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Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

Cell Research 2004年第3期14卷 251-256页

作者： Justin STEBBING,Steve PATTERSON,Simon PORTSMOUTH,Claire THOMAS,Robert GLASSMAN,Adrian WILDFIRE,Frances GOTCH,Mark BOWER,Mark NELSON,Brian GAZZARD The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham Ro

There is increasing recognition of the potential morbidity and mortality associated with HIV-1 and hepatitis C (HCV) co-infection. HIV appears to adversely affect HCV disease while the reciprocal effect of HCV on HIV remains controversial. We therefore studied the effect of co-infection on dendritic cell function versus HIV infection alone, as previous work has shown that HCV impairs dendritic cell (DC) function. HIV-1 positive individuals with HCV were matched for CD4 count, HIV-1 RNA viral load and therapy, to HIV-1 positive patients without HCV. Monocyte-derived DC were generated and mixed leukocyte reactions were performed. We assessed allostimulatory capacity with and without administration of exogenous Thl cytokines, using thymidine uptake and cell division analyses with the vital dye CFSE. We found that monocyte-derived DC from co-infected individuals showed no significant differences in allostimulatory capacity to ex vivo generated DC from HIV-1 infected individuals without HCV. Unlike the situat

关键词： hepatitis C HIV co-infection dendritic cells.

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New insights into the immunology and evolution of HIV

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Cell Research 2003年第1期13卷 1-7页

作者： JUSTINSTEBBING,STEVEPATTERSON,FRANCESGOTCH Department Department Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH United Kingdom of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH United Kingdom of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 fulham road London SW10 9NH United Kingdom

Fewer than one million HIV infected individuals are currently receiving anti-retroviral therapy. The limitations of such treatment have underscored the need to develop more effective strategies to control the spread and pathogenesis of HIV. Typically, naturally occurring protective immune responses provide the paradigm for such development. It is now clear however that HIV can utilise the millieu of an activated immune system to its own replicative advantage. Mobilisation of the immune response, intended to thwart the virus, may instead fuel its dissemination, 'immune escape' and spread. The immense genetic variation of HIV contributes to lack of immune control and the development of progressive disease in the majority of infected, untreated individuals. Further delineation of the intimate interactions between the HIV and the immune system will be critical and recent advances in this direction are discussed.

关键词： HIV immune response CTL evolution vaccine.

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Complex regional pain syndrome: a recent update

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Burns & Trauma 2017年第1期5卷 24-34页

作者： En Lin Goh Swathikan Chidambaram Daqing Ma Anaesthetics Pain Medicine and Intensive CareDepartment of Surgery and CancerFaculty of MedicineImperial College LondonChelsea and Westminster Hospital369 Fulham RoadLondon SW10 9NHUK

Complex regional pain syndrome (CRPS) is a debilitating condition affecting the limbs that can be induced by surgery or trauma. This condition can complicate recovery and impair one’s functional and psychological well-being. The wide variety of terminology loosely used to describe CRPS in the past has led to misdiagnosis of this condition, resulting in poor evidence-base regarding the treatment modalities available and their impact. The aim of this review is to report on the recent progress in the understanding of the epidemiology, pathophysiology and treatment of CRPS and to discuss novel approaches in treating this condition.

关键词： CRPS Epidemiology Pathophysiology Treatment Future therapy

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Complete pathological response following down-staging chemoradiation in locally advanced pancreatic cancer:Challenging the boundaries

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World Journal of Gastroenterology 2007年第47期13卷 6433-6435页

作者： AZ Khan V Pitsinis SS Mudan Department of Gastrointestinal Surgery Royal Marsden HospitalFulham RoadLondonUnited Kingdom

Pancreatic cancer is an aggressive malignancy,relatively resistant to chemotherapy and radiotherapy,which usually presents late. Disease specific mortality approaches unity despite advances in adjuvant therapy. We present the first reported case of complete pathological response following neoadjuvant therapy in a locally advanced pancreatic adenocarcinoma.

关键词： Chemotherapy Pancreatic cancer Pathology

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The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring

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Burns & Trauma 2016年第2期4卷 78-89页

作者： M.Mehta O.A.Branford K.J.Rolfe British College of Osteopathic Medicine(BCOM) Finchley RoadLondon NW35HRUK The Royal Marsden Hospital Fulham RdLondon SW36JJUK

Though survival rate following severe thermal injuries has improved,the incidence and treatment of scarring have not improved at the same *** review discusses the formation of scars and in particular the formation of hypertrophic ***,though there is as yet no gold standard treatment for the prevention or treatment of scarring,a brief overview is included.A number of natural therapeutics have shown beneficial effects both in vivo and in vitro with the potential of becoming clinical therapeutics in the *** natural therapeutics include both plant-based products such as resveratrol,quercetin and epigallocatechin gallate as examples and includes the non-plant-based therapeutic *** review also includes potential mechanism of action for the therapeutics,any recorded adverse events and current administration of the therapeutics *** review discusses a number of potential'treatments'that may reduce or even prevent scarring particularly hypertrophic scarring,which is associated with thermal injuries without compromising wound repair.

关键词： Burns Hypertrophic scar Natural therapeutics Wound healing

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Recent advances in the systemic treatment of gastrointestinal stromal tumors

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Cancer Biology & Medicine 2023年第10期20卷 701-705页

作者： Robin L.Jones Marin Golcic Sarcoma Unit The Royal Marsden NHS Foundation Trust and Institute of Cancer ResearchFulham RoadLondon SW36JJUnited Kingdom Clinic for Tumors Clinical Hospital CenterRijeka 51000Croatia

Historical overview of the treatment for advanced gastrointestinal stromal tumors(GISTs)GISTs represent a relatively rare entity;however,GISTs are still the most common mesenchymal neoplasm in the gastrointestinal *** majority of GISTs express the transmembrane receptor,KIT,a product of the KIT proto-oncogene that can lead to uncontrolled cell proliferation and resistance to apoptosis1-3.

关键词： gastrointestinal tumors treatment

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Endotoxins in the prostatic secretions of chronic prostatitis patients:a need for further biomarkers through the use of proteomics

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Asian Journal of Andrology 2006年第1期8卷 123-124页

作者： Sashi S.Kommu Stewart Reiss The Royal Marsden NHS Foundation Trust Fulham RoadLondon SW3 6JJUK Brighton and Sussex Medical School University of SussexBrighton BN1 9PXUK

Dear Sir,Dai et al.[1] must be commended on their useful investigation of the clinical significance of endotoxins in the expressed prostatic secretions （EPS） of chronic prostatitis （CP） patients. However, we take issue with their conclusion. The conclusion that EPS endotoxin determination is helpful in diagnostic confirmation is plausible,

关键词： Proteomics Bacterial Infections Biological Markers Chronic Disease Endotoxins Humans Male Prostate Prostatitis

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Imaging of liver cancer

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World Journal of Gastroenterology 2009年第11期15卷 1289-1300页

作者： Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim Department of Imaging Imperial College Healthcare NHS Trust Charing Cross Hospital Campus Fulham Palace Road London W6 8RF United Kingdom Department of Hepatology and Gastroenterology Division of Medicine Imperial College London St Mary's Hospital Campus South Wharf Road London W2 1NY United Kingdom

Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality.

关键词： Hepatic cell carcinoma Cholangiocarcinoma Contrast enhanced ultrasound Computed tomography Magnetic resonance imaging

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超声介导经皮穿刺松解弹响指的环形滑车

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国际医学放射学杂志 2009年第6期 596-597页

作者： G.Rajeswaran J.C.Lee R.Eckersley E.Katsarma J.C.Healy 蒋新华 Department of Radiology Chelsea & Westminster Hospital369 Fulham RoadLondon SW10 9NHUK

本研究的目的是描述及评价采用超声介导经皮穿刺的新方法,利用改进的皮下注射针松解环形滑车。收集2006年10月至最近16个月以来在本研究中心手外科就诊的25例病例,共对35个手指行超声介导经皮穿刺松解术纳入标准如下:成年人,弹性痛4个... 详细信息

本研究的目的是描述及评价采用超声介导经皮穿刺的新方法,利用改进的皮下注射针松解环形滑车。收集2006年10月至最近16个月以来在本研究中心手外科就诊的25例病例,共对35个手指行超声介导经皮穿刺松解术纳入标准如下:成年人,弹性痛4个月以上,

关键词：超声介导滑车葫芦(工具) 经皮穿刺弹响指

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英国HIV感染和生育保健的需求与供给

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 38-39页

作者： Frodsham L. C. G. Boag F. Barton S. Gilling-Smith C. 朱亮(译) 党慧敏(校) 不详 Chelsea and Westminster Hospital Assisted Conception Unit 369 Fulham Road London SW109NH United Kingdom

Objective: To collect data on the demand and provision of fertility care in HIV- infected couples in the United Kingdom and data on the etiology of subfertility in this ***: A postal questionnaire survey and audit of causes of infertility in HIV- infected ***: Seventy- four Human Embryology and Fertilisation Authority- registered assisted conception units (ACUs) and 294 genitourinary medicine (GUM) clinics in the United Kingdom were sent ***(s): Sixty- five HIV- infected women attending the Research Clinic at the Chelsea and Westminster ACU. Intervention(s): None. Main Outcome Measure(s): Number of ACUs treating HIV- infected patients and number of GUM clinics receiving requests for referral, as well as the etiology of subfertility in HIV infected women attending our ***-sult(s): Response rates from ACUs and GUM clinics were 93% and 63% , *** ACUs (20% ) were treating HIV- infected men; of these, seven (10% ) performed sperm washing, but only two (3% ) tested sperm for HIV after processing, before *** units (13% ) treated HIV- infected women, but only three ACUs (4% ) had separate laboratories for handling potentially infected gametes or *** the 15, 211 patients registered in 81 GUM clinics, 4% of the men and 16% of the women had requested advice on *** audit of the Chelsea and Westminster HIV fertility clinic demonstrated a 40% prevalence of tubal factor infertility in HIV- infected ***(s): Demand is high, and set to increase, but current suboptimal practice in some centers is placing unaffected partners and the unborn child at risk of seroconversion.

关键词： HIV感染供给和需求生育保健英国输卵管性不孕治疗中心感染妇女低生育力

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