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Efficacy of electroacupuncture on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 1-15页

作者： QIN Xiaoyu WANG Chunai XUE Jianjun ZHANG Jie LU Xiaoting DING Shengshuang GE Long WANG Minzhen the First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730030China Department of Anesthesiology Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Evidence-based Medicine Center Lanzhou UniversityLanzhou 730030China Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 730030China

OBJECTIVE:To evaluate the efficacy of electroacupuncture(EA)intervention on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB).METHODS:Eight databases,including Pub Med,Embase,the Cochrane Library,Web of Science,Chinese Bio Medical Literature Database,China National Knowledge Infrastructure Database,Wanfang Data,China Science and Technology Journal Database,and two clinical trial registries,were *** randomized controlled trials(RCTs)related to EA intervention in cardiac surgery with CPB were *** on the inclusion and exclusion criteria,two researchers independently screened articles and extracted *** the quality evaluation,RevMan 5.3 software was used for ***:Fourteen RCTs involving 836 patients were *** with the control treatment,EA significantly increased the incidence of cardiac automatic rebeat after aortic unclamping[relative risk(RR)=1.15,95%confidence interval(CI)(1.01,1.31),P<0.05;moderate].Twenty-four hours after aortic unclamping,EA significantly increased the superoxide dismutase[standardized mean difference(SMD)=0.96,95%CI(0.32,1.61),P<0.05;low],and interleukin(IL)-2[SMD=1.33,95%CI(0.19,2.47),P<0.05;very low]expression levels and decreased the malondialdehyde[SMD=-1.62,95%CI(-2.15,-1.09),P<0.05;moderate],tumour necrosis factor-α[SMD=-1.28,95%CI(-2.37,-0.19),P<0.05;moderate],and cardiac troponin I[SMD=-1.09,95%CI(-1.85,-0.32),P<0.05;low]expression levels as well as the inotrope scores[SMD=-0.77,95%CI(-1.22,-0.31),P<0.05;high].There was no difference in IL-6 and IL-10 expression *** amount of intraoperative sedative[SMD=-0.31,95%CI(-0.54,-0.09),P<0.05;moderate]and opioid analgesic[SMD=-0.96,95%CI(-1.53,-0.38),P<0.05;low]medication was significantly lower in the EA group than in the control ***,the postoperative tracheal intubation time[SMD=-0.92,95%CI(-1.40,-0.45),P<0.05;low]and intensive care unit stay[SMD=-1.

关键词： electroacupuncture cardiopulmonary bypass thoracic surgery myocardial ischaemia-reperfusion injury myocardial protection postoperative rehabilitation Meta-analysis randomized controlled trial

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Land use and cover change and influencing factor analysis in the Shiyang River Basin,China

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Journal of Arid Land 2024年第2期16卷 246-265页

作者： ZHAO Yaxuan CAO Bo SHA Linwei CHENG Jinquan ZHAO Xuanru GUAN Weijin PAN Baotian Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730030China Shiyang River Basin Scientific Observing Station Lanzhou UniversityLanzhou 730030China

Land use and cover change(LUCC)is the most direct manifestation of the interaction between anthropological activities and the natural environment on Earth's surface,with significant impacts on the environment and social *** economic development and climate change have resulted in significant changes in land use and *** Shiyang River Basin,located in the eastern part of the Hexi Corridor in China,has undergone significant climate change and LUCC over the past few *** this study,we used the random forest classification to obtain the land use and cover datasets of the Shiyang River Basin in 1991,1995,2000,2005,2010,2015,and 2020 based on Landsat *** validated the land use and cover data in 2015 from the random forest classification results(this study),the high-resolution dataset of annual global land cover from 2000 to 2015(AGLC-2000-2015),the global 30 m land cover classification with a fine classification system(GLC_FCS30),and the first Landsat-derived annual China Land Cover Dataset(CLCD)against ground-truth classification results to evaluate the accuracy of the classification results in this ***,we explored and compared the spatiotemporal patterns of LUCC in the upper,middle,and lower reaches of the Shiyang River Basin over the past 30 years,and employed the random forest importance ranking method to analyze the influencing factors of LUCC based on natural(evapotranspiration,precipitation,temperature,and surface soil moisture)and anthropogenic(nighttime light,gross domestic product(GDP),and population)*** results indicated that the random forest classification results for land use and cover in the Shiyang River Basin in 2015 outperformed the AGLC-2000-2015,GLC_FCS30,and CLCD datasets in both overall and partial ***,the classification results in this study exhibited a high level of agreement with the ground truth *** 1991 to 2020,the area of bare land exhibited a decreasing trend,with chan

关键词： land use and cover classification land use and cover change(LUCC) climate change random forest accuracy assessment three-dimensional sampling method Shiyang River Basin

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Roles and application of exosomes in the development,diagnosis and treatment of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 630-642页

作者： Xiao-Li Guan Xiao-Ying Guan Zheng-Yi Zhang Department of General Medicine The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Pathology The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

As important messengers of intercellular communication,exosomes can regulate local and distant cellular communication by transporting specific exosomal con-tents and can also promote or suppress the development and progression of gas-tric cancer(GC)by regulating the growth and proliferation of tumor cells,the tumor-related immune response and tumor *** transport bioactive molecules including DNA,proteins,and RNA(coding and noncoding)from donor cells to recipient cells,causing reprogramming of the target *** this review,we will describe how exosomes regulate the cellular immune respon-se,tumor angiogenesis,proliferation and metastasis of GC cells,and the role and mechanism of exosome-based therapy in human *** will also discuss the potential application value of exosomes as biomarkers in the diagnosis and treat-ment of GC and their relationship with drug resistance.

关键词： Exosomes Gastric cancer Immune regulation Diagnosis Cancer therapy

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Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation

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Virologica Sinica 2024年第4期39卷 587-599页

作者： Zhenfang Yan Jiayu Yue Yaxin Zhang Zhengyang Hou Dianyu Li Yanmei Yang Xiangrong Li Adi Idris Huixia Li Shasha Li Jingying Xie Ruofei Feng Key Laboratory of Biotechnology and Bioengineering of State Ethnic Biomedical Research Center Northwest Minzu UniversityLanzhou730030China College of Life Science and Engineering Northwest Minzu UniversityLanzhou730030China Gansu Tech Innovation Center of Animal Cell Biomedical Research CenterNorthwest Minzu UniversityLanzhou730030China Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine Ministry of EducationBiomedical Research CenterNorthwest Minzu UniversityLanzhou730030China Centre for Immunology and Infection Control School of Biomedical SciencesQueensland University of TechnologyKelvin GroveQueensland4702Australia

Herpesviruses antagonize host antiviral responses through a myriad of molecular strategies culminating in the death of the host *** virus(PRV)is a significant veterinary pathogen in pigs,causing neurological sequalae that ultimately lead to the animal's *** is known to trigger apoptotic cell death during the late stages of *** virion host shutdown protein(VHS)encoded by UL41 plays a crucial role in the PRV infection *** this study,we demonstrate that UL41 inhibits PRV-induced activation of inflammatory cytokine and negatively regulates the cGAS-STING-mediated antiviral activity by targeting IRF3,thereby inhibiting the translocation and phosphorylation of ***,mutating the conserved amino acid sites(E192,D194,and D195)in the RNase domain of UL41 or knocking down UL41 inhibits the immune evasion of PRV,suggesting that UL41 may play a crucial role in PRV's evasion of the host immune response during *** results enhance our understanding of how PRV structural proteins assist the virus in evading the host immune response.

关键词： Pseudorabies virus(PRV) UL41 IRF3 Interferon cGAS-STING

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Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

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World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li Jiang Juan Li Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang Department of Magnetic Resonance Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： Liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

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Construction and evaluation of a liver cancer risk prediction model based on machine learning

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3839-3850页

作者： Ying-Ying Wang Wan-Xia Yang Qia-Jun Du Zhen-Hua Liu Ming-Hua Lu Chong-Ge You Laboratory Medicine Center The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Liver cancer is one of the most prevalent malignant tumors worldwide,and its early detection and treatment are crucial for enhancing patient survival rates and quality of ***,the early symptoms of liver cancer are often not obvious,resulting in a late-stage diagnosis in many patients,which significantly reduces the effectiveness of *** a highly targeted,widely applicable,and practical risk prediction model for liver cancer is crucial for enhancing the early diagnosis and long-term survival rates among affected *** To develop a liver cancer risk prediction model by employing machine learning techniques,and subsequently assess its *** In this study,a total of 550 patients were enrolled,with 190 hepatocellular carcinoma(HCC)and 195 cirrhosis patients serving as the training cohort,and 83 HCC and 82 cirrhosis patients forming the validation *** regression(LR),support vector machine(SVM),random forest(RF),and least absolute shrinkage and selection operator(LASSO)regression models were developed in the training *** performance was assessed in the validation ***,this study conducted a comparative evaluation of the diagnostic efficacy between the ASAP model and the model developed in this study using receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)to determine the optimal predictive model for assessing liver cancer *** Six variables including age,white blood cell,red blood cell,platelet counts,alpha-fetoprotein and protein induced by vitamin K absence or antagonist II levels were used to develop LR,SVM,RF,and LASSO regression *** RF model exhibited superior discrimination,and the area under curve of the training and validation sets was 0.969 and 0.858,*** values significantly surpassed those of the LR(0.850 and 0.827),SVM(0.860 and 0.803),LASSO regression(0.845 and 0.831),and ASAP(0.866 and 0.813)model

关键词： Hepatocellular carcinoma Cirrhosis Prediction model Machine learning Random forest

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酰胺质子转移加权成像联合体素内不相干运动成像诊断宫颈鳞状细胞癌及评估病理分化程度的价值

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中华放射学杂志 2024年第6期58卷 627-632页

作者：辛仲宏彭建鸿卢贤德南江张亚萍陈梓娴王晓慧朱骏雷军强兰州大学第一医院放射科兰州730030 兰州大学第一医院妇产科兰州730030 兰州大学第一医院病理科兰州730030

目的探讨酰胺质子转移加权(APTw)成像联合体素内不相干运动(IVIM)成像诊断宫颈鳞状细胞癌(CSCC)及评估病理分化程度的价值。方法该文为诊断性试验研究,回顾性收集2021年10月至2022年10月间在兰州大学第一医院经病理确诊为CSCC的56例患者... 详细信息

目的探讨酰胺质子转移加权(APTw)成像联合体素内不相干运动(IVIM)成像诊断宫颈鳞状细胞癌(CSCC)及评估病理分化程度的价值。方法该文为诊断性试验研究,回顾性收集2021年10月至2022年10月间在兰州大学第一医院经病理确诊为CSCC的56例患者,为CSCC组。招募2021年10月至2023年10月在兰州大学第一医院进行体检的36例女性健康志愿者,为对照组。根据病理结果,CSCC患者分为中高分化组(n=34)和低分化组(n=22)。将感兴趣区放置于CSCC组病灶和对照组正常宫颈基质,获得APTw成像定量参数不对称性磁化转移率(MTR_(asym))和IVIM定量参数纯扩散系数(D)、假扩散系数(D*)和灌注分数(f)。采用独立样本t检验比较2组间定量参数差异,采用logistic回归模型将2组间差异有统计学意义的定量参数建立联合参数,使用受试者操作特征曲线评估单一定量参数和联合参数区分CSCC组与对照组、CSCC患者中高分化组与低分化组的诊断效能,曲线下面积(AUC)的比较采用DeLong检验。结果CSCC组与对照组间MTR_(asym)、D、f差异有统计学意义(t=-9.79、10.09、11.35,P0.05)。在区分CSCC组与对照组方面,MTR_(asym)、D、f和联合参数(MTR_(asym)+D+f)的AUC(95%CI)分别为0.887(0.804~0.944)、0.940(0.871~0.979)、0.968(0.909~0.993)、0.995(0.950~1.000),联合参数的AUC高于MTR_(asym)和D的AUC,差异有统计学意义(Z=3.07、2.06,P=0.002、0.040)。在区分CSCC中高分化组与低分化组方面,MTR_(asym)、D和联合参数(MTR_(asym)+D)的AUC(95%CI)分别为0.789(0.660~0.887)、0.775(0.644~0.876)、0.852(0.731~0.932),两两间差异无统计学意义(P>0.05)。结论APTw和IVIM成像的定量参数可用于CSCC的诊断和初步评估病理分化程度,联合参数可以提高对CSCC的诊断效能。

关键词：宫颈肿瘤磁共振成像酰胺质子转移加权成像体素内不相干运动

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基于Gaussian Copula-贝叶斯动态模型的桥梁构件时变可靠性分析

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吉林大学学报（工学版） 2024年第2期54卷 485-493页

作者：樊学平周衡刘月飞兰州大学西部灾害与环境力学教育部重点实验室兰州730030 兰州大学土木工程与力学学院兰州730030

针对桥梁构件的各控制监测点之间存在失效非线性相关性的问题。首先考虑到非线性相关性对桥梁构件可靠性的影响,采用贝叶斯动态模型(BDMs),建立监测数据的动态预测模型;再结合Copula理论建立Gaussian Copula-BDMs,进而计算桥梁构件时变... 详细信息

针对桥梁构件的各控制监测点之间存在失效非线性相关性的问题。首先考虑到非线性相关性对桥梁构件可靠性的影响,采用贝叶斯动态模型(BDMs),建立监测数据的动态预测模型;再结合Copula理论建立Gaussian Copula-BDMs,进而计算桥梁构件时变可靠性,同时与不考虑桥梁构件各控制监测点失效相关性得到的可靠性进行比较分析;最后通过算例验证所建模型与方法的合理性。本研究成果将为多元结构体系的可靠性分析提供参考。

关键词：结构工程相关性贝叶斯动态模型高斯Copula贝叶斯动态模型时变可靠性分析

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无胶秸秆基纤维板的研究进展

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复合材料学报 2024年第4期41卷 1750-1763页

作者：苏琼卢新宇石小琴聂宏杰张平王彦斌西北民族大学化工学院兰州730030 环境友好复合材料国家民委重点实验室兰州730030 甘肃省生物质功能复合材料工程研究中心兰州730030 甘肃省高校环境友好复合材料及生物质利用重点实验室兰州730030

无胶秸秆基纤维板是生物质复合材料,具有无毒、可降解、可回收和可再生等特点。因其不消耗石油资源,有利于可持续发展,可替代部分木材应用于地板、建筑材料、家具、室内装修等领域。但对其制板机制及工艺的研究较欠缺,导致市场份额占比... 详细信息

无胶秸秆基纤维板是生物质复合材料,具有无毒、可降解、可回收和可再生等特点。因其不消耗石油资源,有利于可持续发展,可替代部分木材应用于地板、建筑材料、家具、室内装修等领域。但对其制板机制及工艺的研究较欠缺,导致市场份额占比仍较低。本文综述了无胶秸秆基纤维板的自粘结机制和应用现状,分析了近年来无胶秸秆基纤维板的工艺进展,着重从纤维的预处理、纤维尺寸、工艺参数(压制时间、压力和温度)对无胶秸秆基纤维板性能的影响进行了系统综述,并对未来无胶秸秆纤维板的优化设计、大规模生产及推广应用进行了展望。

关键词：无胶秸秆基纤维板生物质自粘结机制制造工艺秸秆预处理

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生姜多糖的提纯工艺、结构及其功能活性研究进展

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食品工业科技 2024年第1期45卷 335-342页

作者：付琳王一红蔺子晗王思璎王漫龙丹凤兰州大学公共卫生学院甘肃兰州730030

生姜作为我国丰富的草本植物资源,从古至今,在食品、药品中扮演着重要角色,也被称为药食同源植物,具有良好的医用和营养价值。生姜多糖是生姜中重要的生物活性物质之一,国内外研究发现其具有多种功能活性。本文系统回顾并比较了生姜多... 详细信息

生姜作为我国丰富的草本植物资源,从古至今,在食品、药品中扮演着重要角色,也被称为药食同源植物,具有良好的医用和营养价值。生姜多糖是生姜中重要的生物活性物质之一,国内外研究发现其具有多种功能活性。本文系统回顾并比较了生姜多糖的提取工艺和纯化方法,总结了生姜多糖的结构表征。同时对生姜多糖的抗氧化、调节免疫、抗肿瘤等功能活性进行了归纳分析,以期为后续生姜多糖的深入研究和产业应用提供参考。

关键词：生姜多糖药食同源提取纯化结构表征功能活性

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