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PIF4 interacts with ABI4 to serve as a transcriptional activator complex to promote seed dormancy by enhancing ABA biosynthesis and signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 909-927页

作者： Xiaofeng Luo Yujia Dai Baoshan Xian Jiahui Xu Ranran Zhang Muhammad Saad Rehmani Chuan Zheng Xiaoting Zhao Kaitao Mao Xiaotong Ren Shaowei Wei Lei Wang Juan He Weiming Tan Junbo Du Weiguo Liu Shu Yuan Kai Shu Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'an 710129China Research&Development Institute of Northwestern Polytechnical University in ShenzhenShenzhen 518057China college of Agronomy and biotechnology China Agricultural UniversityBeijing 100193China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130China college of Resources Sichuan Agricultural UniversityChengdu 611130China

Transcriptional regulation plays a key role in the control of seed dormancy,and many transcription factors(TFs)have been ***,the mechanisms underlying the interactions between different TFs within a transcriptional complex regulating seed dormancy remain largely ***,we showed that TF PHYTOCHROME-INTERACTING FACTOR4(PIF4)physically interacted with the abscisic acid(ABA)signaling responsive TF ABSCISIC ACID INSENSITIVE4(ABI4)to act as a transcriptional complex to promote ABA biosynthesis and signaling,finally deepening primary seed *** pif4 and abi4 single mutants exhibited a decreased primary seed dormancy phenotype,with a synergistic effect in the pif4/abi4 double ***4 binds to ABI4 to form a heterodimer,and ABI4 stabilizes PIF4 at the protein level,whereas PIF4 does not affect the protein stabilization of ***,both TFs independently and synergistically promoted the expression of ABI4 and NCED6,a key gene for ABA *** genetic evidence is also consistent with the phenotypic,physiological and biochemical analysis ***,this study revealed a transcriptional regulatory cascade in which the PIF4–ABI4 transcriptional activator complex synergistically enhanced seed dormancy by facilitating ABA biosynthesis and signaling.

关键词： ABA ABI4 PIF4 seed dormancy and germination transcriptional complex

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Differences in leaf cuticular wax induced by whole-genome duplication in autotetraploid sour jujube

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Horticultural Plant Journal 2024年第1期10卷 66-76页

作者： Meng Li Chenxing Zhang Lu Hou Xinru Liu Hanqing Zhao Xiaoming Pang Wenhao Bo Yingyue Li National Engineering Research Center of Tree Breeding and Ecological Restoration College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants Ministry of EducationCollege of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China The Tree and Ornamental Plant Breeding and biotechnology Laboratory of National Forestry and Grassland Administration Beijing Forestry UniversityBeijing 100083China

Drought-resistant plants exhibit strong water retention *** this regard,the autotetraploid sour jujube leaves exhibit better water retention than diploid *** comparisons and physiological comparisons of diploid and autotetraploid leaves showed that the autotetraploid leaves had thicker leaf cuticles and more leaf wax accumulation than the diploid leaves,which could reduce cuticle permeability and improve the drought tolerance of *** this study,the cuticular wax crystalloids on the adaxial and abaxial sides of young and mature jujube leaves were observed in the two ploidy types,and unique cuticular wax crystalloids covering a large area of the cuticle on autotetraploid sour jujube leaves may provide an advantage in reducing leaf non-stomata transpiration and improving plant drought *** on the transcriptome,115 differentially expressed genes between diploids and autotetraploids were further analyzed and found to be involved in the accumulation of cuticular wax components,including terpenoids,fatty acids,and lipids,as well as ABC transporter and wax biosynthetic ***,14 genes differentially expressed between glossy autotetraploid leaves and nonglossy diploid leaves,such as LOC107414787,LOC107411574 and LOC10741372.,were screened as candidate genes by qRT-PCR *** findings provided insights into how polyploidization improved drought tolerance.

关键词： Autotetraploid Jujube Drought tolerance Cuticular wax RNA-seq

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A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2. and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： Yudi Cheng Xiao Wang Jiao Chen Zihan Zhang Jiadong Ou Mengyao She Fulin Chen Jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

Sulfydryl-contained(-SH)substances including hydrogen sulfide(H_(2.S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various ***,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys/Hcy and H_(2.S with different fluorescent signals(green-red for Cys/Hcy,red for H_(2.S),large Stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSH.Y-NBD was successfully applied to image exogenous/endogenous Cys/Hcy and H_(2.S in various living cancer cells(HeLa,A549,and HepG2.and in *** not only visualized the transformation pathway of several thiols in HepG2.cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver *** work provides a promising tool for imaging Cys/Hcy and H_(2.S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared Hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury

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Microenvironment-responsive nanosystems for osteoarthritis therapy

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Engineered Regeneration 2024年第1期5卷 92-110页

作者： Song Li Yuan Xiong Hao Zhu Tian Ma Xuying Sun Jun Xiao Department of Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Chemical Engineering and biotechnology Nanyang Technological University21 Nanyang LinkSingapore 637371Republic of Singapore

Osteoarthritis(OA)represents an enduring and widespread global burden,causing significant morbidity and disability,whose pathology is characterized by persistent inflammation,progressive cartilage degeneration,ab-normal bone homeostasis,and excessive synovial hyperplasia,resulting from its complex ***,current therapeutic approaches for OA remain suboptimal,prompting increased interest in ad-vanced nanotechnology as a means to enhance therapeutic *** recent years,significant progress has been made in the development of versatile nanoplatforms designed to the specific microenvironment of OA,resulting in promising results and introducing the concept of“OA nanomedicine”.Compared to the conventional therapies like non-steroidal anti-inflammatory drugs(NSAIDs),OA nanomedicine offers precise targeted,controllable and personalized ways for OA therapy,contributing to better ***,a comprehensive review consoli-dating the“OA nanomedicine”is currently absent from ***,in this review,we aim to unravel the key pathological and microenvironmental characteristics of OA while summarizing the properties and advantages of nanosystems possessing microenvironment-reprogramming capabilities for OA ***,we make a retro-spection of the features of OA pathology and OA ***,we provide an overview of the advances in OA ***,we discuss the present challenges associated with OA nanomedicine and provide insights into its future prospects from a clinical-translational *** doing so,this review can foster and propel the successful development of OA nanomedicine,addressing the unmet needs in OA therapy.

关键词： Osteoarthritis Nanomedicine Therapy Microenvironment Cartilage Tissue regeneration

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foxl2. is a germ cell-intrinsic gatekeeper of oogenesis in zebrafish

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Zoological Research 2024年第5期45卷 1116-1130页

作者： Zhiqin Ren Ding Ye Naike Su Chaofan Wang Lijia He Houpeng Wang Mudan He Yonghua Sun Key Laboratory of Breeding biotechnology and Sustainable Aquaculture Hubei Hongshan LaboratoryInstitute of HydrobiologyInnovation Academy for Seed DesignChinese Academy of SciencesWuhanHubei 430072China School of Marine Biology and Fisheries Hainan UniversityHaikouHainan 570228China college of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China college of Fisheries and Life Science Dalian Ocean UniversityDalianLiaoning 116023China

Zebrafish serve as a valuable model organism for studying germ cell biology and reproductive *** AB strain of zebrafish is proposed to exhibit a polygenic sex determination system,where most males initially develop juvenile ovaries before committing to male *** species with chromosomal sex determination,gonadal somatic cells are recognized as key determinants of germ cell ***,the loss of germ cells in zebrafish leads to masculinization,implying that germ cells harbor an intrinsic feminization ***,the specific signal triggering oogenesis in zebrafish remains *** the present study,we identified foxl2. as an oocyte progenitor-specific gene essential for initiating oogenesis in germ *** showed that foxl2.-knockout zebrafish bypassed the juvenile ovary stage and exclusively developed into fertile *** analysis revealed that loss of foxl2. hindered the initiation of oocyte-specific meiosis and prevented entry into oogenesis,leading to premature spermatogenesis during early gonadal ***,while mutation of the pro-male gene dmrt1 led to fertile female differentiation,simultaneous disruption of foxl2. in dmrt1 mutants completely blocked oogenesis,with a large proportion of germ cells arrested as germline stem cells,highlighting the crucial role of foxl2. in ***,this study highlights the unique function of foxl2. as a germ cell-intrinsic gatekeeper of oogenesis in zebrafish.

关键词： foxl2. dmrt1 Oogenesis Sex determination Meiosis

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Aptasensing biosynthesized phosphatidylserine with a AuNPs nanozyme-based colorimetric aptasensor

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Food Science and Human Wellness 2024年第2期13卷 823-829页

作者： Sai Wang Rui Ma Chengqiang Li Ling Zhang Haiyang Zhang Xuehan Li Xiangzhao Mao Qingdao Key Laboratory of Food biotechnology College of Food Science and EngineeringOcean University of ChinaQingdao 266404China Key Laboratory of Biological Processing of Aquatic Products China National Light IndustryQingdao 266404China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Sensitive monitoring of the target products during the biosynthesis process is crucial,and facile analytical approaches are urgently ***,phosphatidylserine(PS)was chosen as the model target,a colorimetric aptasensor was developed for the rapid quantitation in biosynthesis samples.A chimeric aptamer was constructed with two homogeneous original PS *** recognition between the chimeric aptamer and PS results in the desorption of aptamer from the surface of the AuNPs nanozyme,and the peroxidase-like enzymatic activity of the AuNPs nanozyme was weakened in a relationship with the different *** developed aptasensor performed well when applied for analyzing PS in biosynthesis *** aptasensor offers good sensitivity and selectivity,under optimal conditions,achieving monitoring and quantitation of PS in the range of 2.5-80.0μmol/L,with a limit of detection at 536.2.nmol/***,the aptasensor provides good accuracy,with comparison rates of 98.17%-106.40%,when compared with the *** study provides a good reference for monitoring other biosynthesized products and promoting the development of aptamers and aptasensors in real-world applications.

关键词： Phosphatidylserine Chimeric aptamer AuNPs nanozyme Colorimetric aptasensor

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Bioactive chemical constituents from the marine-derived fungus Cladosporium ***-5

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Journal of Oceanology and Limnology 2024年第3期42卷 905-914页

作者： Luting DAI Qingyi XIE Jiaocen GUO Qingyun MA Li YANG Jingzhe YUAN Haofu DAI Zhifang YU Youxing ZHAO college of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Hainan Academy of Tropical Agricultural ResourceHaikou 571101China

A new isochromanone,cladosporinisochromanone(1),accompanied by 15 known compounds(2.16)were obtained from secondary metabolites produced by marine-derived fungus Cladosporium *** and HRESIMS spectra elucidation determined the planar structure of *** electronic circular dichroism(ECD)experiment assigned the absolute configuration of *** 1,2.4–6,and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells *** compounds(1,3–5,and 13)emerged resistance to protein tyrosine phosphatase 1B(PTP1B),further kinetic analysis and molecular docking study indicated that the most potent compound 13(IC50value of 10.74±0.61μmol/L)was found as a noncompetitive inhibitor for *** plasmon resonance(SPR)and molecular docking studies also demonstrated the interaction between compound 12.and Niemann-Pick C1 Like 1(NPC1L1),which has been identified as significant therapeutic target for *** addition,compounds 3,6,and 14 showed attractive inhibitory activity against the phytopathogenic fungi:Colletotrichum ***,library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.

关键词： Cladosporium sp. marine-derived fungus neuroprotective effects protein tyrosine phosphatase 1B(PTP1B) Niemann-Pick C1 Like 1(NPC1L1) antifungal activity

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MOF‐derived 1D/3D N‐doped porous carbon for spatially confined electrochemical CO2.reduction to adjustable syngas

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Carbon Energy 2024年第8期6卷 1-13页

作者： Wei Zhang Hui Li Daming Feng Chenglin Wu Chenghua Sun Baohua Jia Xue Liu Tianyi Ma Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials Institute of Clean Energy ChemistryCollege of ChemistryLiaoning UniversityShenyangLiaoningChina School of Science RMIT UniversityMelbourneVictoriaAustralia School of Pharmaceutical and Chemical Engineering Taizhou UniversityTaizhouZhejiangChina Department of Chemistry and biotechnology Swinburne University of TechnologyHawthornVictoriaAustralia

Electrochemical reduction of CO_(2.to syngas(CO and H_(2.)offers an efficient way to mitigate carbon emissions and store intermittent renewable energy in ***,the hierarchical one‐dimensional/three‐dimensional nitrogen‐doped porous carbon(1D/3D NPC)is prepared by carbonizing the composite of Zn‐MOF‐74 crystals in situ grown on a commercial melamine sponge(MS),for electrochemical CO_(2.reduction reaction(CO_(2.RR).The 1D/3D NPC exhibits a high CO/H_(2.ratio(5.06)and CO yield(31 mmol g^(−1)h^(−1))at−0.55 V,which are 13.7 times and 2..4 times those of 1D porous carbon(derived from Zn‐MOF‐74)and N‐doped carbon(carbonized by MS),*** is attributed to the unique spatial environment of 1D/3D NPC,which increases the adsorption capacity of CO_(2.and promotes electron transfer from the 3D N‐doped carbon framework to 1D carbon,improving the reaction kinetics of CO_(2.*** results and charge density difference plots indicate that the active site of CO_(2.RR is the positively charged carbon atom adjacent to graphitic N on 1D carbon and the active site of HER is the pyridinic N on 1D *** presence of pyridinic N and pyrrolic N reduces the number of electron transfer,decreasing the reaction kinetics and the activity of CO_(2.*** CO/H_(2.ratio is related to the distribution of N species and the specific surface area,which are determined by the degree of spatial confinement *** CO/H_(2.ratios can be regulated by adjusting the carbonization temperature to adjust the degree of spatial confinement *** the low cost of feedstock and easy strategy,1D/3D NPC catalysts have great potential for industrial application.

关键词： electrochemical CO_(2.reduction reaction melamine sponge metal‐organic frameworks porous carbon syngas

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Upregulation of the glycine-rich protein-encoding gene GhGRPL enhances plant tolerance to abiotic and biotic stressors by promoting secondary cell wall development

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Journal of Integrative Agriculture 2024年第10期23卷 3311-3327页

作者： Wanting Yu Yonglu Dai Junmin Chen Aimin Liang Yiping Wu Qingwei Suo Zhong Chen Xingying Yan Chuannan Wang Hanyan Lai Fanlong Wang Jingyi Zhang Qinzhao Liu Yi Wang Yaohua Li Lingfang Ran Jie Xiang Zhiwu Pei Yuehua Xiao Jianyan Zeng college of Agronomy and biotechnology Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China Chongqing Key Laboratory of Crop Molecular Improvement Chongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China

Abiotic and biotic stressors adversely affect plant survival,biomass generation,and crop *** the global availability of arable land declines and the impacts of global warming intensify,such stressors may have increasingly pronounced effects on agricultural ***,researchers face the overarching challenge of comprehensively enhancing plant resilience to abiotic and biotic *** secondary cell wall plays a crucial role in bolstering the stress resistance of *** increase plant resistance to stress through genetic manipulation of the secondary cell wall,we cloned a cell wall protein designated glycine-rich protein-like(GhGRPL)from cotton fibers,and found that it is specifically expressed during the period of secondary cell wall ***,this protein differs from its Arabidopsis homolog,AtGRP,since its glycine-rich domain is deficient in glycine *** is involved in secondary cell wall *** of GhGRPL enhances lignin accumulation and,consequently,the thickness of the secondary cell walls,thereby increasing the plant’s resistance to abiotic stressors,such as drought and salinity,and biotic threats,including Verticillium dahliae ***,interference with GhGRPL expression in cotton reduces lignin accumulation and compromises that *** together,our findings elucidate the role of GhGRPL in regulating secondary cell wall development through its influence on lignin deposition,which,in turn,reinforces cell wall robustness and *** findings highlight the promising near-future prospect of adopting GhGRPL as a viable,effective approach for enhancing plant resilience to abiotic and biotic stress factors.

关键词： glycine-rich protein-like secondary cell wall abiotic stress biotic stress stress resistance

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Nanoparticle drug delivery system for the treatment of brain tumors:Breaching the blood–brain barrier

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2786-2789页

作者： Qiyu Tang Guo Zhao Hong Fang Yale Jiang Peiwen Ma Jiawei Zhoua Dongyan Liu Shujun Xing Gaoquan Li Nian Liu Huiyu Chen Shuhang Wang Ning Li Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Chongqing Upgra biotechnology Co. Ltd.Chongqing 401331China

To the Editor:Malignant brain tumors represent a substantial morbidity and mortality burden globally,with 308,102.new cases and 2.1,32. cancer-related deaths in *** tumors encompass primary tumors originating in the brain and brain metastases(BM)that have been spread from cancer lesions of other ***,BM are the most prevalent intracranial malignant tumor affecting approximately 2.%-40%of cancer patients2.

关键词： Nanoparticle Drug delivery system Blood-brain barrier Tumor Glioma

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