: Which triggers the other?

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World Journal of Clinical Cases 2014年第12期2卷 912-917页

作者： Ibolya File Csilla Trinn Zsolt Mátyus László Ujhelyi József Balla János Mátyus Institute of Internal Medicine University of Debrecen Clinical Centre H-4032 Debrecen Hungary Borsod-Abaúj-Zemplén County and University Teaching Hospital 2nd Department of Internal Medicine H-3526 Miskolc Hungary

Relapsing polychondritis(RP) is a rare autoimmune disease with chronic inflammatory/destructive lesions of the cartilaginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostly with anti-neutrophil cytoplasmic antibody(anca) associated vasculitis(AAV). We report three cases of RP with p-anca positive AAV. In the first patient RP developed 1.5 years after the onset of AAV. In the others the signs of RP were present before the onset of severe crescent glomerulonephritis. Patients responded well on steroid and cyclophosphamide. In dialysis dependent cases plasmapheresis was also used successfully. During the 2 and 1.5 years of follow up, they were symptom-free, and had stable glomerular filtration rate. The first patient died after four years of follow-up due to the complications of sudden unset pancytopenia,which raises the possibility of associated hemophagocytic syndrome. In the setting of RP or AAV physicians should always be aware of the possibility of sudden or insidious appearance of the other disease.

关键词： Relapsing polychondritis Anti-neutrophil cytoplasmic antibody Anti-neutrophil cytoplasmic antibody-associated vasculitis Rapidly progressive glomerulonephritis Immunosuppressive treatment

An automated multiwell plate reading flim microscope for live cell autofluorescence lifetime assays

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 99-113页

作者： Douglas J.Kelly Sean C.Warren Sunil Kumar Joao L.Lagarto Benjamin T.Dyer anca Margineanu Eric W.-F.Lam Chris Dunsby Paul M.W.French Photonics Group Department of PhysicsImperial College London South Kensington CampusLondonSW72AZUK Institute of Chemical Biology Department of Chemistry Imperial College LondonSouth Kensington Campus LondonSWT 2AZUK National Heart&Lung Institute Imperial centre for Eaperimental&Translational Medicine Du Cane Road LondonW12 ONNUK Department of Surgery and Cancer Imperial Cllege London Du Cane RoadLondonW12 ONNUK centre for Histopathology Imperial College London Du Cane RoadLondonW120NNUK

Fluorescence lifetime imaging(FLIM)is increasingly used to read out cellular autofluorescenceoriginating from the coenzyme NADH in the context of investigating cell metabolic *** here an automated multiwell plate reading FLIM microscope optimized for UV illumi-nation with the goal of extending high content fluorescence lifetime asays to readouts ofmetabolism,We demonstrate its application to automated cellular autofluorescence lifetime imaging and discuss the key practical issues associated with its *** particular,weillustrate its capability to read out the NADH-lifetime response of cells to metabolic modulators,thereby illustrating the potential of the instrument for cytotoxicity studies,assays for drugdiscovery and stratified medicine.

关键词： High content analysis FLIM NADH metabolism cisplatin.