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Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

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research 2024年第1期2023卷 315-337页

作者： Chong Qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen Wang Huanhuan Pang Liwei Gu Chengchao Xu Qiuyan Guo Jigang Wang artemisinin research center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Nephrology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuangdong 518020China

Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,smallmolecule drugs,and nucleic ***,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most *** review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport *** strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/*** the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.

关键词： somal drugs finding

Feasible Synthesis of N,O-Bidentate Difluoroboron Chromophores through Direct Functionalization of Quinoxalin-2(1H)-ones with Ketones in One Shot

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Chinese Journal of Chemistry 2024年第13期42卷 1481-1486页

作者： Shuaichen Zhang Jing Zhang Xiang Ling Yifan Zhao Yue Ma Peng Sun State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityState Key Laboratory of Natural MedicinesNanjingJiangsu 210009China

Organic difluoroboron complexes are a kind of potential platforms for a wide range of applications owing to their excellent photophysical ***,we have explored a simple and direct synthesis methodology for a library of N,O-bidentate difluoroboron complexes from quinoxalin-2(1H)-ones and ketones in one *** photophysical properties of the generated complexes were evaluated and the application potential of these compounds on subcellular imaging was also explored.

关键词： N,O-Bidentate difluoroboron Chromophores Quinoxalin-2(1H)-ones Ketones/Green chemistry Synthetic method C-CcouplingI Boron

Synthesis of boron nitride nanorod and its performance as a metalfree catalyst for oxidative desulfurization of diesel fuel

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Chinese Journal of Chemical Engineering 2024年第4期68卷 120-132页

作者： Tanaz Ghanadi Gholamreza Moradi Alimorad Rashidi Catalyst research center Faculty of Chemical and Petroleum EngineeringRazi UniversityKermanshahIran Nanotechnology research center Research Institute of Petroleum Industry(RIPI)TehranIran

In order to reduce the sulfur compounds in diesel fuel,boron nitride(BN)has been used as a novel metal-free catalyst in the present *** nanocatalyst was synthesized via template-free approach followed by heating treatment at 900℃ in nitrogen atmosphere that the characteristics of the sample were identified by the X-ray diffraction,Fourier-transform infrared spectroscopy,Raman spectroscopy,field emission scanning electron microscopy,transmission electron microscopy,atomic force microscopy,and N2 adsorption-desorption *** results of structural and morphological analysis represented that BN has been successfully *** efficacy of the main operating parameters on the process was studied by using response surface methodology based on the Box-Behnken design *** prepared catalyst showed high efficiency in oxidative desulfurization of diesel fuel with initial sulfur content of 8040 mg·kg^(-1)*** statistical analysis,a significant quadratic model was obtained to predict the sulfur removal as a function of efficient *** maximum efficiency of 72.4%was achieved under optimized conditions at oxidant/sulfur molar ratio of 10.2,temperature of 71℃,reaction time of 113.min,and catalyst dosage of 0.3. ***,the reusability of the BN was studied,and the result showed little reduction in activity of the catalyst after 10 times ***,a plausible mechanism was proposed for oxidation of sulfur compounds on the surface of the *** present study shows that BN materials can be selected as promising metal-free catalysts for desulfurization process.

关键词： Desulfurization Boron nitride(BN)nanostructure Experimental design BoxeBehnken

Improved State-space Modelling for Microgrids Without Virtual Resistances

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 584-596页

作者： Paranagamage S.A.Peiris Shaahin Filizadeh Dharshana Muthumuni Department of Electrical and Computer Engineering University of ManitobaWinnipegMBR3T 5V6Canada Manitoba HVDC research center 211 Commerce DriveWinnipegMBR3P 1A3Canada IEEE

Power converters and their interfacing networks are often treated as modular state-space blocks for small-signal stability studies in microgrids;they are interconnected by matching the input and output states of the network and *** resistors have been widely used in existing models to generate a voltage for state-space models of the network that require voltage *** paper accurately quantifies the adverse impacts of adding the virtual resistance and proposes an alternative method for network modelling that eliminates the requirement of the virtual resistor when interfacing converters with *** proposed nonlinear method allows initialization,time-domain simulations of the nonlinear model,and linearization and eigenvalue generation.A numerically linearized small-signal model is used to generate eigenvalues and is compared with the eigenvalues generated using the existing modelling method with virtual *** of the existing method and improvements offered by the proposed modelling method are clearly *** transient(EMT)simulations using detailed switching models are used for validation of the proposed modelling method.

关键词： Low-voltage converter state-space modelling dynamic phasor time-domain simulation eigenvalue analysis

Comparative analysis between single-train passing and double-train intersection in a tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 429-442页

作者： Jianming DU Qian FANG Xuan ZHANG Hualao WANG Bridge and Tunnel research center Research Institute of Highway Ministry of TransportBeijing 100088China Tunnel and Underground Engineering research center of Ministry of Education Beijing Jiaotong UniversityBeijing 00044China

Aerodynamic pressure significantly impacts the scientific evaluation of tunnel service *** aerodynamic pressure of two trains running in a double-track tunnel is considerably more complicated than that of a single *** used the numerical method to investigate the difference in aerodynamic pressure between a single train and two trains running in a double-track ***,the numerical method was verified by comparing the results of numerical simulation and on-site ***,the characteristics of aerodynamic pressure were ***,the influence of various train-tunnel factors on the characteristics of aerodynamic pressure was *** results show that the aerodynamic pressure variation can be divided into stage I:irregular pressure fluctuations before the train tail leaves the tunnel exit,and stage II:periodic pressure declines after the train tail leaves the tunnel *** addition,the aerodynamic pressure simultaneously jumps positively or drops negatively for a single train or two trains running in double-track tunnel *** pressure amplitude in the two-train case is higher than that for a single *** maximum positive peak pressure difference(P_(STP))and maximum negative peak pressure difference(P_(STN))increase as train speed rises to the power from 2.256 to 2.93. in stage *** P_(STP) and P_(STN) first increase and then decrease with the increase of tunnel length in stage *** P_(STP) and P_(STN) increase as the blockage ratio rises to the power from 2.03. to 2.798 in stages I and II.

关键词： Railway tunnel Aerodynamic effect Pressure characteristic Train speed Tunnel length Blockage ratio

Cognitive impairment in cerebral small vessel disease induced by hypertension

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Neural Regeneration research 2024年第7期19卷 1454-1462页

作者： Weipeng Wei Denglei Ma Lin Li Lan Zhang Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijingChina Beijing Geriatric Medical research center Beijing Engineering Research Center for Nervous System DrugsNational Center for Neurological DisordersNational Clinical Research Center for Geriatric DiseasesBeijingChina

Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular *** r,the causal relationship between hypertension and cerebral small vessel disease remains *** has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular *** hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and *** is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of *** review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive *** also discuss drugs to treat cerebral small vessel disease and cognitive impairment.

关键词： blood-brain barrier cerebral small vessel disease cognitive impairment dementia endothelial dysfunction enlarged perivascular space hypertension lacunar infarction neuroinflammation treatment white matter high signal intensity

Pressure-induced hydrogen-dominant high-temperature superconductors

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National Science Review 2024年第7期11卷 14-16页

作者： Ho-kwang Mao Shanghai Advanced research in Physical Sciences center for High Pressure Science and Technology Advanced research

Recent studies of hydrogen-dominant（superhydride） materials have led to putative discoveries of near-room temperature superconductivity at high pressures. The idea started more than half-a-century ago as a by-product of the quest for metallic hydrogen for which a natural consequence of its very high Debye temperature and phonon frequency due to the very low mass of the hydrogen atoms would lead to a high superconducting critical temperature （Tc） in weak coupling Bardeen-Cooper-Schrieffer（BCS） expression.

关键词： HYDRIDE LANTHANUM

Design of Resilient Sensor Networks Balancing Resilience and Efficiency

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International Journal of Disaster Risk Science 2024年第1期15卷 107-115页

作者： Sergey N.Vecherin Kiril D.Ratmanski Luke Hogewood Igor Linkov Cold Regions research and Engineering Laboratory Engineering Research and Development CenterHanoverNH 03755USA Environmental Laboratory Engineering Research and Development CenterVicksburgMS 39180USA

In recent years,the notion of resilience has been developed and applied in many technical areas,becoming exceptionally pertinent to disaster risk *** a disaster situation,accurate sensing information is the key to efficient recovery *** general,resilience aims to minimize the impact of disruptions to systems through the fast recovery of critical functionality,but resilient design may require redundancy and could increase *** this article,we describe a method based on binary linear programming for sensor network design balancing efficiency with *** application of the developed framework is demonstrated for the case of interior building surveillance utilizing infrared sensors in both twoand three-dimensional *** method provides optimal sensor placement,taking into account critical functionality and a desired level of resilience and considering sensor type and *** problem formulation,resilience requirements,and application of the optimization algorithm are described in *** of sensor locations with and without resilience requirements shows that resilient configuration requires redundancy in number of sensors and their intelligent *** tasks are successfully solved by the described method,which can be applied to strengthen the resilience of sensor networks by *** proposed methodology is suitable for large-scale optimization problems with many sensors and extensive coverage areas.

关键词： Binary linear programming Optimal sensor placement Redundant networks Resilience and efciency Resilient sensor networks

Magnetic methods in studies of new superconducting hydrides in a diamond anvil cell

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National Science Review 2024年第7期11卷 16-18页

作者： Viktor V.Struzhkin Ho-kwang Mao center for High Pressure Science&Technology Advanced research

In recent years, we have witnessed great success in discoveries of high-transition-temperature（Tc） hydrides using high-pressure experiments. This has been achieved by creating metallic hydrogen‘alloys’ with other ...

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