Recent advances in the systemic treatment of gastrointestinal stromal tumors

作     者：Robin L.Jones Marin Golcic Robin L.Jones;Marin Golčić

作者机构：Sarcoma UnitThe Royal Marsden NHS Foundation Trust and Institute of Cancer ResearchFulham RoadLondon SW36JJUnited Kingdom Clinic for TumorsClinical Hospital CenterRijeka 51000Croatia 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2023年第20卷第10期

页      面：701-705页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：gastrointestinal tumors treatment 

摘      要：Historical overview of the treatment for advanced gastrointestinal stromal tumors(GISTs)GISTs represent a relatively rare entity;however,GISTs are still the most common mesenchymal neoplasm in the gastrointestinal *** majority of GISTs express the transmembrane receptor,KIT,a product of the KIT proto-oncogene that can lead to uncontrolled cell proliferation and resistance to apoptosis1-3.