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Semi-supervised identification and mapping of surface water extent using street-level monitoring videos

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Big Earth Data 2023年第4期7卷 986-1004页

作者： Ruo-Qian Wang Yangmin Ding Department of Civil and Environmental Engineering RutgersThe State University of New JerseyPiscatawayNJUSA NEC Laboratories America Inc 4 Independence WayPrincetonNJUSA

Urban flooding is becoming a common and devastating hazard,which causes life loss and economic *** and understanding urban flooding in a highly localized scale is a challenging task due to the complicated urban landscape,intri-cate hydraulic process,and the lack of high-quality and resolution *** emerging smart city technology such as monitoring cameras provides an unprecedented opportunity to address the data ***,estimating water ponding extents on land surfaces based on monitoring footage is unreliable using the tradi-tional segmentation technique because the boundary of the water ponding,under the influence of varying weather,background,and ilumination,is usually too fuzzy to identify,and the oblique angle and image distortion in the video monitoring data prevents geor-eferencing and object-based *** paper presents a novel semi-supervised segmentation scheme for surface water extent recognition from the footage of an oblique monitoring *** semi-supervised segmentation algorithm was found suitable to determine the water boundary and the monoplotting method was successfully applied to georeference the pixels of the monitoring video for the virtual quantification of the local drainage *** correlation and mechanism-based analysis demon-strate the value of the proposed method in advancing the under-standing of local drainage *** workflow and created methods in this study have a great potential to study other street-level and earth surface processes.

关键词： Segmentation deep learning monoplotting smart city monocular visual data

一种新的小鼠Gabarap12 cDNA的克隆和鉴定(英文)

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Acta Pharmacologica Sinica 2001年第8期22卷 83-87页

作者：陈政辛玉蓉蒋滢蒋菊香 23823 bpo way piscataway 上海中国 200433 Rutgers University 复旦大学遗传所苏州大学生命科学院苏州大学生命科学院苏州 215006

目的:克隆一个新的小鼠GABAA受体相关蛋白相似蛋白2基因(Gabarapl2),并对其功能进行初步分析。方法:将已知的人GABARAPL2 cDNA序列为信息探针筛选GenBank小鼠EST数据库,将获得的一系列互相重叠的同源度较高的EST序列进行拼接。经过实验... 详细信息

目的:克隆一个新的小鼠GABAA受体相关蛋白相似蛋白2基因(Gabarapl2),并对其功能进行初步分析。方法:将已知的人GABARAPL2 cDNA序列为信息探针筛选GenBank小鼠EST数据库,将获得的一系列互相重叠的同源度较高的EST序列进行拼接。经过实验验证,在小鼠中分离和鉴定了新基因。自行制备小鼠RNA印迹膜,用杂交方法分析该基因在不同组织中的表达情况。结果:新基因在GenBank注册,登录号AF190644。同源比较显示,该推导蛋白与人GABARAPL2基因编码的蛋白完全相同,被基因命名委员会命名为小鼠Gabarapl2。该基因的推导蛋白含多个蛋白激酶磷酸化位点。杂交显示,该基因在脑、胸腺等组织表达较高,转录本大小约1.35kb。结论:克隆到一个新的小鼠Gabarapl2基因。

关键词： GABAA受体人类小鼠氨基酸序列同源性分子模型逆转录聚合酶链反应 RNA印迹法 DNA

Toward a neurobiology of auditory object perception： What can we learn from the songbird forebrain？

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Current Zoology 2011年第6期57卷 671-683页

作者： Kai LU, David S. VICARIO Department of Psychology Rutgers University Piscataway NJ 08854 USA

In the acoustic world, no sounds occur entirely in isolation; they always reach the ears in combination with other sounds. How any given sound is discriminated and perceived as an independent auditory object is a challenging question in neuroscience. Although our knowledge of neural processing in the auditory pathway has expanded over the years, no good theory exists to explain how perception of auditory objects is achieved. A growing body of evidence suggests that the selectivity of neurons in the auditory forebrain is under dynamic modulation, and this plasticity may contribute to auditory object perception. We propose that stimulus-specific adaptation in the auditory forebrain of the songbird (and perhaps in other systems) may play an important role in modulating sensitivity in a way that aids discrimination, and thus can potentially contribute to auditory object perception.

关键词：神经生物学听觉感知前脑鸣禽听觉通路动态调制全隔离声音

Integration of the Coupled Orbit-Attitude Dynamics Using Modified Chebyshev-Picard Iteration Methods

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Computer Modeling in Engineering & Sciences 2016年第2期111卷 129-146页

作者： Xiaoli Bai John L.Junkins Rutgers The State University of New JerseyPiscatawayNJU.S.A Texas A&M College StationTXU.S.A

This paper presents Modified Chebyshev-Picard Iteration(MCPI)methods for long-term integration of the coupled orbit and attitude *** most orbit predictions for operational satellites have assumed that the attitude dynamics is decoupled from the orbit dynamics,the fully coupled dynamics is required for the solutions of uncontrolled space debris and space objects with high area-to-mass ratio,for which cross sectional area is constantly changing leading to significant change on the solar radiation pressure and atmospheric *** is a set of methods for solution of initial value problems and boundary value *** methods refine an orthogonal function approximation of long-time-interval segments of state trajectories iteratively by fusing Chebyshev polynomials with the classical Picard iteration and have been applied to multiple challenging aerospace *** the studies on integrating a torque-free rigid body rotation and a long-term integration of the coupled orbit-attitude dynamics through the effect of solar radiation pressure,MCPI methods are shown to achieve several times speedup over the Runge-Kutta 7(8)methods with several orders of magnitudes of better *** methods are further optimized by integrating the decoupled dynamics at the beginning of the iteration and coupling the full dynamics when the attitude solutions and orbit solutions are converging during the *** approach of decoupling and then coupling during iterations provides a unique and promising perspective on the way to warm start the solution process for the longterm integration of the coupled orbit-attitude ***,an attractive feature of MCPI in maintaining the unity constraint for the integration of quaternions within machine accuracy is illustrated to be very appealing.

关键词： Orbit propagation orbit-attitude dynamics Modified Chebyshev-Picard Iteration(MCPI)Methods

Toward point-of-care management of chronic respiratory conditions:Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide

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Microsystems & Nanoengineering 2017年第1期3卷 286-293页

作者： Azam Gholizadeh Damien Voiry Clifford Weisel Andrew Gow Robert Laumbach Howard Kipen Manish Chhowalla Mehdi Javanmard Department of Electrical and Computer Engineering Rutgers UniversityPiscatawayNJ 08854USA Department of Material Science and Engineering Rutgers UniversityPiscatawayNJ 08854USA Environmental Occupational Health Sciences Institute Rutgers UniversityPiscatawayNJ 08854USA School of Pharmacy Rutgers UniversityPiscatawayNJ 08854USA

We present a portable non-invasive approach for measuring indicators of inflammation and oxidative stress in the respiratory tract by quantifying a biomarker in exhaled breath condensate(EBC).We discuss the fabrication and characterization of a miniaturized electrochemical sensor for detecting nitrite content in EBC using reduced graphene *** nitrite content in EBC has been demonstrated to be a promising biomarker of inflammation in the respiratory tract,particularly in *** utilized the unique properties of reduced graphene oxide(rGO);specifically,the material is resilient to corrosion while exhibiting rapid electron transfer with electrolytes,thus allowing for highly sensitive electrochemical detection with minimal *** rGO sensor was housed in an electrochemical cell fabricated from polydimethyl siloxane(PDMS),which was necessary to analyze small EBC sample *** sensor is capable of detecting nitrite at a low over-potential of 0.7 V with respect to an Ag/AgCl reference *** characterized the performance of the sensors using standard nitrite/buffer solutions,nitrite spiked into EBC,and clinical EBC *** sensor demonstrated a sensitivity of 0.21μAμM^(−1) cm^(−2) in the range of 20–100μM and of 0.1μAμM^(−1) cm^(−2) in the range of 100–1000μM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC *** benchmark our platform,we tested our sensors using seven pre-characterized clinical EBC samples with concentrations ranging between 0.14 and 6.5μ*** enzyme-free and label-free method of detecting biomarkers in EBC can pave the way for the development of portable breath analyzers for diagnosing and managing changes in respiratory inflammation and disease.

关键词： exhaled breath condensate nitrite electrochemistry square wave voltammetry thin-layer-reduced graphene oxide

Bioengineering models of female reproduction

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Bio-Design and Manufacturing 2020年第3期3卷 237-251页

作者： Maria EZubizarreta Shuo Xiao Department of Environmental Health Sciences Arnold School of Public HealthUniversity of South CarolinaColumbiaSC 29208USA Department of Pharmacology and Toxicology Ernest Mario School of PharmacyEnvironmental Health Sciences InstituteRutgers University170 Frelinghuysen RoadPiscatawayNJ 08854USA

The female reproductive system consists of the ovaries,the female gonads,and the reproductive tract organs of the fallopian tubes,uterus,cervix,and *** functions to provide hormonal support and anatomical structure for the production of new offspring.A number of endogenous and exogenous factors can impact female reproductive health and fertility,including genetic vulnerability,medications,environmental exposures,age,nutrition,and *** date,due to the ethical concerns of using human subjects in biomedical research,the majority of studies use in vivo animal models and 2D cell/tissue culture models to study female ***,the complexity and species difference of the female reproductive system in humans make it difficult to compare to those of ***,the monolayered cells cultured on flat plastics or glass lose their 3D architecture as well as the physical and/or biochemical contacts with other cells in ***,all reproductive organs do not work alone but interconnect with each other and also with non-reproductive organs to support female reproductive,endocrine,and systemic *** facts suggest that there is an urgent and unmet need to develop representative,effective,and efficient in vitro models for studying human female *** prodigious advancements of bioengineering(e.g.,biomaterials,3D printing,and organ-on-a-chip)allow us to study female reproduction in an entirely new ***,we review recent advances that use bioengineering methods to study female reproduction,including the bioengineering models of the ovary,fallopian tube,uterus,embryo implantation,placenta,and reproductive disease.

关键词： Female reproduction Bioengineering Biomaterials 3D printing Microfluidics

Quasiparticle approach to diffusional atomic scale self-assembly of complex structures: from disorder to complex crystals and double-helix polymers

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npj Computational Materials 2016年第1期2卷 256-264页

作者： Mykola Lavrskyi Helena Zapolsky Armen G Khachaturyan GPM UMR 6634University of RouenSaint-Etienne du RouvrayFrance Department of Materials Science&Engineering Rutgers UniversityPiscatawayNJUSA Department of Materials Science&Engineering University of CaliforniaBerkeleyBerkeleyCAUSA

A self-organisation is an universal phenomenon in nature and,in particular,is highly important in materials *** goal was to develop a new theory that provides a computationally effective approach to this *** this paper a quasiparticle theory of a diffusional self-organisation of atoms in continuum space during the diffusional time scale has been *** became possible due to two novelties,a concept of quasiparticles,fratons,used for a description of dynamic degrees of freedom and model Hamiltonian taking into account a directionality,length and strength of interatomic *** illustrate a predictive power and achievable level of complexity of self-assembled structures,the challenging cases of self-assembling of the diamond,zinc-blende,helix and double-helix structures,from a random atomic distribution,have been successfully *** approach opens a way to model a self-assembling of complex atomic and molecular structures in the atomic scale during diffusional time.

关键词： diffusion helix particle

Dying T lymphocytes call for the death of tumor cells

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Cell Research 2006年第8期16卷 679-680页

作者： ArthurIRoberts Envei Sun Department of Molecular Genetics Microbiology and ImmunologyUniversity of Medicine and Dentistry of New JerseyRobert Wood Johnson Medical SchoolPiscatawayNJ 08854USA Institute of Transplantation Immunology Organ Transplantation DepartmentZhujiang HospitalSouthern Medical UniversityGuangzhou510282China

Immunotherapy that specifically targets tumor cells is the preferred approach to induce tumor *** the pastdecade,significant progress has been made in devising various methods to direct the immune system to respond to *** major hurdle for successful immunotherapy is to overcome immune tolerance in the tumor *** clinical trials with dendritic cell-based vaccination[1,2]and CTLA4 blocking antibodies[3]have shown greatpromise,though complete cancer regression is not always achieved[4].Currently,alternative strategies potentially leadingto cancer eradication or regression in animal or clinical models are being enthusiastically *** this issue of CellResearch,Wang et *** a novel way to induce tumor immunity by the use of irradiated autologous T cells[5].

关键词： Dying T lymphocytes call for the death of tumor cells

Higher-Order Interactions： Understanding the knowledge capacity of social groups using simplicial sets

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Current Zoology 2015年第1期61卷 114-127页

作者： Bradford R GREENING Jr Noa PINTER-WOLLMAN Nina H FEFFERMAN Department of Ecology Evolution and Natural Resources Rutgers University New Brunswick NJ 08901 USA BioCircuits Institute University of Califomia at San Diego 9500 Gilman Dr. Mail Code 0328 La Jolla CA 92093 USA DIMACS Rutgers University 96 Frelinghuysen Road Piscataway NJ 08854 USA

A predominant benefit of social living is the ability to share knowledge that cannot be gained through the information an individual accumulates based on its personal experience alone. Traditional computational models have portrayed sharing knowledge through interactions among members of social groups via dyadic networks. Such models aim at understanding the percolation of information among individuals and groups to identify potential limitations to successful knowledge transfer. However, because many real-world interactions are not solely pairwise, i.e., several group members may obtain information from one another simultaneously, it is necessary to understand more than dyadic communication and learning processes to capture their full complexity. We detail a modeling framework based on the simplicial set, a concept from algebraic topology, which allows elegant encapsulation of multi-agent interactions. Such a model system allows us to analyze how individual information within groups accumulates as the group’s collective set of knowledge, which may be different than the simple union of individually contained information. Furthermore, the simplicial modeling approach we propose allows us to investigate how information accumulates via sub-group interactions, offering insight into complex aspects of multi-way communication systems. The fundamental change in modeling strategy we offer here allows us to move from portraying knowledge as a “token”, passed from signaler to receiver, to portraying knowledge as a set of accumulating building blocks from which novel ideas can emerge. We provide an explanation of relevant mathematical concepts in a way that promotes accessibility to a general audience.

关键词：知识转移相互作用社会群体能力高阶通信系统个人经验社会生活