检索结果-南通市图书馆

Emerging drug design strategies in anti-influenza drug discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第12期13卷 4715-4732页

作者： Chuanfeng Liu Lide Hu Guanyu Dong Ying Zhang Edeildo Ferreira da Silva-Jinior Xinyong Liu Luis Menendez-Arias Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China Laboratory of Medicinal Chemistry Institute of Pharmaceutical SciencesFederal University of AlagoasMaceio 57072-970AlagoasBrazil Centro de Biologia Molecular“Severo Ochoa”(Consejo Superior de Investigaciones Cientificas&Universidad Autonoma de madrid) Madrid 28049Spain

Influenza is an acute respiratory infection caused by influenza viruses(IFV),According to the World Health Organization(WHO),seasonal IFV epidemics result in approximately 3-5 million cases of severe illness,leading to about half a million deaths worldwide,along with severe economic losses and social ***,frequent mutations in IFV lead to a certain lag in vaccine development as well as resistance to existing antiviral ***,it is of great importance to develop anti-IFV drugs with high efficiency against wild-type and resistant strains,needed in the fight against current and future outbreaks caused by different IFV *** this review,we summarize general strategies used for the discovery and development of antiviral agents targeting multiple IFV strains(including those resistant to available drugs).Structure-based drug design,mechanism-based drug design,multivalent interaction-based drug design and drug repurposing are amongst the most relevant strategies that provide a framework for the development of antiviral drugs targeting IFV.

关键词： Influenza virus Drug design strategies Anti-drugresistance High efficiency Broad spectrum

Electronic energy loss and ion velocity correlation effects in track production in swift-ion-irradiated LiNbO_(3):A quantitative assessment between structural damage morphology and energy deposition

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第21期116卷 30-40页

作者： Xinqing Han Qing Huang Miguel L.Crespillo Eva Zarkadoula Yong Liu Xuelin Wang Peng Liu Institute of Frontier and Interdisciplinary Science and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityQingdao 266237China Shanghai Institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai 201800China Centro de Micro-Análisis de Materiales(CMAM) Universidad Autónoma de MadridMadrid E-28049Spain Materials Science&Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA

The primary motivation for studying how irradiation modifies the structures and properties of solid materials involves the understanding of undesirable phenomena,including irradiation-induced degradation of components in nuclear reactors and space exploration,and beneficial applications,including material performance tailoring through ion beam modification and defect *** this work,the formation mechanism of latent tracks with different damage morphologies in LiNbO_(3)crystals under 0.09-6.17 Me V/u ion irradiation with an electronic energy loss from 2.6-13.2 ke V/nm is analyzed by experimental characterizations and numerical ***-induced damage is preliminarily evaluated via the prism coupling technique to analyze the correlation between the dark-mode spectra and energy loss profiles of irradiated *** the irradiation conditions of different ion velocities and electronic energy losses,different damage morphologies,from individual spherical defects to discontinuous and continuous tracks,are experimentally *** ion penetration process,the ion velocity determines the spatiotemporal distribution of deposited irradiation energy induced by electronic energy loss,meaning that the two essential factors including electronic energy loss and ion velocity coaffect the track *** inelastic thermal spike model is used to numerically calculate the spatiotemporal evolutions of energy deposition and the corresponding atomic temperature under different irradiation conditions,and a quantitative relationship is proposed by comparison with corresponding experimentally observed track damage *** obtained quantitative relationship between irradiation conditions and track damage provides deep insight and guidance for understanding the damage behavior of crystal materials in extreme radiation environments and selecting irradiation parameters,including ion species and energies,for ion beam technique application in atom

关键词： Latent track damage Thermal spike model Electronic energy loss Velocity effect Ion modification

p38γand p38δas biomarkers in the interplay of colon cancer and inflammatory bowel diseases

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2022年第9期42卷 897-901页

作者： Pilar Fajardo Maria Taskova Miguel A.Martín-Serrano Jonas Hansen Sofie Slott Anna K.Jakobsen Marie-Louise Wibom Beñat Salegi Alberto Muñoz Antonio Barbachano Arpita Sharma John Mark Gubatan Aida Habtezion Juan J.Sanz-Ezquerro Kira Astakhova Ana Cuenda Department of Immunology and Oncology National Centre of Biotechnology/Consejo Superior de Investigaciones CientíficasDarwin 3Madrid 28049Spain PhD Programme in Molecular Bioscience Doctoral SchoolUniversidad Autónoma de MadridMadrid 28049Spain Department of Chemistry Technical University of Denmark2800 Kongens LyngbyDenmark Adolphe Merkle Institute University of FribourgChemin des Verdiers 41700 FribourgSwitzerland Stanford School of Medicine StanfordCA 94305USA Instituto de Investigaciones Biomédicas“Alberto Sols” Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de MadridMadrid 28029Spain Centro de Investigación Biomédica en Red-Cáncer Instituto de Salud Carlos IIIMadrid 28029Spain Instituto de Investigación Sanitaria del Hospital Universitario La Paz Madrid 28029Spain Department of Medicine Division of Gastroenterology and HepatologyStanford University School of MedicineStanfordCA 94305USA Department of Molecular and Cellular Biology Centro Nacional de Biotecnología/Consejo Superior de Investigaciones CientíficasDarwin 3Madrid 28049Spain

Dear Editor,Colorectal cancer(CRC)is the second leading cause of cancer death according to the World Health *** with inflammatory bowel disease(IBD),ulcerative colitis(UC)or Crohn’s disease(CD)are at increased risk of developing colitis-associated CRC(CAC)[1];however,our understanding of the inflammationcancer interplay at the molecular level is still limited.

关键词： inflammatory death p38 CRC

On SIR epidemic models with generally distributed infectious periods： Number of secondary cases and probability of infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2017年第2期10卷 157-169页

作者： A. Gomez-Corral M. Lopez-Garcia Instituto de Ciencias Matemdticas CSIC- UAM- UC3M- UCM Calle Nicolds Cabrera 13-15 Madrid 28049 Spain Department of Applied Mathematics School of Mathematics University of Leeds Leeds LS29JT UK

Recently, Clancy [SIR epidemic models with general infectious period distribution, Statist. Prob. Left. 85 （2014） 1-5] has shown how SIR epidemics in which individuals＇ infection periods are not necessarily exponentially distributed may be modeled in terms of a piecewise-deterministic Markov process （PDMP）. In this paper, we present a more detailed description of the underlying PDMP, from which we analyze the population transmission number and the infection probability of a certain susceptible individual.

关键词： Number of secondary cases piecewise-deterministic Markov process proba-bility of infection SIR epidemic model.

1.3 μm emitting SrF2：Nd^3＋ nanoparticles for high contrast in vivo imaging in the second biological window

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2015年第2期8卷 649-665页

作者： Irene Villa Anna Vedda Irene Xochilt Cantarelli Marco Pedroni Fabio Piccinelli Marco Bettinelli Adolfo Speghini Marta Quintanilla Fiorenzo Vetrone Ueslen Rocha Carlos Jacinto Elisa Carrasco Francisco Sanz Rodrfguez Angeles Juarranz Blanca del Rosal Dirk H. Ortgies Patricia Haro Gonzalez Jose Garcia Sole Daniel Jaque Garcia Department of Materials Science University of Milano-Bicocca Via R. Cozzi 55 20125 Milano Italy Dipartimento di Biotecnologie Universita di Verona and INSTM UdR Verona Strada le Grazie 15 37134 Verona Italy Institut National de la Recherche Scientifique-Energie Materiaux et Telecommunications Universitd du Quebec Varennes QC PQ J3X 1S2 Canada Grupo de Fotonica e Fluidos Complexos Instituto de Fisica Universidade Federal de Alagoas 57072-970 Maceio Alagoas Brazil Departamento de Biologia Facultad de Ciencias Campus de Cantoblanco Universidad Autdnoma de Madrid Madrid 28049 Spain Fluorescence Imaging Group Departamento de Fisica de Maferiales Facultad de Ciencias Campus de Cantoblanco Universidad Aut6noma de Madrid Madrid 28049 Spain

Novel approaches for high contrast, deep tissue, in vivo fluorescence biomedical imaging are based on infrared-emitting nanoparticles working in the so-called second biological window （1,000-1,400 nm）. This allows for the acquisition of high resolution, deep tissue images due to the partial transparency of tissues in this particular spectral range. In addition, the optical excitation with low energy （infrared） photons also leads to a drastic reduction in the contribution of autofluorescence to the in vivo image. Nevertheless, as is demonstrated here, working solely in this biological window does not ensure a complete removal of autofluorescence as the specimens diet shows a remarkable infrared fluorescence that extends up to 1,100 nm. In this work, we show how the 1,340 nm emission band of Nd3. ions embedded in SrF2 nanoparticles can be used to produce autofluorescence free, high contrast in vivo fluorescence images. It is also dem- onstrated that the complete removal of the food-related infrared autofluorescence is imperative for the development of reliable biodistribution studies.

关键词： fluorescence imaging rare earth dopednanoparticles nanomedicine

Thickness determination of MoS2,MoSe2,WS2 and WSe2 on transparent stamps used for deterministic transfer of 2D materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2019年第7期12卷 1691-1695页

作者： Najme S. Taghavi Patricia Gant Peng Huang Iris Niehues Robert Schmidt Steffen Michaelis de Vasconcellos Rudolf Bratschitsch Mar Garcia-Hernandez Riccardo Frisenda Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid (ICMM)Consejo Superior de Investigaciones Cientificas (CSIC)Sor Juana Ines de la Cruz 328049 MadridSpain Faculty of Physics Khaje Nasir Toosi University of Technology (KNTU)Tehran 19697 64499Iran State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Institute of Physics and Center for Nanotechnology University of Munster48149 MunsterGermany

Here,we propose a method to determine the thickness of the most common transition metal dichalcogenides (TMDCs) placed on the surface of transparent stamps,used for the deterministic placement of two-dimensional materials,by analyzing the red,green and blue channels of transmission-mode optical microscopy images of the *** particular,the blue channel transmittance shows a large and monotonic thickness dependence,making it a very convenient probe of the flake *** method proves to be robust given the small flake-to-flake variation and the insensitivity to doping changes of *** also tested the method for MoSe2,WS2 and *** results provide a reference guide to identify the number of layers of this family of materials on transparent substrates only using optical microscopy.

关键词： transition metal dichalcogenides optical identification transparent substrate trasmittance

Solvent-free fabrication of broadband WS2 photodetectors on paper

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Opto-Electronic Advances 2023年第3期6卷 1-11页

作者： Wenliang Zhang Onur Çakıroğlu Abdullah Al-Enizi Ayman Nafady Xuetao Gan Xiaohua Ma Sruthi Kuriakose Yong Xie Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710129China School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710071China

Paper-based devices have attracted extensive attention due to the growing demand for disposable flexible ***,we integrate semiconducting devices on cellulose paper substrate through a simple abrasion technique that yields high-performance photodetectors.A solvent-free WS_(2) film deposited on paper favors an effective electron-hole separation and hampers *** as-prepared paper-based WS2 photodetectors exhibit a sensitive photoresponse over a wide spectral range spanning from ultraviolet(365 nm)to near-infrared(940 nm).Their responsivity value reaches up to~270 mA W^(−1) at 35 V under a power density of 35 mW cm^(−2).A high performance photodetector was achieved by controlling the environmental exposure as the ambient oxygen molecules were found to decrease the photoresponse and stability of the WS_(2) ***,we have built a spectrometer using such a paperbased WS_(2) device as the photodetecting component to illustrate its potential *** present work could promote the development of cost-effective disposable photodetection devices.

关键词： paper electronics photodetector van der Waals materials solvent-free deposition tungsten disulfide

Highly accessible aqueous synthesis of well-dispersed dendrimer type platinum nanoparticles and their catalytic applications

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第5期12卷 1083-1092页

作者： Adrian Fernandez-Lodeiro Jamila Djafari David Lopez-Tejedor Carlos Perez-Rizquez Benito Rodriguez-Gonzalez Jose Luis Capelo Jose M.Palomo Carlos Lodeiro Javier Fernandez-Lodeiro BIOSCOPE Group LAQV@REQUIMTEChemistry DepartmentFaculty of Science and TechnologyUniversity NOVA of LisbonCaparica CampusCaparica 2829-516Portugal PROTEOMASS Scientific Society Rua dos InventoresMadan ParqueCaparica CampusCaparica 2829-516Portugal Department of Biocatalysis Institute of Catalysis(CSIC)MadridSpainMarie Curie 2CantoblancoUAM CampusMadrid 28049Spain Scientific and Technological Research Assistance Center(CACTI) University of VigoLagoas-MarcosendeVigo 36310Spain

The application of novel methodologies to the synthesis of nanomaterials is still a challenge in many different technological and scientific *** efficient and reproducible synthetic methodologies,that produce fewer residues and reduce the cost of raw materials must be *** the present work,we have explored the attractive possibility to apply the cheap iron (Ⅱ) sulphate salt in the reduction process of the K2PtCl4 to produce colloids *** synthesis took places in water and was assisted by sodium citrate (SC) using polyvinylpyrrolidone (PVP) as a *** adjustment of this novelty process allows obtaining well-dispersed and sub-20 nm dendrimer-type platinum nanoparticles (Pt D-NPs).The nano-dendrimers produced have been characterized using dynamic light scattering (DLS),transmission electron microscopy (TEM),high-resolution TEM (HR-TEM),XRD spectroscopy,inductive couple plasma (ICP) analysis,Fourier transform infrared (FT-IR) and ultraviolet-visible (UV-vis) *** conformational results derived from the size and shape will be *** application of the Pt D-NPs has been explored in the reduction of p-nitrophenol (p-NP) to p-aminophenol (p-AP) in aqueous media at room temperature obtained TOF value of 253 min^-***,our Pt D-NPs were tested as artificial metalloenzyme showing catechol oxidase activity for oxidation of L-DOPA.

关键词： platinum dendrimer NPs catalytic application green synthesis cateohol oxidase-like activity

Biomedical overview of *** molecular modeling,synthesis mechanism,and supramolecular properties regarding melanoma therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第6期46卷 1391-1415页

作者： JUAN CARLOS STOCKERT ALFONSO BLÁZQUEZ-CASTRO Facultad de Medicina Instituto de Oncología“Angel H.Roffo”Universidad de Buenos AiresBuenos AiresC1417DTBArgentina Centro Integrativo de Biología y Química Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiago8370854Chile Departamento de Biología Facultad de CienciasUniversidad Autónoma de MadridMadrid28049Spain

Melanins represent one of the most ancient and important group of natural macromolecular *** have multiple biological roles in almost all organisms across the Phyla,examples being photoprotection,anti-oxidative action,radical scavenger activity,and heavy metal *** the biomedical point of view,melanocytes are involved in the origin of melanoma tumors,and the main therapeutic advances for their treatment have been revised in Part 1 of this *** chemical structure of eumelanin is a biological concern of great importance,and therefore,exploring theoretical molecular models and synthesis mechanisms will be here described,as well as molecular orbital features and supramolecular organization,which are responsible for the key properties that make these biological pigments so important,and so ***,this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin,in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.

关键词： Eumelanin Melanin models Melanin synthesis Molecular orbitals Supramolecular structure