Dying T lymphocytes call for the death of tumor cells

作     者：ArthurIRoberts Envei Sun 

作者机构：Department of Molecular GeneticsMicrobiology and ImmunologyUniversity of Medicine and Dentistry of New JerseyRobert Wood Johnson Medical SchoolPiscatawayNJ 08854USA Institute of Transplantation ImmunologyOrgan Transplantation DepartmentZhujiang HospitalSouthern Medical UniversityGuangzhou510282China 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2006年第16卷第8期

页      面：679-680页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Dying T lymphocytes call for the death of tumor cells 

摘      要：Immunotherapy that specifically targets tumor cells is the preferred approach to induce tumor *** the pastdecade,significant progress has been made in devising various methods to direct the immune system to respond to *** major hurdle for successful immunotherapy is to overcome immune tolerance in the tumor *** clinical trials with dendritic cell-based vaccination[1,2]and CTLA4 blocking antibodies[3]have shown greatpromise,though complete cancer regression is not always achieved[4].Currently,alternative strategies potentially leadingto cancer eradication or regression in animal or clinical models are being enthusiastically *** this issue of CellResearch,Wang et *** a novel way to induce tumor immunity by the use of irradiated autologous T cells[5].