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Calabi-Yau Topology of Primordial Fermions

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Journal of Modern Physics 2024年第1期15卷 132-158页

作者： Edwin Eugene Klingman Cybernetic Micro Systems Inc. San Gregorio CA USA

Quantum field theory creates fermions via abstract operators exciting abstract fields, with a specific field for each type of specific particle. This operator algebra lends itself well to quantum statistics, nevertheless, our physical understanding of this process is nonintuitive at best. In this paper we analyze the creation of fermions from primordial gauge field quantum gravity loops in the context of Calabi-Yau manifold theory. I extend a prior mass-gap treatment based on Yang-Mills gauge theory of higher order self-interaction to inc.ude the half-integral spin of fermions.

关键词： Calabi-Yau Topology Fermion Spin Particle Genesis Primordial Field Self-Interaction Equations Yang-Mills Gravity

Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

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Genes & Diseases 2024年第1期11卷 23-25页

作者： Andrew Fesler Ga-Ram Hwang Jingfang Ju Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The Northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics inc. WoburnMA 01801USA

One of the major obstacles for nucleic acid-based medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRNA-based therapy with a unique modification strategy that also further enhances therapeutic *** discovery may be of great importance for the development of siRNA-based therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRNA using a siRNA that targets B-cell lymphoma-2(BCL-2).

关键词： eliminate uptake modified

Drought-Tolerant Rice at Molecular Breeding Eras:An Emerging Reality

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Rice science 2024年第2期31卷 179-189页

作者： ZHU Chengqi YE Yuxuan QIU Tian HUANG Yafan YING Jifeng SHEN Zhicheng Institute of Insect Sciences Zhejiang UniversityHangzhou 310058China Performance Plants inc. 1287 Gardiners RoadKingstonOntario K7P 3J6Canada China National Rice Research Institute Hangzhou 310006China

Rice(Oryza sativa L.)stands as the most significantly influential food crop in the developing world,with its total production and yield stability affected by environmental *** stress impacts about 45%of the world’s rice area,affecting plants at molecular,biochemical,physiological,and phenotypic *** conventional breeding method,predominantly employing single pedigree selection,has been widely utilized in breeding numerous drought-tolerant rice varieties sinc. the Green *** rapid progress in plant molecular biology,hundreds of drought-tolerant QTLs/genes have been identified and tested in rice crops under both indoor and field *** genes have been introgressed into elite germplasm to develop commercially accepted drought-tolerant varieties,resulting in the development of several drought-tolerant rice varieties through marker-assisted selection and genetically engineered *** review provides up-to-date information on proof-of-concept genes and breeding methods in the molecular breeding era,offering guidance for rice breeders to develop drought-tolerant rice varieties.

关键词： conventional breeding drought stress drought tolerant rice genetic engineering marker-assisted selection breeding

Quantized Redshift and its Significance for Recent Observation

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Research in Astronomy and Astrophysics 2024年第9期24卷 156-166页

作者： Arindam Mal Sarbani Palit Christopher C.Fulton Sisir Roy Indian Space Research Organization Space Applications CentreAhmedabadIndia Indian Statistical Institute CVPR UnitKolkataIndia Protostar Inc.15652 Carrousel DriveCanyon CountryCA 91387USA National Institute of Advanced Studies IISC CampusBangaloreIndia

With the recent observational evidence in extragalactic astronomy,the interpretation of the nature of quasar redshift continues to be a research *** high redshifts are being detected for extragalactic objects that are presumably very distant and young while also exhibiting properties that are characteristic of a more mature galaxy such as *** to Halton Arp and Geoffrey Burbidge,redshift disparities consist of an intrinsic component and are related to an evolutionary *** observed redshift periodicity at integer multiples of0.089 in log scale and Burbidge observed redshift periodicity at integer multiples of 0.061 in linear *** Singular Value Decomposition based periodicity estimation is known to be superior for noisy data sets,especially when the data contain multiple harmonics and overtones,mainly irregular in nature,we have chosen it to be our primary tool for analysis of the quasar-galaxy pair redshift *** have observed a fundamental periodicity of0.051 with a confidence interval of 95%in linear scale with the site-available Sloan Digital Sky Survey Data Release 7(SDSS DR7)quasar-galaxy pair data *** have independently generated quasar-galaxy pair data sets from both 2d F and SDSS and found fundamental periodicities of 0.077 and 0.089,respectively,in log scale with a confidence interval of 95%.

关键词： galaxies:distances and redshifts (galaxies:)quasars:absorption lines cosmology:observations

Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes

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Genes & Diseases 2024年第4期11卷 134-137页

作者： Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Jecho Laboratories Inc.FrederickMD 21704USA Jecho Institute Co. Ltd.Shanghai 200240China

The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic *** and recent studies indicate that monoclonal antibodies can be efficacious in preventing and treating SARSCoV-1 and SARS-CoV-2 *** a phage display platform,we have identified dozens of monoclonal antibodies that bind to diverse epitope groups on the SARS-CoV-2 spike *** of them bound to the receptor binding domain(RBD)and inhibited ACE2-RBD interaction.

关键词： antibodies inhibited monoclonal

Transforming Digital Experiences: The Evolution of Digital Experience Platforms (DXPs) from Monoliths to Microservices: A Practical Guide

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Journal of Computer and Communications 2024年第2期12卷 142-155页

作者： Sourabh Sethi Sarah Panda Infosys Limited New York NY USA Microsoft inc. Seattle WA USA

The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape.

关键词： Digital Experience Platforms (DXPs) Microservices Software Evolution Distributed Systems Architectural Patterns

The optimal stent pusher position to achieve successful ureteral stent insertion under fluoroscopic guidance

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Asian Journal of Urology 2024年第2期11卷 311-315页

作者： Makoto Taguchi Kaneki Yasuda Hidefumi Kinoshita Department of Urology Osaka Saiseikai Izuo Hospital Based on Social Welfare Organization“Saiseikai”Imperial Gift Foundation Inc.OsakaJapan Department of Urology and Andrology Kansai Medical UniversityHirakataOsakaJapan

Objective: To examine factors to predict the optimal stent pusher position when inserting ureteral stents under ***: We retrospectively reviewed 327 patients who underwent ureteral stent insertion. We considered the pubic bone as a useful anatomical landmark to insert ureteral stents under fluoroscopic guidance. Thus, we categorized patients into three groups (proximal, middle, and distal groups) according to the position of the radiopaque tip of the push catheter when inserting the ureteral stent. Success was defined as a completely curled ureteral stent tail. We compared stent insertion success rates among the three groups. A multivariate analysis was performed to identify the factors affecting stent insertion ***: In men, 36 (63.2%) cases were deemed successful in the proximal group compared with 40 (80.0%) cases in the middle group and 12 (20.7%) cases in the distal group (p<0.001). In women, 26 (45.6%) cases were deemed successful in the proximal group compared with 54 (98.2%) cases in the middle group and 38 (76.0%) cases in the distal group (p<0.001). With the multivariate analysis, the stent pusher position was the most significant factor influencing successful stent insertion (men: odds ratio 6.00, 95% confidence interval 2.66-13.51, p<0.001;women: odds ratio 37.80, 95% confidence interval 4.94-289.22, p<0.001).Conclusion: The position of the stent pusher affects stent insertion success. The middle of the pubic symphysis is the optimal position for the radiopaque tip of the pusher when inserting ureteral stents under fluoroscopic guidance.

关键词： Stent Cystoscopy Fluoroscopy Ureter

Efficiency improvement by using metal–insulator‑semiconductor structure in InGaN/GaN micro‑light‑emitting diodes

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Frontiers of Optoelectronics 2024年第1期17卷 77-84页

作者： Jian Yin David Hwang Hossein Zamani Siboni Ehsanollah Fathi Reza Chaji Dayan Ban Department of Electrical and Computer Engineering Waterloo Institute NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada Vuereal inc. 440 Philip StreetUnit 100WaterlooON N2L 5R9Canada

InGaN/GaN micro-light-emitting diodes(micro-LEDs)with a metal–insulator-semiconductor(MIS)structure on the sidewall are proposed to improve *** this MIS structure,a sidewall electrode is deposited on the insulating layer-coated sidewall of the device mesa between a cathode on the bottom and an anode on the ***(EL)measurements of fabricated devices with a mesa diameter of 10μm show that the application of negative biases on the sidewall electrode can inc.ease the device external quantum efficiency(EQE).In contrast,the application of positive biases can decrease the *** band structure analysis reveals that the EQE is impacted because the application of sidewall electric fields manipulates the local surface electron density along the mesa sidewall and thus controls surface Shockley–Read–Hall(SRH)*** suggested strategies,reducing insulator layer thickness and exploring alternative materials,can be implemented to further improve the EQE of MIS micro-LEDs in future fabrication.

关键词： Micro-LED GaN EQE improvement Micro-fabrication

From Digital Human Modeling to Human Digital Twin: Framework and Perspectives in Human Factors

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 1-14页

作者： Qiqi He Li Li Dai Li Tao Peng Xiangying Zhang Yinc.eng Cai Xujun Zhang Renzhong Tang State Key Laboratory of Fluid Power Components and Mechatronic Systems Zhejiang UniversityHangzhou 310027China ZJU-Sunon Joint Research Center for Smart Furniture Zhejiang UniversityHangzhou 310027China PICO-Lab Bytedance Inc.Shanghai 200233China Sunon Technology Co. Ltd.Hangzhou 311215China

The human digital twin(HDT)emerges as a promising human-centric technology in Industry 5.0,but challenges remain in human modeling and *** human modeling(DHM)provides solutions for modeling and simulating human physical and cognitive aspects to support ergonomic ***,it has limitations in real-time data usage,personalized services,and timely *** emerging HDT concept offers new possibilities by integrating multi-source data and artificial intelligence for continuous monitoring and ***,this paper reviews the evolution from DHM to HDT and proposes a unified HDT framework from a human factors *** framework comprises the physical twin,the virtual twin,and the linkage between these *** virtual twin integrates human modeling and AI engines to enable model-data-hybrid-enabled *** can potentially upgrade traditional ergonomic methods to intelligent services through real-time analysis,timely feedback,and bidirectional ***,the future perspectives of HDT for industrial applications as well as technical and social challenges are *** general,this study outlines a human factors perspective on HDT for the first time,which is useful for cross-disciplinary research and human factors innovation to enhance the development of HDT in industry.

关键词： Human digital twin Digital human modeling Human factors Human-centric technology