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SArS-CoV-2.envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou national Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2.SArS-CoV-2.infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTr),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SArS-CoV-2.E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLr)2.4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4d(PdE4d)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PdE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SArS-CoV-2.E protein in airway epithelial damage and the ongoing airway inflammation during SArS-CoV-2.infection.

关键词： airway inflammation elevated

Quantized bound states around a vortex in anisotropic superconductors

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Science china(Physics,Mechanics & Astronomy) 2024年第6期67卷 146-155页

作者： Ke Xiang da Wang Qiang-Hua Wang national Laboratory of Solid State Microstructures&School of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation center of Advanced Microstructures Nanjing 210093China

The bound states around a vortex in anisotropic superconductors is a longstanding yet important *** this work,we develop a variational theory on the basis of the Andreev approximation to obtain the energy levels and wave functions of the low-energy quantized bound states in superconductors with anisotropic pairing on arbitrary Fermi *** the case of circular Fermi surface,the effective Schr¨odinger equation yielding the bound state energies gets back to the theory proposed by Volovik and Kopnin many years *** generalization here enables us to prove the equidistant energy spectrum inside a vortex in a broader class of *** importantly,we are now able to obtain the wave functions of these bound states by projecting the quasiclassical wave function on the eigenmodes of the effective Schr¨odinger equation,going beyond the quasiclassical Eilenberger results,which,as we find,are sensitive to the scattering *** the case of isotropic Fermi surface,the spatial profile of the low-energy local density of states is dominated near the vortex center and elongates along the gap antinode directions,in addition to the ubiquitous Friedel oscillation arising from the quantum inteference neglected in the Eilenberger ***,as a consequence of the pairing anisotropy,the quantized wave functions develop a peculiar distribution of winding number,which reduces stepwise towards the vortex *** work provides a flexible way to study the vortex bound states in the future.

关键词： vortex bound state anisotropic superconductor Andreev approximation

The roadmap of 2. Materials and devices Toward Chips

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Nano-Micro Letters 2024年第6期16卷 343-438页

作者： Anhan Liu Xiaowei Zhang Ziyu Liu Yuning Li Xueyang Peng Xin Li Yue Qin Chen Hu Yanqing Qiu Han Jiang Yang Wang Yifan Li Jun Tang Jun Liu Hao Guo Tao deng Songang Peng He Tian Tian‑Ling ren School of Integrated Circuits and Beijing national research center for Information Science and Technology(BNrist) Tsinghua UniversityBeijing 100049People’s Republic of China School of Microelectronics Fudan UniversityShanghai 200433People’s Republic of China State Key Laboratory of dynamic Measurement Technology Shanxi Province Key Laboratory of Quantum Sensing and Precision MeasurementNorth University of ChinaTaiyuan 030051People’s Republic of China High‑Frequency High‑Voltage device and Integrated Circuits r&d center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029People’s Republic of China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049People’s Republic of China IMECAS-HKUST-Joint Laboratory of Microelectronics Beijing 100029People’s Republic of China

due to the constraints imposed by physical effects and performance degra certain limitations in sustaining the advancement of Moore’s ***-dimensional(2.)materials have emerged as highly promising candidates for the post-Moore era,offering significant potential in domains such as integrated circuits and next-generation ***,in this review,the progress of 2. semiconductors in process engineering and various electronic applications are summarized.A careful introduction of material synthesis,transistor engineering focused on device configuration,dielectric engineering,contact engineering,and material integration are given *** 2. transistors for certain electronic applications including digital and analog circuits,heterogeneous integration chips,and sensing circuits are ***,several promising applications(artificial intelligence chips and quantum chips)based on specific mechanism devices are ***,the challenges for 2. materials encountered in achieving circuit-level or system-level applications are analyzed,and potential development pathways or roadmaps are further speculated and outlooked.

关键词： Two-dimensional materials roadmap Integrated circuits Post-Moore era

Overcoming the Na-ion conductivity bottleneck for the cost-competitive chloride solid electrolytes

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Journal of Energy Chemistry 2024年第8期95卷 1-8,I0001页

作者： Lv Hu Hui Li Fang Chen Yating Liu Jinzhu Wang Cheng Ma Hefei national research center for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026AnhuiChina national Synchrotron radiation Laboratory Hefei 230026AnhuiChina

Chloride solid electrolytes possess multiple advantages for the construction of safe,energy-dense allsolid-state sodium batteries,but presently the chlorides with sufficiently high cost-competitiveness for commercialization almost all exhibit low Na-ion conductivities of around 10^(-5)S cm^(-1)or ***,we report a chloride solid electrolyte,Na_(2.7)ZFCl_(5.3)O_(0.7),which reaches a Na-ion conductivity of 2.2.×10^(-4)S cm^(-1)at 2.℃without involving overly expensive raw materials such as rare-earth chlorides or Na_(2.*** addition to the efficient ion transport,Na_(2.7)ZrCl_(5.3)O_(0.7)also shows an excellent deformability surpassing that of the widely studied Na_(3)PS_(4),Na_(3)SbS_(4),and Na_(2.ZrCl_(6)solid *** combination of these advantages allows the all-solid-state cell based on Na_(2.7)ZrCl_(5.3)O_(0.7)and NaCrO_(2.to realize stable room-temperature cycling at a much higher specific current than those based on other non-viscoelastic chloride solid electrolytes in literature(12. mA g^(-1)vs.12.55 mA g^(-1));after 100 cycles at such a high rate,the Na_(2.7)ZFCl_(5.3)O_(0.7)-based cell can still deliver a discharge capacity of 80 mAh g^(-1)at2.℃.

关键词： All-solid-state sodium batteries Ionic conductivities Solid electrolytes Chlorides High voltage stability

Virtual source approach for maximizing resolution in high-penetration gamma-ray imaging

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Matter and radiation at Extremes 2024年第3期9卷 19-30页

作者： Yuchi Wu Shaoyi Wang Bin Zhu Yonghong Yan Minghai Yu Gang Li Xiaohui Zhang Yue Yang Fang Tan Feng Lu Bi Bi Xiaoqin Mao Zhonghai Wang Zongqing Zhao Jingqin Su Weimin Zhou Yuqiu Gu national Key Laboratory of Plasma Physics Laser Fusion Research CenterCAEPMianyangSichuan 621900China College of Physics Sichuan UniversityChengdu 610065China

High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NdT)tool in various *** high-energy photons,point projection radiography is almost the only feasible imaging method,and its spatial resolution is primarily constrained by the size of the gamma-ray *** conventional industrial applications,gamma-ray sources are commonly based on electron beams driven by accelerators,utilizing the process of bremsstrahlung *** size of the gamma-ray source is dependent on the dimensional characteristics of the electron *** research has been conducted on various advanced accelerator technologies that have the potential to greatly improve spatial resolution in *** our investigation of laser-driven gamma-ray sources,a spatial resolution of about 90μm is achieved when the areal density of the penetrated object is 12. g/cm^(2..A virtual source approach is proposed to optimize the size of the gamma-ray source used for imaging,with the aim of maximizing spatial *** this virtual source approach,the gamma ray can be considered as being emitted from a virtual source within the convertor,where the equivalent gamma-ray source size in imaging is much smaller than the actual emission *** the basis of Monte Carlo simulations,we derive a set of evaluation formulas for virtual source scale and gamma-ray emission *** optimal conditions,the virtual source size can be as small as 15μm,which can significantly improve the spatial resolution of high-penetration imaging to less than 50μm.

关键词： resolution approach utilizing

Photothermal properties of Cu@polycarbonate composites with strong localized surface plasmon resonances

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Nano research 2024年第9期17卷 8513-8520页

作者： Fengyi Wang Jiangling He Junshan Hu Zhihui Chen Yumeng Shi Qing-Hua Xu SZU-NUS Collaborative Innovation center for Optoelectronic Science and Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Copper is relatively low cost and highly abundant compared with the well-studied noble metals such as gold and ***,the poor plasmonic and high susceptibility towards oxidation limit the study of its optical properties and applications as ***,copper nanoparticles@polycarbonate(Cu@PC)composites were prepared by using a facile one-step solvothermal *** Cu@PC composites have strong localized surface plasmon resonances(LSPr)due to that the PC shell can induce the particles to form many-particles system with different particle numbers,which not only lead to overlap and hybridize of the LSPr modes,but also shift the LSPr away from the interband transitions,and the PC layer also prevents the oxidation of Cu *** photothermal conversion efficiency of Cu@PC composites reaches 41.1%under 808 nm continuous wave(CW)laser irradiation which is higher than previously reported Cu nanomaterials that have been ***,the composites also have high photothermal ***,interfacial evaporator is prepared by assembling the Cu@PC composites on scouring sponge as light absorption layer which has>92.8%absorption in entire solar spectrum *** seawater evaporation rate is 3.177 kg·m^(-2.·h^(-1)with a E_(evaporator)/E_(water)of *** high evaporation rate interfacial evaporator with low cost,simple,and scalable approach shows great application value in the field of photothermal evaporation.

关键词： Cu nanoparticles localized surface plasmon resonances(LSPr) photothermal interfacial evaporation

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MrN-ATM axis in the dNA damage response

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Genes & diseases 2024年第1期11卷 19-22页

作者： Zhenhai Li Wenchao Xu Feng Chen Jun Zhang Wei-Guo Zhu Guangdong Key Laboratory of Genome Instability and Human disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines r&d {2. International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed Brd4,one of the main targets of BET inhibitors,was involved in dNA damage response(ddr)via the homologous recombination(Hr)repair pathway.

关键词： etoposide damage cancer

Structural analysis of conformational changes in the mpox virus A7 protein

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Virologica Sinica 2024年第2期39卷 331-334页

作者： Xincheng Ni Kai Wang Yinze Han Jian Lei national Clinical research center for Geriatrics and State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu610041China

dear Editor,The mpox(formerly known as monkeypox)disease caused by the mpox virus(MPXV)has infected more than 89,700 people and is linked to 157 deaths in 114 countries worldwide as of September 2.2.(***).Mpox is a zoonotic disease,the first human case of which was reported in 1970(Breman et al.,1980).Common symptoms in mpox-infected individuals include fever,myalgia,fatigue,headache,and a characteristic rash(Isidro et al.,2.2.).Current treatments for mpox remain limited,and an in-depth investigation of essential viral protein(s)will help to explore novel drug targets.

关键词： infected headache

regulating atomic Fe-rh site distance for efficient oxygen reduction reaction

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Science china Chemistry 2024年第4期67卷 1352-1359页

作者： Tong Liu Yudan Chen Airong Xu Xiaokang Liu dong Liu Sicheng Li Hui Huang Li Xu Shuaiwei Jiang Qiquan Luo Tao ding Tao Yao national Synchrotron radiation Laboratory University of Science and Technology of ChinaHefei 230029China Key Laboratory of Precision and Intelligent Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China

Exploring the atomic interaction mechanisms of dense single-atom catalysts(SACs)is of great significance for their application in oxygen reduction reaction(Orr).However,the intrinsic mechanism of the site-distance effect on the catalytic performance has been largely ***,we demonstrate the site-distance effect of Fe-rh_(x)@NC catalysts in Orr theoretically and *** charge analysis reveals that the strong interaction between Fe and rh atoms at a certain atomic distance(dFe-rh)alters the catalytic electronic structure,facilitating the optimization of catalyst adsorption *** by the theoretical calculations,we designed and synthesized the Fe-rhx@NC catalysts through a spatial confinement *** characterization results prove that the Fe-rh_(2.@NC has the optimal d_(Fe-rh),which improves its intrinsic Orr activity,providing a half wave potential of 0.91 V,higher than that of the commercial Pt/C(0.86 V).This study emphasizes the importance of determining the basic mechanism of the site-distance effect in dissimilar metal atoms catalysts,which is conducive to the design of efficient catalyst systems for practical applications.

关键词： density functional theory single-atom catalyst in-situ encapsulating site-distance effect oxygen reduction reaction