检索结果-南通市图书馆

Treatment of Postmenopausal Osteoporosis with Yang Huo San Zi Tang—A Report of 30 Cases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2004年第2期24卷 102-104页

作者：邱仁斌沈瑞子张培钦毛树章 The Central Hospital of Shenzhen Municipality Shenzhen 518116 Guangdong Province The Central Hospital of Shenzhen Municipality Shenzhen 518116Guangdong Province

From June 2000 to June 2003, 30 cases of postmenopausal osteoporosis (PMOP) were treated with Yang Huo San Zi Tang (羊藿三子汤) in a controlled study. The following is the clinical report with a brief discussion on it... 详细信息

关键词：妇女绝经后骨质疏松羊藿三子汤病例分析 PMOP

Clinical Observation in 40 Cases of Postmenopausal Coronary Heart Disease Treated with Yanghuo Sanzi Tang

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2003年第3期23卷 182-184页

作者：张培钦邱仁斌沈瑞子梁劲荃王薇 Longgang Central Hospital Shenzhen 518116Guangdong Province

Modern researches have shown that the incidence of coronary heart disease (CHD) among the women before menopause is only 30% of that in ***, the incidence and mortality of CHD among the women after menopause jumps by ... 详细信息

关键词： Phytotherapy Postmenopause Aged Angina Pectoris Drug Combinations Drugs, Chinese Herbal Estradiol Female Humans Male Middle Aged Myocardial Infarction

Printed Biosensors for the Detection of Alzheimer’s Disease Based on Blood Biomarkers

在线全文

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2024年第2期8卷 133-142页

作者： Yu Zeng Zhen Huang Yibiao Liu Tailin Xu Longgang Central Hospital of Shenzhen Shenzhen518116China School of Biomedical Engineering Shenzhen UniversityShenzhen518060China

Alzheimer’s disease(AD)is a chronic neurodegenerative disorder,and early diagnosis plays a crucial role in its prevention and *** recent years,blood-based biomarkers for early AD diagnosis have gained attention due to their non-invasiveness and minimal adverse reactions,which make them an attractive *** the onset of the COVID-19 pandemic,visiting large medical examination centers for blood tests has become increasingly *** trend is shifting towards community or home-based sampling,which relies on the development and application of portable,miniaturized,and highly sensitive *** the various sensors used for detecting blood biomarkers in AD,printed sensors demonstrate great potential in AD blood biomarker detection due to their ease of miniaturization,scalability for mass production,and compatibility with various detection *** this review,we focus on discussing the application of printed sensors in the analysis of blood biomarkers for *** also explore the challenges faced by printed sensors in early diagnosis based on AD blood biomarkers and propose potential solutions to address these challenges.

关键词： Printed biosensors Alzheimer’s disease Blood biomarkers Printing technology

Outcome of 2 284 cases with acute traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2001年第3期4卷 152-155页

作者：张俊江基尧钟天安于明琨朱诚 Department of Neurosurgery Ronggang Hospital Shenzhen 518116 China.

Objective: To analyze the prognosis of 2 284 cases with acute traumatic brain injury and discuss possible methods to improve the outcome of head injuries. Methods: The relationship between trauma cause, trauma severity and management and patients outcome was retrospectively analyzed. Results: Good recovery was achieved in 60.20% , moderate disability was 13.22 %, severe disability 15.24 %, vegetative status 0.31 % and mortality 11.03 %. The mortality was 1.07 % in cases with GCS 15 13, 2.47 % in cases with GCS 12 9, 13.29 % in cases with GCS 8 6, and 57.4 % in cases with GCS 5 3. Conclusions: To prevent hypoxia, remove intracranial hematoma as soon as possible, use standard large traumatic craniotomy and apply mild hypothermia may be useful means for improving the outcome of severely head injured patients.

关键词： Brain injuries Outcome

Effect of Loss-of-function of the Herpes Simplex Virus-1 microRNA H6-5p on Virus Replication

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2019年第4期34卷 386-396页

作者： Rongquan Huang Xusha Zhou Shuqi Ren Xianjie Liu Zhiyuan Han Grace Guoying Zhou School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China Shenzhen International Institute for Biomedical Research Shenzhen 518116China

To date, 29 distinct microRNAs(miRNAs) have been reported to be expressed during herpes simplex virus *** analysis of mature herpes simplex virus-1(HSV-1) miRNAs revealed five sets of miRNAs that are complementary to each other: miR-H6-5p/H1-3p, miR-H6-3p/H1-5p, H2-5p/H14-3p, miR-H2-3p/H14-5p, and miR-H7/***, the roles of individual miRNAs and consequences of this complementarity remain unclear. Here, we focus on two of these complementary miRNAs, miR-H6-5p and miR-H1-3p, using loss-of-function experiments in vitro and in a mouse model of infection using an miRNA sponge approach, including tandem multiplex artificial miRNA-binding sequences that do not match perfectly to the target miRNA inserted downstream of a green fluorescent protein reporter gene. Infection with recombinant virus expressing the miR-H6-5p sponge reduced viral protein levels and virus *** accumulation of viral proteins was also observed at early stages of infection in the presence of both an miR-H6-5p inhibitor and plasmid-expressed miR-H1-3p. Moreover, establishment of latency and reactivation did not differ between the recombinant virus expressing the miR-H6-5p sponge and wild-type HSV-1. Taken together, these data suggest that miR-H6-5p has an as-yet-unidentified role in the early stages of viral infection, and its complement miR-H1-3p suppresses this role in later stages of infection. This report extends understanding of the roles of miRNAs in infection by herpes simplex viruses, supporting a model of infection in which the production of virus and its virulent effects are tightly controlled to maximize persistence in the host and population.

关键词： miR-H6-5p miR-H1-3p Sponge Replication Herpes simplex virus-1(HSV-1)

Termination of Transcription of LAT Increases the Amounts of ICP0 mRNA but Does Not Alter the Course of HSV-1 Infection in Latently Infected Murine Ganglia

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2021年第2期36卷 264-272页

作者： Haifang Jiang Jiaming Wu Xianjie Liu Ruitao Lu Manling Zhou Meiling Chen Yonghong Liu Grace Guoying Zhou Wenmin Fu School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China Shenzhen International Institute for Biomedical Research Shenzhen 518116China

On entering sensory ganglia,herpes simplex viruses 1(HSV-1)establishes a latent infection with the synthesis of a latency associated transcript(LAT)or initiates productive infection with expression of a set of immediate early viral *** precise mechanisms how expression of a genes is suppressed during the latency are *** mechanism that has been proposed is illustrated in the case of ICP0,a key immediate early viral regulatory ***,the 2 kb LAT intron is complementary to the 30 terminal portion of ICP0 m *** test the hypothesis that accumulation of LAT negatively affects the accumulation of ICP0 m RNA,we inserted a DNA fragment encoding two poly(A)sequences into LAT to early terminate LAT transcript without interrupting the complementary sequence of ICP0 transcript(named as SR1603).Comparisons of the parent(SR1601)and mutant(SR1603)HSV-1 viruses showed the following:Neurons harboring latent SR1603 virus accumulated equivalent amounts of viral DNA but higher amounts of ICP0 m RNA and lower amounts of LAT,when compared to neurons harboring the SR1601 *** notable difference between the two viruses is that viral RNA accumulation in explanted ganglia harboring SR1603 virus initiated significantly sooner than that in neurons harboring SR1601 virus,suggesting that ICP0 may act as an activator of viral gene expression in permissive ***,these data suggest that increased ICP0 m RNA by suppressed LAT did not affect the establishment of latency in latently infected murine ganglia.

关键词： Herpes simplex viruses 1(HSV-1) Latency associated transcript(LAT) ICP0 Latency

CT biliary cystoscopy of gallbladder polyps

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2004年第8期10卷 1204-1207页

作者： Ming-WuLou Wei-DongHu Yi.Fan Jin-HuaChen Zhan-SenE Guang-FuYang DepartmentofRadiology LonggangCentralHospitalofShenzhenCityShenzhen518116GuangdongProvinceChina

AIM:CT virtual endoscopy has been used in the study of various organs of body including the biliary tract,however, CT virtual endoseopy in diagnosis of gallbladder polyps has not yet been *** study was to evaluate the diagnostic value of CT virtual endoscopy in polyps of the gallbladder. METHODS:Thirty-two cases of gallbladder polyps were examined by CT virtual endoscopy,ultrasound,CT scan with oral biliary contrast separately and confirmed by operation and *** biliary cystoscopic findings were analyzed and compared with those of ultrasound and CT scan with oral biliary contrast,and evaluated in comparison with operative and pathologic findings in all cases. RESULTS:The detection rate of gallbladder polyps was 93.8%(90/96),96.9%(93/96)and 79.2%(76/96)for CT cystoscopy,ultrasound and CT scan with oral contrast, *** biliary cystoscopy corresponded well with ultrasound as well as pathology in demonstrating the location,size and configuration of *** endoscopy was superior to ultrasound in viewing the polyps in a more precise way,3 dimensionally from any angle in space,and showing the surface in *** biliary cystoscopy was also superior to CT scan with oral biliary contrast in terms of observation of the base of polyps for the presence of a pedicle,detection rates as well as image *** smallest polyp detected by CT biliary cystoscopy was measured 1.5 mm×2.2 mm×2.5 mm. CONCLUSION:CT biliary cystoscopy is a non-invasive and accurate technique for diagnosis and management of gallbladder polyps.

关键词：胆囊息肉膀胱镜检查 CT检查影像学诊断病理分型

失水事故后燃料厂房空气自然循环及氢气分布实验研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原子能科学技术 2020年第5期54卷 916-922页

作者：陆雨洲贠相羽张会勇张诗琪中广核研究院有限公司广东深圳518116

针对乏燃料水池失水、乏燃料裸露的事故情景,通过实验研究了燃料厂房内空气自然循环及氢气分布的基本规律,得到了空间气体温度场及浓度分布实验数据。结果表明,由于空气自然循环的热量输运作用,各区域升温速率随温度的升高而降低;与外... 详细信息

针对乏燃料水池失水、乏燃料裸露的事故情景,通过实验研究了燃料厂房内空气自然循环及氢气分布的基本规律,得到了空间气体温度场及浓度分布实验数据。结果表明,由于空气自然循环的热量输运作用,各区域升温速率随温度的升高而降低;与外界自然对流通风的简单方式可显著减缓温度上升,实验24 h后加热元件温度低于490℃;喷淋则可迅速降低所覆盖区域温度,空间气体平均温度在喷淋后5 min内下降了100℃。氢气在空气环境中将形成浓度分层,喷淋搅混可在2 min内破坏该分层;对于氢气/蒸汽混合气体,随着蒸汽凝结及外界空气涌入逐渐具有可燃性,喷淋对此无积极作用。基于上述研究结果,提出了能动和非能动的事故缓解措施建议。

关键词：乏燃料裸露冷却水丧失自然循环氢气分布事故缓解

Cerebrospinal fluid flow in empty sella syndrome and normal sellar regions measured by phase-contrast quantitative magnetic resonance

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2011年第11期6卷 816-820页

作者： Weidong HU Li Xiang Xiurong Wang Department of Radiology Central Hospital of Longgang District Shenzhen 518116 Guangdong Province China Deparment of Intemal Medicine Central Hospital of Longgang District Shenzhen 518116 Guangdong Province China

We used MRI to examine 38 healthy females and 38 female patients with empty sella syndrome. Cerebrospinal fluid flow was examined in six regions of interest, including the anterior clinoid processes, posterior clinoid processes, and 1.0 mm, 1.0 mm, 2.0 mm, --2.0 mm from the midpoint of the line between the anterior and posterior clinoid processes. The results revealed no significant differences in cerebrospinal fluid flow velocity and discharge in a single cardiac cycle, or indicators of cardiac cycles in the control group, indicating that the cerebrospinal fluid flow was relatively steady in the saddle area of the normal brain. In the empty sella syndrome group, cerebrospinal fluid hernia into the saddle area triggered a fluctuation of the anterior and posterior clinoid processes in the saddle area, while the flow in other regions in the saddle area was relatively steady this resulted in significant differences in cerebrospinal fluid flow velocity and discharge, as well as the cardiac cycle.

关键词： cerebrospinal fluid magnetic resonance imaging empty sella syndrome cardiac cycle neuroimaging