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Dry environment on the expression of lacrimal gland S100A9,Anxa1,and Clu in rats via proteomics

International Journal of Ophthalmology(English edition) 2024年第3期17卷 435-443页

作者： Yi-Lin Sun A-Yuan Cui Li-Xin Wang Wang-Wang Zhang Hong Shi College of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina Research on High Incidence of Diseases in xinjiang region Key Laboratory of the Ministry of Education(Xinjiang Medical University)Urumqi 830011Xinjiang Uygur Autonomous RegionChina

●AIM:To investigate the underlying mechanism of dry environment(autumn dryness)affecting the lacrimal glands in rats.●METHODS:Twenty Sprague-Dawley rats were randomly divided into two *** rats were fed in specific pathogen free environment as the control group(n=10),and the rats fed in dry environment as the dryness group(n=10).After 24d,lacrimal glands were collected from the *** tissues morphology was observed by hematoxylineosin(HE)*** mass tags(TMT)quantitative proteomics analysis technology was used to screen the differential expressed proteins of lacrimal glands between the two groups,then bioinformatics analysis was ***,the immunohistochemical(IHC)method was used to verify the target proteins.●RESULTS:In dryness group,the lacrimal glands lobule atrophied,the glandular cavities enlarged,the sparse nuclear distribution and scattered inflammatory infiltration between the acinus were *** proteomics exhibited that a total of 195 up-regulated and 23. downregulated differential expressed proteins screened from the lacrimal glands of *** was indicated that the biological processes(BP)of differential expressed proteins mainly included cell processes and single *** cellular compositions of differential expressed proteins mainly located in cells,*** molecular functions of differential expressed proteins mainly included binding,catalytic ***,the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that the differential expressed proteins mainly involved lysosome,complement and coagulation cascade,and ribosome *** IHC result verified that the up-regulated expression proteins of Protein S100A9(S100A9),Annexin A1(Anxa1),and Clusterin(Clu)in lacrimal glands of rats in dryness group were higher than control group.●CONCLUSION:The up-regulated expression proteins of S100A9,Anxa1,and Clu may be the potential mechanisms of dry eye symptoms caused by dry *** study pr

关键词： dry eye lacrimal gland S100A9 Clu Anxa1 environment rats

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Mediating role of social support in dysphoria,despondency,and quality of life in patients undergoing maintenance hemodialysis

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World Journal of Psychiatry 2024年第3期14卷 409-420页

作者： Xiang Zhou Hong Jiang Yi-Peng Zhou Xiao-Yu Wang Hai-Yan Ren Xue-Fei Tian Qing-Qing Zhang Department of Nephrology People’s Hospital of Xinjiang Uygur Autonomous RegionXinjiang Clinical Research Center for Kidney DiseaseUrumqi 832000Xinjiang Uygur Autonomous RegionChina Department of Endocrinology and Metabolism People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 832000Xinjiang Uygur Autonomous RegionChina Section of Nephrology Department of Internal MedicineYale University School of MedicineNew HavenCT 06510United States

BACKGROUND Dysphoria and despondency are prevalent psychological issues in patients undergoing Maintenance Hemodialysis(MHD)that significantly affect their quality of life(QOL).High levels of social support can significantly improve the physical and mental well-being of patients undergoing ***,there is limited research on how social support mediates the relationship between dysphoria,despondency,and overall QOL in patients undergoing *** is imperative to investigate this mediating effect to mitigate dysphoria and despondency in patients undergoing MHD,ultimately enhancing their overall *** To investigate the mediating role of social support in relationships between dysphoria,despondency,and QOL among patients undergoing *** Participants comprised 289 patients undergoing MHD,who were selected using a random sampling *** Social Support Rating Scale,Self-Rating Anxiety Scale,Self-Rating Depression Scale,and QOL Scale were *** analysis was performed to examine the associations between social support,dysphoria,despondency,and QOL in patients undergoing *** assess the mediating impact of social support on dysphoria,despondency,and QOL in patients undergoing MHD,a bootstrap method was *** Significant correlations among social support,dysphoria,despondency,and quality in patients undergoing MHD were observed(all P<0.01).Dysphoria and despondency negatively correlated with social support and QOL(P<0.01).Dysphoria and despondency had negative predictive impacts on the QOL of patients undergoing MHD(P<0.05).The direct effect of dysphoria on QOL was statistically significant(P<0.05).Social support mediated the relationship between dysphoria and QOL,and this mediating effect was significant(P<0.05).Similarly,the direct effect of despondency on QOL was significant(P<0.05).Moreover,social support played a mediating role between despondency and QOL,with a significant mediating effect(P<0.05).CONCLUSION These find

关键词： Maintenance hemodialysis Social support Dysphoria Despondency Quality of life Mediating effect

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Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3.pathway

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2296-2307页

作者： Shan-Shan Xie Yong Zhi Chang-Ming Shao Bin-Fang Zeng Department of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830017Xinjiang Uygur Autonomous RegionChina

BACKGROUND The Chinese medicine Yangyin Huowei mixture(YYHWM)exhibits good clinical efficacy in the treatment of chronic atrophic gastritis(CAG),but the mechanisms underlying its activity remain *** To investigate the therapeutic effects of YYHWM and its underlying mechanisms in a CAG rat *** Sprague-Dawley rats were allocated into control,model,vitacoenzyme,and low,medium,and high-dose YYHWM *** was induced in rats using Nmethyl-N′-nitro-N-nitrosoguanidine,ranitidine hydrochloride,hunger and satiety perturbation,and ethanol *** an 8-wk intervention period,stomach samples were taken,stained,and examined for histopathological *** was utilized to quantify serum levels of PG-I,PG-II,G-17,IL-1β,IL-6,and TNF-α.Western blot analysis was performed to evaluate protein expression of IL-10,JAK1,and *** The model group showed gastric mucosal layer disruption and inflammatory cell *** with the blank control group,serum levels of PGI,PGII,and G-17 in the model group were significantly reduced(82.41±3.53.vs 3..52±1.71,23.06±0.96 vs 11.06±0.70,and 493.09±12.17 vs 225.52±17.44,P3..15±3.07 vs 80.98±4.47,69.05±12.72 vs 110.85±6.68,and 209.24±11.62 vs 3.3.3.±3..77,P3.were higher in gastric mucosal tissues(0.47±0.10 vs 1.11±0.09,0.49±0.05 vs 0.99±0.07,and 0.24±0.05 vs 1.04±0.14,P3..52±1.71 vs 50.41±3.53.11.06±0.70 vs 15.3.±1.24,and 225.52±17.44 vs 3.9.22±29.11,P3.3.3.±3..77 vs 267.3.±9.3.,P3.in gastric mucosal tissues(1

关键词： Yangyin Huowei mixture IL-10/JAK1/STAT3.pathway Chronic atrophic gastritis Inflammatory factor Gastric secretory function

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Fifty-five cases of hepatic alveolar echinococcosis combined with lymph node metastasis:A retrospective study

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World Journal of Gastroenterology 2024年第23期30卷 2981-2990页

作者： Yilizhati Aimaitijiang Tie-Min Jiang Ying-Mei Shao Tuerganaili Aji State Key Laboratory on Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaThe First Clinical CollegeXinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina The First Ward of Hepatobiliary and Pancreatic Surgery Tumor Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina Department of Hepatobiliary&Hydatid Diseases Digestive&Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina xinjiang Clinical Research Center for Echinococcosis and Hepatobiliary Diseases The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina

BACKGROUND Lymph node metastasis is a specific type of metastasis in hepatic alveolar echinococcosis(AE).Currently,there is a scarcity of describing the clinical characteristics and lymph node metastasis rules of patients with hepatic AE combined with lymph node metastasis and its mechanism and management are still *** hepatectomy combined with regional lymph node dissection is a better *** To analyse the clinical features of hepatic AE combined with lymph node metastasis to explore its treatment and *** A total of 623.patients with hepatic AE admitted to the First Affiliated Hospital of xinjiang Medical University from 1 January 2012 to 1 January 2022 were retrospectively ***-five patients with combined lymph node metastasis were analysed for their clinical data,diagnosis and treatment methods,follow-up efficacy,and characteristics of lymph node ***,we comparatively analysed the lymph node metastasis rates at different *** variables are expressed as frequencies and percentages,and the analysis of difference was performed using theχ2 *** Bonferroni method was used for pairwise comparisons when statistical differences existed between multiple categorical *** A lymph node metastasis rate of 8.8%(55/623.was reported in patients with hepatic AE,with a female predilection(69.1%)and a statistically significant sex difference(χ2=8.018,P=0.005).Of the 55 patients with lymph node metastasis,72.7%had a parasite lesion,neighbouring organ invasion,and metastasis stage of P3.1M0 and above,of which 67.3.,78.2%,and 3..5%of hepatic AE lesions invaded the bile ducts,blood vessels,and distant metastases,*** rates of lymph node metastasis of 16.4%,21.7%,and 3..2%were reported for a preoperative abdominal ultrasound,magnetic resonance imaging,and computed tomography *** patients were intraoperatively suspected with enlarged lymph nodes and underwent radica

关键词： Echinococcosis Radical hepatectomy Lymph node metastasis Lymph node dissection Alveolar echinococcosis Hepatic

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Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 945-967页

作者： Jia-Li Hu Mei-Jin Huang Halike Halina Kun Qiao Zhi-Yuan Wang Jia-Jie Lu Cheng-Liang Yin Feng Gao Department of Gastroenterology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina xinjiang Clinical Research Center for Digestive Disease Urumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Oncology 920th Hospital of PLA Joint Logistics Support ForceKunming 650032Yunnan ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination *** is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of *** also affects the prognosis of GC *** reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour ***,the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still *** To investigate inflammatory-related biomarkers in predicting the prognosis of GC *** constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO *** patients from the GSE26253.cohort were used for *** and multivariate Cox analyses were used to determine the independent prognostic factors,and a prognostic nomogram was *** calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the *** decision curve analysis results were plotted to quantify and assess the clinical value of the *** set enrichment analysis was performed to explore the potential regulatory pathways *** relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and ***,we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy *** A prognostic model consisting of three inflammatory-related genes(MRPS17,GUF1,and PDK4)was *** prognostic analysis revealed that the risk score was a separate prognostic factor in GC *** to the risk score,GC patients were stratified into high-and low-risk groups,and patients in the high-risk group ha

关键词： Gastric cancer Inflammation Immune infiltration Prognosis signature Subt

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Retrospective analysis based on a clinical grading system for patients with hepatic hemangioma:A single center experience

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2047-2053页

作者： Cheng-Ming Zhou Jun Cao Shao-Ke Chen Tuerhongjiang Tuxun Shadike Apaer Jing Wu Jin-Ming Zhao Hao Wen Department of Liver and Laparoscopic Surgery Digestive and Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Operation Management The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of General Surgery The First Teaching CollegeXinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina

BACKGROUND The optimal approach for managing hepatic hemangioma is *** To evaluate a clinical grading system for management of hepatic hemangioma based on our 17-year of single institution *** A clinical grading system was retrospectively applied to 1171 patients with hepatic hemangioma from January 2002 to December *** were classified into four groups based on the clinical grading system and treatment:(1)Observation group with score3.Observation group with score≥4(Obs score≥4);and(4)Surgical group with score≥4(Sur score≥4).The clinico-pathological index and outcomes were *** There were significantly fewer symptomatic patients in surgical groups(Sur score≥4 vs Obs score≥4,P0.05;χ^(2)=1.68,P>0.05).CONCLUSION This clinical grading system appeared as a practical tool for hepatic *** can be suggested for patients with a score≥*** those with<4,follow-up should be proposed.

关键词： Hepatic hemangioma Clinical grading system Surgical indication Outcome Postoperative complications

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Characteristics of wind-sand transportation along railways in the eastern fringe of the Taklimakan Desert and sand control system

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Transportation Safety and Environment 2024年第3期6卷 152-166页

作者： Hongguang Dong Jianjun Cheng Benteng Ma Yupeng Li Yuanqing Chen College of Water Conservancy&Architectural Engineering Shihezi UniversityShihezi 832003Xinjiang Uygur Autonomous RegionChina

This paper focuses on the Korla-Ruoqiang desert railway line,utilizing ERAS(ERA5 is the fifth generation of ECMWF(European Centre for Medium-Range Weather Forecasts)atmospheric reanalysis global climate data)wind data to conduct a comprehensive analysis of the wind energy environment along the line in all aspects,reveals the characteristics of wind-sand transport,and puts forward the countermeasures to prevent and control wind-sand *** results of the study indicate that:(1)the wind-sand along the line mainly occurs in the spring and summer seasons,and the dominant sand-moving directions are easterly(ENE,E and NNE)and northeasterly(NE).(2)The average annual sand-moving wind speed ranges from 5.80 m/s to 7.25 m/s,and the annual frequency of sand-moving ranges from 11.99%to 3..26%.(3.The annual sand drift potential(DP)along the line ranges from 69.20 VU to 607.24 VU,with three types of wind energy environments:low,medium and *** resultant drift potential(RDP)ranges from 45.52 VU to 547.49 VU,and the wind variability index(RDP/DP)is between 0.54 and 0.90.(4)The average sand transport quantity along the line ranges from 2.92 m^(3./m/a to 9.09 m3.m/*** on these results,we optimize the sand blocking,sand fixing and wind erosion prevention measures for different types of wind-sand environments,establish a scientific and efficient wind-sand protection and control system to solve the wind-sand problems and provide a scientific foundation for the prevention and control of wind-sand disasters along the line.

关键词： desert railway wind energy environment sand-moving speed sand transport activities sand control system

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An Industrial Intrusion Detection Method Based on Hybrid Convolutional Neural Networks with Improved TCN

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Computers, Materials & Continua 2024年第1期78卷 411-433页

作者： Zhihua Liu Shengquan Liu Jian Zhang College of Computer Science and Technology Xinjiang UniversityXinjiang Uygur Autonomous RegoinUrumqi830000China

Network intrusion detection systems(NIDS)based on deep learning have continued to make significant ***,the following challenges remain:on the one hand,simply applying only Temporal Convolutional Networks(TCNs)can lead to models that ignore the impact of network traffic features at different scales on the detection *** the other hand,some intrusion detection methods considermulti-scale information of traffic data,but considering only forward network traffic information can lead to deficiencies in capturing multi-scale temporal *** address both of these issues,we propose a hybrid Convolutional Neural Network that supports a multi-output strategy(BONUS)for industrial internet intrusion ***,we create a multiscale Temporal Convolutional Network by stacking TCN of different scales to capture the multiscale information of network ***,we propose a bi-directional structure and dynamically set the weights to fuse the forward and backward contextual information of network traffic at each scale to enhance the model’s performance in capturing the multi-scale temporal features of network *** addition,we introduce a gated network for each of the two branches in the proposed method to assist the model in learning the feature representation of each *** experiments reveal the effectiveness of the proposed approach on two publicly available traffic intrusion detection datasets named UNSW-NB15 and NSL-KDD with F1 score of 85.03. and 99.3.%,respectively,which also validates the effectiveness of enhancing the model’s ability to capture multi-scale temporal features of traffic data on detection performance.

关键词： Intrusion detection industrial internet channel spatial attention multiscale features dynamic fusion multi-output learning strategy

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Comparative analysis of the short and medium-term efficacy of the Da Vinci robot versus laparoscopic total mesangectomy for rectal cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1681-1690页

作者： Wei-Ge Gao Wen Shi Xu-Chen Gong Zhi-Wen Li Yiminjiang Tuoheti Department of Anorectal Surgery People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Anus and Intestine Surgery Cancer Hospital of Chinese Academy of Medical SciencesBeijing 100084China

BACKGROUND The Da Vinci robot-assisted surgery technique has been widely used in laparo-scopic mesangectomy for rectal ***,the short-term efficacy of these procedures compared to traditional laparoscopic surgery remains *** purpose of this study was to compare and analyze the short-and medium-term efficacy of Da Vinci robot and laparoscopic surgery in total mesangectomy(TME)for rectal cancer,so as to provide guidance and reference for clinical *** To investigate the safety and long-term efficacy of robotic and laparoscopic total mesorectal resection for the treatment of rectal *** The clinicopathologic data of 240 patients who underwent TME for rectal cancer in the Anorectal Department of People’s Hospital of xinjiang uygur autonomous {3. from August 2018 to March 2023.were retrospectively *** them,112 patients underwent laparoscopic TME(L-TME)group,and 128 patients underwent robotic TME(R-TME)*** intraoperative,postoperative,and follow-up conditions of the two groups were *** The conversion rate of the L-TME group was greater than that of the R-TME group(5.4%vs 0.8%,χ^(2)=4.417,P=0.03.).The complication rate of the L-TME group was greater than that of the R-TME group(3..1%vs 17.2%,χ^(2)=7.290,P=0.007).The percentage of positive annular margins in the L-TME group was greater than that in the R-TME group(7.1%vs 1.6%,χ^(2)=4.658,P=0.03.).The 3.year disease-free survival(DFS)rate and overall survival(OS)rate of the L-TME group were lower than those of the R-TME group(74.1%vs 85.2%,χ^(2)=4.962,P=0.026;81.3.vs 91.4%,χ^(2)=5.494,P=0.019);in patients with American Joint Committee on Cancer stage Ⅲ DFS rate and OS rate in the L-TME group were significantly lower than those in the R-TME group(52.5%vs 76.1%,χ^(2)=5.799,P=0.016;65.0%vs 84.8%,χ^(2)=4.787,P=0.029).CONCLUSION Compared with the L-TME group,the R-TME group had a better tumor prognosis and was more favorable for patients with rectal cancer

关键词： Rectal tumor Robots Laparoscopy Total mesangectomy Survival prognosis Retrospective analysis

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Genotypes and Phenotypes of uygur Children With Xeroderma Pigmentosum: A Case Study in xinjiang, China

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International Journal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Yun Qiu Wei-Jia Wang Jun-Qin Liang Buwajieer Yakeya Peng Wang Jing-Zhan Zhang Xiao-Jing Kang Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous Region 830001China xinjiang Clinical Research Center for Dermatologic Diseases UrumqiXinjiang Uygur Autonomous Region 830001China xinjiang Key Laboratory of Dermatology Research(XJYS1707) UrumqiXinjiang Uygur Autonomous Region 830001China

Objective:Xeroderma pigmentosum(XP)is a rare autosomal recessive dermatosis caused by genetic defects of DNA *** study was performed to detect and analyze the genes of 2 uygur patients with XP and their families and assess the patients’phenotypes,which may enrich the understanding of the genetic skin disorder spectrum in xinjiang ***:We collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family *** patients’DNA was sequenced and detected by Sanger sequencing,and gene mutations were ***:The proband in family 1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary to a facial *** proband had a homozygous nucleotide variation of XPC c.2251-2A>G(A change from A to G in the penultimate position of the intron before the 2251 position in the coding region),which was a shear *** this family,both parents were heterozygous,and no similar mutation detected in the *** family 2,the proband had scattered black brown spots and papules on the trunk and *** his younger sister was also a *** proband and his younger sister had homonucleotide variation of XPA c.63.C>T,which was nonsense mutation,resulting in the codon for Arg No.211 being changed into termination codon(***211X),thus terminating the peptide chain synthesis *** the normal individuals in the two families were heterozygotes,and homozygous mutations occurred in all the patients,which was consistent with the autosomal recessive ***:XP is rare in uygur *** study expanded the mutation spectrum of XP and provided a basis for early diagnosis,treatment,prognostic prediction,and prenatal genetic consultation.

关键词： xeroderma pigmentosum gene mutation XPA gene XPC gene

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