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Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia

World Journal of Gastroenterology 2007年第16期13卷 2333-2338页

作者： Gilles Gargala Stéphane Lecleire Arnaud Franois Serge Jacquot Pierre Déchelotte Jean Jacques Ballet Loic Favennec Philippe Ducrotté Parasitology Department Rouen University Hospital & EA 3234-IFRMP 23 University of Rouen France Gastroenterology Department Rouen University Hospital & EA 3234-IFRMP 23 University of Rouen France Pathology Department Rouen University Hospital France Immunology Department Rouen University Hospital & U.519-IFRMP 23 University of Rouen France Immunology Department Caen University Hospital & UPRES-EA 2128 University of Caen France

AIM： To quantify the intraepithelial lymphocytes （IELs） and to document the membrane expression of CD4, CD8, TCRγδ and adhesion and/or activation-associated molecules （CD103, CD28, CD44, CD69, HLA-DR, CD95/ Fas） in the duodenal mucosa of patients with functional dyspepsia （FD） in order to provide arguments for an immunological process in FD. METHODS： Twenty-six FD patients according to Rome Ⅱ criteria （20 were H pylori negative） were studied and compared to 12 healthy adults. IELs were isolated from five duodenal biopsy samples, then quantified by microscopy and flow cytometry while the membrane phenotypes were determined by cytofluorometry. RESULTS： Duodenal histological examination was normal. In H pylori negative patients, the number of IELs was not different from that in healthy controls. Median percentage expression of CD4, CD8, or TCRy8 and CD103, CD44, CD28, CD69 on CD3＋ IELs, among the adhesion/activation associated molecules tested, was not different from that in healthy controls. In contrast, the median percentage expression of CD95/ Fas [22 （9-65） vs 45 （19-88）, P = 0.03] and HLADR expressing CD3＋ IELs [4 （0-30） vs 13 （4-42）, P = 0.04] was significantly lower in the H pylori negative FD group than in healthy controls, respectively. The number of IELs was significantly greater in H pylori positive FD patients than in healthy controls [median ratio for 100 enterocytes 27.5 （6.7-62.5） vs 10.8 （3-33.3）, P = 0.02] due to a higher number of CD8＋ CD3＋ IELs. CONCLUSION： In H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD.

关键词： Functional dyspepsia Intraepithelial T lymphocytes Gut CD95/Fas HLA-DR

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The Minimal Free Resolution of a Fat Star-Configuration in Pn

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Algebra Colloquium 2014年第1期21卷 157-166页

作者： Jeaman Ahn Yong Su Shin Department of Mathematics Education Kongju National University 182 Shinkwan-dong Kongju Chungnam 314-701 Korea Department of Mathematics Sungshin Women's University Seoul 136-742 Korea

Abstract. We find the minimal free resolution of a fat star-configuration X in Pn of type （r, s,t） defined by general forms of degrees d1,...,dr, and show that a fat linear star- configuration X in P2 never has generic Hilbert function if （s,t） ≠ （1, 1） or （2, 2）. These two results generalize the interesting results of [2].

关键词： Hilbert functions minimal free resolutions weak Lefschetz property fat star-configurations

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The non—local implementation of a CNOT gate and single—qubit rotation

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Chinese Physics B 2002年第9期11卷 881-884页

作者：陈立冻 LaboratoryofQuantumCommunicationandQuantumComputation UniversityofScienceandTechnologyofChinaHefei23

We show how a CNOT gate and single-qubit rotation can be implemented non-locally. We also report on thequantitative relations between these quantum actions, entanglement and classical communication resources required ... 详细信息

关键词： non-local implementation CNOT gate single-qubit rotation entangled state

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Application of topological soliton in modeling protein folding: Recent progress and perspective

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Chinese Physics B 2020年第10期29卷 24-32页

作者： Xu-Biao Peng Jiao-Jiao Liu Jin Dai Antti J Niemi Jian-Feng He School of Physics Beijing Institute of TechnologyBeijing 100081China Nordita Stockholm UniversityRoslagstullsbacken 23SE-10691 StockholmSweden

Proteins are important biological molecules whose structures are closely related to their specific functions. Understanding how the protein folds under physical principles, known as the protein folding problem, is one of the main tasks in modern biophysics. Coarse-grained methods play an increasingly important role in the simulation of protein folding, especially for large proteins. In recent years, we proposed a novel coarse-grained method derived from the topological soliton model, in terms of the backbone Cα chain. In this review, we will first systematically address the theoretical method of topological soliton. Then some successful applications will be displayed, including the thermodynamics simulation of protein folding, the property analysis of dynamic conformations, and the multi-scale simulation scheme. Finally, we will give a perspective on the development and application of topological soliton.

关键词： protein folding coarse-grained method Landau free energy function topological soliton

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我国特岗教师职业发展现状——基于Citespace的知识图谱分析

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教育实践与研究 2024年第18期 11-13页

作者：李静马文宣河北省教育科学研究院河北石家庄050061 石家庄市第23中学河北石家庄050041

特岗教师作为我国教育事业的重要力量,其职业发展状况对于提高教育质量、促进教育公平具有重要意义。研究基于Citespace软件,对特岗教师相关文献进行了知识图谱分析,旨在揭示我国特岗教师职业发展的现状、研究热点及趋势,为特岗教师的... 详细信息

特岗教师作为我国教育事业的重要力量,其职业发展状况对于提高教育质量、促进教育公平具有重要意义。研究基于Citespace软件,对特岗教师相关文献进行了知识图谱分析,旨在揭示我国特岗教师职业发展的现状、研究热点及趋势,为特岗教师的职业发展提供理论支持和实践指导。通过系统梳理相关文献,研究发现特岗教师职业发展存在一定的挑战和机遇,同时指出未来研究方向应更加关注特岗教师的职业发展路径和支持体系建设。

关键词：特岗教师职业发展 Citespace 知识图谱分析

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Rare earth silicates as gain media for silicon photonics [Invited]

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Photonics Research 2014年第3期2卷 S0045-S0055页

作者： Hideo Isshiki Fangli Jing Takuya Sato Takayuki Nakajima Tadamasa Kimura Department of Engineering Science The University of Electro-Communications182-8585 TokyoJapan

Er_(x)Y_(2−x)SiO_(5) and Er_(x)Yb_(y)Y_(2−x−y)SiO_(5) crystalline thin films were investigated to apply to the high-gain media for silicon *** addition to the sol–gel method,the directed self-assembly approach,using layer-by-layer deposition techniques,was also introduced to improve the *** relaxation processes in Er ions were discussed to clarify the contribution of the energy transfer and cooperative *** optimization of the Er content,a Si photonic crystal slot Er_(x)Y_(2−x)SiO_(5) waveguide amplifier was fabricated,and a 30 dB∕cm modal gain was *** achievement demonstrates the potential for compact and high optical gain devices on Si chips.

关键词： amplifier waveguide media

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Usefulness of magnifying endoscopy in post-endoscopic resection scar for early gastric neoplasm:A prospective short-term follow-up endoscopy study

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World Journal of Gastroenterology 2009年第3期15卷 349-355页

作者： Tae Hoon Lee Il-Kwun Chung Ji-Young Park Chang Kyun Lee Suck-Ho Lee Hong Soo Kim Sang-Heum Park Sun-Joo Kim Hyun-Deuk Cho Young Hwangbo Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineCheonan Hospital23-20 Bongmyung-dongCheonan330-721South Korea Department of Pathology Soonchunhyang University College of MedicineCheonan Hospital23-20 Bongmyung-dongCheonan330-721South Korea Department of Preventive Medicine Soonchunhyang University College of MedicineCheonan Hospital23-20 Bongmyung-dongCheonan330-721South Korea

AIM： To investigate the relationship between postendoscopic resection （ER） scars on magnifying endoscopy （ME） and the pathological diagnosis in order to validate the clinical significance of ME. METHODS： From January, 2007 to June, 2008, 124 patients with 129 post-ER scar lesions were enrolled. Mucosal pit patterns on ME were compared with conventional endoscopy （CE） findings and histological results obtained from targeted biopsies. RESULTS： CE findings showed nodular scars （53/129）, erythematous scars （85/129）, and ulcerative scars （4/129）. The post-ER scars were classified into four pit patterns of sulci and ridges on ME：（ Ⅰ ） 47 round; （Ⅱ） 54 short rod or tubular; （Ⅲ） 19 branched or gyrus-like;and （Ⅳ） 9 destroyed pits. Sensitivity and specificity were 88.9% and 62.5%, respectively, by the presence of nodularity on CE. Erythematous lesions were high sensitivity （100%）, but specificity was as low as 36.7%. The range of the positive predictive va ue （PPV） on CE was as low as 10.6%-25%. Nine type N pit patterns were diagnosed as tumor lesions, and 120 cases of type Ⅰ-Ⅲ pit patterns revealed non-neoplastic lesions. Thus, the sensitivity, specificity, and the PPV of ME were 100%. CONCLUSION： ME findings can detect the presence of tumor in post-ER scar lesions, and make evident the biopsy target site in short-term follow-up. Further large-scale and long-term studies are needed to determine whether ME can replace endoscopic biopsy.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Magnifying endoscopy Pitpattern Scar

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Isotopic Ages of the Penglai Group in the Jiaobei Belt and Their Geotectonic Implications

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Acta Geologica Sinica(English Edition) 1994年第4期68卷 417-433页

作者： W.R.Fitches C.J.N.Fletcher Institute of Earth Studies University College of WalesAberystwythSY23 3D B U KBritish Geological SurveyAberystwythSY 23 4BYU K

The Penglai Group in the Jiaobei Belt is the only remaining cover of the Archaean to Early Proterozoic crystalline basement in eastern Shandong. The ages of deposition of the Penglai Group and of its deformation and metamorphism have long been a subject of speculation. Whole-rock Rb-Sr ages, illite-whole-rock pair Rb-Sr ages and illite K-Ar ages recently obtained from the Penglai Group slates are reported and interpreted in this paper. On the basis of structural and metamorphic studies coupled with analyses of illite crystallinity, XRD and SEM , a whole-rock age of 473±32 Ma (Ordovician) is interpreted as the time of termination of burial metamorphism experienced by the Penglai Group. Therefore, the age of the Penghai Group is older than Ordovician. The first-phase folding and syntectonic low greenschist facies metamorphism in the Penglai Group, i.e. the Penglai Movement, took place before 299±4 Ma B.P., i.e in the Late Carboniferous. The Penglai Movement that occurred in the Jiaobei Belt on the southern margin of the North China Plate is attributed to collision between the North China and Yangtze plates along the Jiaonan Collision Belt. This demonstrates that the continent-continent collision between the North China and Yangtze plates east of the Tan-Lu Fault Zone took place in the Late Carboniferous. The collision caused N-S compression and deformation in the southern margin belt of the North China Plate north of the Qinling-Dabieshan-Jiaonan Collision Belt.

关键词： illite age Jiaobei Belt North China Plate Yangtze Plate plate collision

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Barriers and facilitators to participating in cardiac rehabilitation and physical activity:A cross-sectional survey

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World Journal of Cardiology 2022年第2期14卷 83-95页

作者： Matthew James Fraser Stephen J Leslie Trish Gorely Emma Foster Ronie Walters Division of Biomedical Science University of the Highlands and IslandsInverness IV23JHUnited Kingdom Department of Cardiology NHS HighlandInverness IV23UJUnited Kingdom Department of Nursing and Midwifery University of the Highlands and IslandsInverness IV23JHUnited Kingdom Cardiac Unit NHSH NHS HighlandInverness IV23JHUnited Kingdom

BACKGROUND Cardiovascular diseases(CVD)have been shown to be the greatest cause of death worldwide and rates continue to *** is recommended that CVD patients attend cardiac rehabilitation(CR)following a cardiac event to reduce mortality,improve recovery and positively influence behaviour around CVD risk *** the recognised benefits and international recommendations for exercisebased CR,uptake and attendance remain suboptimal.A greater understanding of CR barriers and facilitators is required,not least to inform service *** understanding current cardiac patients’attitudes and opinions around CR and physical activity(PA)could inform patient-led ***,through understanding aspects of CR and PA that participants like/dislike could provide healthcare providers and policy makers with information around what elements to target in the *** To investigate participants’attitudes and opinions around CR and *** This study employed a cross-sectional survey design on 567 cardiac *** patients who were referred for standard CR classes at a hospital in the Scottish Highlands,from May 2016 to May 2017 were *** part of a larger survey,the current study analysed the free-text responses to 5 open-ended questions included within the wider *** were related to the participants’experience of CR,reasons for non-attendance,ideas to increase attendance and their opinions on *** data were analysed using a 6-step,reflexive thematic *** Two main topic areas were explored:“Cardiac rehabilitation experience”and“physical activity”.Self-efficacy was increased as a result of attending CR due to exercising with similar individuals and the safe environment *** ranged from age and health to distance and starting times of the classes which increased travel time and ***,responses demonstrated a lack of information and communication around the *** h

关键词： Cardiovascular disease Cardiac rehabilitation Physical activity Barriers Facilitators Patient experience

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Dynamic Modeling of a Roller Chain Drive System Considering the Flexibility of Input Shaft

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Chinese Journal of Mechanical Engineering 2010年第3期23卷 367-374页

作者： XU Lixin YANG Yuhu1 CHANG Zongyu LIU Jianping School of Mechanical Engineering Tianjin University 23anjin 300072 China College of Engineering Ocean University of China Qingdao 266100 China

Roller chain drives are widely used in various high-speed, high-load and power transmission applications, but their complex dynamic behavior is not well researched. Most studies were only focused on the analysis of the vibration of chain tight span, and in these models, many factors are neglected. In this paper, a mathematical model is developed to calculate the dynamic response of a roller chain drive working at constant or variable speed condition. In the model, the complete chain transmission with two sprockets and the necessary tight and slack spans is used. The effect of the flexibility of input shaft on dynamic response of the chain system is taken into account, as well as the elastic deformation in the chain, the inertial forces, the gravity and the torque on driven shaft. The nonlinear equations of movement are derived from using Lagrange equations and solved numerically. Given the center distance and the two initial position angles of teeth on driving and driven sprockets corresponding to the first seating roller on each side of the tight span, dynamics of any roller chain drive with two sprockets and two spans can be analyzed by the procedure. Finally, a numerical example is given and the validity of the procedure developed is demonstrated by analyzing the dynamic behavior of a typical roller chain drive. The model can well simulate the transverse and longitudinal vibration of the chain spans and the torsional vibration of the sprockets. This study can provide an effective method for the analysis of the dynamic characteristics of all the chain drive systems.

关键词： roller chain dynamic modeling Lagrange equations

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